John Hunter Peel Alexander, MD

Professor of Medicine
Member in the Duke Clinical Research Institute
Campus mail 200 Morris Street, Durham, NC 27701
Phone (919) 668-8955
Email address john.h.alexander@duke.edu

John H. Alexander, MD, MHS is a cardiologist and Professor of Medicine in the Department of Medicine, Division of Cardiology at Duke University School of Medicine, as well as the Vice Chief, Clinical Research in the Division of Cardiology. He is the Director of Cardiovascular Research at the Duke Clinical Research Institute where he oversees a large group of clinical research faculty and a broad portfolio of cardiovascular clinical trials and observational clinical research programs. He is a member of the American Society of Clinical Investigation.

Dr. Alexander’s clinical interests are in acute and general cardiovascular disease, valvular heart disease, and echocardiology. His research is focused on the translation of novel therapeutic concepts into clinical data through clinical trials, specifically on the therapeutics of acute coronary syndromes, chronic coronary artery disease, and cardiac surgery and on novel methodological approaches to clinical trials. He was on the Executive Committee of the ARISTOTLE trial of apixaban in patients with atrial fibrillation and was the Principal Investigator of the APPRAISE-2 trial of apixaban in patients with acute coronary syndromes.

Dr. Alexander has published extensively and has served as the principal investigator of numerous multicenter clinical trials. He currently serves as the co-chair of the Clinical Trial Transformation Initiative (CTTI).

Education and Training

  • Fellow in Cardiology, Medicine, Duke University, 1996 - 2000
  • Medical Resident, Medicine, Children's Hospital Boston, 1993 - 1996
  • M.D., University of Pennsylvania, 1993

Publications

Macedo, Ariane Vieira Scarlatelli, Pedro Gabriel Melo de Barros E Silva, Thiago Ceccatto de Paula, Renata Junqueira Moll-Bernardes, Tiago Mendonça Dos Santos, Lilian Mazza, Andre Feldman, et al. “Discontinuing vs continuing ACEIs and ARBs in hospitalized patients with COVID-19 according to disease severity: Insights from the BRACE CORONA trial.” Am Heart J 249 (July 2022): 86–97. https://doi.org/10.1016/j.ahj.2022.04.001.

PMID
35405099
Full Text

Verma, Sanam, Sarah Rathwell, Stephen Fremes, Yinggan Zheng, Rajendra Mehta, Renato D. Lopes, John H. Alexander, Shaun G. Goodman, Sean van Diepen, and Sean van LEVO-CTS investigators. “Associated factors and clinical outcomes in mechanical circulatory support use in patients undergoing high risk on-pump cardiac surgery: Insights from the LEVO-CTS trial.” Am Heart J 248 (June 2022): 35–41. https://doi.org/10.1016/j.ahj.2022.02.013.

PMID
35263653
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Bahit, M Cecilia, Amit N. Vora, Zhuokai Li, Daniel M. Wojdyla, Laine Thomas, Shaun G. Goodman, Ronald Aronson, et al. “Apixaban or Warfarin and Aspirin or Placebo After Acute Coronary Syndrome or Percutaneous Coronary Intervention in Patients With Atrial Fibrillation and Prior Stroke: A Post Hoc Analysis From the AUGUSTUS Trial.” Jama Cardiol, May 25, 2022. https://doi.org/10.1001/jamacardio.2022.1166.

PMID
35612866
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Caruba, Thibaut, Anaïs Charles-Nelson, John H. Alexander, Rajendra H. Mehta, Matthias Heringlake, Wolfgang Toller, Amelie Yavchitz, Brigitte Sabatier, Gilles Chatellier, and Bernard Cholley. “Prophylactic levosimendan in patients with low ejection fraction undergoing coronary artery bypass grafting: A pooled analysis of two multicentre randomised controlled trials.” Anaesth Crit Care Pain Med, May 25, 2022, 101107. https://doi.org/10.1016/j.accpm.2022.101107.

PMID
35643391
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Aulin, Julia, Ziad Hijazi, Johan Lindbäck, John H. Alexander, Bernard J. Gersh, Christopher B. Granger, Michael Hanna, et al. “Biomarkers and heart failure events in patients with atrial fibrillation in the ARISTOTLE trial evaluated by a multi-state model.” Am Heart J 251 (May 13, 2022): 13–24. https://doi.org/10.1016/j.ahj.2022.03.009.

PMID
35569564
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De Caterina, Raffaele, Giuseppe Patti, Johan Westerbergh, John Horowitz, Justin A. Ezekowitz, Basil S. Lewis, Renato D. Lopes, et al. “Heterogeneity of diabetes as a risk factor for major adverse cardiovascular events in anticoagulated patients with atrial fibrillation: an analysis of the ARISTOTLE trial.” Eur Heart J Cardiovasc Pharmacother 8, no. 3 (May 5, 2022): 227–35. https://doi.org/10.1093/ehjcvp/pvaa140.

PMID
33367487
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Bagiella, Emilia, John D. Puskas, Alan J. Moskowitz, Annetine C. Gelijns, John H. Alexander, Jagat Narula, Peter K. Smith, et al. “Rationale and design of a randomized trial evaluating an external support device for saphenous vein coronary grafts.” Am Heart J 246 (April 2022): 12–20. https://doi.org/10.1016/j.ahj.2021.12.009.

PMID
34936861
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Harskamp, Ralf E., Alexander C. Fanaroff, Renato D. Lopes, Daniel M. Wojdyla, Shaun G. Goodman, Laine E. Thomas, Ronald Aronson, et al. “Antithrombotic Therapy in Patients With Atrial Fibrillation After Acute Coronary Syndromes or Percutaneous Intervention.” J Am Coll Cardiol 79, no. 5 (February 8, 2022): 417–27. https://doi.org/10.1016/j.jacc.2021.11.035.

PMID
35115097
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Welsh, Robert C., Payam Dehghani, Renato Lopes, Daniel M. Wojdyla, Ronald Aronson, Christopher B. Granger, Stephan Windecker, et al. “Impact of prior oral anticoagulant use and outcomes on patients from secondary analysis in the AUGUSTUS trial.” Open Heart 9, no. 1 (February 2022). https://doi.org/10.1136/openhrt-2021-001892.

PMID
35172988
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Pages