Ian James Welsby, MBBS

Professor of Anesthesiology
Professor of Medicine
Campus mail 2301 Erwin Road, 5691H Hafs Building, Durham, NC 27710
Phone (919) 681-6752
Email address ian.welsby@duke.edu

As a practicing cardiothoracic anesthesiologist, I have contributed to the better understanding of the management and of perioperative thrombosis (particularly HIT). This has been as a Duke site PI for the Rare Thrombotic Diseases Consortium led by Dr T.L Ortel and a clinical collaborator with the basic and translational science approach to HIT led by Dr G Arepally. I have also championed novel approaches to dealing with perioperative HIT such as plasmaperesis.

Similarly, I have been a local leader in establishing management of transfusion approaches to major cardiac surgery including the novel introduction of autologous plateletpheresis to limit exposure to allogeneic platelet transfusions in this highly transfused population, identifying the transfusion requirements during thoracic aortic reconstruction and promoting use of a lower dose of rFVIIa use in this population, changing established clinical practice.

My research interests focus on perioperative transfusion and hematology concerns. Recently, Dr Kor (Mayo Clinic) and I received a multiple PI R-01 award to evaluate point-of-care/bedside washing of packed red blood cells to reduce perioperative lung injury. This novel repurposing of commonly available “cell-saver” technology is, for most surgical cases, the only practical means of delivering a washed product, and promises to be a critical advancement in perioperative transfusion medicine. I also have a longstanding interest in the rejuvenation of RBCs to normalize oxygen delivery capacity of transfused RBCs. Such a development will be of tremendous importance to transfusion practice, particularly for highly transfused populations. 

In summary, I have dedicated my research career to improving the outcome of patients undergoing cardiothoracic surgery, understanding perioperative coagulopathy, and optimizing transfusion practice. 

Education and Training

  • Anaesthetic Registrar, Anaesthetics, Royal London Hospital (United Kingdom), 1995 - 1995
  • Anaesthetic registrar, Anaesthetic, Royal London Hospital (United Kingdom), 1994 - 1995
  • Temporary Registrar, Anaesthetics, Royal London Hospital (United Kingdom), 1993 - 1994
  • Senior House Officer, Anesthetics, Royal London Hospital (United Kingdom), 1992 - 1993
  • Senior House Officer, Intensive Care, Royal London Hospital (United Kingdom), 1992 - 1992
  • Senior House Officer, Accident And Emergency, Royal London Hospital (United Kingdom), 1991 - 1992
  • House Officer, General And Vascular Surgery, Royal London Hospital (United Kingdom), 1991 - 1991
  • House Officer, Chest And General Medicine, Royal London Hospital (United Kingdom), 1990 - 1991
  • Anaesthetic Registrar, Anaesthetics, Royal London Hospital (United Kingdom), 1990 - 1990
  • M.B.B.S., University College London (United Kingdom), 1990

Publications

Sun, Gina H., Visal Patel, Ingrid Moreno-Duarte, Farhad Zahedi, Eric Ursprung, Greg Couper, Fred Y. Chen, et al. “Intraoperative Administration of 4-Factor Prothrombin Complex Concentrate Reduces Blood Requirements in Cardiac Transplantation.” J Cardiothorac Vasc Anesth 32, no. 1 (February 2018): 161–67. https://doi.org/10.1053/j.jvca.2017.08.011.

PMID
29198634
Full Text

Hobbs, Juliann C., Ian J. Welsby, Cynthia L. Green, Ishwori B. Dhakal, and Samuel S. Wellman. “Epsilon Aminocaproic Acid to Reduce Blood Loss and Transfusion After Total Hip and Total Knee Arthroplasty.” J Arthroplasty 33, no. 1 (January 2018): 55–60. https://doi.org/10.1016/j.arth.2017.08.020.

PMID
28939033
Full Text

Srinivasan, Amudan J., Kyle Kausch, Collin Inglut, Alan Gray, Matthew Landrigan, Jessica L. Poisson, Jacob N. Schroder, and Ian J. Welsby. “Estimation of Achievable Oxygen Consumption Following Transfusion With Rejuvenated Red Blood Cells.” Semin Thorac Cardiovasc Surg 30, no. 2 (2018): 134–41. https://doi.org/10.1053/j.semtcvs.2018.02.009.

PMID
29432891
Full Text

Srinivasan, Amudan J., Jessica Poisson, Erica Falcon, Andrea Ansari, Matthew Landrigan, Nirmish Shah, and Ian J. Welsby. “Pre-Transfusion Rejuvenation of RBCs for Red Blood Cell Exchange: Report of Feasibility.” In Blood, Vol. 130. AMER SOC HEMATOLOGY, 2017.

Scholars@Duke

Levy, Jerrold H., Kamrouz Ghadimi, Quintin J. Quinones, Raquel R. Bartz, and Ian Welsby. “Adjuncts to Blood Component Therapies for the Treatment of Bleeding in the Intensive Care Unit.” Transfus Med Rev 31, no. 4 (October 2017): 258–63. https://doi.org/10.1016/j.tmrv.2017.04.001.

PMID
28552276
Full Text

Karhausen, Jörn A., Alan M. Smeltz, Igor Akushevich, Mary Cooter, Mihai V. Podgoreanu, Mark Stafford-Smith, Susan M. Martinelli, Manuel L. Fontes, and Miklos D. Kertai. “Platelet Counts and Postoperative Stroke After Coronary Artery Bypass Grafting Surgery.” Anesth Analg 125, no. 4 (October 2017): 1129–39. https://doi.org/10.1213/ANE.0000000000002187.

PMID
28632537
Full Text

Warner, Matthew A., Ian J. Welsby, Phillip J. Norris, Christopher C. Silliman, Sarah Armour, Erica D. Wittwer, Paula J. Santrach, et al. “Point-of-care washing of allogeneic red blood cells for the prevention of transfusion-related respiratory complications (WAR-PRC): a protocol for a multicenter randomised clinical trial in patients undergoing cardiac surgery.” Bmj Open 7, no. 8 (August 18, 2017): e016398. https://doi.org/10.1136/bmjopen-2017-016398.

PMID
28821525
Full Text

Esper, S. A., I. J. Welsby, K. Subramaniam, W. John Wallisch, J. H. Levy, J. H. Waters, D. J. Triulzi, J. W. A. Hayanga, and G. J. Schears. “Adult extracorporeal membrane oxygenation: an international survey of transfusion and anticoagulation techniques.” Vox Sang 112, no. 5 (July 2017): 443–52. https://doi.org/10.1111/vox.12514.

PMID
28466601
Full Text

Srinivasan, Amudan J., Clare Morkane, Daniel S. Martin, and Ian J. Welsby. “Should modulation of p50 be a therapeutic target in the critically ill?” Expert Rev Hematol 10, no. 5 (May 2017): 449–58. https://doi.org/10.1080/17474086.2017.1313699.

PMID
28402148
Full Text

Pages