Jennifer Leigh Ingram, PhD

Assistant Professor in Medicine
Assistant Professor in Pathology
Assistant Professor in the Department of Surgery
Campus mail 201 Msrb1 Bldg, Durham, NC 27710
Phone (919) 668-1439
Email address jennifer.ingram@duke.edu

Dr. Ingram's research interests focus on the study of airway remodeling in human asthma. Proliferation, migration, and invasion of airway fibroblasts are key features of airway remodeling that contribute to diminished lung function over time. Dr. Ingram uses molecular biology approaches to define the effects of interleukin-13 (IL-13), a cytokine abundantly produced in the asthmatic airway, in the human airway fibroblast. She has identified important regulatory functions of several proteins prevalent in asthma that control fibroblast growth and pro-fibrotic growth factor production in response to IL-13. By understanding these pathways and their role in human asthma and the chronic effects of airway remodeling, novel treatment strategies may be developed.

Education and Training

  • Ph.D., North Carolina State University, 2000

Publications

Huggins, M. J., N. Lugogo, T. D. Church, J. L. Ingram, D. Francisco, R. Firszt, D. Beaver, D. Jinwright, and M. Kraft. “LL Leptin Modulates The Expression Of Procollagen 1 alpha In Airway Fibroblasts In Asthma.” American Journal of Respiratory and Critical Care Medicine 181 (January 1, 2010).

Scholars@Duke

Church, T. D., J. L. Ingram, D. Francisco, D. Beaver, D. Jinwright, and M. Kraft. “Elastin Expression Is Differentially Modulated In The Proximal And Distal Lung Compartments In Asthma.” American Journal of Respiratory and Critical Care Medicine 181 (January 1, 2010).

Scholars@Duke

Ingram, J. L., M. J. Huggins, T. D. Church, D. Francisco, D. M. Beaver, and M. Kraft. “Dexamethasone Modulates IL-13 and IL-4 Receptor Subunit Expression in Airway Fibroblasts in Asthma.” American Journal of Respiratory and Critical Care Medicine 179 (January 1, 2009).

Scholars@Duke

Kraft, M., K. B. Adler, J. L. Ingram, A. L. Crews, T. P. Atkinson, C. B. Cairns, D. C. Krause, and H. W. Chu. “Mycoplasma pneumoniae induces airway epithelial cell expression of MUC5AC in asthma.” Eur Respir J 31, no. 1 (January 2008): 43–46. https://doi.org/10.1183/09031936.00103307.

PMID
18166592
Full Text

Ingram, Jennifer L., Aurita Antao-Menezes, Elizabeth A. Turpin, Duncan G. Wallace, James B. Mangum, Linda J. Pluta, Russell S. Thomas, and James C. Bonner. “Genomic analysis of human lung fibroblasts exposed to vanadium pentoxide to identify candidate genes for occupational bronchitis.” Respir Res 8 (April 25, 2007): 34. https://doi.org/10.1186/1465-9921-8-34.

PMID
17459161
Full Text

Ingram, Jennifer L., Aurita Antao-Menezes, James B. Mangum, Otis Lyght, Patty J. Lee, Jack A. Elias, and James C. Bonner. “Opposing actions of Stat1 and Stat6 on IL-13-induced up-regulation of early growth response-1 and platelet-derived growth factor ligands in pulmonary fibroblasts.” J Immunol 177, no. 6 (September 15, 2006): 4141–48. https://doi.org/10.4049/jimmunol.177.6.4141.

PMID
16951379
Full Text

Walters, Dianne M., Aurita Antao-Menezes, Jennifer L. Ingram, Annette B. Rice, Abraham Nyska, Yoshiro Tani, Steven R. Kleeberger, and James C. Bonner. “Susceptibility of signal transducer and activator of transcription-1-deficient mice to pulmonary fibrogenesis.” The American Journal of Pathology 167, no. 5 (November 2005): 1221–29. https://doi.org/10.1016/s0002-9440(10)61210-2.

PMID
16251407
Full Text

Ingram, Jennifer L., Annette B. Rice, Kristen Geisenhoffer, David K. Madtes, and James C. Bonner. “IL-13 and IL-1beta promote lung fibroblast growth through coordinated up-regulation of PDGF-AA and PDGF-Ralpha.” Faseb J 18, no. 10 (July 2004): 1132–34. https://doi.org/10.1096/fj.03-1492fje.

PMID
15155567
Full Text

Wang, Yi-Zhe, Jennifer L. Ingram, Dianne M. Walters, Annette B. Rice, Janine H. Santos, Bennett Van Houten, and James C. Bonner. “Vanadium-induced STAT-1 activation in lung myofibroblasts requires H2O2 and P38 MAP kinase.” Free Radic Biol Med 35, no. 8 (October 15, 2003): 845–55. https://doi.org/10.1016/s0891-5849(03)00399-x.

PMID
14556849
Full Text

Pages