Jennifer Leigh Ingram, PhD

Assistant Professor in Medicine
Campus mail 275 MSRB Bldg, Durham, NC 27710
Phone (919) 668-1439
Email address jennifer.ingram@duke.edu

Dr. Ingram's research interests focus on the study of airway remodeling in human asthma. Proliferation, migration, and invasion of airway fibroblasts are key features of airway remodeling that contribute to diminished lung function over time. Dr. Ingram uses molecular biology approaches to define the effects of interleukin-13 (IL-13), a cytokine abundantly produced in the asthmatic airway, in the human airway fibroblast. She has identified important regulatory functions of several proteins prevalent in asthma that control fibroblast growth and pro-fibrotic growth factor production in response to IL-13. By understanding these pathways and their role in human asthma and the chronic effects of airway remodeling, novel treatment strategies may be developed.

Education and Training

  • Ph.D., North Carolina State University, 2000

Publications

Lugogo, N, Francisco, D, Addison, KJ, Manne, A, Pederson, W, Ingram, JL, Green, CL, Suratt, BT, Lee, JJ, Sunday, ME, Kraft, M, and Ledford, JG. "Obese asthmatic patients have decreased surfactant protein A levels: Mechanisms and implications." The Journal of allergy and clinical immunology 141, no. 3 (March 2018): 918-926.e3.

PMID
28624607
Full Text

Walker, JKL, Theriot, BS, Ghio, M, Trempus, CS, Wong, JE, McQuade, VL, Liang, J, Jiang, D, Noble, PW, Garantziotis, S, Kraft, M, and Ingram, JL. "Targeted HAS2 Expression Lessens Airway Responsiveness in Chronic Murine Allergic Airway Disease." American journal of respiratory cell and molecular biology 57, no. 6 (December 2017): 702-710.

PMID
28787175
Full Text

Trempus, CS, Song, W, Lazrak, A, Yu, Z, Creighton, JR, Young, BM, Heise, RL, Yu, YR, Ingram, JL, Tighe, RM, Matalon, S, and Garantziotis, S. "A novel role for primary cilia in airway remodeling." American journal of physiology. Lung cellular and molecular physiology 313, no. 2 (August 2017): L328-L338.

PMID
28473325
Full Text

Ingram, JL. "Modeling Human Lung Fibroblast Responses in Asthma and Airway Disease." June 2017.

Scholars@Duke

Hackett, T-L, Ferrante, SC, Hoptay, CE, Engelhardt, JF, Ingram, JL, Zhang, Y, Alcala, SE, Shaheen, F, Matz, E, Pillai, DK, and Freishtat, RJ. "A Heterotopic Xenograft Model of Human Airways for Investigating Fibrosis in Asthma." American journal of respiratory cell and molecular biology 56, no. 3 (March 2017): 291-299.

PMID
27788019
Full Text

Ingram, JL, Ghio, M, Hegde, A, Wong, J, D'Alessio, D, Que, L, Walker, JK, and McQuade, V. "Opposing Actions Of Leptin And Glucagon-Like Peptide-1 (glp-1) To Regulate Interleukin-13 (il-13)-Directed Airway Fibroblast Responses." 2017.

Scholars@Duke

Ingram, JL, Slade, D, Church, TD, Francisco, D, Heck, K, Sigmon, RW, Ghio, M, Murillo, A, Firszt, R, Lugogo, NL, Que, L, Sunday, ME, and Kraft, M. "Role of Matrix Metalloproteinases-1 and -2 in Interleukin-13-Suppressed Elastin in Airway Fibroblasts in Asthma." American journal of respiratory cell and molecular biology 54, no. 1 (January 2016): 41-50.

PMID
26074138
Full Text

Ingram, JL, Ghio, M, Sigmon, RW, Wong, J, Theriot, B, Hegde, A, Walker, JKL, and Kraft, M. "Interleukin-17 And Leptin Contribute To Airway Fibrosis And Altered Interleukin-13 Receptor Expression In Obese Asthma." 2016.

Scholars@Duke

Ferrante, SC, Hackett, T-L, Hoptay, CE, Engelhardt, J, Ingram, JL, Alcala, S, Zhang, Y, Shaheen, F, Matz, E, Pillai, DK, and Freishtat, RJ. "An In Vivo Model Of Human Airways For Investigating Fibrosis." 2016.

Scholars@Duke

Ferrante, S, Hackett, T-L, Engelhardt, JF, Ingram, JL, Reynolds, S, Zhang, Y, Hoptay, CE, Alcala, SE, Shaheen, F, Matz, E, Pillai, DK, and Freishtat, RJ. "IN VIVO EVIDENCE IN A XENOGRAFT MODEL FOR ASTHMATIC EPITHELIUM DRIVING AIRWAY REMODELING." JOURNAL OF INVESTIGATIVE MEDICINE 63, no. 3 (March 2015): 569-569.

Scholars@Duke

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