James Abbruzzese, MD

Professor of Medicine
D. C. I. Professor of Medical Oncology
Chief, Division of Medical Oncology
Member of the Duke Cancer Institute
Campus mail 440 Mudd Building, Box 3406, Durham, NC 27710
Email address james.abbruzzese@duke.edu

My research interests include the clinical study and treatment of pancreatic cancer.

In Their Words

Education and Training

  • Resident, Internal Medicine, Johns Hopkins University School of Medicine, 1979 - 1981
  • Intern, Internal Medicine, Johns Hopkins University School of Medicine, 1978 - 1979
  • M.D., University of Chicago, 1978

Publications

Hassan, Manal M., Ahmed Kaseb, Carol J. Etzel, Hashem El-Serag, Margaret R. Spitz, Ping Chang, Katherine S. Hale, et al. “Genetic variation in the PNPLA3 gene and hepatocellular carcinoma in USA: risk and prognosis prediction..” Mol Carcinog 52 Suppl 1 (November 2013): E139–47. https://doi.org/10.1002/mc.22057.

PMID
23776098
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Khalil, Mohamed A., Wei Qiao, Peter Carlson, Binsah George, Milind Javle, Michael Overman, Gauri Varadhachary, Robert A. Wolff, James L. Abbruzzese, and David R. Fogelman. “The addition of erlotinib to gemcitabine and cisplatin does not appear to improve median survival in metastatic pancreatic cancer..” Invest New Drugs 31, no. 5 (October 2013): 1375–83. https://doi.org/10.1007/s10637-013-9967-2.

PMID
23645398
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Kaseb, Ahmed O., Junichi Shindoh, Yehuda Z. Patt, Robert E. Roses, Giuseppe Zimmitti, Richard D. Lozano, Manal M. Hassan, et al. “Modified cisplatin/interferon α-2b/doxorubicin/5-fluorouracil (PIAF) chemotherapy in patients with no hepatitis or cirrhosis is associated with improved response rate, resectability, and survival of initially unresectable hepatocellular carcinoma..” Cancer 119, no. 18 (September 15, 2013): 3334–42. https://doi.org/10.1002/cncr.28209.

PMID
23821538
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Overman, M. J., J. Zhang, S. Kopetz, M. Davies, Z. Q. Jiang, K. Stemke-Hale, P. Rümmele, et al. “Erratum: Gene expression profiling of ampullary carcinomas classifies ampullary carcinomas into biliary-like and intestinal-like subtypes that are prognostic of outcome (PLoS ONE (2013) 8:7 DOI: 10.1371/annotation/6afdd046- e1a7-4421-b7ec-0c9492ce2544).” Plos One 8, no. 7 (July 3, 2013). https://doi.org/10.1371/annotation/6afdd046-e1a7-4421-b7ec-0c9492ce2544.

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Tzeng, Ching-Wei D., Daniel E. Abbott, Scott B. Cantor, Jason B. Fleming, Jeffrey E. Lee, Peter W. T. Pisters, Gauri R. Varadhachary, et al. “Frequency and intensity of postoperative surveillance after curative treatment of pancreatic cancer: a cost-effectiveness analysis..” Ann Surg Oncol 20, no. 7 (July 2013): 2197–2203. https://doi.org/10.1245/s10434-013-2889-6.

PMID
23408126
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Foo, Wai Chin, Asif Rashid, Hua Wang, Matthew H. Katz, Jeffrey E. Lee, Peter W. Pisters, Robert A. Wolff, James L. Abbruzzese, Jason B. Fleming, and Huamin Wang. “Loss of phosphatase and tensin homolog expression is associated with recurrence and poor prognosis in patients with pancreatic ductal adenocarcinoma..” Hum Pathol 44, no. 6 (June 2013): 1024–30. https://doi.org/10.1016/j.humpath.2012.09.001.

PMID
23260327
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Chang, Zhe, Zhongkui Li, Xiaoyang Wang, Ya’an Kang, Yuhui Yuan, Jiangong Niu, Huamin Wang, et al. “Deciphering the mechanisms of tumorigenesis in human pancreatic ductal epithelial cells..” Clin Cancer Res 19, no. 3 (February 1, 2013): 549–59. https://doi.org/10.1158/1078-0432.CCR-12-0032.

PMID
23340292
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Li, Lei, Mohammad Othman, Asif Rashid, Hua Wang, Zhaoshen Li, Matthew H. Katz, Jeffrey E. Lee, et al. “Solid pseudopapillary neoplasm of the pancreas with prominent atypical multinucleated giant tumour cells..” Histopathology 62, no. 3 (February 2013): 465–71. https://doi.org/10.1111/his.12023.

PMID
23134473
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Yao, Yixin, Milind Suraokar, Bryant G. Darnay, Brett G. Hollier, Tattym E. Shaiken, Takayuki Asano, Chien-Hung Chen, et al. “BSTA promotes mTORC2-mediated phosphorylation of Akt1 to suppress expression of FoxC2 and stimulate adipocyte differentiation..” Sci Signal 6, no. 257 (January 8, 2013). https://doi.org/10.1126/scisignal.2003295.

PMID
23300339
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Overman, Michael J., Janhavi Modak, Scott Kopetz, Ravi Murthy, James C. Yao, Marshall E. Hicks, James L. Abbruzzese, and Alda L. Tam. “Use of research biopsies in clinical trials: are risks and benefits adequately discussed?.” J Clin Oncol 31, no. 1 (January 1, 2013): 17–22. https://doi.org/10.1200/JCO.2012.43.1718.

PMID
23129736
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Pages