Education and Training
- Ph.D., Engelhardt Institute of Molecular Biology, Russian Academy of Sciences (Russia), 2002
Bu, P, Chen, K-Y, Xiang, K, Johnson, C, Crown, SB, Rakhilin, N, Ai, Y, Wang, L, Xi, R, Astapova, I, Han, Y, Li, J, Barth, BB, Lu, M, Gao, Z, Mines, R, Zhang, L, Herman, M, Hsu, D, Zhang, G-F, and Shen, X. "Aldolase B-Mediated Fructose Metabolism Drives Metabolic Reprogramming of Colon Cancer Liver Metastasis." Cell metabolism 27, no. 6 (June 2018): 1249-1262.e4.
White, PJ, McGarrah, RW, Grimsrud, PA, Tso, S-C, Yang, W-H, Haldeman, JM, Grenier-Larouche, T, An, J, Lapworth, AL, Astapova, I, Hannou, SA, George, T, Arlotto, M, Olson, LB, Lai, M, Zhang, G-F, Ilkayeva, O, Herman, MA, Wynn, RM, Chuang, DT, and Newgard, CB. "The BCKDH Kinase and Phosphatase Integrate BCAA and Lipid Metabolism via Regulation of ATP-Citrate Lyase." Cell Metabolism 27, no. 6 (June 2018): 1281-1293.e7.
Mendoza, A, Astapova, I, Shimizu, H, Gallop, MR, Al-Sowaimel, L, MacGowan, SMD, Bergmann, T, Berg, AH, Tenen, DE, Jacobs, C, Lyubetskaya, A, Tsai, L, and Hollenberg, AN. "NCoR1-independent mechanism plays a role in the action of the unliganded thyroid hormone receptor." Proceedings of the National Academy of Sciences of the United States of America 114, no. 40 (October 2017): E8458-E8467.
Astapova, I. "Role of co-regulators in metabolic and transcriptional actions of thyroid hormone." Journal of molecular endocrinology 56, no. 3 (April 2016): 73-97. (Review)
Singh, BK, Sinha, RA, Zhou, J, Tripathi, M, Ohba, K, Wang, M-E, Astapova, I, Ghosh, S, Hollenberg, AN, Gauthier, K, and Yen, PM. "Hepatic FOXO1 Target Genes Are Co-regulated by Thyroid Hormone via RICTOR Protein Deacetylation and MTORC2-AKT Protein Inhibition." The Journal of biological chemistry 291, no. 1 (January 2016): 198-214.
Kurmann, AA, Serra, M, Hawkins, F, Rankin, SA, Mori, M, Astapova, I, Ullas, S, Lin, S, Bilodeau, M, Rossant, J, Jean, JC, Ikonomou, L, Deterding, RR, Shannon, JM, Zorn, AM, Hollenberg, AN, and Kotton, DN. "Regeneration of Thyroid Function by Transplantation of Differentiated Pluripotent Stem Cells." Cell Stem Cell 17, no. 5 (November 2015): 527-542.
Shimizu, H, Astapova, I, Ye, F, Bilban, M, Cohen, RN, and Hollenberg, AN. "NCoR1 and SMRT play unique roles in thyroid hormone action in vivo." Molecular and Cellular Biology 35, no. 3 (February 2015): 555-565.
Domouzoglou, EM, Fisher, FM, Astapova, I, Fox, EC, Kharitonenkov, A, Flier, JS, Hollenberg, AN, and Maratos-Flier, E. "Fibroblast growth factor 21 and thyroid hormone show mutual regulatory dependency but have independent actions in vivo." Endocrinology 155, no. 5 (May 2014): 2031-2040.
Vella, KR, Ramadoss, P, Costa-E-Sousa, RH, Astapova, I, Ye, FD, Holtz, KA, Harris, JC, and Hollenberg, AN. "Thyroid hormone signaling in vivo requires a balance between coactivators and corepressors." Molecular and Cellular Biology 34, no. 9 (May 2014): 1564-1575.
Astapova, I, Ramadoss, P, Costa-e-Sousa, RH, Ye, F, Holtz, KA, Li, Y, Niepel, MW, Cohen, DE, and Hollenberg, AN. "Hepatic nuclear corepressor 1 regulates cholesterol absorption through a TRβ1-governed pathway." The Journal of Clinical Investigation 124, no. 5 (May 2014): 1976-1986.