Herbert Ira Hurwitz, MD

Adjunct Professor in the Department of Medicine
Campus mail 439 Seeley-Mudd Bldg, 10 Bryan Searle Drive, Duke University M, Durham, NC 27710
Phone (919) 681-6006
Email address hurwi004@mc.duke.edu

Particular Clinical Interests and Skills: Phase I clinical trials involving new anti cancer drugs; drug combinations; and combinations of new drugs with radiation; cancers of the GI system

Education and Training

  • Clinical Oncology Fellow, Medicine, Johns Hopkins University, 1992 - 1996
  • Medical Resident, Medicine, Michael Reese Hospital & Medical Center, 1988 - 1991
  • M.D., Thomas Jefferson University, 1988

Publications

Liu, Y, Starr, MD, Brady, JC, Rushing, C, Pang, H, Adams, B, Alvarez, D, Theuer, CP, Hurwitz, HI, and Nixon, AB. "Modulation of Circulating Protein Biomarkers in Cancer Patients Receiving Bevacizumab and the Anti-Endoglin Antibody, TRC105." Molecular Cancer Therapeutics 17, no. 10 (October 2018): 2248-2256.

PMID
29997150
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Hurwitz, H, Van Cutsem, E, Bendell, J, Hidalgo, M, Li, C-P, Salvo, MG, Macarulla, T, Sahai, V, Sama, A, Greeno, E, Yu, KH, Verslype, C, Dawkins, F, Walker, C, Clark, J, and O'Reilly, EM. "Ruxolitinib + capecitabine in advanced/metastatic pancreatic cancer after disease progression/intolerance to first-line therapy: JANUS 1 and 2 randomized phase III studies." Investigational New Drugs 36, no. 4 (August 2018): 683-695.

PMID
29508247
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Vlahovic, G, Meadows, KL, Hatch, AJ, Jia, J, Nixon, AB, Uronis, HE, Morse, MA, Selim, MA, Crawford, J, Riedel, RF, Zafar, SY, Howard, LA, O'Neill, M, Meadows, JJ, Haley, ST, Arrowood, CC, Rushing, C, Pang, H, and Hurwitz, HI. "A Phase I Trial of the IGF-1R Antibody Ganitumab (AMG 479) in Combination with Everolimus (RAD001) and Panitumumab in Patients with Advanced Cancer." The Oncologist 23, no. 7 (July 2018): 782-790.

PMID
29572245
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Sjoquist, KM, Renfro, LA, Simes, RJ, Tebbutt, NC, Clarke, S, Seymour, MT, Adams, R, Maughan, TS, Saltz, L, Goldberg, RM, Schmoll, H-J, Van Cutsem, E, Douillard, J-Y, Hoff, PM, Hecht, JR, Tournigand, C, Punt, CJA, Koopman, M, Hurwitz, H, Heinemann, V, Falcone, A, Porschen, R, Fuchs, C, Diaz-Rubio, E, Aranda, E, Bokemeyer, C, Souglakos, I, Kabbinavar, FF, Chibaudel, B, Meyers, JP, Sargent, DJ, de Gramont, A, Zalcberg, JR, and Fondation Aide et Recherche en Cancerologie Digestive Group (ARCAD), . "Personalizing Survival Predictions in Advanced Colorectal Cancer: The ARCAD Nomogram Project." Journal of the National Cancer Institute 110, no. 6 (June 2018): 638-648.

PMID
29267900
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Hainsworth, JD, Meric-Bernstam, F, Swanton, C, Hurwitz, H, Spigel, DR, Sweeney, C, Burris, H, Bose, R, Yoo, B, Stein, A, Beattie, M, and Kurzrock, R. "Reply to J.J. Tao et al." Journal of Clinical Oncology (June 2018): JCO.2018.78.639-JCO.2018.78.639.

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Siena, S, Sartore-Bianchi, A, Marsoni, S, Hurwitz, HI, McCall, SJ, Penault-Llorca, F, Srock, S, Bardelli, A, and Trusolino, L. "Targeting the human epidermal growth factor receptor 2 (HER2) oncogene in colorectal cancer." Annals of Oncology : Official Journal of the European Society for Medical Oncology 29, no. 5 (May 2018): 1108-1119.

PMID
29659677
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Berlin, J, Ramanathan, RK, Strickler, JH, Subramaniam, DS, Marshall, J, Kang, Y-K, Hetman, R, Dudley, MW, Zeng, J, Nickner, C, Xiong, H, Komarnitsky, P, Shepherd, SP, Hurwitz, H, and Lenz, H-J. "A phase 1 dose-escalation study of veliparib with bimonthly FOLFIRI in patients with advanced solid tumours." April 2018.

PMID
29527010
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Seligmann, JF, Hatch, AJ, Richman, SD, Elliott, F, Jacobs, B, Brown, S, Hurwitz, H, Barrett, JH, Quirke, P, Nixon, AB, and Seymour, MT. "Association of Tumor HER3 Messenger RNA Expression With Panitumumab Efficacy in Advanced Colorectal Cancer." Jama Oncology 4, no. 4 (April 2018): 564-568.

PMID
29075780
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Duan, B, Hu, J, Liu, H, Wang, Y, Li, H, Liu, S, Xie, J, Owzar, K, Abbruzzese, J, Hurwitz, H, Gao, H, and Wei, Q. "Genetic variants in the platelet-derived growth factor subunit B gene associated with pancreatic cancer risk." International Journal of Cancer 142, no. 7 (April 2018): 1322-1331.

PMID
29168174
Full Text

Hainsworth, JD, Meric-Bernstam, F, Swanton, C, Hurwitz, H, Spigel, DR, Sweeney, C, Burris, H, Bose, R, Yoo, B, Stein, A, Beattie, M, and Kurzrock, R. "Targeted Therapy for Advanced Solid Tumors on the Basis of Molecular Profiles: Results From MyPathway, an Open-Label, Phase IIa Multiple Basket Study." February 20, 2018.

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