Medical Oncology

Ivan Spasojevic, PhD

Associate Professor in Medicine
Member of the Duke Cancer Institute
Campus mail 5317 Orange Zone, Duke Hospital South, Durham, NC 27710
Phone (919) 684-8311

Education and Training

  • Ph.D., Duke University, 1999

Grants

Publications

Batinic-Haberle, Ines, Artak Tovmasyan, and Ivan Spasojevic. “Mn Porphyrin-Based Redox-Active Drugs: Differential Effects as Cancer Therapeutics and Protectors of Normal Tissue Against Oxidative Injury.” Antioxid Redox Signal 29, no. 16 (December 1, 2018): 1691–1724. https://doi.org/10.1089/ars.2017.7453.

PMID
29926755
Full Text

Tovmasyan, Artak, Jacqueline C. Bueno-Janice, Melba C. Jaramillo, Romulo S. Sampaio, Julio S. Reboucas, Natalia Kyui, Ludmil Benov, et al. “Radiation-Mediated Tumor Growth Inhibition Is Significantly Enhanced with Redox-Active Compounds That Cycle with Ascorbate.” Antioxid Redox Signal 29, no. 13 (November 1, 2018): 1196–1214. https://doi.org/10.1089/ars.2017.7218.

PMID
29390861
Full Text

Wang, Jiangbo, Robert A. Mook, Xiu-Rong Ren, Qingfu Zhang, Genevieve Jing, Min Lu, Ivan Spasojevic, H Kim Lyerly, David Hsu, and Wei Chen. “Identification of DK419, a potent inhibitor of Wnt/β-catenin signaling and colorectal cancer growth.” Bioorg Med Chem 26, no. 20 (November 1, 2018): 5435–42. https://doi.org/10.1016/j.bmc.2018.09.016.

PMID
30274939
Full Text

Il’yasova, Dora, Luigi Fontana, Manjushri Bhapkar, Carl F. Pieper, Ivan Spasojevic, Leanne M. Redman, Sai Krupa Das, Kim M. Huffman, William E. Kraus, and William E. CALERIE Study Investigators. “Effects of 2 years of caloric restriction on oxidative status assessed by urinary F2-isoprostanes: The CALERIE 2 randomized clinical trial.” Aging Cell 17, no. 2 (April 2018). https://doi.org/10.1111/acel.12719.

PMID
29424490
Full Text

Cline, John Mark, Greg Dugan, John Daniel Bourland, Donna L. Perry, Joel D. Stitzel, Ashley A. Weaver, Chen Jiang, et al. “Post-Irradiation Treatment with a Superoxide Dismutase Mimic, MnTnHex-2-PyP5+, Mitigates Radiation Injury in the Lungs of Non-Human Primates after Whole-Thorax Exposure to Ionizing Radiation.” Antioxidants (Basel) 7, no. 3 (March 7, 2018). https://doi.org/10.3390/antiox7030040.

PMID
29518913
Full Text

Waitkus, Matthew S., Christopher J. Pirozzi, Casey J. Moure, Bill H. Diplas, Landon J. Hansen, Austin B. Carpenter, Rui Yang, et al. “Adaptive Evolution of the GDH2 Allosteric Domain Promotes Gliomagenesis by Resolving IDH1R132H-Induced Metabolic Liabilities.” Cancer Res 78, no. 1 (January 1, 2018): 36–50. https://doi.org/10.1158/0008-5472.CAN-17-1352.

PMID
29097607
Full Text

Abaffy, Tatjana, James R. Bain, Michael J. Muehlbauer, Ivan Spasojevic, Shweta Lodha, Elisa Bruguera, Sara K. O’Neal, So Young Kim, and Hiroaki Matsunami. “A Testosterone Metabolite 19-Hydroxyandrostenedione Induces Neuroendocrine Trans-Differentiation of Prostate Cancer Cells via an Ectopic Olfactory Receptor.” Front Oncol 8 (2018): 162. https://doi.org/10.3389/fonc.2018.00162.

PMID
29892571
Full Text

Bhattacharyya, Jayanta, Xiu-Rong Ren, Robert A. Mook, Jiangbo Wang, Ivan Spasojevic, Richard T. Premont, Xinghai Li, Ashutosh Chilkoti, and Wei Chen. “Niclosamide-conjugated polypeptide nanoparticles inhibit Wnt signaling and colon cancer growth.” Nanoscale 9, no. 34 (August 31, 2017): 12709–17. https://doi.org/10.1039/c7nr01973d.

PMID
28828438
Full Text

Leu, David, Ivan Spasojevic, Huy Nguyen, Brian Deng, Artak Tovmasyan, Tin Weitner, Romulo S. Sampaio, Ines Batinic-Haberle, and Ting-Ting Huang. “CNS bioavailability and radiation protection of normal hippocampal neurogenesis by a lipophilic Mn porphyrin-based superoxide dismutase mimic, MnTnBuOE-2-PyP5.” Redox Biol 12 (August 2017): 864–71. https://doi.org/10.1016/j.redox.2017.04.027.

PMID
28454069
Full Text

Pages