Joe Brice Weinberg, MD

Professor of Medicine
Associate Professor of Obstetrics and Gynecology
Professor of Immunology
Affiliate, Duke Global Health Institute
Member of the Duke Cancer Institute
Campus mail Duke Box 3396, Durham, NC 27708
Phone (919) 286-6833
Email address weinb001@duke.edu

Dr. Weinberg is a board-certified hematologist and medical oncologist who serves as Professor of Medicine and Immunology and Associate Professor of Obstetrics and Gynecology at the Duke University Medical Center, and staff physician in hematology-oncology at the Durham V.A. Medical Center. His clinical interests are in hematology and oncology, and his research focuses on blood cells, nitric oxide (NO), and leukemia. The work includes studies of resistance to infection, pathways of inflammation, and regulation of normal and leukemic cell life and death. His current work includes studies of leukemia (primarily chronic lymphocytic leukemia); the roles of NO and arginine in the resistance to malaria; and the interactions of NO, prostaglandins, and mechanical force in inflammation and arthritis.

Education and Training

  • Fellowship, Hematology Oncology, University of Utah School of Medicine, 1973 - 1976
  • Internship & Residency, University of Arkansas at Little Rock, 1969 - 1971
  • M.D., University of Arkansas at Little Rock, 1969
  • B.S., University of Arkansas, Fayetteville, 1966

Publications

Kleinstern, G, Camp, NJ, Goldin, LR, Vachon, CM, Vajdic, CM, de Sanjose, S, Weinberg, JB, Benavente, Y, Casabonne, D, Liebow, M, Nieters, A, Hjalgrim, H, Melbye, M, Glimelius, B, Adami, H-O, Boffetta, P, Brennan, P, Maynadie, M, McKay, J, Cocco, PL, Shanafelt, TD, Call, TG, Norman, AD, Hanson, C, Robinson, D, Chaffee, KG, Brooks-Wilson, AR, Monnereau, A, Clavel, J, Glenn, M, Curtin, K, Conde, L, Bracci, PM, Morton, LM, Cozen, W, Severson, RK, Chanock, SJ, Spinelli, JJ, Johnston, JB, Rothman, N, Skibola, CF, Leis, JF, Kay, NE, Smedby, KE, Berndt, SI, Cerhan, JR, Caporaso, N, and Slager, SL. "Association of polygenic risk score with the risk of chronic lymphocytic leukemia and monoclonal B-cell lymphocytosis." Blood 131, no. 23 (June 2018): 2541-2551.

PMID
29674426
Full Text

Winkler, MT, Bushey, RT, Gottlin, EB, Campa, MJ, Guadalupe, ES, Volkheimer, AD, Weinberg, JB, and Patz, EF. "Enhanced CDC of B cell chronic lymphocytic leukemia cells mediated by rituximab combined with a novel anti-complement factor H antibody." Plos One 12, no. 6 (January 2017): e0179841-null.

PMID
28658265
Full Text

Yeo, TW, Florence, SM, Kalingonji, AR, Chen, Y, Granger, DL, Anstey, NM, Mwaikambo, ED, and Weinberg, JB. "Decreased Microvascular Function in Tanzanian Children With Severe and Uncomplicated Falciparum Malaria." Open Forum Infectious Diseases 4, no. 2 (January 2017): ofx079-null.

PMID
28852670
Full Text

Barber, BE, William, T, Grigg, MJ, Piera, KA, Chen, Y, Wang, H, Weinberg, JB, Yeo, TW, and Anstey, NM. "Nitric Oxide-Dependent Endothelial Dysfunction and Reduced Arginine Bioavailability in Plasmodium vivax Malaria but No Greater Increase in Intravascular Hemolysis in Severe Disease." The Journal of Infectious Diseases 214, no. 10 (November 2016): 1557-1564.

PMID
27630198
Full Text

Siska, PJ, van der Windt, GJW, Kishton, RJ, Cohen, S, Eisner, W, MacIver, NJ, Kater, AP, Weinberg, JB, and Rathmell, JC. "Suppression of Glut1 and Glucose Metabolism by Decreased Akt/mTORC1 Signaling Drives T Cell Impairment in B Cell Leukemia." Journal of Immunology (Baltimore, Md. : 1950) 197, no. 6 (September 2016): 2532-2540.

