Jennifer Leigh Ingram, PhD

Assistant Professor in Medicine
Assistant Professor in Pathology
Assistant Professor in the Department of Surgery
Campus mail 201 Msrb1 Bldg, Durham, NC 27710
Phone (919) 668-1439
Email address jennifer.ingram@duke.edu

Dr. Ingram's research interests focus on the study of airway remodeling in human asthma. Proliferation, migration, and invasion of airway fibroblasts are key features of airway remodeling that contribute to diminished lung function over time. Dr. Ingram uses molecular biology approaches to define the effects of interleukin-13 (IL-13), a cytokine abundantly produced in the asthmatic airway, in the human airway fibroblast. She has identified important regulatory functions of several proteins prevalent in asthma that control fibroblast growth and pro-fibrotic growth factor production in response to IL-13. By understanding these pathways and their role in human asthma and the chronic effects of airway remodeling, novel treatment strategies may be developed.

Education and Training

  • Ph.D., North Carolina State University, 2000

Publications

Ihrie, Mark D., and Jennifer L. Ingram. “Orchestrating Airway Smooth Muscle Cell Migration: GMFγ Phosphorylation Is the Key..” Am J Respir Cell Mol Biol 61, no. 2 (August 2019): 136–38. https://doi.org/10.1165/rcmb.2019-0074ED.

PMID
30950633
Full Text

Cyphert-Daly, Jaime M., Zhonghui Yang, Jennifer L. Ingram, Robert M. Tighe, and Loretta G. Que. “Physiologic response to chronic house dust mite exposure in mice is dependent on lot characteristics..” In J Allergy Clin Immunol, 2019. https://doi.org/10.1016/j.jaci.2019.07.019.

PMID
31369802
Full Text

Guerron, Alfredo D., Camila B. Ortega, Hui-Jie Lee, Gerardo Davalos, Jennifer Ingram, and Dana Portenier. “Asthma medication usage is significantly reduced following bariatric surgery..” Surg Endosc 33, no. 6 (June 2019): 1967–75. https://doi.org/10.1007/s00464-018-6500-x.

PMID
30334159
Full Text

Ihrie, Mark, Victoria McQuade, Akhil Hegde, Jingjing Niu, Jenny Tong, David D’Alessio, Julia K. L. Walker, Loretta G. Que, and Jennifer L. Ingram. “Sleeve gastrectomy surgery reduces airway resistance and inflammation in chronically allergen-challenged obese mice.” In Journal of Allergy and Clinical Immunology, 143:AB307–AB307. Elsevier BV, 2019. https://doi.org/10.1016/j.jaci.2018.12.935.

Full Text

Yu, Y. A., J. Daly, S. Phelan, R. I. Cumming, A. Birukova, Y. Malakhau, J. L. Ingram, M. D. Gunn, L. G. Que, and R. M. Tighe. “Replacement of Fetal-Derived with Bone Marrow-Derived Pulmonary Resident Macrophages Reduces House Dust Mite-Induced Airway Hyperresponsiveness.” In American Journal of Respiratory and Critical Care Medicine, Vol. 199. AMER THORACIC SOC, 2019.

Scholars@Duke

Lugogo, Njira, Dave Francisco, Kenneth J. Addison, Akarsh Manne, William Pederson, Jennifer L. Ingram, Cynthia L. Green, et al. “Obese asthmatic patients have decreased surfactant protein A levels: Mechanisms and implications..” J Allergy Clin Immunol 141, no. 3 (March 2018): 918-926.e3. https://doi.org/10.1016/j.jaci.2017.05.028.

PMID
28624607
Full Text

Yang, Z., J. Daly, D. E. Winnica, F. Holguin, V. McQuade, J. L. Ingram, R. M. Tighe, and L. G. Que. “Characterization of Paraoxonases in Mice with Obese Allergic Asthma.” In American Journal of Respiratory and Critical Care Medicine, Vol. 197. AMER THORACIC SOC, 2018.

Scholars@Duke

Ingram, J. L., V. McQuade, B. Theriot, J. Niu, J. Daly, J. Wong, J. Tong, R. M. Tighe, L. G. Que, and D. D’Alessio. “Vertical Sleeve Gastrectomy in Allergen-Challenged Obese Mice Is Associated with Reduced Airway Resistance and Fibrosis.” In American Journal of Respiratory and Critical Care Medicine, Vol. 197. AMER THORACIC SOC, 2018.

Scholars@Duke

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