Jennifer Leigh Ingram, PhD

Assistant Professor in Medicine
Assistant Professor in Pathology
Assistant Professor in the Department of Surgery
Campus mail 201 Msrb1 Bldg, Durham, NC 27710
Phone (919) 668-1439
Email address jennifer.ingram@duke.edu

Dr. Ingram's research interests focus on the study of airway remodeling in human asthma. Proliferation, migration, and invasion of airway fibroblasts are key features of airway remodeling that contribute to diminished lung function over time. Dr. Ingram uses molecular biology approaches to define the effects of interleukin-13 (IL-13), a cytokine abundantly produced in the asthmatic airway, in the human airway fibroblast. She has identified important regulatory functions of several proteins prevalent in asthma that control fibroblast growth and pro-fibrotic growth factor production in response to IL-13. By understanding these pathways and their role in human asthma and the chronic effects of airway remodeling, novel treatment strategies may be developed.

Education and Training

  • Ph.D., North Carolina State University, 2000

Publications

Ingram, J. L., A. B. Rice, J. Santos, B. Van Houten, and J. C. Bonner. “Vanadium-induced HB-EGF expression in human lung fibroblasts is oxidant dependent and requires MAP kinases.” American Journal of Physiology  Lung Cellular and Molecular Physiology 284, no. 5 28-5 (May 1, 2003). https://doi.org/10.1152/ajplung.00189.2002.

Full Text

Ingram, Jennifer L., Annette B. Rice, Janine Santos, Bennett Van Houten, and James C. Bonner. “Vanadium-induced HB-EGF expression in human lung fibroblasts is oxidant dependent and requires MAP kinases.” Am J Physiol Lung Cell Mol Physiol 284, no. 5 (May 2003): L774–82. https://doi.org/10.1152/ajplung.00189.2002.

PMID
12676768
Full Text

Ingram, J. L., A. Rice, K. Geisenhoffer, D. K. Madtes, and J. C. Bonner. “Interleukin-13 stimulates the proliferation of lung myofibroblasts via a signal transducer and activator of transcription-6-dependent mechanism: A possible mechanism for the development of airway fibrosis in asthma.” Chest 123, no. 3 SUPPL. (March 1, 2003): 422S-424S.

Scholars@Duke

Ingram, Jennifer L., Annette Rice, Kristen Geisenhoffer, David K. Madtes, and James C. Bonner. “Interleukin-13 stimulates the proliferation of lung myofibroblasts via a signal transducer and activator of transcription-6-dependent mechanism: a possible mechanism for the development of airway fibrosis in asthma.” Chest 123, no. 3 Suppl (March 2003): 422S-424S. https://doi.org/10.1378/chest.123.3_suppl.422s.

PMID
12629010
Full Text

Rice, Annette B., Jennifer L. Ingram, and James C. Bonner. “p38 mitogen-activated protein kinase regulates growth factor-induced mitogenesis of rat pulmonary myofibroblasts.” Am J Respir Cell Mol Biol 27, no. 6 (December 2002): 759–65. https://doi.org/10.1165/rcmb.2002-0070OC.

PMID
12444037
Full Text

Bonner, James C., Annette B. Rice, Jennifer L. Ingram, Cindy R. Moomaw, Abraham Nyska, Alyce Bradbury, Alisha R. Sessoms, et al. “Susceptibility of cyclooxygenase-2-deficient mice to pulmonary fibrogenesis.” Am J Pathol 161, no. 2 (August 2002): 459–70. https://doi.org/10.1016/S0002-9440(10)64202-2.

PMID
12163371
Full Text

Ascenzi, R., J. L. Ingram, M. Massel, W. F. Thompson, S. Spiker, and A. K. Weissinger. “The role of cell differentiation state and HMG-I/Y in the expression of transgenes flanked by matrix attachment regions.” Transgenic Res 10, no. 5 (October 2001): 465–70. https://doi.org/10.1023/a:1012082602587.

PMID
11708656
Full Text

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