James Abbruzzese, MD

Professor of Medicine
D. C. I. Professor of Medical Oncology
Chief, Division of Medical Oncology
Member of the Duke Cancer Institute
Campus mail 440 Mudd Building, Box 3406, Durham, NC 27710
Email address james.abbruzzese@duke.edu

My research interests include the clinical study and treatment of pancreatic cancer.

In Their Words

Education and Training

  • Resident, Internal Medicine, Johns Hopkins University School of Medicine, 1979 - 1981
  • Intern, Internal Medicine, Johns Hopkins University School of Medicine, 1978 - 1979
  • M.D., University of Chicago, 1978

Publications

Fogelman, D, Sugar, EA, Oliver, G, Shah, N, Klein, A, Alewine, C, Wang, H, Javle, M, Shroff, R, Wolff, RA, Abbruzzese, JL, Laheru, D, and Diaz, LA. "Family history as a marker of platinum sensitivity in pancreatic adenocarcinoma." Cancer chemotherapy and pharmacology 76, no. 3 (September 2015): 489-498.

PMID
26126726
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Lu, W, Yang, Y, Wang, X, Liu, Y, Luo, Y, Wolff, RA, Abbruzzese, JL, and Logsdon, CD. "Abstract 891: FGF21 prevents high fat diet-induced pancreatic cancer in mice expressing oncogenic Kras." August 1, 2015.

Full Text

Reddy, SM, Kopetz, S, Morris, J, Parikh, N, Qiao, W, Overman, MJ, Fogelman, D, Shureiqi, I, Jacobs, C, Malik, Z, Jimenez, CA, Wolff, RA, Abbruzzese, JL, Gallick, G, and Eng, C. "Phase II study of saracatinib (AZD0530) in patients with previously treated metastatic colorectal cancer." Investigational new drugs 33, no. 4 (August 2015): 977-984.

PMID
26062928
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Zhao, J, Wu, C, Abbruzzese, J, Hwang, RF, and Li, C. "Cyclopamine-loaded core-cross-linked polymeric micelles enhance radiation response in pancreatic cancer and pancreatic stellate cells." Molecular pharmaceutics 12, no. 6 (June 2015): 2093-2100.

PMID
25936695
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Zhang, T, Boominathan, R, Foulk, B, Connelly, MC, Rao, C, Kemeny, G, Strickler, JH, Abbruzzese, JL, Harrison, MR, George, DJ, Hurwitz, H, Garcia-Blanco, MA, and Armstrong, AJ. "Evaluation of a novel c-MET based circulating tumor cell (CTC) biomarker in patients with gastrointestinal (GI) and genitourinary (GU) malignancies." May 20, 2015.

Scholars@Duke

Li, D, Mao, Y, Chang, P, Liu, C, Hassan, MM, Yeung, SJ, and Abbruzzese, JL. "Impacts of new-onset and long-term diabetes on clinical outcome of pancreatic cancer." American Journal of Cancer Research 5, no. 10 (January 1, 2015): 3260-3269.

Scholars@Duke

Koay, EJ, Baio, FE, Ondari, A, Truty, MJ, Cristini, V, Thomas, RM, Chen, R, Chatterjee, D, Kang, Y, Zhang, J, Court, L, Bhosale, PR, Tamm, EP, Qayyum, A, Crane, CH, Javle, M, Katz, MH, Gottumukkala, VN, Rozner, MA, Shen, H, Lee, JE, Wang, H, Chen, Y, Plunkett, W, Abbruzzese, JL, Wolff, RA, Maitra, A, Ferrari, M, Varadhachary, GR, and Fleming, JB. "Intra-tumoral heterogeneity of gemcitabine delivery and mass transport in human pancreatic cancer." Physical biology 11, no. 6 (November 26, 2014): 065002-.

PMID
25427073
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Wang, H, Estrella, JS, Chatterjee, D, Katz, MH, Rashid, A, Wang, H, Wolff, RA, Varadhachary, GR, Lee, JE, Pisters, PW, Abbruzzese, JL, and Fleming, JB. "Hepatobiliary/Pancreas Pathology: SY11-3 PANCREATIC DUCTAL ADENOCARCINOMA: NEOADJUVANT THERAPIES AND PATHOLOGY." Pathology 46 Suppl 2 (October 2014): S25-.

PMID
25188109
Full Text

Abbruzzese, JL, and Hess, KR. "New option for the initial management of metastatic pancreatic cancer?." Journal of clinical oncology : official journal of the American Society of Clinical Oncology 32, no. 23 (August 2014): 2405-2407.

PMID
24982449
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Kaseb, AO, Xiao, L, Hassan, MM, Chae, YK, Lee, J-S, Vauthey, J-N, Krishnan, S, Cheung, S, Hassabo, HM, Aloia, T, Conrad, C, Curley, SA, Vierling, JM, Jalal, P, Raghav, K, Wallace, M, Rashid, A, Abbruzzese, JL, Wolff, RA, and Morris, JS. "Development and validation of insulin-like growth factor-1 score to assess hepatic reserve in hepatocellular carcinoma." JNCI Journal of the National Cancer Institute 106, no. 5 (May 9, 2014).

PMID
24815863
Full Text

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