Gregory David Sempowski, PhD

Professor in Medicine
Professor of Pathology
Affiliate, Duke Global Health Institute
Member of the Duke Human Vaccine Institute
Campus mail 909 S. Lasalle St, Rm 1019 Global Health Research Building,, Durham, NC 27705
Phone (919) 684-4386
Email address greg.sempowski@duke.edu

Dr. Sempowski earned his PhD in Immunology from the University of Rochester and was specifically trained in the areas of inflammation, wound healing, and host response (innate and adaptive).  Dr. Sempowski contributed substantially to the field of lung inflammation and fibrosis defining the roles of pulmonary fibroblast heterogeneity and CD40/CD40L signaling in regulating normal and pathogenic lung inflammation.  During his postdoctoral training with Dr. Barton F. Haynes at Duke University, Dr. Sempowski focused on human immunology and more specifically immune reconstitution in settings of immune deficiency.  This resulted in publication of seminal findings regarding the cellular and molecular mechanisms that drive attenuation of immune function in the elderly. 

Since joining the Duke School of Medicine faculty in 2000, Dr. Sempowski has developed an independent research program studying immune deficiency associated with aging and radiation exposure. Dr. Sempowski is highly collaborative and works closely with investigators across the US, Europe, Australia and Japan and is internationally recognized as a thought leader in thymic aging, immunosenescence and multiplex biomarker analysis.

In 2017 Dr. Sempowski assumed Directorship of the Duke Global Health Research Building, a division of the Duke Human Vaccine Institute.  This state-of-the-art Regional Biocontainment Laboratory (RBL) was built with funding from the NIH to support basic research to develop drugs, diagnostics and vaccines for emerging/reemerging infections and biodefense.  The Duke RBL has a comprehensive safety and operations program to provide the Duke and RTP communities biocontainment facilities for BSL2, BSL3, and Select Agent research.  The facility is home to a portfolio of sponsored research programs focused on biosafety and biopreparedness, vaccine and therapeutic development, host response and immune monitoring and assay proficiency and quality assurance. 

Education and Training

  • Ph.D., University of Rochester, 1996

Publications

Xiao, Shiyun, Ivo D. Shterev, Wen Zhang, Lauren Young, Jae-Hung Shieh, Malcolm Moore, Marcel van den Brink, Gregory D. Sempowski, and Nancy R. Manley. “Sublethal Total Body Irradiation Causes Long-Term Deficits in Thymus Function by Reducing Lymphoid Progenitors.” J Immunol 199, no. 8 (October 15, 2017): 2701–12. https://doi.org/10.4049/jimmunol.1600934.

PMID
28931604
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Jin, Cong, Christopher P. Shelburne, Guojie Li, Erin N. Potts, Kristina J. Riebe, Gregory D. Sempowski, W Michael Foster, and Soman N. Abraham. “Particulate allergens potentiate allergic asthma in mice through sustained IgE-mediated mast cell activation.” J Clin Invest 127, no. 10 (October 2, 2017): 3913. https://doi.org/10.1172/JCI97321.

PMID
28920926
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Netzer, Christoph, Tilo Knape, Laura Kuchler, Andreas Weigert, Kai Zacharowski, Waltraud Pfeilschifter, Gregory Sempowski, Michael J. Parnham, Bernhard Brüne, and Andreas von Knethen. “Apoptotic Diminution of Immature Single and Double Positive Thymocyte Subpopulations Contributes to Thymus Involution During Murine Polymicrobial Sepsis.” Shock 48, no. 2 (August 2017): 215–26. https://doi.org/10.1097/SHK.0000000000000842.

PMID
28708784
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Ito, Reiko, Laura P. Hale, Susan M. Geyer, Jie Li, Andrew Sornborger, Junko Kajimura, Yoichiro Kusunoki, et al. “Late Effects of Exposure to Ionizing Radiation and Age on Human Thymus Morphology and Function.” Radiat Res 187, no. 5 (May 2017): 589–98. https://doi.org/10.1667/RR4554.1.

PMID
28319462
Full Text

Linz, Brandon M. L., Crystal J. Neely, Laurel B. Kartchner, April E. Mendoza, Amal L. Khoury, Agnieszka Truax, Gregory Sempowski, et al. “Innate Immune Cell Recovery Is Positively Regulated by NLRP12 during Emergency Hematopoiesis.” J Immunol 198, no. 6 (March 15, 2017): 2426–33. https://doi.org/10.4049/jimmunol.1601048.

PMID
28159904
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Linz, Brandon M. L., Crystal J. Neely, Laurel B. Kartchner, April E. Mendoza, Amal L. Khoury, Agnieszka Truax, Gregory Sempowski, et al. “Innate Immune Cell Recovery Is Positively Regulated by NLRP12 during Emergency Hematopoiesis.” Journal of Immunology 198, no. 6 (March 15, 2017): 2426–33. https://doi.org/10.4049/j.immunol.1601048.

Full Text

Pardi, Norbert, Michael J. Hogan, Rebecca S. Pelc, Hiromi Muramatsu, Hanne Andersen, Christina R. DeMaso, Kimberly A. Dowd, et al. “Zika virus protection by a single low-dose nucleoside-modified mRNA vaccination.” Nature 543, no. 7644 (March 2017): 248–51. https://doi.org/10.1038/nature21428.

PMID
28151488
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Thome, Joseph J. C., Boris Grinshpun, Brahma V. Kumar, Masa Kubota, Yoshiaki Ohmura, Harvey Lerner, Gregory D. Sempowski, Yufeng Shen, and Donna L. Farber. “Longterm maintenance of human naive T cells through in situ homeostasis in lymphoid tissue sites.” Sci Immunol 1, no. 6 (December 2016). https://doi.org/10.1126/sciimmunol.aah6506.

PMID
28361127
Full Text

Kajimura, J., H. E. Lynch, S. Geyer, M. Yamaoka, I. Shterev, S. Kyoizumi, G. D. Sempowski, K. Nakachi, and Y. Kusunoki. “Effect of past radiation exposure on the circulating dendritic cell populations in A-bomb survivors.” In European Journal of Immunology, 46:945–945. WILEY-BLACKWELL, 2016.

Scholars@Duke

Jones, Dorothy I., Charles E. McGee, Christopher J. Sample, Gregory D. Sempowski, David J. Pickup, and Herman F. Staats. “Modified Vaccinia Ankara Virus Vaccination Provides Long-Term Protection against Nasal Rabbitpox Virus Challenge.” Clin Vaccine Immunol 23, no. 7 (July 2016): 648–51. https://doi.org/10.1128/CVI.00216-16.

PMID
27146001
Full Text

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