James Abbruzzese, MD

Professor of Medicine
D. C. I. Distinguished Professor of Medical Oncology
Chief, Division of Medical Oncology
Member of the Duke Cancer Institute
Campus mail 440 Mudd Building, Box 3406, Durham, NC 27710
Email address james.abbruzzese@duke.edu

My research interests include the clinical study and treatment of pancreatic cancer.

In Their Words

Education and Training

  • Resident, Internal Medicine, Johns Hopkins University School of Medicine, 1979 - 1981
  • Intern, Internal Medicine, Johns Hopkins University School of Medicine, 1978 - 1979
  • M.D., The University of Chicago, 1978

Publications

Moschos, Stergios J., Zeynep Eroglu, Nikhil I. Khushalani, Kari L. Kendra, George Ansstas, Gino K. In, Peng Wang, et al. “Targeting the IL-2 inducible kinase in melanoma; a phase 2 study of ibrutinib in systemic treatment-refractory distant metastatic cutaneous melanoma: preclinical rationale, biology, and clinical activity (NCI9922).” Melanoma Res 31, no. 2 (April 1, 2021): 162–72. https://doi.org/10.1097/CMR.0000000000000726.

PMID
33661190
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Liu, Muyun, Dan Wang, Yongde Luo, Lianghao Hu, Yawei Bi, Juntao Ji, Haojie Huang, et al. “Selective killing of cancer cells harboring mutant RAS by concomitant inhibition of NADPH oxidase and glutathione biosynthesis.” Cell Death Dis 12, no. 2 (February 16, 2021): 189. https://doi.org/10.1038/s41419-021-03473-6.

PMID
33594044
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Luo, Yongde, Xiaokun Li, Jianjia Ma, James L. Abbruzzese, and Weiqin Lu. “Pancreatic Tumorigenesis: Oncogenic KRAS and the Vulnerability of the Pancreas to Obesity.” Cancers (Basel) 13, no. 4 (February 13, 2021). https://doi.org/10.3390/cancers13040778.

PMID
33668583
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DeVito, Nicholas C., Colm Kelleher, Kyle C. Strickland, James Abbruzzese, Carey Anders, Brent A. Hanks, Jingquan Jia, et al. “A case report of microsatellite instability (MSI)-high, HER2 amplified pancreatic adenocarcinoma with central nervous system metastasis.” Ame Case Rep 5 (2021): 14. https://doi.org/10.21037/acr-20-154.

PMID
33912803
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Turner, Megan C., Sabran J. Masoud, Marcelo Cerullo, Mohamed A. Adam, Kevin N. Shah, Dan G. Blazer, James L. Abbruzzese, and Sabino Zani. “Improved overall survival is still observed in patients receiving delayed adjuvant chemotherapy after pancreaticoduodenectomy for pancreatic adenocarcinoma.” Hpb (Oxford) 22, no. 11 (November 2020): 1542–48. https://doi.org/10.1016/j.hpb.2020.03.006.

PMID
32299656
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Liu, Xiaowen, Danwen Qian, Hongliang Liu, James L. Abbruzzese, Sheng Luo, Kyle M. Walsh, and Qingyi Wei. “Genetic variants of the peroxisome proliferator-activated receptor (PPAR) signaling pathway genes and risk of pancreatic cancer.” Mol Carcinog 59, no. 8 (August 2020): 930–39. https://doi.org/10.1002/mc.23208.

PMID
32367578
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Liu, Joyce F., Su-Chun Cheng, Robert M. Wenham, Andrea E Wahner Hendrickson, Deborah K. Armstrong, Nancy Chan, David E. Cohn, et al. “Abstract A074: Correlation of homologous recombination deficiency (HRD) status by BROCA-HR sequencing with response to combination cediranib and olaparib in relapsed ovarian cancer.” In Clinical Trials. American Association for Cancer Research, 2019. https://doi.org/10.1158/1535-7163.targ-19-a074.

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Monjazeb, Arta, Anita Giobbie-Hurder, Ana Lako, Mark Awad, Ryan Gentzler, Carrie Lee, Joleen Hubbard, et al. “A randomized multi-center phase 2 study of combined PD-L1/CTLA-4 inhibition with or without radiation in non-small cell lung cancer patients who progressed on PD-(L)1 directed therapy: ETCTN 10021.” In Journal for Immunotherapy of Cancer, Vol. 7. BMC, 2019.

Scholars@Duke

Luo, Yongde, Yaying Yang, Muyun Liu, Dan Wang, Feng Wang, Yawei Bi, Juntao Ji, et al. “Oncogenic KRAS Reduces Expression of FGF21 in Acinar Cells to Promote Pancreatic Tumorigenesis in Mice on a High-Fat Diet.” Gastroenterology 157, no. 5 (November 2019): 1413-1428.e11. https://doi.org/10.1053/j.gastro.2019.07.030.

PMID
31352001
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Kent, C. L., D. Marin, D. Niedzwiecki, S. J. Stephens, E. Duffy, M. Malicki, J. Abbruzzese, et al. “Imaging & Biomarker Correlates on Outcomes in a Phase II Trial of Neoadjuvant Gemcitabine/Nab-Paclitaxel and Hypofractionated Image-Guided Radiotherapy (HIGRT) in Potentially Resectable Pancreas Cancer.” In International Journal of Radiation Oncology*Biology*Physics, 105:E238–39. Elsevier BV, 2019. https://doi.org/10.1016/j.ijrobp.2019.06.2014.

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