John Hunter Peel Alexander, MD

Professor of Medicine
Member in the Duke Clinical Research Institute
Campus mail 200 Morris Street, Durham, NC 27701
Phone (919) 668-8955
Email address john.h.alexander@duke.edu

John H. Alexander, MD, MHS is a cardiologist and Professor of Medicine in the Department of Medicine, Division of Cardiology at Duke University School of Medicine, as well as the Vice Chief, Clinical Research in the Division of Cardiology. He is the Director of Cardiovascular Research at the Duke Clinical Research Institute where he oversees a large group of clinical research faculty and a broad portfolio of cardiovascular clinical trials and observational clinical research programs. He is a member of the American Society of Clinical Investigation.

Dr. Alexander’s clinical interests are in acute and general cardiovascular disease, valvular heart disease, and echocardiology. His research is focused on the translation of novel therapeutic concepts into clinical data through clinical trials, specifically on the therapeutics of acute coronary syndromes, chronic coronary artery disease, and cardiac surgery and on novel methodological approaches to clinical trials. He was on the Executive Committee of the ARISTOTLE trial of apixaban in patients with atrial fibrillation and was the Principal Investigator of the APPRAISE-2 trial of apixaban in patients with acute coronary syndromes.

Dr. Alexander has published extensively and has served as the principal investigator of numerous multicenter clinical trials. He currently serves as the co-chair of the Clinical Trial Transformation Initiative (CTTI).

Education and Training

  • Fellow in Cardiology, Medicine, Duke University, 1996 - 2000
  • Medical Resident, Medicine, Children's Hospital Boston, 1993 - 1996
  • M.D., University of Pennsylvania, 1993

Publications

Lopes, Renato D., Celestia S. Higano, Susan F. Slovin, Adam J. Nelson, Robert Bigelow, Per S. Sørensen, Chiara Melloni, et al. “Cardiovascular Safety of Degarelix versus Leuprolide in Patients with Prostate Cancer: The Primary Results of the PRONOUNCE Randomized Trial.” Circulation, August 30, 2021. https://doi.org/10.1161/CIRCULATIONAHA.121.056810.

PMID
34459214
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Siegbahn, Agneta, Johan Lindbäck, Ziad Hijazi, Mikael Åberg, John H. Alexander, John W. Eikelboom, Renato D. Lopes, et al. “Multiplex protein screening of biomarkers associated with major bleeding in patients with atrial fibrillation treated with oral anticoagulation.” J Thromb Haemost, August 14, 2021. https://doi.org/10.1111/jth.15498.

PMID
34390530
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Pol, Tymon, Ziad Hijazi, Johan Lindbäck, Jonas Oldgren, John H. Alexander, Stuart J. Connolly, John W. Eikelboom, et al. “Using multimarker screening to identify biomarkers associated with cardiovascular death in patients with atrial fibrillation.” Cardiovasc Res, August 6, 2021. https://doi.org/10.1093/cvr/cvab262.

PMID
34358298
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Schwartz, Gregory G., Michael Szarek, Vera A. Bittner, Rafael Diaz, Shaun G. Goodman, J Wouter Jukema, Ulf Landmesser, et al. “Lipoprotein(a) and Benefit of PCSK9 Inhibition in Patients With Nominally Controlled LDL Cholesterol.” J Am Coll Cardiol 78, no. 5 (August 3, 2021): 421–33. https://doi.org/10.1016/j.jacc.2021.04.102.

PMID
34325831
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Gaudino, Mario, Antonino Di Franco, John H. Alexander, Faisal Bakaeen, Natalia Egorova, Paul Kurlansky, Andreas Boening, et al. “Sex differences in outcomes after coronary artery bypass grafting: a pooled analysis of individual patient data.” Eur Heart J, August 2, 2021. https://doi.org/10.1093/eurheartj/ehab504.

PMID
34338767
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Lopes, Renato D., Pedro Gabriel Melo de Barros E Silva, Remo H. M. Furtado, Ariane Vieira Scarlatelli Macedo, Eduardo Ramacciotti, Lucas Petri Damini, Bruna Bronhara, et al. “Randomized clinical trial to evaluate a routine full anticoagulation Strategy in Patients with Coronavirus Infection (SARS-CoV2) admitted to hospital: Rationale and design of the ACTION (AntiCoagulaTlon cOroNavirus)-Coalition IV trial.” American Heart Journal 238 (August 2021): 1–11. https://doi.org/10.1016/j.ahj.2021.04.005.

PMID
33891907
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Goyal, Akash, Tony Schibler, Brooke Alhanti, Karen L. Hannan, Christopher B. Granger, Michael A. Blazing, Renato D. Lopes, et al. “Assessment of North American Clinical Research Site Performance During the Start-up of Large Cardiovascular Clinical Trials.” Jama Netw Open 4, no. 7 (July 1, 2021): e2117963. https://doi.org/10.1001/jamanetworkopen.2021.17963.

PMID
34297072
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Lopes, Renato D., Pedro Gabriel Melo de Barros E Silva, Remo H. M. Furtado, Ariane Vieira Scarlatelli Macedo, Bruna Bronhara, Lucas Petri Damiani, Lilian Mazza Barbosa, et al. “Therapeutic versus prophylactic anticoagulation for patients admitted to hospital with COVID-19 and elevated D-dimer concentration (ACTION): an open-label, multicentre, randomised, controlled trial.” Lancet 397, no. 10291 (June 12, 2021): 2253–63. https://doi.org/10.1016/S0140-6736(21)01203-4.

PMID
34097856
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Carnicelli, Anthony P., Sana M. Al-Khatib, Denis Xavier, Frederik Dalgaard, Peter D. Merrill, Daniel M. Wojdyla, Basil S. Lewis, et al. “Premature permanent discontinuation of apixaban or warfarin in patients with atrial fibrillation.” Heart 107, no. 9 (May 2021): 713–20. https://doi.org/10.1136/heartjnl-2020-317229.

PMID
32938772
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Gaudino, Mario, Antonino Di Franco, Deepak L. Bhatt, John H. Alexander, Antonio Abbate, Lorenzo Azzalini, Sigrid Sandner, et al. “The association between coronary graft patency and clinical status in patients with coronary artery disease.” Eur Heart J 42, no. 14 (April 7, 2021): 1433–41. https://doi.org/10.1093/eurheartj/ehab096.

PMID
33709098
Full Text

Pages