James Abbruzzese, MD

Professor of Medicine
D. C. I. Professor of Medical Oncology
Chief, Division of Medical Oncology
Member of the Duke Cancer Institute
Campus mail 440 Mudd Building, Box 3406, Durham, NC 27710
Email address james.abbruzzese@duke.edu

My research interests include the clinical study and treatment of pancreatic cancer.

In Their Words

Education and Training

  • Resident, Internal Medicine, Johns Hopkins University School of Medicine, 1979 - 1981
  • Intern, Internal Medicine, Johns Hopkins University School of Medicine, 1978 - 1979
  • M.D., University of Chicago, 1978

Publications

Abbruzzese, JL, Andersen, DK, Borrebaeck, CAK, Chari, ST, Costello, E, Cruz-Monserrate, Z, Eibl, G, Engleman, EG, Fisher, WE, Habtezion, A, Kim, SK, Korc, M, Logsdon, C, Lyssiotis, CA, Pandol, SJ, Rustgi, A, Wolfe, BM, Zheng, L, and Powers, AC. "The Interface of Pancreatic Cancer With Diabetes, Obesity, and Inflammation: Research Gaps and Opportunities: Summary of a National Institute of Diabetes and Digestive and Kidney Diseases Workshop." Pancreas 47, no. 5 (May 1, 2018): 516-525. (Academic Article)

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Duan, B, Hu, J, Liu, H, Wang, Y, Li, H, Liu, S, Xie, J, Owzar, K, Abbruzzese, J, Hurwitz, H, Gao, H, and Wei, Q. "Genetic variants in the platelet-derived growth factor subunit B gene associated with pancreatic cancer risk." International Journal of Cancer 142, no. 7 (April 2018): 1322-1331.

PMID
29168174
Full Text

Safe, S, Abbruzzese, JL, Abdelrahim, M, and Hedrick, E. "Specificity Protein Transcription Factors and Cancer: Opportunities for Drug Development." Cancer prevention research (Philadelphia, Pa.) (March 15, 2018).

PMID
29545399
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Berlin, JD, Feng, Y, Catalano, P, Abbruzzese, JL, Philip, PA, McWilliams, RR, Lowy, AM, Benson Iii, AB, and Blackstock, AW. "An Intergroup Randomized Phase II Study of Bevacizumab or Cetuximab in Combination with Gemcitabine and in Combination with Chemoradiation in Patients with Resected Pancreatic Carcinoma: A Trial of the ECOG-ACRIN Cancer Research Group (E2204)." Oncology 94, no. 1 (January 2018): 39-46.

PMID
29040974
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Andersen, DK, Korc, M, Petersen, GM, Eibl, G, Li, D, Rickels, MR, Chari, ST, and Abbruzzese, JL. "Diabetes, Pancreatogenic Diabetes, and Pancreatic Cancer." Diabetes 66, no. 5 (May 2017): 1103-1110.

PMID
28507210
Full Text

Capello, M, Bantis, LE, Scelo, G, Zhao, Y, Li, P, Dhillon, DS, Patel, NJ, Kundnani, DL, Wang, H, Abbruzzese, JL, Maitra, A, Tempero, MA, Brand, R, Brennan, L, Feng, E, Taguchi, I, Janout, V, Firpo, MA, Mulvihill, SJ, Katz, MH, and Hanash, SM. "Sequential Validation of Blood-Based Protein Biomarker Candidates for Early-Stage Pancreatic Cancer." Journal of the National Cancer Institute 109, no. 4 (April 2017).

PMID
27986802
Scholars@Duke

Capello, M, Bantis, LE, Scelo, G, Zhao, Y, Li, P, Dhillon, DS, Patel, NJ, Kundnani, DL, Wang, H, Abbruzzese, JL, Maitra, A, Tempero, MA, Brand, R, Firpo, MA, Mulvihill, SJ, Katz, MH, Brennan, P, Feng, Z, Taguchi, A, and Hanash, SM. "Sequential Validation of Blood-Based Protein Biomarker Candidates for Early-Stage Pancreatic Cancer." Journal of the National Cancer Institute 109, no. 4 (April 2017).

PMID
28376157
Full Text

Cloyd, JM, Katz, MHG, Prakash, L, Varadhachary, GR, Wolff, RA, Shroff, RT, Javle, M, Fogelman, D, Overman, M, Crane, CH, Koay, EJ, Das, P, Krishnan, S, Minsky, BD, Lee, JH, Bhutani, MS, Weston, B, Ross, W, Bhosale, P, Tamm, EP, Wang, H, Maitra, A, Kim, MP, Aloia, TA, Vauthey, J-N, Fleming, JB, Abbruzzese, JL, Pisters, PWT, Evans, DB, and Lee, JE. "Preoperative Therapy and Pancreatoduodenectomy for Pancreatic Ductal Adenocarcinoma: a 25-Year Single-Institution Experience." Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract 21, no. 1 (January 2017): 164-174.

PMID
27778257
Full Text

Ye, M, Lu, W, Wang, X, Wang, C, Abbruzzese, JL, Liang, G, Li, X, and Luo, Y. "FGF21-FGFR1 Coordinates Phospholipid Homeostasis, Lipid Droplet Function, and ER Stress in Obesity." Endocrinology 157, no. 12 (December 2016): 4754-4769.

PMID
27690692
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Palta, M, Czito, B, Abbruzzese, J, Uronis, H, Duffy, EA, Blazer, DT, and Willett, CG. "Interim Acute Toxicity Analysis and Surgical Outcomes of Neoadjuvant Gemcitabine/nab-Paclitaxel and Hypofractionated Image Guided Intensity Modulated Radiation Therapy in Resectable and Borderline Resectable Pancreatic Cancer (ANCHOR) Study." October 1, 2016.

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