Joe Brice Weinberg, MD

Professor of Medicine
Associate Professor of Obstetrics and Gynecology
Professor of Immunology
Affiliate, Duke Global Health Institute
Member of the Duke Cancer Institute
Campus mail Duke Box 3396, Durham, NC 27708
Phone (919) 286-6833
Email address weinb001@duke.edu

Dr. Weinberg is a board-certified hematologist and medical oncologist who serves as Professor of Medicine and Immunology and Associate Professor of Obstetrics and Gynecology at the Duke University Medical Center, and staff physician in hematology-oncology at the Durham V.A. Medical Center. His clinical interests are in hematology and oncology, and his research focuses on blood cells, nitric oxide (NO), and leukemia. The work includes studies of resistance to infection, pathways of inflammation, and regulation of normal and leukemic cell life and death. His current work includes studies of leukemia (primarily chronic lymphocytic leukemia); the roles of NO and arginine in the resistance to malaria; and the interactions of NO, prostaglandins, and mechanical force in inflammation and arthritis.

Education and Training

  • Fellowship, Hematology Oncology, University of Utah School of Medicine, 1973 - 1976
  • Internship & Residency, University of Arkansas at Little Rock, 1969 - 1971
  • M.D., University of Arkansas at Little Rock, 1969
  • B.S., University of Arkansas, Fayetteville, 1966

Publications

Winkler, MT, Bushey, RT, Gottlin, EB, Campa, MJ, Guadalupe, ES, Volkheimer, AD, Weinberg, JB, and Patz, EF. "Enhanced CDC of B cell chronic lymphocytic leukemia cells mediated by rituximab combined with a novel anti-complement factor H antibody." PloS one 12, no. 6 (January 2017): e0179841-.

PMID
28658265
Full Text

Barber, BE, William, T, Grigg, MJ, Piera, KA, Chen, Y, Wang, H, Weinberg, JB, Yeo, TW, and Anstey, NM. "Nitric Oxide-Dependent Endothelial Dysfunction and Reduced Arginine Bioavailability in Plasmodium vivax Malaria but No Greater Increase in Intravascular Hemolysis in Severe Disease." The Journal of infectious diseases 214, no. 10 (November 2016): 1557-1564.

PMID
27630198
Full Text

Dennis, PA, Weinberg, JB, Calhoun, PS, Watkins, LL, Sherwood, A, Dennis, MF, and Beckham, JC. "An investigation of vago-regulatory and health-behavior accounts for increased inflammation in posttraumatic stress disorder." Journal of psychosomatic research 83 (April 2016): 33-39.

PMID
27020074
Full Text

Berndt, SI, Camp, NJ, Skibola, CF, Vijai, J, Wang, Z, Gu, J, Nieters, A, Kelly, RS, Smedby, KE, Monnereau, A, Cozen, W, Cox, A, Wang, SS, Lan, Q, Teras, LR, Machado, M, Yeager, M, Brooks-Wilson, AR, Hartge, P, Purdue, MP, Birmann, BM, Vajdic, CM, Cocco, P, Zhang, Y, Giles, GG, Zeleniuch-Jacquotte, A, Lawrence, C, Montalvan, R, Burdett, L, Hutchinson, A, Ye, Y, Call, TG, Shanafelt, TD, Novak, AJ, Kay, NE, Liebow, M, Cunningham, JM, Allmer, C, Hjalgrim, H, Adami, H-O, Melbye, M, and Glimelius, B et al. "Meta-analysis of genome-wide association studies discovers multiple loci for chronic lymphocytic leukemia." Nature communications 7 (March 9, 2016): 10933-.

PMID
26956414
Full Text

Vakkalanka, S, Penmetsa, KV, Chasse, D, Chen, Y, Viswanadha, S, Friedman, DR, and Weinberg, JB. "Abstract A24: The dual PI3K δ/γ inhibitor, RP6530, in combination with ibrutinib or fludarabine, synergistically enhances cytotoxicity in primary CLL cells in vitro." September 1, 2015.

Full Text

Brander, D, Christensen, D, Volkheimer, A, Stewart, T, Chen, Y, Friedman, D, and Weinberg, JB. "Set alpha/beta-mrna isoform ratio by a novel qpcr assay has prognostic significance in chronic lymphocytic leukemia and may be modulated by treatment." LEUKEMIA & LYMPHOMA 56 (September 1, 2015): 121-122.

Scholars@Duke

Friedman, DR, Stewart, T, Guadalupe, E, Brander, DM, Pisetsky, DS, and Weinberg, JB. "Pan-caspase peptide inhibitor to induce primary chronic lymphocytic leukemia (CLL) cell death through a non-apoptotic and non-necroptotic mechanism." May 20, 2015.

Scholars@Duke

Yeo, TW, Lampah, DA, Kenangalem, E, Tjitra, E, Price, RN, Weinberg, JB, Hyland, K, Granger, DL, and Anstey, NM. "Impaired systemic tetrahydrobiopterin bioavailability and increased dihydrobiopterin in adult falciparum malaria: association with disease severity, impaired microvascular function and increased endothelial activation." PLoS pathogens 11, no. 3 (March 12, 2015): e1004667-.

PMID
25764397
Full Text

Rubach, MP, Mukemba, J, Florence, S, Lopansri, BK, Hyland, K, Volkheimer, AD, Yeo, TW, Anstey, NM, Weinberg, JB, Mwaikambo, ED, and Granger, DL. "Impaired systemic tetrahydrobiopterin bioavailability and increased oxidized biopterins in pediatric falciparum malaria: association with disease severity." PLoS pathogens 11, no. 3 (March 12, 2015): e1004655-.

PMID
25764173
Full Text

Heyman, BM, Volkheimer, AD, Weinberg, JB, and Lanasa, M. "Double IGHV Gene Rearrangements in Chronic Lymphocytic Leukemia." December 6, 2014.

Scholars@Duke

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