Jeffrey Crawford, MD

Professor of Medicine
George Barth Geller Distinguished Professor of Immunology
Member of the Duke Cancer Institute
Campus mail 443 Seeley G. Mudd Bldg, Durham, NC 27710
Phone (919) 681-9509
Email address crawf006@mc.duke.edu

1. Lung cancer/new treatment approaches.
2. Clinical trials of hematopoietic growth factors, biological agents and targeted drug development.
3. Cancer in the elderly and supportive care

Accomplishments

1. Lead Investigator of the U. S. multicenter, randomized trial of Filgrastim (G-CSF, Neupogen) to reduce the morbidity of chemotherapy-related neutropenia, leading to FDA approval 2/91.
2. Lead Investigator of the U. S. multicenter, randomized trial of Vinorelbine (Navelbine) in treatment of patients with advanced non small cell carcinoma of lung (NSCLC), leading to FDA approval 12/94.
3. Principal Investigator in initial phase I clinical trials of stem cell factor (SCF), megakaryocyte growth and development factor (MGDF), pegylated granulocyte-colony-stimulating factor and other novel hematopoietic growth factors.

In Their Words

Education and Training

  • M.D., Ohio State University, 1974

Publications

Boyer, Matthew J., Lin Gu, Xiaofei Wang, Chris R. Kelsey, David S. Yoo, Mark W. Onaitis, Frank R. Dunphy, Jeffrey Crawford, Neal E. Ready, and Joseph K. Salama. “Toxicity of definitive and post-operative radiation following ipilimumab in non-small cell lung cancer.” Lung Cancer 98 (August 2016): 76–78. https://doi.org/10.1016/j.lungcan.2016.05.014.

PMID
27393510
Full Text

Crawford, Jeffrey, Carla M. M. Prado, Mary Ann Johnston, Richard J. Gralla, Ryan P. Taylor, Michael L. Hancock, and James T. Dalton. “Study Design and Rationale for the Phase 3 Clinical Development Program of Enobosarm, a Selective Androgen Receptor Modulator, for the Prevention and Treatment of Muscle Wasting in Cancer Patients (POWER Trials).” Curr Oncol Rep 18, no. 6 (June 2016): 37. https://doi.org/10.1007/s11912-016-0522-0.

PMID
27138015
Full Text

Raftopoulos, Haralambos, Abderrahmane Laadem, Paul J. Hesketh, Jerome Goldschmidt, Nashat Gabrail, Cynthia Osborne, Muhammad Ali, et al. “Sotatercept (ACE-011) for the treatment of chemotherapy-induced anemia in patients with metastatic breast cancer or advanced or metastatic solid tumors treated with platinum-based chemotherapeutic regimens: results from two phase 2 studies.” Support Care Cancer 24, no. 4 (April 2016): 1517–25. https://doi.org/10.1007/s00520-015-2929-9.

PMID
26370220
Full Text

Salama, Joseph K., Lin Gu, Xiaofei Wang, Herbert H. Pang, Jeffrey A. Bogart, Jeffrey Crawford, Steven E. Schild, Everett E. Vokes, and Neal E. Ready. “Positive Interaction between Prophylactic Cranial Irradiation and Maintenance Sunitinib for Untreated Extensive-Stage Small Cell Lung Cancer Patients After Standard Chemotherapy: A Secondary Analysis of CALGB 30504 (ALLIANCE).” J Thorac Oncol 11, no. 3 (March 2016): 361–69. https://doi.org/10.1016/j.jtho.2015.11.001.

PMID
26723241
Full Text

Lyman, Gary H., Jeffrey Crawford, Dianne Tomita, Sadie Whittaker, and David C. Dale. “Changing patterns of chemotherapy relative dose intensity and supportive care for aggressive B-cell non-Hodgkin lymphoma.” In Leuk Lymphoma, 57:283–90, 2016. https://doi.org/10.3109/10428194.2015.1045894.

PMID
25926064
Full Text

Crawford, Jeffrey, Paul Wheatley-Price, and Josephine Louella Feliciano. “Treatment of Lung Cancer in Medically Compromised Patients.” Am Soc Clin Oncol Educ Book 35 (2016): e484–91. https://doi.org/10.1200/EDBK_158713.

PMID
27249757
Full Text

Lyman, Gary H., Marek S. Poniewierski, Jeffrey Crawford, David C. Dale, and Eva Culakova. “Cost of Hospitalization in Patients with Cancer and Febrile Neutropenia and Impact of Comorbid Conditions.” In Blood, 126:2089–2089. American Society of Hematology, 2015. https://doi.org/10.1182/blood.v126.23.2089.2089.

Full Text

Fearon, Kch, J. M. Argiles, V. E. Baracos, R. Bernabei, Ajs Coats, J. Crawford, N. E. Deutz, et al. “Request for regulatory guidance for cancer cachexia intervention trials.” J Cachexia Sarcopenia Muscle 6, no. 4 (December 2015): 272–74. https://doi.org/10.1002/jcsm.12083.

PMID
26675232
Full Text

Wang, Xiaofei, Lin Gu, Ying Zhang, Daniel J. Sargent, William Richards, Apar Kishor Ganti, Jeffery Crawford, et al. “Validation of survival prognostic models for non-small-cell lung cancer in stage- and age-specific groups.” Lung Cancer 90, no. 2 (November 2015): 281–87. https://doi.org/10.1016/j.lungcan.2015.08.007.

PMID
26319317
Full Text

Pages