Inna Astapova, PhD

Assistant Professor in Medicine
Member of Duke Molecular Physiology Institute
Email address inna.astapova@duke.edu

Education and Training

  • Ph.D., Engelhardt Institute of Molecular Biology, Russian Academy of Sciences (Russia), 2002

Publications

Bu, P, Chen, K-Y, Xiang, K, Johnson, C, Crown, SB, Rakhilin, N, Ai, Y, Wang, L, Xi, R, Astapova, I, Han, Y, Li, J, Barth, BB, Lu, M, Gao, Z, Mines, R, Zhang, L, Herman, M, Hsu, D, Zhang, G-F, and Shen, X. "Aldolase B-Mediated Fructose Metabolism Drives Metabolic Reprogramming of Colon Cancer Liver Metastasis." Cell metabolism 27, no. 6 (June 2018): 1249-1262.e4.

PMID
29706565
Full Text

White, PJ, McGarrah, RW, Grimsrud, PA, Tso, S-C, Yang, W-H, Haldeman, JM, Grenier-Larouche, T, An, J, Lapworth, AL, Astapova, I, Hannou, SA, George, T, Arlotto, M, Olson, LB, Lai, M, Zhang, G-F, Ilkayeva, O, Herman, MA, Wynn, RM, Chuang, DT, and Newgard, CB. "The BCKDH Kinase and Phosphatase Integrate BCAA and Lipid Metabolism via Regulation of ATP-Citrate Lyase." Cell Metabolism 27, no. 6 (June 2018): 1281-1293.e7.

PMID
29779826
Full Text

Mendoza, A, Astapova, I, Shimizu, H, Gallop, MR, Al-Sowaimel, L, MacGowan, SMD, Bergmann, T, Berg, AH, Tenen, DE, Jacobs, C, Lyubetskaya, A, Tsai, L, and Hollenberg, AN. "NCoR1-independent mechanism plays a role in the action of the unliganded thyroid hormone receptor." Proceedings of the National Academy of Sciences of the United States of America 114, no. 40 (October 2017): E8458-E8467.

PMID
28923959
Full Text

Astapova, I. "Role of co-regulators in metabolic and transcriptional actions of thyroid hormone." Journal of molecular endocrinology 56, no. 3 (April 2016): 73-97. (Review)

PMID
26673411
Full Text

Singh, BK, Sinha, RA, Zhou, J, Tripathi, M, Ohba, K, Wang, M-E, Astapova, I, Ghosh, S, Hollenberg, AN, Gauthier, K, and Yen, PM. "Hepatic FOXO1 Target Genes Are Co-regulated by Thyroid Hormone via RICTOR Protein Deacetylation and MTORC2-AKT Protein Inhibition." The Journal of biological chemistry 291, no. 1 (January 2016): 198-214.

PMID
26453307
Full Text

Kurmann, AA, Serra, M, Hawkins, F, Rankin, SA, Mori, M, Astapova, I, Ullas, S, Lin, S, Bilodeau, M, Rossant, J, Jean, JC, Ikonomou, L, Deterding, RR, Shannon, JM, Zorn, AM, Hollenberg, AN, and Kotton, DN. "Regeneration of Thyroid Function by Transplantation of Differentiated Pluripotent Stem Cells." Cell Stem Cell 17, no. 5 (November 2015): 527-542.

PMID
26593959
Full Text

Shimizu, H, Astapova, I, Ye, F, Bilban, M, Cohen, RN, and Hollenberg, AN. "NCoR1 and SMRT play unique roles in thyroid hormone action in vivo." Molecular and Cellular Biology 35, no. 3 (February 2015): 555-565.

PMID
25421714
Full Text

Domouzoglou, EM, Fisher, FM, Astapova, I, Fox, EC, Kharitonenkov, A, Flier, JS, Hollenberg, AN, and Maratos-Flier, E. "Fibroblast growth factor 21 and thyroid hormone show mutual regulatory dependency but have independent actions in vivo." Endocrinology 155, no. 5 (May 2014): 2031-2040.

PMID
24564398
Full Text

Vella, KR, Ramadoss, P, Costa-E-Sousa, RH, Astapova, I, Ye, FD, Holtz, KA, Harris, JC, and Hollenberg, AN. "Thyroid hormone signaling in vivo requires a balance between coactivators and corepressors." Molecular and Cellular Biology 34, no. 9 (May 2014): 1564-1575.

PMID
24550004
Full Text

Astapova, I, Ramadoss, P, Costa-e-Sousa, RH, Ye, F, Holtz, KA, Li, Y, Niepel, MW, Cohen, DE, and Hollenberg, AN. "Hepatic nuclear corepressor 1 regulates cholesterol absorption through a TRβ1-governed pathway." The Journal of Clinical Investigation 124, no. 5 (May 2014): 1976-1986.

PMID
24713658
Full Text

Pages