James Abbruzzese, MD

Professor of Medicine
D. C. I. Professor of Medical Oncology
Chief, Division of Medical Oncology
Member of the Duke Cancer Institute
Campus mail 440 Mudd Building, Box 3406, Durham, NC 27710
Email address james.abbruzzese@duke.edu

My research interests include the clinical study and treatment of pancreatic cancer.

In Their Words

Education and Training

  • Resident, Internal Medicine, Johns Hopkins University School of Medicine, 1979 - 1981
  • Intern, Internal Medicine, Johns Hopkins University School of Medicine, 1978 - 1979
  • M.D., University of Chicago, 1978

Publications

Wang, D, Bi, Y, Hu, L, Luo, Y, Ji, J, Mao, AZ, Logsdon, CD, Li, E, Abbruzzese, JL, Li, Z, Yang, VW, and Lu, W. "Obesogenic high-fat diet heightens aerobic glycolysis through hyperactivation of oncogenic KRAS." Cell Communication and Signaling : Ccs 17, no. 1 (February 28, 2019): 19-null.

PMID
30819189
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Luo, Y, Wang, D, Abbruzzese, JL, and Lu, W. "Measurement of Reactive Oxygen Species by Fluorescent Probes in Pancreatic Cancer Cells." Methods in Molecular Biology (Clifton, N.J.) 1882 (January 2019): 207-219.

PMID
30378057
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Stephens, SJ, Czito, B, Zhang, X, Duffy, E, Malicki, M, Pitcher, B, Niedzwiecki, D, Abbruzzese, J, Uronis, H, Blobe, G, Blazer, DG, Willett, CG, and Palta, M. "Surgical and Pathologic Outcomes in Patients on a Phase II Trial of Neoadjuvant Chemotherapy and Hypofractionated Image-Guided Intensity Modulated Radiation Therapy (HIGRT) in Resectable and Borderline Resectable Pancreatic Cancer.": Elsevier BV, November 2018.

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Turner, MC, Cerullo, M, Adam, M, Shah, KN, Blazer, DG, Abbruzzese, JL, and Zani, S. "Adjuvant Chemotherapy Should Follow Pancreaticoduodenectomy for Pancreatic Adenocarcinoma, Despite Delays.": Elsevier BV, October 2018.

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Moschos, SJ, Eroglu, Z, Khushalani, NI, Kendra, KL, Ansstas, G, In, GK, Wang, P, Liu, G, Collichio, FA, Arrowood, CC, Reed, JE, Garrett-Mead, N, Thomas, NE, Ollila, DW, Ivy, SP, Ivanova, A, Dees, EC, and Abbruzzese, JL. "NCI 9922: Phase II study of ibrutinib in treatment-refractory distant metastatic cutaneous melanoma (DMCM)." 43rd ESMO Congress (ESMO). Munich, GERMANY. October 19, 2018 - October 23, 2018.: OXFORD UNIV PRESS, October 1, 2018.

Scholars@Duke

Safe, S, Abbruzzese, J, Abdelrahim, M, and Hedrick, E. "Specificity Protein Transcription Factors and Cancer: Opportunities for Drug Development." Cancer Prevention Research (Philadelphia, Pa.) 11, no. 7 (July 2018): 371-382. (Review)

PMID
29545399
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Palta, M, Czito, BG, Duffy, E, Malicki, M, Niedzwiecki, D, Abbruzzese, JL, Uronis, HE, Blobe, GC, Blazer, DG, and Willett, C. "A phase II trial of neoadjuvant gemcitabine/nab-paclitaxel and SBRT for potentially resectable pancreas cancer: An evaluation of acute toxicity.": American Society of Clinical Oncology (ASCO), May 20, 2018.

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Abbruzzese, JL, Andersen, DK, Borrebaeck, CAK, Chari, ST, Costello, E, Cruz-Monserrate, Z, Eibl, G, Engleman, EG, Fisher, WE, Habtezion, A, Kim, SK, Korc, M, Logsdon, C, Lyssiotis, CA, Pandol, SJ, Rustgi, A, Wolfe, BM, Zheng, L, and Powers, AC. "The Interface of Pancreatic Cancer With Diabetes, Obesity, and Inflammation: Research Gaps and Opportunities: Summary of a National Institute of Diabetes and Digestive and Kidney Diseases Workshop." Pancreas 47, no. 5 (May 2018): 516-525.

PMID
29702529
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Choe, JH, and Abbruzzese, JL. "Emerging therapeutic targets in pancreatic adenocarcinoma." In Pancreatic Cancer, 1613-1641. April 11, 2018.

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Neoptolemos, JP, Urrutia, R, Abbruzzese, JL, and Büchler, MW. Preface. April 11, 2018.

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