James Abbruzzese, MD

Professor of Medicine
D. C. I. Professor of Medical Oncology
Chief, Division of Medical Oncology
Member of the Duke Cancer Institute
Campus mail 440 Mudd Building, Box 3406, Durham, NC 27710
Email address james.abbruzzese@duke.edu

My research interests include the clinical study and treatment of pancreatic cancer.

In Their Words

Education and Training

  • Resident, Internal Medicine, Johns Hopkins University School of Medicine, 1979 - 1981
  • Intern, Internal Medicine, Johns Hopkins University School of Medicine, 1978 - 1979
  • M.D., University of Chicago, 1978

Publications

Frazier, M. L., E. Fernández, R. de Llorens, N. M. Brown, S. Pathak, K. R. Cleary, J. L. Abbruzzese, et al. “Pancreatic adenocarcinoma cell line, MDAPanc-28, with features of both acinar and ductal cells.” Int J Pancreatol 19, no. 1 (February 1996): 31–38. https://doi.org/10.1007/BF02788373.

PMID
8656025
Full Text

Staley, C. A., J. E. Lee, K. R. Cleary, J. L. Abbruzzese, C. J. Fenoglio, T. A. Rich, and D. B. Evans. “Preoperative chemoradiation, pancreaticoduodenectomy, and intraoperative radiation therapy for adenocarcinoma of the pancreatic head.” Am J Surg 171, no. 1 (January 1996): 118–24. https://doi.org/10.1016/S0002-9610(99)80085-3.

PMID
8554125
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Pazdur, R., N. J. Meropol, E. S. Casper, C. Fuchs, H. O. Douglass, M. Vincent, and J. L. Abbruzzese. “Phase II trial of ZD1694 (Tomudex) in patients with advanced pancreatic cancer.” Invest New Drugs 13, no. 4 (1996): 355–58. https://doi.org/10.1007/bf00873144.

PMID
8824356
Full Text

Abbruzzese, J. L. “Phase I studies with the novel nucleoside analog gemcitabine.” Seminars in Oncology 23, no. 5 SUPPL. 10 (1996): 25–31.

Scholars@Duke

Moore, D. F., R. Pazdur, S. Sugarman, D. Jones, S. M. Lippman, B. Bready, and J. L. Abbruzzese. “Pilot phase II trial of 13-cis-retinoic acid and interferon-alpha combination therapy for advanced pancreatic adenocarcinoma.” Am J Clin Oncol 18, no. 6 (December 1995): 525–27. https://doi.org/10.1097/00000421-199512000-00013.

PMID
8526197
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Jones, D. V., R. J. Winn, B. W. Brown, L. B. Levy, R. P. Pugh, J. L. Wade, H. M. Gross, K. B. Pendergrass, B. Levin, and J. L. Abbruzzese. “Randomized phase III study of 5-fluorouracil plus high dose folinic acid versus 5-fluorouracil plus folinic acid plus methyl-lomustine for patients with advanced colorectal cancer.” Cancer 76, no. 10 (November 15, 1995): 1709–14. https://doi.org/10.1002/1097-0142(19951115)76:10<1709::aid-cncr2820761006>3.0.co;2-5.

PMID
8625038
Full Text

Evans, D. B., J. L. Abbruzzese, K. R. Cleary, D. J. Buchholz, C. J. Fenoglio, C. Collier, and T. A. Rich. “Preoperative chemoradiation for adenocarcinoma of the pancreas: excessive toxicity of prophylactic hepatic irradiation.” Int J Radiat Oncol Biol Phys 33, no. 4 (November 1, 1995): 913–18. https://doi.org/10.1016/0360-3016(94)00615-2.

PMID
7591902
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Lenzi, R., M. N. Raber, S. B. Schmidt, and J. L. Abbruzzese. “A pilot study of paclitaxel in previously treated patients with metastatic unknown primary carcinomas.” Oncology Reports 2, no. 6 (October 23, 1995): 1127–28.

Scholars@Duke

Evans, O. B., J. L. Abbruzzese, K. R. Cleary, J. E. Lee, D. J. Buchholz, and T. A. Rich. “Rapid-fractionation pre-operative chemoradiation for malignant periampullary neoplasms.” J R Coll Surg Edinb 40, no. 5 (October 1995): 319–23.

PMID
8523311
Scholars@Duke

Pazdur, R., B. Bready, J. A. Ajani, J. L. Abbruzzese, A. Markowitz, S. Sugarman, D. Jones, and B. Levin. “Phase II trial of isotretinoin and recombinant interferon alfa-2a in metastatic colorectal carcinoma.” Am J Clin Oncol 18, no. 5 (October 1995): 436–38. https://doi.org/10.1097/00000421-199510000-00015.

PMID
7572763
Full Text

Pages