Harvey Jay Cohen, MD

Professor of Medicine
Walter Kempner Distinguished Professor of Medicine, in the School of Medicine
Emeritus Director, Center for the Study of Aging & Human Development
Faculty Research Scholar of DuPRI's Center for Population Health & Aging
Member of the Duke Cancer Institute
Campus mail 2509 Blue Zone Duke Clinic, Center for Aging, Trent Drive, Durham, NC 27710
Phone (919) 660-7503
Email address harvey.cohen@duke.edu

Dr. Cohen's research program includes clinical research relating to aspects of the pathways to functional decline and reilience with aging, geriatric assessment, and cancer and anemia in the elderly.

Pathways to functional decline are being explored through the NIA funded Claude Pepper Older Americans Independence Center, and includes studies of the contributions of age related physiologic change, in particular changes in inflammatory parameters, comorbid diseases and conditions, environment, genetics, and the interactionas among them. Data are derived from several current studies as well as previously collected data sets from the Established Populations for Epidemiologic Studies of the Elderly (EPESE), National Long Term Care Survey, and the Chinese Longevity Study (with Dr. Zeng Yi). Previous work has demonstrated the important contributions of age related inflammation and coagulation activation to functional status. He is Co-PI of the Pepper Center Physical Performance Across the LifeSpan (PALS) study, which is a longitudinal cohort study of community dwelling adults from age 30-90+and includes functional measures and biomarkers on inflammation and metabolism.
 
Geriatric assessment approaches have been studied in a number of randomized and controlled studies and work is now concentrating on the application of Comprehensive Geriatric Assessment tools to the evaluation and treatment of elderly patients with cancer. This is an extension and continuation of a long standing interest in geriatric oncology. Previous studies have elucidated age-related patterns of disease presentation, treatment approaches, clinical trials, survivorship, quality of life, impact of comrobidities and functional outcomes. Dr. Cohen was co-chair, and now member of the Cancer in the Older Adult Committee of the Alliance for Clinical Trials in Oncology (ALLIANCE). A number of active studies and ongoing data bases aree being utilized to address these questions.

Anemia in the older adult is being addressed through an NIA funded U01 consortium (Dr. Cohen Co-PI). the current main study is an observational study followed by a pragmatic treatment trial for anemia in older adults with CHF, in collaboration with the Cardiovascular Research Network (CVRN) of the Health services research network (HSRN) 

Education and Training

  • M.D., State University of New York, Brooklyn, 1965

Publications

Sedrak, Mina S., Canlan Sun, Hyman Muss, Rachel A. Freedman, Allison Magnuson, Cary P. Gross, William P. Tew, et al. “Inflammation and coagulation biomarkers associated with physical resilience in older women receiving chemotherapy for early breast cancer.” In Cancer Research, Vol. 81, 2021.

Scholars@Duke

Huang, Qianyang, Shiying Hao, Xiaoming Yao, Jin You, Xiao Li, Donghai Lai, Chunle Han, et al. “High-throughput quantitation of serological ceramides/dihydroceramides by LC/MS/MS: Pregnancy baseline biomarkers and potential metabolic messengers.” J Pharm Biomed Anal 192 (January 5, 2021): 113639. https://doi.org/10.1016/j.jpba.2020.113639.

PMID
33017796
Full Text

Sedrak, Mina S., Rachel A. Freedman, Harvey J. Cohen, Hyman B. Muss, Aminah Jatoi, Heidi D. Klepin, Tanya M. Wildes, et al. “Older adult participation in cancer clinical trials: A systematic review of barriers and interventions.” Ca Cancer J Clin 71, no. 1 (January 2021): 78–92. https://doi.org/10.3322/caac.21638.

PMID
33002206
Full Text

Sylvester, Karl G., Shiying Hao, Jin You, Le Zheng, Lu Tian, Xiaoming Yao, Lihong Mo, et al. “Maternal metabolic profiling to assess fetal gestational age and predict preterm delivery: a two-centre retrospective cohort study in the US.” Bmj Open 10, no. 12 (December 2, 2020): e040647. https://doi.org/10.1136/bmjopen-2020-040647.

PMID
33268420
Full Text

Artz, Andrew S., Alisa J. Stephens-Shields, Shalender Bhasin, Susan S. Ellenberg, Harvey J. Cohen, and Peter J. Snyder. “Markers of Iron Flux during Testosterone-Mediated Erythropoiesis in Older Men with Unexplained or Iron-Deficiency Anemia.” J Clin Endocrinol Metab 105, no. 11 (November 1, 2020). https://doi.org/10.1210/clinem/dgaa521.

PMID
32785689
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Bartlett, David B., Gloria Broadwater, Heidi K. White, Rebecca Shelby, Leah L. Zullig, Jessica Robertson, Ravindran Kanesvaran, Harvey Jay Cohen, and Gretchen Kimmick. “Factors associated with falls in older women with breast cancer: the use of a brief geriatric screening tool in clinic.” Breast Cancer Res Treat 184, no. 2 (November 2020): 445–57. https://doi.org/10.1007/s10549-020-05862-5.

PMID
32794062
Full Text

Parker, Daniel C., Bryce N. Bartlett, Harvey J. Cohen, Gerda Fillenbaum, Janet L. Huebner, Virginia Byers Kraus, Carl Pieper, and Daniel W. Belsky. “Association of Blood Chemistry Quantifications of Biological Aging With Disability and Mortality in Older Adults.” J Gerontol a Biol Sci Med Sci 75, no. 9 (September 16, 2020): 1671–79. https://doi.org/10.1093/gerona/glz219.

PMID
31693736
Full Text

Nobuhara, Chloe K., W Michael Bullock, Thomas Bunning, Brian Colin, Mary Cooter, Michael J. Devinney, Michael N. Ferrandino, et al. “A protocol to reduce self-reported pain scores and adverse events following lumbar punctures in older adults.” J Neurol 267, no. 7 (July 2020): 2002–6. https://doi.org/10.1007/s00415-020-09797-1.

PMID
32198714
Full Text

Ambrosy, Andrew P., Jesse K. Fitzpatrick, Grace H. Tabada, Jerry H. Gurwitz, Andrew Artz, Stanley L. Schrier, Sunil V. Rao, et al. “A reduced transferrin saturation is independently associated with excess morbidity and mortality in older adults with heart failure and incident anemia.” Int J Cardiol 309 (June 15, 2020): 95–99. https://doi.org/10.1016/j.ijcard.2020.03.020.

PMID
32201101
Full Text

Kobayashi, Lindsay C., Harvey Jay Cohen, Wanting Zhai, Xingtao Zhou, Brent J. Small, George Luta, Arti Hurria, et al. “Cognitive function prior to systemic therapy and subsequent well-being in older breast cancer survivors: Longitudinal findings from the Thinking and Living with Cancer Study.” Psychooncology 29, no. 6 (June 2020): 1051–59. https://doi.org/10.1002/pon.5376.

PMID
32154959
Full Text

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