Jen-Tsan Ashley Chi, MD, PhD

Associate Professor in Molecular Genetics and Microbiology
Assistant Professor of Medicine
Assistant Professor in Radiation Oncology
Associate Professor of Pharmacology and Cancer Biology
Member of the Duke Cancer Institute
Campus mail 101 Science Dr, Dumc3382, Room 2177A, CIEMAS Bldg, Durham, NC 27708
Phone (919) 668-4759
Email address jentsan.chi@duke.edu

Education and Training

  • Postdoctoral Research, Biochemistry, Stanford University, 2000 - 2004
  • Ph.D., Stanford University, 2000
  • M.D., National Taiwan University, 1991

Publications

Walzer, Katelyn A., Danielle M. Kubicki, Xiaohu Tang, and Jen-Tsan Ashley Chi. “Single-Cell Analysis Reveals Distinct Gene Expression and Heterogeneity in Male and Female Plasmodium falciparum Gametocytes..” Msphere 3, no. 2 (April 25, 2018). https://doi.org/10.1128/mSphere.00130-18.

PMID
29643077
Full Text

Lin, Chao-Chieh, Mayumi Kitagawa, Xiaohu Tang, Ming-Hsin Hou, Jianli Wu, Dan Chen Qu, Vinayaka Srinivas, et al. “CoA synthase regulates mitotic fidelity via CBP-mediated acetylation..” In Nat Commun, Vol. 9, 2018. https://doi.org/10.1038/s41467-018-03422-6.

PMID
29531224
Full Text

Justus, Calvin R., Edward J. Sanderlin, Lixue Dong, Tianai Sun, Jen-Tsan Chi, Kvin Lertpiriyapong, and Li V. Yang. “Contextual tumor suppressor function of T cell death-associated gene 8 (TDAG8) in hematological malignancies..” J Transl Med 15, no. 1 (October 10, 2017). https://doi.org/10.1186/s12967-017-1305-6.

PMID
29017562
Full Text

Chen, Po-Han, Timothy J. Smith, Jianli Wu, Priscila F. Siesser, Brittany J. Bisnett, Farhan Khan, Maxwell Hogue, et al. “Glycosylation of KEAP1 links nutrient sensing to redox stress signaling..” Embo J 36, no. 15 (August 1, 2017): 2233–50. https://doi.org/10.15252/embj.201696113.

PMID
28663241
Full Text

Lee, Chen-Ting, Yingchun Zhou, Kingshuk Roy-Choudhury, Sharareh Siamakpour-Reihani, Kenneth Young, Peter Hoang, John P. Kirkpatrick, Jen-Tsan A. Chi, Mark W. Dewhirst, and Janet K. Horton. “Subtype-Specific Radiation Response and Therapeutic Effect of FAS Death Receptor Modulation in Human Breast Cancer..” Radiat Res 188, no. 2 (August 2017): 169–80. https://doi.org/10.1667/RR14664.1.

PMID
28598289
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Tang, X., C. -. K. Ding, J. Wu, J. Sjol, S. Wardell, I. Spasojevic, D. George, et al. “Cystine addiction of triple-negative breast cancer associated with EMT augmented death signaling..” Oncogene 36, no. 30 (July 27, 2017): 4235–42. https://doi.org/10.1038/onc.2016.394.

PMID
27869167
Full Text

Walzer, Katelyn A., and Jen-Tsan Chi. “Trans-kingdom small RNA transfer during host-pathogen interactions: The case of P. falciparum and erythrocytes..” Rna Biol 14, no. 4 (April 3, 2017): 442–49. https://doi.org/10.1080/15476286.2017.1294307.

PMID
28277932
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Alfaqih, Mahmoud A., Erik R. Nelson, Wen Liu, Rachid Safi, Jeffery S. Jasper, Everardo Macias, Joseph Geradts, et al. “CYP27A1 Loss Dysregulates Cholesterol Homeostasis in Prostate Cancer..” Cancer Res 77, no. 7 (April 1, 2017): 1662–73. https://doi.org/10.1158/0008-5472.CAN-16-2738.

PMID
28130224
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Siska, Peter J., Bumki Kim, Xiangming Ji, Megan D. Hoeksema, Pierre P. Massion, Kathryn E. Beckermann, Jianli Wu, Jen-Tsan Chi, Jiyong Hong, and Jeffrey C. Rathmell. “Fluorescence-based measurement of cystine uptake through xCT shows requirement for ROS detoxification in activated lymphocytes..” J Immunol Methods 438 (November 2016): 51–58. https://doi.org/10.1016/j.jim.2016.08.013.

PMID
27594594
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Geer Wallace, M Ariel, Do-Yeon Kwon, Douglas H. Weitzel, Chen-Ting Lee, Tesia N. Stephenson, Jen-Tsan Chi, Robert A. Mook, Mark W. Dewhirst, Jiyong Hong, and Michael C. Fitzgerald. “Discovery of Manassantin A Protein Targets Using Large-Scale Protein Folding and Stability Measurements..” J Proteome Res 15, no. 8 (August 5, 2016): 2688–96. https://doi.org/10.1021/acs.jproteome.6b00237.

PMID
27322910
Full Text

Pages