Howard Allan Rockman, MD

Professor of Medicine
Edward S. Orgain Professor of Cardiology, in the School of Medicine
Professor in Molecular Genetics and Microbiology
Professor in Cell Biology
Campus mail 226 Clin Res Lab Bldg, Durham, NC 27710
Phone (919) 668-2520
Email address h.rockman@duke.edu

Rockman Lab: Molecular Mechanisms of Hypertrophy and Heart Failure

Overall Research Direction: The major focus of this laboratory is to understand the molecular mechanisms of hypertrophy and heart failure. My laboratory uses a strategy that combines state of the art molecular techniques to generate transgenic and gene targeted mouse models, combined with sophisticated physiologic measures of in vivo cardiac function. In this manner, candidate molecules are either selectively overexpressed in the mouse heart or ablated by homologous recombination, which is followed by an in-depth analysis of the physiological phenotype. To model human cardiac disease, we have created several models of cardiac overload in the mouse using both microsurgical techniques and genetic models of cardiac dysfunction.

Areas of Research
1) Signaling: G protein-coupled receptor signaling in hypertrophy and heart failure focusing on the concept of biased signaling of 7 transmembrane receptors.

2) Molecular physiology: In depth physiological analysis of cardiac function in genetically altered mice to understand the role of G protein-coupled receptor signaling pathways on the development of heart failure in vivo.

3) Deletion screens in Drosophila: To detect novel genes important for cardiac function in the adult fly .

Education and Training

  • Cardiology Fellow, Medicine, University of California at San Diego, 1987 - 1991
  • Medical Resident, Medicine, Montreal General Hospital, 1984 - 1987
  • M.D., McGill University (Canada), 1983

Publications

Mehra, MR, Rockman, HA, and Greenberg, BH. "Highlights of the 2007 Scientific Meeting of the Heart Failure Society of America: Washington, DC, September 16-19, 2007." J Am Coll Cardiol 51, no. 3 (January 22, 2008): 320-327.

PMID
18206743
Full Text

Esposito, G, Perrino, C, Ozaki, T, Takaoka, H, Defer, N, Petretta, MP, De Angelis, MC, Mao, L, Hanoune, J, Rockman, HA, and Chiariello, M. "Increased myocardial contractility and enhanced exercise function in transgenic mice overexpressing either adenylyl cyclase 5 or 8." Basic Res Cardiol 103, no. 1 (January 2008): 22-30.

PMID
18034275
Full Text

Allikian, MJ, Bhabha, G, Dospoy, P, Heydemann, A, Ryder, P, Earley, JU, Wolf, MJ, Rockman, HA, and McNally, EM. "Reduced life span with heart and muscle dysfunction in Drosophila sarcoglycan mutants." Hum Mol Genet 16, no. 23 (December 1, 2007): 2933-2943.

PMID
17855453
Full Text

Chin, BB, Metzler, SD, Lemaire, A, Curcio, A, Vemulapalli, S, Greer, KL, Petry, NA, Turkington, TG, Coleman, RE, Rockman, H, and Jaszczak, RJ. "Left ventricular functional assessment in mice: feasibility of high spatial and temporal resolution ECG-gated blood pool SPECT." Radiology 245, no. 2 (November 2007): 440-448.

PMID
17940303
Full Text

Salzler, HR, Griffiths, R, Ruiz, P, Chi, L, Frey, C, Marchuk, DA, Rockman, HA, and Le, TH. "Hypertension and albuminuria in chronic kidney disease mapped to a mouse chromosome 11 locus." Kidney Int 72, no. 10 (November 2007): 1226-1232.

PMID
17851470
Full Text

Mohler, PJ, Healy, JA, Xue, H, Puca, AA, Kline, CF, Allingham, RR, Kranias, EG, Rockman, HA, and Bennett, V. "Ankyrin-B syndrome: enhanced cardiac function balanced by risk of cardiac death and premature senescence. (Published online)" PLoS One 2, no. 10 (October 17, 2007): e1051-.

PMID
17940615
Full Text

Noma, T, Lemaire, A, Naga Prasad, SV, Barki-Harrington, L, Tilley, DG, Chen, J, Le Corvoisier, P, Violin, JD, Wei, H, Lefkowitz, RJ, and Rockman, HA. "Beta-arrestin-mediated beta1-adrenergic receptor transactivation of the EGFR confers cardioprotection." J Clin Invest 117, no. 9 (September 2007): 2445-2458.

PMID
17786238
Full Text

Perrino, C, and Rockman, HA. "Reversal of cardiac remodeling by modulation of adrenergic receptors: a new frontier in heart failure." Curr Opin Cardiol 22, no. 5 (September 2007): 443-449. (Review)

PMID
17762546
Full Text

Badea, CT, Hedlund, LW, Mackel, JFB, Mao, L, Rockman, HA, and Johnson, GA. "Cardiac micro-computed tomography for morphological and functional phenotyping of muscle LIM protein null mice." Mol Imaging 6, no. 4 (July 2007): 261-268.

PMID
17711781
Scholars@Duke

Whalen, EJ, Foster, MW, Matsumoto, A, Ozawa, K, Violin, JD, Que, LG, Nelson, CD, Benhar, M, Keys, JR, Rockman, HA, Koch, WJ, Daaka, Y, Lefkowitz, RJ, and Stamler, JS. "Regulation of beta-adrenergic receptor signaling by S-nitrosylation of G-protein-coupled receptor kinase 2." Cell 129, no. 3 (May 4, 2007): 511-522.

PMID
17482545
Full Text

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