Inna Astapova, PhD

Assistant Professor in Medicine
Member of Duke Molecular Physiology Institute
Email address inna.astapova@duke.edu

Education and Training

  • Ph.D., Engelhardt Institute of Molecular Biology, Russian Academy of Sciences (Russia), 2002

Publications

Freudenthal, Bernard, Samiksha Shetty, Natalie C. Butterfield, John G. Logan, Cho Rong Han, Xuguang Zhu, Inna Astapova, et al. “Genetic and Pharmacological Targeting of Transcriptional Repression in Resistance to Thyroid Hormone Alpha..” Thyroid 29, no. 5 (May 2019): 726–34. https://doi.org/10.1089/thy.2018.0399.

PMID
30760120
Full Text

Bu, Pengcheng, Kai-Yuan Chen, Kun Xiang, Christelle Johnson, Scott B. Crown, Nikolai Rakhilin, Yiwei Ai, et al. “Aldolase B-Mediated Fructose Metabolism Drives Metabolic Reprogramming of Colon Cancer Liver Metastasis..” Cell Metab 27, no. 6 (June 5, 2018): 1249-1262.e4. https://doi.org/10.1016/j.cmet.2018.04.003.

PMID
29706565
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White, Phillip J., Robert W. McGarrah, Paul A. Grimsrud, Shih-Chia Tso, Wen-Hsuan Yang, Jonathan M. Haldeman, Thomas Grenier-Larouche, et al. “The BCKDH Kinase and Phosphatase Integrate BCAA and Lipid Metabolism via Regulation of ATP-Citrate Lyase..” Cell Metab 27, no. 6 (June 5, 2018): 1281-1293.e7. https://doi.org/10.1016/j.cmet.2018.04.015.

PMID
29779826
Full Text

Mendoza, Arturo, Inna Astapova, Hiroaki Shimizu, Molly R. Gallop, Lujain Al-Sowaimel, SM Dileas MacGowan, Tim Bergmann, et al. “NCoR1-independent mechanism plays a role in the action of the unliganded thyroid hormone receptor..” Proc Natl Acad Sci U S A 114, no. 40 (October 3, 2017): E8458–67. https://doi.org/10.1073/pnas.1706917114.

PMID
28923959
Full Text

Singh, Brijesh K., Rohit A. Sinha, Jin Zhou, Madhulika Tripathi, Kenji Ohba, Mu-En Wang, Inna Astapova, et al. “Hepatic FOXO1 Target Genes Are Co-regulated by Thyroid Hormone via RICTOR Protein Deacetylation and MTORC2-AKT Protein Inhibition..” J Biol Chem 291, no. 1 (January 1, 2016): 198–214. https://doi.org/10.1074/jbc.M115.668673.

PMID
26453307
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Kurmann, Anita A., Maria Serra, Finn Hawkins, Scott A. Rankin, Munemasa Mori, Inna Astapova, Soumya Ullas, et al. “Regeneration of Thyroid Function by Transplantation of Differentiated Pluripotent Stem Cells..” Cell Stem Cell 17, no. 5 (November 5, 2015): 527–42. https://doi.org/10.1016/j.stem.2015.09.004.

PMID
26593959
Full Text

Shimizu, Hiroaki, Inna Astapova, Felix Ye, Martin Bilban, Ronald N. Cohen, and Anthony N. Hollenberg. “NCoR1 and SMRT play unique roles in thyroid hormone action in vivo..” Mol Cell Biol 35, no. 3 (February 2015): 555–65. https://doi.org/10.1128/MCB.01208-14.

PMID
25421714
Full Text

Astapova, Inna, Preeti Ramadoss, Ricardo H. Costa-e-Sousa, Felix Ye, Kaila A. Holtz, Yingxia Li, Michele W. Niepel, David E. Cohen, and Anthony N. Hollenberg. “Hepatic nuclear corepressor 1 regulates cholesterol absorption through a TRβ1-governed pathway..” The Journal of Clinical Investigation 124, no. 5 (May 2014): 1976–86. https://doi.org/10.1172/JCI73419.

PMID
24713658
Full Text

Domouzoglou, Eleni M., Ffolliott Martin Fisher, Inna Astapova, Elliott C. Fox, Alexei Kharitonenkov, Jeffrey S. Flier, Anthony N. Hollenberg, and Eleftheria Maratos-Flier. “Fibroblast growth factor 21 and thyroid hormone show mutual regulatory dependency but have independent actions in vivo..” Endocrinology 155, no. 5 (May 2014): 2031–40. https://doi.org/10.1210/en.2013-1902.

PMID
24564398
Full Text

Pages