Herbert Ira Hurwitz, MD

Adjunct Professor in the Department of Medicine
Campus mail 439 Seeley-mudd Bldg, 10 Bryan Searle Drive, Duke University M, Durham, NC 27710
Phone (919) 681-6006
Email address hurwi004@mc.duke.edu

Particular Clinical Interests and Skills: Phase I clinical trials involving new anti cancer drugs; drug combinations; and combinations of new drugs with radiation; cancers of the GI system

Education and Training

  • Clinical Oncology Fellow, Medicine, Johns Hopkins University, 1992 - 1996
  • Medical Resident, Medicine, Michael Reese Hospital & Medical Center, 1988 - 1991
  • M.D., Thomas Jefferson University, 1988

Publications

Chan, E, Chiorean, EG, O Dwyer, PJ, Gabrail, NY, Alcindor, T, Potvin, D, Chao, R, and Hurwitz, H. "Phase I/II study of mocetinostat in combination with gemcitabine for patients with advanced pancreatic cancer and other advanced solid tumors." Cancer Chemotherapy and Pharmacology 81, no. 2 (February 1, 2018): 355-364.

Full Text

Grothey, A, Strosberg, JR, Renfro, LA, Hurwitz, HI, Marshall, JL, Safran, H, Guarino, MJ, Kim, GP, Hecht, JR, Weil, SC, Heyburn, J, Wang, W, Schweizer, C, O'Shannessy, DJ, and Diaz, LA. "A Randomized, Double-Blind, Placebo-Controlled Phase II Study of the Efficacy and Safety of Monotherapy Ontuxizumab (MORAb-004) Plus Best Supportive Care in Patients with Chemorefractory Metastatic Colorectal Cancer." Clinical cancer research : an official journal of the American Association for Cancer Research 24, no. 2 (January 2018): 316-325.

PMID
29084918
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Duan, B, Hu, J, Liu, H, Wang, Y, Li, H, Liu, S, Xie, J, Owzar, K, Abbruzzese, J, Hurwitz, H, Gao, H, and Wei, Q. "Genetic variants in the platelet-derived growth factor subunit B gene associated with pancreatic cancer risk." International journal of cancer (November 23, 2017).

PMID
29168174
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Ronald, J, Nixon, AB, Marin, D, Gupta, RT, Janas, G, Chen, W, Suhocki, PV, Pabon-Ramos, W, Sopko, DR, Starr, MD, Brady, JC, Hurwitz, HI, and Kim, CY. "Pilot Evaluation of Angiogenesis Signaling Factor Response after Transcatheter Arterial Embolization for Hepatocellular Carcinoma." Radiology 285, no. 1 (October 2017): 311-318.

PMID
28787261
Full Text

Renfro, LA, Goldberg, RM, Grothey, A, Sobrero, A, Adams, R, Seymour, MT, Heinemann, V, Schmoll, H-J, Douillard, J-Y, Hurwitz, H, Fuchs, CS, Diaz-Rubio, E, Porschen, R, Tournigand, C, Chibaudel, B, Hoff, PM, Kabbinavar, FF, Falcone, A, Tebbutt, NC, Punt, CJA, Hecht, JR, Souglakos, J, Bokemeyer, C, Van Cutsem, E, Saltz, L, de Gramont, A, Sargent, DJ, and ARCAD Clinical Trials Program, . "Clinical Calculator for Early Mortality in Metastatic Colorectal Cancer: An Analysis of Patients From 28 Clinical Trials in the Aide et Recherche en Cancérologie Digestive Database." Journal of clinical oncology : official journal of the American Society of Clinical Oncology 35, no. 17 (June 2017): 1929-1937.

PMID
28414610
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García-Carbonero, R, van Cutsem, E, Rivera, F, Jassem, J, Gore, I, Tebbutt, N, Braiteh, F, Argiles, G, Wainberg, ZA, Funke, R, Anderson, M, McCall, B, Stroh, M, Wakshull, E, Hegde, P, Ye, W, Chen, D, Chang, I, Rhee, I, and Hurwitz, H. "Randomized Phase II Trial of Parsatuzumab (Anti-EGFL7) or Placebo in Combination with FOLFOX and Bevacizumab for First-Line Metastatic Colorectal Cancer." The oncologist 22, no. 4 (April 2017): 375-e30.

PMID
28275117
Full Text

Riedel, RF, Meadows, KL, Lee, PH, Morse, MA, Uronis, HE, Blobe, GC, George, DJ, Crawford, J, Niedzwiecki, D, Rushing, CN, Arrowood, CC, and Hurwitz, HI. "Phase I study of pazopanib plus TH-302 in advanced solid tumors." Cancer chemotherapy and pharmacology 79, no. 3 (March 2017): 611-619.

PMID
28238078
Full Text

Langman, EL, Suhocki, PV, Hurwitz, HI, Morse, MA, Burbridge, RA, Smith, TP, and Kim, CY. "Percutaneous biliary drainage catheter insertion in patients with extensive hepatic metastatic tumor burden." Journal of gastrointestinal oncology 7, no. 6 (December 2016): 875-881.

PMID
28078111
Full Text

Hatch, AJ, Sibley, AB, Starr, MD, Brady, JC, Jiang, C, Jia, J, Bowers, DL, Pang, H, Owzar, K, Niedzwiecki, D, Innocenti, F, Venook, AP, Hurwitz, HI, Nixon, AB, and Alliance for Clinical Trials in Oncology, . "Blood-based markers of efficacy and resistance to cetuximab treatment in metastatic colorectal cancer: results from CALGB 80203 (Alliance)." Cancer medicine 5, no. 9 (September 2016): 2249-2260.

PMID
27465221
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Zhang, T, Boominathan, R, Foulk, B, Rao, C, Kemeny, G, Strickler, JH, Abbruzzese, JL, Harrison, MR, Hsu, DS, Healy, P, Li, J, Pi, C, Prendergast, KM, Hobbs, C, Gemberling, S, George, DJ, Hurwitz, HI, Connelly, M, Garcia-Blanco, MA, and Armstrong, AJ. "Development of a Novel c-MET-Based CTC Detection Platform." Molecular cancer research : MCR 14, no. 6 (June 2016): 539-547.

PMID
26951228
Full Text

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