John Hunter Peel Alexander, MD

Professor of Medicine
Member in the Duke Clinical Research Institute
Campus mail 2400 Pratt St, Durham, NC 27705
Phone (919) 668-8955
Email address john.h.alexander@duke.edu

John H. Alexander, MD, MHS is a cardiologist and Professor of Medicine in the Department of Medicine, Division of Cardiology at Duke University School of Medicine, as well as the Vice Chief, Clinical Research in the Division of Cardiology. He is the Director of Cardiovascular Research at the Duke Clinical Research Institute where he oversees a large group of clinical research faculty and a broad portfolio of cardiovascular clinical trials and observational clinical research programs. He is a member of the American Society of Clinical Investigation.

Dr. Alexander’s clinical interests are in acute and general cardiovascular disease, valvular heart disease, and echocardiology. His research is focused on the translation of novel therapeutic concepts into clinical data through clinical trials, specifically on the therapeutics of acute coronary syndromes, chronic coronary artery disease, and cardiac surgery and on novel methodological approaches to clinical trials. He was on the Executive Committee of the ARISTOTLE trial of apixaban in patients with atrial fibrillation and was the Principal Investigator of the APPRAISE-2 trial of apixaban in patients with acute coronary syndromes.

Dr. Alexander has published extensively and has served as the principal investigator of numerous multicenter clinical trials. He currently serves as the co-chair of the Clinical Trial Transformation Initiative (CTTI).

Education and Training

  • Fellow in Cardiology, Medicine, Duke University, 1996 - 2000
  • Medical Resident, Medicine, Children's Hospital Boston, 1993 - 1996
  • M.D., University of Pennsylvania, 1993

Publications

Goto, S, Merrill, P, Wallentin, L, Wojdyla, DM, Hanna, M, Avezum, A, Easton, JD, Harjola, V-P, Huber, K, Lewis, BS, Parkhomenko, A, Zhu, J, Granger, CB, Lopes, RD, and Alexander, JH. "Antithrombotic therapy use and clinical outcomes following thrombo-embolic events in patients with atrial fibrillation: insights from ARISTOTLE." European heart journal. Cardiovascular pharmacotherapy 4, no. 2 (April 2018): 75-81.

PMID
29385429
Full Text

Berwanger, O, de Barros e Silva, PGM, Dall Orto, FTC, de Andrade, PB, de Castro Bienert, IR, Bosso, CE, Mangione, J, Polanczyk, CA, Sousa, A, Kalil, R, de Moura Santos, L, Sposito, AC, Rech, RL, Sousa, ACS, Baldissera, F, Nascimento, BR, de Andrade Jesuíno, I, Santucci, EV, Damiani, LP, Laranjeira, LN, Borges de Oliveira, JA, Giraldez, RR, Cavalcanti, AB, Pereira, SB, Mattos, LA, Armaganijan, LV, Guimarães, HP, Sousa, JE, Alexander, JH, Granger, CB, and Lopes, RD. "Rationale and design of the Statins Evaluation in Coronary procedUres and REvascularization: The SECURE-PCI Trial." American Heart Journal 198 (April 2018): 129-134.

Full Text

Berwanger, O, Santucci, EV, de Barros E Silva, PGM, Jesuíno, IDA, Damiani, LP, Barbosa, LM, Santos, RHN, Laranjeira, LN, Egydio, FDM, Borges de Oliveira, JA, Dall Orto, FTC, Beraldo de Andrade, P, Bienert, IRDC, Bosso, CE, Mangione, JA, Polanczyk, CA, Sousa, AGDMR, Kalil, RAK, Santos, LDM, Sposito, AC, Rech, RL, Sousa, ACS, Baldissera, F, Nascimento, BR, Giraldez, RRCV, Cavalcanti, AB, Pereira, SB, Mattos, LA, Armaganijan, LV, Guimarães, HP, Sousa, JEMR, Alexander, JH, Granger, CB, and Lopes, RD et al. "Effect of Loading Dose of Atorvastatin Prior to Planned Percutaneous Coronary Intervention on Major Adverse Cardiovascular Events in Acute Coronary Syndrome: The SECURE-PCI Randomized Clinical Trial." JAMA 319, no. 13 (April 2018): 1331-1340.

