James Abbruzzese, MD

Professor of Medicine
D. C. I. Professor of Medical Oncology
Chief, Division of Medical Oncology
Member of the Duke Cancer Institute
Campus mail 440 Mudd Building, Box 3406, Durham, NC 27710
Email address james.abbruzzese@duke.edu

My research interests include the clinical study and treatment of pancreatic cancer.

In Their Words

Education and Training

  • Resident, Internal Medicine, Johns Hopkins University School of Medicine, 1979 - 1981
  • Intern, Internal Medicine, Johns Hopkins University School of Medicine, 1978 - 1979
  • M.D., University of Chicago, 1978

Publications

Yang, Wenjun, Hongliang Liu, Bensong Duan, Xinyuan Xu, Dennis Carmody, Sheng Luo, Kyle M. Walsh, et al. “Three novel genetic variants in NRF2 signaling pathway genes are associated with pancreatic cancer risk..” Cancer Sci 110, no. 6 (June 2019): 2022–32. https://doi.org/10.1111/cas.14017.

PMID
30972876
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Xu, Xinyuan, Danwen Qian, Hongliang Liu, Diana Cruz, Sheng Luo, Kyle M. Walsh, James L. Abbruzzese, Xuefeng Zhang, and Qingyi Wei. “Genetic variants in the liver kinase B1-AMP-activated protein kinase pathway genes and pancreatic cancer risk..” Mol Carcinog, April 17, 2019. https://doi.org/10.1002/mc.23018.

PMID
30997723
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Wang, Dan, Yawei Bi, Lianghao Hu, Yongde Luo, Juntao Ji, Albert Z. Mao, Craig D. Logsdon, et al. “Obesogenic high-fat diet heightens aerobic glycolysis through hyperactivation of oncogenic KRAS..” Cell Commun Signal 17, no. 1 (February 28, 2019). https://doi.org/10.1186/s12964-019-0333-7.

PMID
30819189
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Luo, Yongde, Dan Wang, James L. Abbruzzese, and Weiqin Lu. “Measurement of Reactive Oxygen Species by Fluorescent Probes in Pancreatic Cancer Cells..” Methods Mol Biol 1882 (2019): 207–19. https://doi.org/10.1007/978-1-4939-8879-2_19.

PMID
30378057
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Stephens, S. J., B. Czito, X. Zhang, E. Duffy, M. Malicki, B. Pitcher, D. Niedzwiecki, et al. “Surgical and Pathologic Outcomes in Patients on a Phase II Trial of Neoadjuvant Chemotherapy and Hypofractionated Image-Guided Intensity Modulated Radiation Therapy (HIGRT) in Resectable and Borderline Resectable Pancreatic Cancer.” In International Journal of Radiation Oncology*Biology*Physics, 102:S180–S180. Elsevier BV, 2018. https://doi.org/10.1016/j.ijrobp.2018.07.056.

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Turner, Megan C., Marcelo Cerullo, Mohamed Adam, Kevin N. Shah, Dan G. Blazer, James L. Abbruzzese, and Sabino Zani. “Adjuvant Chemotherapy Should Follow Pancreaticoduodenectomy for Pancreatic Adenocarcinoma, Despite Delays.” In Journal of the American College of Surgeons, 227:S169–S169. Elsevier BV, 2018. https://doi.org/10.1016/j.jamcollsurg.2018.07.359.

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Moschos, S. J., Z. Eroglu, N. I. Khushalani, K. L. Kendra, G. Ansstas, G. K. In, P. Wang, et al. “NCI 9922: Phase II study of ibrutinib in treatment-refractory distant metastatic cutaneous melanoma (DMCM).” In Annals of Oncology, 29:453–453. OXFORD UNIV PRESS, 2018.

Scholars@Duke

Safe, Stephen, James Abbruzzese, Maen Abdelrahim, and Erik Hedrick. “Specificity Protein Transcription Factors and Cancer: Opportunities for Drug Development..” Cancer Prev Res (Phila) 11, no. 7 (July 2018): 371–82. https://doi.org/10.1158/1940-6207.CAPR-17-0407.

PMID
29545399
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Palta, Manisha, Brian G. Czito, Eileen Duffy, Mary Malicki, Donna Niedzwiecki, James L. Abbruzzese, Hope Elizabeth Uronis, Gerard C. Blobe, Dan G. Blazer, and Christopher Willett. “A phase II trial of neoadjuvant gemcitabine/nab-paclitaxel and SBRT for potentially resectable pancreas cancer: An evaluation of acute toxicity..” In Journal of Clinical Oncology, 36:4121–4121. American Society of Clinical Oncology (ASCO), 2018. https://doi.org/10.1200/jco.2018.36.15_suppl.4121.

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