Endocrinology, Metabolism, and Nutrition

James R. Bain, PhD

Associate Professor in Medicine
Member of Sarah W. Stedman Nutrition and Metabolism Center
Senior Fellow in the Center for Study of Aging
Campus mail 300 North Duke Street, Room 48-201, Duke Molecular Physiology Institute, Durham, NC 27701-2047
Phone (919) 479-2320
Email address james.bain@duke.edu

Education and Training

  • Ph.D., University of Washington, 2001

Grants

Publications

Parry, TL, Starnes, JW, O Neal, SK, Bain, JR, Muehlbauer, MJ, Honcoop, A, Ilaiwy, A, Christopher, P, Patterson, C, and Willis, MS. "Untargeted metabolomics analysis of ischemia–reperfusion-injured hearts ex vivo from sedentary and exercise-trained rats." Metabolomics 14, no. 1 (January 1, 2018).

Full Text

Jensen, BC, Parry, TL, Huang, W, Beak, JY, Ilaiwy, A, Bain, JR, Newgard, CB, Muehlbauer, MJ, Patterson, C, Johnson, GL, and Willis, MS. "Effects of the kinase inhibitor sorafenib on heart, muscle, liver and plasma metabolism in vivo using non-targeted metabolomics analysis." British journal of pharmacology 174, no. 24 (December 2017): 4797-4811.

PMID
28977680
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Wang, H, Muehlbauer, MJ, O'Neal, SK, Newgard, CB, Hauser, ER, Bain, JR, and Shah, SH. "Recommendations for Improving Identification and Quantification in Non-Targeted, GC-MS-Based Metabolomic Profiling of Human Plasma." Metabolites 7, no. 3 (August 25, 2017).

PMID
28841195
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Starnes, JW, Parry, TL, O'Neal, SK, Bain, JR, Muehlbauer, MJ, Honcoop, A, Ilaiwy, A, Christopher, PM, Patterson, C, and Willis, MS. "Exercise-Induced Alterations in Skeletal Muscle, Heart, Liver, and Serum Metabolome Identified by Non-Targeted Metabolomics Analysis." Metabolites 7, no. 3 (August 8, 2017).

PMID
28786928
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Wang, H, Anstrom, K, Ilkayeva, O, Muehlbauer, MJ, Bain, JR, McNulty, S, Newgard, CB, Kraus, WE, Hernandez, A, Felker, GM, Redfield, M, and Shah, SH. "Sildenafil Treatment in Heart Failure With Preserved Ejection Fraction: Targeted Metabolomic Profiling in the RELAX Trial." JAMA cardiology 2, no. 8 (August 2017): 896-901.

PMID
28492915
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Abdullah, M, Kornegay, JN, Honcoop, A, Parry, TL, Balog-Alvarez, CJ, O'Neal, SK, Bain, JR, Muehlbauer, MJ, Newgard, CB, Patterson, C, and Willis, MS. "Non-Targeted Metabolomics Analysis of Golden Retriever Muscular Dystrophy-Affected Muscles Reveals Alterations in Arginine and Proline Metabolism, and Elevations in Glutamic and Oleic Acid In Vivo." Metabolites 7, no. 3 (July 29, 2017).

PMID
28758940
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Ilaiwy, A, Quintana, MT, Bain, JR, Muehlbauer, MJ, Brown, DI, Stansfield, WE, and Willis, MS. "Erratum to 'Cessation of biomechanical stretch model of C2C12 cells modelsmyocyte atrophy and anaplerotic changes in metabolism usingnon-targeted metabolomics analysisAmro' [Int. J. Biochem. Cell Biol. (2016) 80-92]." The international journal of biochemistry & cell biology 88 (July 2017): 238-240.

PMID
28330772
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Jacob, S, Nodzenski, M, Reisetter, AC, Bain, JR, Muehlbauer, MJ, Stevens, RD, Ilkayeva, OR, Lowe, LP, Metzger, BE, Newgard, CB, Scholtens, DM, Lowe, WL, and HAPO Study Cooperative Research Group, . "Targeted Metabolomics Demonstrates Distinct and Overlapping Maternal Metabolites Associated With BMI, Glucose, and Insulin Sensitivity During Pregnancy Across Four Ancestry Groups." Diabetes care 40, no. 7 (July 2017): 911-919.

PMID
28637889
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Lowe, WL, Bain, JR, Nodzenski, M, Reisetter, AC, Muehlbauer, MJ, Stevens, RD, Ilkayeva, OR, Lowe, LP, Metzger, BE, Newgard, CB, Scholtens, DM, and HAPO Study Cooperative Research Group, . "Maternal BMI and Glycemia Impact the Fetal Metabolome." Diabetes care 40, no. 7 (July 2017): 902-910.

PMID
28637888
Full Text

Jensen, BC, Parry, TL, Huang, W, Ilaiwy, A, Bain, JR, Muehlbauer, MJ, O'Neal, SK, Patterson, C, Johnson, GL, and Willis, MS. "Non-Targeted Metabolomics Analysis of the Effects of Tyrosine Kinase Inhibitors Sunitinib and Erlotinib on Heart, Muscle, Liver and Serum Metabolism In Vivo." Metabolites 7, no. 3 (June 22, 2017).

PMID
28640223
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