James Abbruzzese, MD

Professor of Medicine
D. C. I. Distinguished Professor of Medical Oncology
Member of the Duke Cancer Institute
Campus mail 440 Mudd Building, Box 3406, Durham, NC 27710
Email address james.abbruzzese@duke.edu

My research interests include the clinical study and treatment of pancreatic cancer.

In Their Words

Education and Training

  • Resident, Internal Medicine, Johns Hopkins University School of Medicine, 1979 - 1981
  • Intern, Internal Medicine, Johns Hopkins University School of Medicine, 1978 - 1979
  • M.D., The University of Chicago, 1978

Publications

Chang, David Z., Ying Ma, Baoan Ji, Huamin Wang, Defeng Deng, Yan Liu, James L. Abbruzzese, Yong-jun Liu, Craig D. Logsdon, and Patrick Hwu. “Mast cells in tumor microenvironment promotes the in vivo growth of pancreatic ductal adenocarcinoma.” Clin Cancer Res 17, no. 22 (November 15, 2011): 7015–23. https://doi.org/10.1158/1078-0432.CCR-11-0607.

PMID
21976550
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Kaseb, Ahmed O., Jeffrey S. Morris, Manal M. Hassan, Adnan M. Siddiqui, E. Lin, Lianchun Xiao, Eddie K. Abdalla, et al. “Clinical and prognostic implications of plasma insulin-like growth factor-1 and vascular endothelial growth factor in patients with hepatocellular carcinoma.” J Clin Oncol 29, no. 29 (October 10, 2011): 3892–99. https://doi.org/10.1200/JCO.2011.36.0636.

PMID
21911725
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Carbone, Carmine, Tania Moccia, Cihui Zhu, Genni Paradiso, Alfredo Budillon, Paul J. Chiao, James L. Abbruzzese, and Davide Melisi. “Anti-VEGF treatment-resistant pancreatic cancers secrete proinflammatory factors that contribute to malignant progression by inducing an EMT cell phenotype.” Clin Cancer Res 17, no. 17 (September 1, 2011): 5822–32. https://doi.org/10.1158/1078-0432.CCR-11-1185.

PMID
21737511
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Melisi, Davide, Qianghua Xia, Genni Paradiso, Jianhua Ling, Tania Moccia, Carmine Carbone, Alfredo Budillon, James L. Abbruzzese, and Paul J. Chiao. “Modulation of pancreatic cancer chemoresistance by inhibition of TAK1.” J Natl Cancer Inst 103, no. 15 (August 3, 2011): 1190–1204. https://doi.org/10.1093/jnci/djr243.

PMID
21743023
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Crane, Christopher H., Gauri R. Varadhachary, John S. Yordy, Gregg A. Staerkel, Milind M. Javle, Howard Safran, Waqar Haque, et al. “Phase II trial of cetuximab, gemcitabine, and oxaliplatin followed by chemoradiation with cetuximab for locally advanced (T4) pancreatic adenocarcinoma: correlation of Smad4(Dpc4) immunostaining with pattern of disease progression.” J Clin Oncol 29, no. 22 (August 1, 2011): 3037–43. https://doi.org/10.1200/JCO.2010.33.8038.

PMID
21709185
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El-Rayes, Bassel Fuad, Philip A. Philip, Fazlul H. Sarkar, Anthony F. Shields, Ann Marie Ferris, Kenneth Hess, Ahmad O. Kaseb, et al. “A phase II study of isoflavones, erlotinib, and gemcitabine in advanced pancreatic cancer.” Invest New Drugs 29, no. 4 (August 2011): 694–99. https://doi.org/10.1007/s10637-010-9386-6.

PMID
20107864
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Tanaka, Motofumi, Ping Chang, Yanan Li, Donghui Li, Michael Overman, Dipen M. Maru, Salil Sethi, et al. “Association of CHFR promoter methylation with disease recurrence in locally advanced colon cancer.” Clin Cancer Res 17, no. 13 (July 1, 2011): 4531–40. https://doi.org/10.1158/1078-0432.CCR-10-0763.

PMID
21551253
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Varadhachary, Gauri R., Yael Spector, James L. Abbruzzese, Shai Rosenwald, Huamin Wang, Ranit Aharonov, Heather R. Carlson, et al. “Prospective gene signature study using microRNA to identify the tissue of origin in patients with carcinoma of unknown primary.” Clin Cancer Res 17, no. 12 (June 15, 2011): 4063–70. https://doi.org/10.1158/1078-0432.CCR-10-2599.

PMID
21531815
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Kaseb, Ahmed O., Manal M. Hassan, E. Lin, Lianchun Xiao, Vikas Kumar, Priyanka Pathak, Richard Lozano, Asif Rashid, James L. Abbruzzese, and Jeffrey S. Morris. “V-CLIP: Integrating plasma vascular endothelial growth factor into a new scoring system to stratify patients with advanced hepatocellular carcinoma for clinical trials.” Cancer 117, no. 11 (June 1, 2011): 2478–88. https://doi.org/10.1002/cncr.25791.

PMID
24048796
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Pages