Ian James Welsby, MBBS

Professor of Anesthesiology
Professor of Medicine
Campus mail 2301 Erwin Road, 5691H Hafs Building, Durham, NC 27710
Phone (919) 681-6752
Email address ian.welsby@duke.edu

As a practicing cardiothoracic anesthesiologist, I have contributed to the better understanding of the management and of perioperative thrombosis (particularly HIT). This has been as a Duke site PI for the Rare Thrombotic Diseases Consortium led by Dr T.L Ortel and a clinical collaborator with the basic and translational science approach to HIT led by Dr G Arepally. I have also championed novel approaches to dealing with perioperative HIT such as plasmaperesis.

Similarly, I have been a local leader in establishing management of transfusion approaches to major cardiac surgery including the novel introduction of autologous plateletpheresis to limit exposure to allogeneic platelet transfusions in this highly transfused population, identifying the transfusion requirements during thoracic aortic reconstruction and promoting use of a lower dose of rFVIIa use in this population, changing established clinical practice.

My research interests focus on perioperative transfusion and hematology concerns. Recently, Dr Kor (Mayo Clinic) and I received a multiple PI R-01 award to evaluate point-of-care/bedside washing of packed red blood cells to reduce perioperative lung injury. This novel repurposing of commonly available “cell-saver” technology is, for most surgical cases, the only practical means of delivering a washed product, and promises to be a critical advancement in perioperative transfusion medicine. I also have a longstanding interest in the rejuvenation of RBCs to normalize oxygen delivery capacity of transfused RBCs. Such a development will be of tremendous importance to transfusion practice, particularly for highly transfused populations. 

In summary, I have dedicated my research career to improving the outcome of patients undergoing cardiothoracic surgery, understanding perioperative coagulopathy, and optimizing transfusion practice. 

Education and Training

  • Anaesthetic Registrar, Anaesthetics, Royal London Hospital (United Kingdom), 1995 - 1995
  • Anaesthetic registrar, Anaesthetic, Royal London Hospital (United Kingdom), 1994 - 1995
  • Temporary Registrar, Anaesthetics, Royal London Hospital (United Kingdom), 1993 - 1994
  • Senior House Officer, Anesthetics, Royal London Hospital (United Kingdom), 1992 - 1993
  • Senior House Officer, Intensive Care, Royal London Hospital (United Kingdom), 1992 - 1992
  • Senior House Officer, Accident And Emergency, Royal London Hospital (United Kingdom), 1991 - 1992
  • House Officer, General And Vascular Surgery, Royal London Hospital (United Kingdom), 1991 - 1991
  • House Officer, Chest And General Medicine, Royal London Hospital (United Kingdom), 1990 - 1991
  • Anaesthetic Registrar, Anaesthetics, Royal London Hospital (United Kingdom), 1990 - 1990
  • M.B.B.S., University College London (United Kingdom), 1990

Publications

Pollak, A. L., J. Poisson, M. Cooter, Y. D. Barac, B. Bryner, J. Haney, M. G. Hartwig, et al. “Effects of a Goal Directed Transfusion Protocol on Severe Primary Graft Dysfunction after Lung Transplantation.” In The Journal of Heart and Lung Transplantation : The Official Publication of the International Society for Heart Transplantation, 39:S330, 2020. https://doi.org/10.1016/j.healun.2020.01.349.

Full Text

Ansari, Andrea, Julien Cobert, Neelima Navuluri, George Cheng, John C. Haney, and Ian Welsby. “Intrapulmonary Activated Factor VII for Hemoptysis Complicating Pulmonary Thromboendarterectomy.” Ann Thorac Surg 109, no. 4 (April 2020): e243–45. https://doi.org/10.1016/j.athoracsur.2019.06.102.

PMID
31470015
Full Text

Sun, Gina H., Claudia Bruguera, Siavash Saadat, David Moss, Roman Schumann, Ian J. Welsby, Ethan Y. Brovman, and Frederick C. Cobey. “ABO Blood Group and Transfusions In the Intraoperative and Postoperative Period After LVAD Implantation.” J Cardiothorac Vasc Anesth 34, no. 4 (April 2020): 906–11. https://doi.org/10.1053/j.jvca.2019.09.015.

PMID
31590941
Full Text

Groves, Danja S., Ian J. Welsby, Bhiken I. Naik, Kenichi Tanaka, Jennifer N. Hauck, Charles S. Greenberg, Deborah A. Winegar, and Francesco Viola. “Multicenter Evaluation of the Quantra QPlus System in Adult Patients Undergoing Major Surgical Procedures.” Anesth Analg 130, no. 4 (April 2020): 899–909. https://doi.org/10.1213/ANE.0000000000004659.

PMID
32032102
Full Text

Noubouossie, Denis F., Michael W. Henderson, Micah Mooberry, Anton Ilich, Patrick Ellsworth, Mark Piegore, Sarah C. Skinner, et al. “Red blood cell microvesicles activate the contact system, leading to factor IX activation via 2 independent pathways.” Blood 135, no. 10 (March 5, 2020): 755–65. https://doi.org/10.1182/blood.2019001643.

PMID
31971571
Full Text

Raphael, Jacob, C David Mazer, Andrew Wilkey, Sudhakar Subramani, Andrew Schroeder, Mohamed Abdalla, Renata Ferreira, et al. “Corrigendum to 'Society of Cardiovascular Anesthesiologists (SCA) Clinical Practice Improvement (CPI) Advisory for Management of Perioperative Bleeding and Hemostasis in Cardiac Surgery Patients' [Journal of Cardiothoracic and Vascular Anesthesia 33 (2019) 2887-2899].” J Cardiothorac Vasc Anesth 34, no. 3 (March 2020): 840–41. https://doi.org/10.1053/j.jvca.2019.11.004.

PMID
31759860
Full Text

Barac, Yaron D., Adam Nevo, Oliver Jawitz, Nazish K. Hashmi, Peter Henkel, Laura J. Blue, Joseph Kelly, et al. “Prothrombin Complex Concentrate Use in Durable and Short-Term Left Ventricular Assist Device Implantation.” Asaio J 66, no. 1 (January 2020): e8–10. https://doi.org/10.1097/MAT.0000000000000937.

PMID
30688689
Full Text

Raphael, Jacob, C David Mazer, Sudhakar Subramani, Andrew Schroeder, Mohamed Abdalla, Renata Ferreira, Philip E. Roman, et al. “Society of Cardiovascular Anesthesiologists Clinical Practice Improvement Advisory for Management of Perioperative Bleeding and Hemostasis in Cardiac Surgery Patients.” J Cardiothorac Vasc Anesth 33, no. 11 (November 2019): 2887–99. https://doi.org/10.1053/j.jvca.2019.04.003.

PMID
31604540
Full Text

Raphael, Jacob, C David Mazer, Sudhakar Subramani, Andrew Schroeder, Mohamed Abdalla, Renata Ferreira, Philip E. Roman, et al. “Society of Cardiovascular Anesthesiologists Clinical Practice Improvement Advisory for Management of Perioperative Bleeding and Hemostasis in Cardiac Surgery Patients.” Anesth Analg 129, no. 5 (November 2019): 1209–21. https://doi.org/10.1213/ANE.0000000000004355.

PMID
31613811
Full Text

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