Medical Oncology

Ivan Spasojevic, PhD

Associate Professor in Medicine
Member of the Duke Cancer Institute
Campus mail 5317 Orange Zone, Duke Hospital South, Durham, NC 27710
Phone (919) 684-8311

Education and Training

  • Ph.D., Duke University, 1999

Grants

Publications

Batinic-Haberle, I, Tovmasyan, A, and Spasojevic, I. "Mn Porphyrin-Based Redox-Active Drugs: Differential Effects as Cancer Therapeutics and Protectors of Normal Tissue Against Oxidative Injury." Antioxidants & Redox Signaling 29, no. 16 (December 2018): 1691-1724.

PMID
29926755
Full Text

Tovmasyan, A, Bueno-Janice, JC, Jaramillo, MC, Sampaio, RS, Reboucas, JS, Kyui, N, Benov, L, Deng, B, Huang, T-T, Tome, ME, Spasojevic, I, and Batinic-Haberle, I. "Radiation-Mediated Tumor Growth Inhibition Is Significantly Enhanced with Redox-Active Compounds That Cycle with Ascorbate." Antioxidants & Redox Signaling 29, no. 13 (November 2018): 1196-1214.

PMID
29390861
Full Text

Wang, J, Mook, RA, Ren, X-R, Zhang, Q, Jing, G, Lu, M, Spasojevic, I, Lyerly, HK, Hsu, D, and Chen, W. "Identification of DK419, a potent inhibitor of Wnt/β-catenin signaling and colorectal cancer growth." Bioorganic & Medicinal Chemistry 26, no. 20 (November 2018): 5435-5442.

PMID
30274939
Full Text

Il'yasova, D, Fontana, L, Bhapkar, M, Pieper, CF, Spasojevic, I, Redman, LM, Das, SK, Huffman, KM, Kraus, WE, and CALERIE Study Investigators, . "Effects of 2 years of caloric restriction on oxidative status assessed by urinary F2-isoprostanes: The CALERIE 2 randomized clinical trial." Aging Cell 17, no. 2 (April 2018).

PMID
29424490
Full Text

Cline, JM, Dugan, G, Bourland, JD, Perry, DL, Stitzel, JD, Weaver, AA, Jiang, C, Tovmasyan, A, Owzar, K, Spasojevic, I, Batinic-Haberle, I, and Vujaskovic, Z. "Post-Irradiation Treatment with a Superoxide Dismutase Mimic, MnTnHex-2-PyP5+, Mitigates Radiation Injury in the Lungs of Non-Human Primates after Whole-Thorax Exposure to Ionizing Radiation." Antioxidants (Basel, Switzerland) 7, no. 3 (March 7, 2018).

PMID
29518913
Full Text

Waitkus, MS, Pirozzi, CJ, Moure, CJ, Diplas, BH, Hansen, LJ, Carpenter, AB, Yang, R, Wang, Z, Ingram, BO, Karoly, ED, Mohney, RP, Spasojevic, I, McLendon, RE, Friedman, HS, He, Y, Bigner, DD, and Yan, H. "Adaptive Evolution of the GDH2 Allosteric Domain Promotes Gliomagenesis by Resolving IDH1R132H-Induced Metabolic Liabilities." Cancer Research 78, no. 1 (January 2018): 36-50.

PMID
29097607
Full Text

Abaffy, T, Bain, JR, Muehlbauer, MJ, Spasojevic, I, Lodha, S, Bruguera, E, O'Neal, SK, Kim, SY, and Matsunami, H. "A Testosterone Metabolite 19-Hydroxyandrostenedione Induces Neuroendocrine Trans-Differentiation of Prostate Cancer Cells via an Ectopic Olfactory Receptor." Frontiers in Oncology 8 (January 2018): 162-null.

PMID
29892571
Full Text

Bogdanović Pristov, J, and Spasojević, I. "A One-Step Staining Protocol for In-Gel Fluorescent Visualization of Proteins.", 149-158. January 2018.

PMID
30097940
Full Text

Boss, MK, Dewhirst, MW, Sampaio, RS, Bennett, A, Tovmasyan, A, Berman, KG, Beaven, AW, Rizzieri, DA, Batinic-Haberle, I, Hauck, ML, and Spasojevic, I. "Potential for a novel manganese porphyrin compound as adjuvant canine lymphoma therapy." Cancer Chemotherapy and Pharmacology 80, no. 2 (August 2017): 421-431.

PMID
28685347
Full Text

Bhattacharyya, J, Ren, X-R, Mook, RA, Wang, J, Spasojevic, I, Premont, RT, Li, X, Chilkoti, A, and Chen, W. "Niclosamide-conjugated polypeptide nanoparticles inhibit Wnt signaling and colon cancer growth." Nanoscale 9, no. 34 (August 2017): 12709-12717.

PMID
28828438
Full Text

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