Howard Allan Rockman, MD

Professor of Medicine
Edward S. Orgain Professor of Cardiology, in the School of Medicine
Professor in Molecular Genetics and Microbiology
Professor in Cell Biology
Campus mail 226 Clin Res Lab Bldg, Durham, NC 27710
Phone (919) 668-2520
Email address h.rockman@duke.edu

Rockman Lab: Molecular Mechanisms of Hypertrophy and Heart Failure

Overall Research Direction: The major focus of this laboratory is to understand the molecular mechanisms of hypertrophy and heart failure. My laboratory uses a strategy that combines state of the art molecular techniques to generate transgenic and gene targeted mouse models, combined with sophisticated physiologic measures of in vivo cardiac function. In this manner, candidate molecules are either selectively overexpressed in the mouse heart or ablated by homologous recombination, which is followed by an in-depth analysis of the physiological phenotype. To model human cardiac disease, we have created several models of cardiac overload in the mouse using both microsurgical techniques and genetic models of cardiac dysfunction.

Areas of Research
1) Signaling: G protein-coupled receptor signaling in hypertrophy and heart failure focusing on the concept of biased signaling of 7 transmembrane receptors.

2) Molecular physiology: In depth physiological analysis of cardiac function in genetically altered mice to understand the role of G protein-coupled receptor signaling pathways on the development of heart failure in vivo.

3) Deletion screens in Drosophila: To detect novel genes important for cardiac function in the adult fly .

Education and Training

  • Cardiology Fellow, Medicine, University of California at San Diego, 1987 - 1991
  • Medical Resident, Medicine, Montreal General Hospital, 1984 - 1987
  • M.D., McGill University (Canada), 1983

Publications

Salzler, HR, Griffiths, R, Ruiz, P, Chi, L, Frey, C, Marchuk, DA, Rockman, HA, and Le, TH. "Hypertension and albuminuria in chronic kidney disease mapped to a mouse chromosome 11 locus." Kidney Int 72, no. 10 (November 2007): 1226-1232.

PMID
17851470
Full Text

Mohler, PJ, Healy, JA, Xue, H, Puca, AA, Kline, CF, Allingham, RR, Kranias, EG, Rockman, HA, and Bennett, V. "Ankyrin-B syndrome: enhanced cardiac function balanced by risk of cardiac death and premature senescence. (Published online)" PLoS One 2, no. 10 (October 17, 2007): e1051-.

PMID
17940615
Full Text

Noma, T, Lemaire, A, Naga Prasad, SV, Barki-Harrington, L, Tilley, DG, Chen, J, Le Corvoisier, P, Violin, JD, Wei, H, Lefkowitz, RJ, and Rockman, HA. "Beta-arrestin-mediated beta1-adrenergic receptor transactivation of the EGFR confers cardioprotection." J Clin Invest 117, no. 9 (September 2007): 2445-2458.

PMID
17786238
Full Text

Perrino, C, and Rockman, HA. "Reversal of cardiac remodeling by modulation of adrenergic receptors: a new frontier in heart failure." Curr Opin Cardiol 22, no. 5 (September 2007): 443-449. (Review)

PMID
17762546
Full Text

Badea, CT, Hedlund, LW, Mackel, JFB, Mao, L, Rockman, HA, and Johnson, GA. "Cardiac micro-computed tomography for morphological and functional phenotyping of muscle LIM protein null mice." Mol Imaging 6, no. 4 (July 2007): 261-268.

PMID
17711781
Scholars@Duke

Whalen, EJ, Foster, MW, Matsumoto, A, Ozawa, K, Violin, JD, Que, LG, Nelson, CD, Benhar, M, Keys, JR, Rockman, HA, Koch, WJ, Daaka, Y, Lefkowitz, RJ, and Stamler, JS. "Regulation of beta-adrenergic receptor signaling by S-nitrosylation of G-protein-coupled receptor kinase 2." Cell 129, no. 3 (May 4, 2007): 511-522.

PMID
17482545
Full Text

Salazar, NC, Chen, J, and Rockman, HA. "Cardiac GPCRs: GPCR signaling in healthy and failing hearts." Biochim Biophys Acta 1768, no. 4 (April 2007): 1006-1018. (Review)

PMID
17376402
Full Text

Donahue, MP, Marchuk, DA, and Rockman, HA. "Reply." Journal of the American College of Cardiology 49, no. 10 (2007): 1106-1107.

Full Text

Rajagopal, K, Whalen, EJ, Violin, JD, Stiber, JA, Rosenberg, PB, Premont, RT, Coffman, TM, Rockman, HA, and Lefkowitz, RJ. "Beta-arrestin2-mediated inotropic effects of the angiotensin II type 1A receptor in isolated cardiac myocytes." Proc Natl Acad Sci U S A 103, no. 44 (October 31, 2006): 16284-16289.

PMID
17060617
Full Text

Donahue, MP, Marchuk, DA, and Rockman, HA. "Redefining heart failure: the utility of genomics." J Am Coll Cardiol 48, no. 7 (October 3, 2006): 1289-1298. (Review)

PMID
17010784
Full Text

Pages