John Hunter Peel Alexander, MD

Professor of Medicine
Member in the Duke Clinical Research Institute
Campus mail 200 Morris Street, Durham, NC 27701
Phone (919) 668-8955
Email address john.h.alexander@duke.edu

John H. Alexander, MD, MHS is a cardiologist and Professor of Medicine in the Department of Medicine, Division of Cardiology at Duke University School of Medicine, as well as the Vice Chief, Clinical Research in the Division of Cardiology. He is the Director of Cardiovascular Research at the Duke Clinical Research Institute where he oversees a large group of clinical research faculty and a broad portfolio of cardiovascular clinical trials and observational clinical research programs. He is a member of the American Society of Clinical Investigation.

Dr. Alexander’s clinical interests are in acute and general cardiovascular disease, valvular heart disease, and echocardiology. His research is focused on the translation of novel therapeutic concepts into clinical data through clinical trials, specifically on the therapeutics of acute coronary syndromes, chronic coronary artery disease, and cardiac surgery and on novel methodological approaches to clinical trials. He was on the Executive Committee of the ARISTOTLE trial of apixaban in patients with atrial fibrillation and was the Principal Investigator of the APPRAISE-2 trial of apixaban in patients with acute coronary syndromes.

Dr. Alexander has published extensively and has served as the principal investigator of numerous multicenter clinical trials. He currently serves as the co-chair of the Clinical Trial Transformation Initiative (CTTI).

Education and Training

  • Fellow in Cardiology, Medicine, Duke University, 1996 - 2000
  • Medical Resident, Medicine, Children's Hospital Boston, 1993 - 1996
  • M.D., University of Pennsylvania, 1993

Publications

Gaudino, Mario, Antonino Di Franco, John H. Alexander, Faisal Bakaeen, Natalia Egorova, Paul Kurlansky, Andreas Boening, et al. “Sex differences in outcomes after coronary artery bypass grafting: a pooled analysis of individual patient data.” Eur Heart J 43, no. 1 (December 28, 2021): 18–28. https://doi.org/10.1093/eurheartj/ehab504.

PMID
34338767
Full Text

Fudim, Marat, Daniel M. Wojdyla, John H. Alexander, Shaun G. Goodman, Roxana Mehran, Stephan Windecker, Ronald Aronson, et al. “Efficacy and Safety of Antithrombotic Therapy in Patients With Atrial Fibrillation, Recent Acute Coronary Syndrome, or Percutaneous Coronary Intervention and a History of Heart Failure: Insights From the AUGUSTUS Trial.” J Am Heart Assoc 10, no. 24 (December 21, 2021): e023143. https://doi.org/10.1161/JAHA.121.023143.

PMID
34873913
Full Text

Bagiella, Emilia, John D. Puskas, Alan J. Moskowitz, Annetine C. Gelijns, John H. Alexander, Jagat Narula, Peter K. Smith, et al. “Rationale and Design of a Randomized Trial Evaluating an External Support Device for Saphenous Vein Coronary Grafts.” Am Heart J, December 19, 2021. https://doi.org/10.1016/j.ahj.2021.12.009.

PMID
34936861
Full Text

Gelijns, Annetine C., Alan J. Moskowitz, Patrick T. O’Gara, Gennaro Giustino, Michael J. Mack, Donna M. Mancini, Emilia Bagiella, et al. “Transcatheter mitral valve repair for functional mitral regurgitation: Evaluating the evidence.” J Thorac Cardiovasc Surg 162, no. 5 (November 2021): 1504–11. https://doi.org/10.1016/j.jtcvs.2020.02.132.

PMID
32359794
Full Text

Siegbahn, Agneta, Johan Lindbäck, Ziad Hijazi, Mikael Åberg, John H. Alexander, John W. Eikelboom, Renato D. Lopes, et al. “Multiplex protein screening of biomarkers associated with major bleeding in patients with atrial fibrillation treated with oral anticoagulation.” J Thromb Haemost 19, no. 11 (November 2021): 2726–37. https://doi.org/10.1111/jth.15498.

PMID
34390530
Full Text

Lopes, Renato D., Celestia S. Higano, Susan F. Slovin, Adam J. Nelson, Robert Bigelow, Per S. Sørensen, Chiara Melloni, et al. “Cardiovascular Safety of Degarelix Versus Leuprolide in Patients With Prostate Cancer: The Primary Results of the PRONOUNCE Randomized Trial.” Circulation 144, no. 16 (October 19, 2021): 1295–1307. https://doi.org/10.1161/CIRCULATIONAHA.121.056810.

PMID
34459214
Full Text

Lopes, Renato D., Pedro Gabriel Melo de Barros E Silva, Remo H. M. Furtado, John H. Alexander, and Otavio Berwanger. “Age-adjusted D-dimer cutoffs to guide anticoagulation in COVID-19 - Authors' reply.” Lancet 398, no. 10308 (October 9, 2021): 1304. https://doi.org/10.1016/S0140-6736(21)01909-7.

PMID
34627488
Full Text

Pol, Tymon, Ziad Hijazi, Johan Lindbäck, Jonas Oldgren, John H. Alexander, Stuart J. Connolly, John W. Eikelboom, et al. “Using multimarker screening to identify biomarkers associated with cardiovascular death in patients with atrial fibrillation.” Cardiovasc Res, August 6, 2021. https://doi.org/10.1093/cvr/cvab262.

PMID
34358298
Full Text

Schwartz, Gregory G., Michael Szarek, Vera A. Bittner, Rafael Diaz, Shaun G. Goodman, J Wouter Jukema, Ulf Landmesser, et al. “Lipoprotein(a) and Benefit of PCSK9 Inhibition in Patients With Nominally Controlled LDL Cholesterol.” J Am Coll Cardiol 78, no. 5 (August 3, 2021): 421–33. https://doi.org/10.1016/j.jacc.2021.04.102.

PMID
34325831
Full Text

Lopes, Renato D., Pedro Gabriel Melo de Barros E Silva, Remo H. M. Furtado, Ariane Vieira Scarlatelli Macedo, Eduardo Ramacciotti, Lucas Petri Damini, Bruna Bronhara, et al. “Randomized clinical trial to evaluate a routine full anticoagulation Strategy in Patients with Coronavirus Infection (SARS-CoV2) admitted to hospital: Rationale and design of the ACTION (AntiCoagulaTlon cOroNavirus)-Coalition IV trial.” Am Heart J 238 (August 2021): 1–11. https://doi.org/10.1016/j.ahj.2021.04.005.

PMID
33891907
Full Text

Pages