John Hunter Peel Alexander, MD

Professor of Medicine
Member in the Duke Clinical Research Institute
Campus mail 200 Morris Street, Durham, NC 27701
Phone (919) 668-8955
Email address john.h.alexander@duke.edu

John H. Alexander, MD, MHS is a cardiologist and Professor of Medicine in the Department of Medicine, Division of Cardiology at Duke University School of Medicine, as well as the Vice Chief, Clinical Research in the Division of Cardiology. He is the Director of Cardiovascular Research at the Duke Clinical Research Institute where he oversees a large group of clinical research faculty and a broad portfolio of cardiovascular clinical trials and observational clinical research programs. He is a member of the American Society of Clinical Investigation.

Dr. Alexander’s clinical interests are in acute and general cardiovascular disease, valvular heart disease, and echocardiology. His research is focused on the translation of novel therapeutic concepts into clinical data through clinical trials, specifically on the therapeutics of acute coronary syndromes, chronic coronary artery disease, and cardiac surgery and on novel methodological approaches to clinical trials. He was on the Executive Committee of the ARISTOTLE trial of apixaban in patients with atrial fibrillation and was the Principal Investigator of the APPRAISE-2 trial of apixaban in patients with acute coronary syndromes.

Dr. Alexander has published extensively and has served as the principal investigator of numerous multicenter clinical trials. He currently serves as the co-chair of the Clinical Trial Transformation Initiative (CTTI).

Education and Training

  • Fellow in Cardiology, Medicine, Duke University, 1996 - 2000
  • Medical Resident, Medicine, Children's Hospital Boston, 1993 - 1996
  • M.D., University of Pennsylvania, 1993

Publications

DeRose, J. J., D. M. Mancini, H. L. Chang, M. Argenziano, F. Dagenais, G. Ailawadi, L. P. Perrault, et al. “Pacemaker Implantation After Mitral Valve Surgery With Atrial Fibrillation Ablation.” Journal of the American College of Cardiology 73, no. 19 (May 21, 2019): 2427–35. https://doi.org/10.1016/j.jacc.2019.02.062.

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Hohnloser, Stefan H., Marat Fudim, John H. Alexander, Daniel M. Wojdyla, Justin A. Ezekowitz, Michael Hanna, Dan Atar, et al. “Efficacy and Safety of Apixaban Versus Warfarin in Patients With Atrial Fibrillation and Extremes in Body Weight..” Circulation 139, no. 20 (May 14, 2019): 2292–2300. https://doi.org/10.1161/CIRCULATIONAHA.118.037955.

PMID
30773022
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Guimarães, Patricia O., Sean D. Pokorney, Renato D. Lopes, Daniel M. Wojdyla, Bernard J. Gersh, Anna Giczewska, Anthony Carnicelli, et al. “Efficacy and safety of apixaban vs warfarin in patients with atrial fibrillation and prior bioprosthetic valve replacement or valve repair: Insights from the ARISTOTLE trial..” Clin Cardiol 42, no. 5 (May 2019): 568–71. https://doi.org/10.1002/clc.23178.

PMID
30907005
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Lopes, Renato D., Gretchen Heizer, Ronald Aronson, Amit N. Vora, Tyler Massaro, Roxana Mehran, Shaun G. Goodman, et al. “Antithrombotic Therapy after Acute Coronary Syndrome or PCI in Atrial Fibrillation..” N Engl J Med 380, no. 16 (April 18, 2019): 1509–24. https://doi.org/10.1056/NEJMoa1817083.

PMID
30883055
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Guimarães, Patricia O., Renato D. Lopes, John H. Alexander, Laine Thomas, Anne S. Hellkamp, Ziad Hijazi, Elaine M. Hylek, et al. “International normalized ratio control and subsequent clinical outcomes in patients with atrial fibrillation using warfarin..” Journal of Thrombosis and Thrombolysis, April 10, 2019. https://doi.org/10.1007/s11239-019-01858-1.

PMID
30972712
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Washam, Jeffrey B., Stefan H. Hohnloser, Renato D. Lopes, Daniel M. Wojdyla, Dragos Vinereanu, John H. Alexander, Bernard J. Gersh, et al. “Interacting medication use and the treatment effects of apixaban versus warfarin: results from the ARISTOTLE Trial..” Journal of Thrombosis and Thrombolysis 47, no. 3 (April 2019): 345–52. https://doi.org/10.1007/s11239-019-01823-y.

PMID
30790160
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Christersson, Christina, Lars Wallentin, Ulrika Andersson, John H. Alexander, Marco Alings, Raffaele De Caterina, Bernard J. Gersh, et al. “Effect of apixaban compared with warfarin on coagulation markers in atrial fibrillation..” Heart 105, no. 3 (February 2019): 235–42. https://doi.org/10.1136/heartjnl-2018-313351.

PMID
30209126
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Ranney, David N., Judson B. Williams, Hillary Mulder, Daniel Wojdyla, Morgan L. Cox, C Michael Gibson, Michael J. Mack, Mani A. Daneshmand, John H. Alexander, and Renato D. Lopes. “Comparison of Outcomes and Frequency of Graft Failure With Use of Free Versus In Situ Internal Mammary Artery Bypass Conduits (from the PREVENT IV Trial)..” The American Journal of Cardiology 123, no. 4 (February 2019): 571–75. https://doi.org/10.1016/j.amjcard.2018.11.029.

PMID
30538035
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Fanaroff, Alexander C., Robert Clare, Karen S. Pieper, Kenneth W. Mahaffey, Chiara Melloni, Jennifer B. Green, John H. Alexander, et al. “Frequency, Regional Variation, and Predictors of Undetermined Cause of Death in Cardiometabolic Clinical Trials: A Pooled Analysis of 9259 Deaths in 9 Trials..” Circulation 139, no. 7 (February 2019): 863–73. https://doi.org/10.1161/circulationaha.118.037202.

PMID
30586739
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Alexander, Karen P., Marc A. Brouwer, Hillary Mulder, Dragos Vinereanu, Renato D. Lopes, Marco Proietti, Sana M. Al-Khatib, et al. “Outcomes of apixaban versus warfarin in patients with atrial fibrillation and multi-morbidity: Insights from the ARISTOTLE trial..” American Heart Journal 208 (February 2019): 123–31. https://doi.org/10.1016/j.ahj.2018.09.017.

PMID
30579505
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