PMID
27511728
Full Text

Weinberg, JB, Volkheimer, AD, Rubach, MP, Florence, SM, Mukemba, JP, Kalingonji, AR, Langelier, C, Chen, Y, Bush, M, Yeo, TW, Granger, DL, Anstey, NM, and Mwaikambo, ED. "Monocyte polarization in children with falciparum malaria: relationship to nitric oxide insufficiency and disease severity." Scientific Reports 6 (July 7, 2016): 29151-null.

PMID
27385484
Full Text

Friedman, DR, Sibley, AB, Owzar, K, Chaffee, KG, Slager, S, Kay, NE, Hanson, CA, Ding, W, Shanafelt, TD, Weinberg, JB, and Wilcox, RA. "Relationship of blood monocytes with chronic lymphocytic leukemia aggressiveness and outcomes: a multi-institutional study." American Journal of Hematology 91, no. 7 (July 2016): 687-691.

PMID
27037726
Full Text

Heyman, B, Volkheimer, AD, and Weinberg, JB. "Double IGHV DNA gene rearrangements in CLL: influence of mixed-mutated and -unmutated rearrangements on outcomes in CLL." Blood Cancer Journal 6, no. 7 (July 2016): e440-null. (Letter)

PMID
27367477
Full Text

Dennis, PA, Weinberg, JB, Calhoun, PS, Watkins, LL, Sherwood, A, Dennis, MF, and Beckham, JC. "An investigation of vago-regulatory and health-behavior accounts for increased inflammation in posttraumatic stress disorder." Journal of psychosomatic research 83 (April 2016): 33-39.

PMID
27020074
Full Text

Berndt, SI, Camp, NJ, Skibola, CF, Vijai, J, Wang, Z, Gu, J, Nieters, A, Kelly, RS, Smedby, KE, Monnereau, A, Cozen, W, Cox, A, Wang, SS, Lan, Q, Teras, LR, Machado, M, Yeager, M, Brooks-Wilson, AR, Hartge, P, Purdue, MP, Birmann, BM, Vajdic, CM, Cocco, P, Zhang, Y, Giles, GG, Zeleniuch-Jacquotte, A, Lawrence, C, Montalvan, R, Burdett, L, Hutchinson, A, Ye, Y, Call, TG, Shanafelt, TD, Novak, AJ, Kay, NE, Liebow, M, Cunningham, JM, Allmer, C, Hjalgrim, H, Adami, H-O, Melbye, M, Glimelius, B, Chang, ET, Glenn, M, Curtin, K, Cannon-Albright, LA, Diver, WR, Link, BK, Weiner, GJ, Conde, L, Bracci, PM, Riby, J, Arnett, DK, Zhi, D, Leach, JM, Holly, EA, Jackson, RD, Tinker, LF, Benavente, Y, Sala, N, Casabonne, D, Becker, N, Boffetta, P, Brennan, P, Foretova, L, Maynadie, M, McKay, J, Staines, A, Chaffee, KG, Achenbach, SJ, Vachon, CM, Goldin, LR, Strom, SS, Leis, JF, Weinberg, JB, Caporaso, NE, Norman, AD, De Roos, AJ, Morton, LM, Severson, RK, Riboli, E, Vineis, P, Kaaks, R, Masala, G, Weiderpass, E, Chirlaque, M-D, Vermeulen, RCH, Travis, RC, Southey, MC, Milne, RL, Albanes, D, Virtamo, J, Weinstein, S, Clavel, J, Zheng, T, Holford, TR, Villano, DJ, Maria, A, Spinelli, JJ, Gascoyne, RD, Connors, JM, Bertrand, KA, Giovannucci, E, Kraft, P, Kricker, A, Turner, J, Ennas, MG, Ferri, GM, Miligi, L, Liang, L, Ma, B, Huang, J, Crouch, S, Park, J-H, Chatterjee, N, North, KE, Snowden, JA, Wright, J, Fraumeni, JF, Offit, K, Wu, X, de Sanjose, S, Cerhan, JR, Chanock, SJ, Rothman, N, and Slager, SL. "Meta-analysis of genome-wide association studies discovers multiple loci for chronic lymphocytic leukemia." Nature Communications 7 (March 9, 2016): 10933-null.

PMID
26956414
Full Text

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