PMID
29525821
Full Text

Alexander, JH. "Ticagrelor Following Coronary Artery Bypass Grafting: For Better Vein Graft Patency or Better Patient Outcomes?." Jama 319, no. 16 (April 2018): 1661-1662.

PMID
29710146
Full Text

Rosenstock, J, Perkovic, V, Alexander, JH, Cooper, ME, Marx, N, Pencina, MJ, Toto, RD, Wanner, C, Zinman, B, Baanstra, D, Pfarr, E, Mattheus, M, Broedl, UC, Woerle, H-J, George, JT, von Eynatten, M, McGuire, DK, and CARMELINA® investigators, . "Rationale, design, and baseline characteristics of the CArdiovascular safety and Renal Microvascular outcomE study with LINAgliptin (CARMELINA®): a randomized, double-blind, placebo-controlled clinical trial in patients with type 2 diabetes and high cardio-renal risk." Cardiovascular diabetology 17, no. 1 (March 14, 2018): 39-.

PMID
29540217
Full Text

Rao, MP, Vinereanu, D, Wojdyla, DM, Alexander, JH, Atar, D, Hylek, EM, Hanna, M, Wallentin, L, Lopes, RD, Gersh, BJ, Granger, CB, and Apixaban for Reduction in Stroke Other Thromboembolic Events in Atrial Fibrillation (ARISTOTLE) Investigators, . "Clinical Outcomes and History of Fall in Patients with Atrial Fibrillation Treated with Oral Anticoagulation: Insights From the ARISTOTLE Trial." The American journal of medicine 131, no. 3 (March 2018): 269-275.e2.

PMID
29122636
Full Text

Sherwood, MW, Lopes, RD, Sun, JL, Liaw, D, Harrington, RA, Wallentin, L, Laskowitz, DT, James, SK, Goodman, SG, Darius, H, Lewis, BS, Gibson, CM, Pieper, KS, and Alexander, JH. "Apixaban following acute coronary syndromes in patients with prior stroke: Insights from the APPRAISE-2 trial." American heart journal 197 (March 2018): 1-8.

PMID
29447769
Full Text

Kopin, D, Jones, WS, Sherwood, MW, Wojdyla, DM, Wallentin, L, Lewis, BS, Verheugt, FWA, Vinereanu, D, Bahit, MC, Halvorsen, S, Huber, K, Parkhomenko, A, Granger, CB, Lopes, RD, and Alexander, JH. "Percutaneous coronary intervention and antiplatelet therapy in patients with atrial fibrillation receiving apixaban or warfarin: Insights from the ARISTOTLE trial." American Heart Journal 197 (March 2018): 133-141.

PMID
29447773
Full Text

Chiarito, M, Cao, D, Cannata, F, Godino, C, Lodigiani, C, Ferrante, G, Lopes, RD, Alexander, JH, Reimers, B, Condorelli, G, and Stefanini, GG. "Direct Oral Anticoagulants in Addition to Antiplatelet Therapy for Secondary Prevention After Acute Coronary Syndromes: A Systematic Review and Meta-analysis." JAMA cardiology 3, no. 3 (March 2018): 234-241.

PMID
29417147
Full Text

Lopes, RD, Rordorf, R, De Ferrari, GM, Leonardi, S, Thomas, L, Wojdyla, DM, Ridefelt, P, Lawrence, JH, De Caterina, R, Vinereanu, D, Hanna, M, Flaker, G, Al-Khatib, SM, Hohnloser, SH, Alexander, JH, Granger, CB, Wallentin, L, and ARISTOTLE Committees and Investigators, . "Digoxin and Mortality in Patients With Atrial Fibrillation." Journal of the American College of Cardiology 71, no. 10 (March 2018): 1063-1074.

PMID
29519345
Full Text

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