James Abbruzzese, MD

Professor of Medicine
D. C. I. Professor of Medical Oncology
Chief, Division of Medical Oncology
Member of the Duke Cancer Institute
Campus mail 440 Mudd Building, Box 3406, Durham, NC 27710
Email address james.abbruzzese@duke.edu

My research interests include the clinical study and treatment of pancreatic cancer.

In Their Words

Education and Training

  • Resident, Internal Medicine, Johns Hopkins University School of Medicine, 1979 - 1981
  • Intern, Internal Medicine, Johns Hopkins University School of Medicine, 1978 - 1979
  • M.D., University of Chicago, 1978

Publications

Kaseb, AO, Shama, M, Sahin, IH, Nooka, A, Hassabo, HM, Vauthey, J-N, Aloia, T, Abbruzzese, JL, Subbiah, IM, Janku, F, Curley, S, and Hassan, MM. "Prognostic indicators and treatment outcome in 94 cases of fibrolamellar hepatocellular carcinoma." Oncology 85, no. 4 (January 2013): 197-203.

PMID
24051705
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Overman, MJ, Zhang, J, Kopetz, S, Davies, M, Jiang, Z-Q, Stemke-Hale, K, Rümmele, P, Pilarsky, C, Grützmann, R, Hamilton, S, Hwang, R, Abbruzzese, JL, Varadhachary, G, Broom, B, and Wang, H. "Gene expression profiling of ampullary carcinomas classifies ampullary carcinomas into biliary-like and intestinal-like subtypes that are prognostic of outcome." PloS one 8, no. 6 (January 2013): e65144-.

PMID
23776447
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Katz, MHG, Fleming, JB, Bhosale, P, Varadhachary, G, Lee, JE, Wolff, R, Wang, H, Abbruzzese, J, Pisters, PWT, Vauthey, J-N, Charnsangavej, C, Tamm, E, Crane, CH, and Balachandran, A. "Response of borderline resectable pancreatic cancer to neoadjuvant therapy is not reflected by radiographic indicators." Cancer 118, no. 23 (December 2012): 5749-5756.

PMID
22605518
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Weng, S, Wang, H, Chen, W, Katz, MH, Chatterjee, D, Lee, JE, Pisters, PW, Gomez, HF, Abbruzzese, JL, Fleming, JB, and Wang, H. "Overexpression of protein phosphatase 4 correlates with poor prognosis in patients with stage II pancreatic ductal adenocarcinoma." Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 21, no. 8 (August 2012): 1336-1343.

PMID
22665577
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Wang, J, Estrella, JS, Peng, L, Rashid, A, Varadhachary, GR, Wang, H, Lee, JE, Pisters, PWT, Vauthey, J-N, Katz, MH, Gomez, HF, Evans, DB, Abbruzzese, JL, Fleming, JB, and Wang, H. "Histologic tumor involvement of superior mesenteric vein/portal vein predicts poor prognosis in patients with stage II pancreatic adenocarcinoma treated with neoadjuvant chemoradiation." Cancer 118, no. 15 (August 2012): 3801-3811.

PMID
22180096
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Truty, MJ, Thomas, RM, Katz, MH, Vauthey, J-N, Crane, C, Varadhachary, GR, Wolff, RA, Abbruzzese, JL, Lee, JE, and Fleming, JB. "Multimodality therapy offers a chance for cure in patients with pancreatic adenocarcinoma deemed unresectable at first operative exploration." Journal of the American College of Surgeons 215, no. 1 (July 2012): 41-51.

PMID
22608401
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Chatterjee, D, Katz, MH, Rashid, A, Varadhachary, GR, Wolff, RA, Wang, H, Lee, JE, Pisters, PWT, Vauthey, J-N, Crane, C, Gomez, HF, Abbruzzese, JL, Fleming, JB, and Wang, H. "Histologic grading of the extent of residual carcinoma following neoadjuvant chemoradiation in pancreatic ductal adenocarcinoma: a predictor for patient outcome." Cancer 118, no. 12 (June 2012): 3182-3190.

PMID
22028089
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Dong, X, Li, Y, Chang, P, Hess, KR, Abbruzzese, JL, and Li, D. "DNA mismatch repair network gene polymorphism as a susceptibility factor for pancreatic cancer." Molecular carcinogenesis 51, no. 6 (June 2012): 491-499.

PMID
21681824
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Overman, MJ, Hu, C-Y, Kopetz, S, Abbruzzese, JL, Wolff, RA, and Chang, GJ. "A population-based comparison of adenocarcinoma of the large and small intestine: insights into a rare disease." Annals of surgical oncology 19, no. 5 (May 2012): 1439-1445.

PMID
22187121
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Tomblyn, MB, Goldman, BH, Thomas, CR, Benedetti, JK, Lenz, H-J, Mehta, V, Beeker, T, Gold, PJ, Abbruzzese, JL, Blanke, CD, and SWOG GI Committee, . "Cetuximab plus cisplatin, irinotecan, and thoracic radiotherapy as definitive treatment for locally advanced, unresectable esophageal cancer: a phase-II study of the SWOG (S0414)." Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 7, no. 5 (May 2012): 906-912.

PMID
22481235
Full Text

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