John Hunter Peel Alexander, MD

Professor of Medicine
Member in the Duke Clinical Research Institute
Campus mail 2400 Pratt St, Durham, NC 27705
Phone (919) 668-8955
Email address john.h.alexander@duke.edu

John H. Alexander, MD, MHS is a cardiologist and Professor of Medicine in the Department of Medicine, Division of Cardiology at Duke University School of Medicine, as well as the Vice Chief, Clinical Research in the Division of Cardiology. He is the Director of Cardiovascular Research at the Duke Clinical Research Institute where he oversees a large group of clinical research faculty and a broad portfolio of cardiovascular clinical trials and observational clinical research programs. He is a member of the American Society of Clinical Investigation.

Dr. Alexander’s clinical interests are in acute and general cardiovascular disease, valvular heart disease, and echocardiology. His research is focused on the translation of novel therapeutic concepts into clinical data through clinical trials, specifically on the therapeutics of acute coronary syndromes, chronic coronary artery disease, and cardiac surgery and on novel methodological approaches to clinical trials. He was on the Executive Committee of the ARISTOTLE trial of apixaban in patients with atrial fibrillation and was the Principal Investigator of the APPRAISE-2 trial of apixaban in patients with acute coronary syndromes.

Dr. Alexander has published extensively and has served as the principal investigator of numerous multicenter clinical trials. He currently serves as the co-chair of the Clinical Trial Transformation Initiative (CTTI).

Education and Training

  • Fellow in Cardiology, Medicine, Duke University, 1996 - 2000
  • Medical Resident, Medicine, Children's Hospital Boston, 1993 - 1996
  • M.D., University of Pennsylvania, 1993

Publications

Manning, MW, Cooter, M, Mathew, J, Alexander, J, Peterson, E, Ferguson, TB, Lopes, R, and Podgoreanu, M. "Angiotensin Receptor Blockade Improves Cardiac Surgical Outcomes in Patients With Metabolic Syndrome." The Annals of thoracic surgery 104, no. 1 (July 2017): 98-105.

PMID
28131423
Full Text

Hijazi, Z, Lindahl, B, Oldgren, J, Andersson, U, Lindbäck, J, Granger, CB, Alexander, JH, Gersh, BJ, Hanna, M, Harjola, V-P, Hylek, EM, Lopes, RD, Siegbahn, A, and Wallentin, L. "Repeated Measurements of Cardiac Biomarkers in Atrial Fibrillation and Validation of the ABC Stroke Score Over Time." Journal of the American Heart Association 6, no. 6 (June 23, 2017).

PMID
28645934
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Lopes, RD, Guimarães, PO, Kolls, BJ, Wojdyla, DM, Bushnell, CD, Hanna, M, Easton, JD, Thomas, L, Wallentin, L, Al-Khatib, SM, Held, C, Gabriel Melo de Barros E Silva, P, Alexander, JH, Granger, CB, and Diener, H-C. "Intracranial hemorrhage in patients with atrial fibrillation receiving anticoagulation therapy." Blood 129, no. 22 (June 2017): 2980-2987.

PMID
28356246
Full Text

Ailawadi, G, Chang, HL, O'Gara, PT, O'Sullivan, K, Woo, YJ, DeRose, JJ, Parides, MK, Thourani, VH, Robichaud, S, Gillinov, AM, Taddei-Peters, WC, Miller, MA, Perrault, LP, Smith, RL, Goldsmith, L, Horvath, KA, Doud, K, Baio, K, Gelijns, AC, Moskowitz, AJ, Bagiella, E, Alexander, JH, and Iribarne, A. "Pneumonia after cardiac surgery: Experience of the National Institutes of Health/Canadian Institutes of Health Research Cardiothoracic Surgical Trials Network." The Journal of thoracic and cardiovascular surgery 153, no. 6 (June 2017): 1384-1391.e3.

PMID
28341473
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Newman, JH, Rich, S, Abman, SH, Alexander, JH, Barnard, J, Beck, GJ, Benza, RL, Bull, TM, Chan, SY, Chun, HJ, Doogan, D, Dupuis, J, Erzurum, SC, Frantz, RP, Geraci, M, Gillies, H, Gladwin, M, Gray, MP, Hemnes, AR, Herbst, RS, Hernandez, AF, Hill, NS, Horn, EM, Hunter, K, Jing, Z-C, Johns, R, Kaul, S, Kawut, SM, Lahm, T, Leopold, JA, Lewis, GD, Mathai, SC, McLaughlin, VV, Michelakis, ED, Nathan, SD, Nichols, W, Page, G, Rabinovitch, M, Rich, J, Rischard, F, Rounds, S, Shah, SJ, and Tapson, VF et al. "Enhancing Insights into Pulmonary Vascular Disease through a Precision Medicine Approach. A Joint NHLBI-Cardiovascular Medical Research and Education Fund Workshop Report." American journal of respiratory and critical care medicine 195, no. 12 (June 2017): 1661-1670.

PMID
28430547
Full Text

Guimarães, PO, Lopes, RD, Wojdyla, DM, Abdul-Rahim, AH, Connolly, SJ, Flaker, GC, Wang, J, Hanna, M, Granger, CB, Wallentin, L, Lees, KR, Alexander, JH, and McMurray, JJV. "Effect of Apixaban on All-Cause Death in Patients with Atrial Fibrillation: a Meta-Analysis Based on Imputed Placebo Effect." Cardiovascular Drugs and Therapy 31, no. 3 (June 2017): 295-301.

PMID
28516318
Full Text

van Diepen, S, Merrill, PD, Carrier, M, Tardif, J-C, Podgoreanu, M, Alexander, JH, and Lopes, RD. "Association between CK-MB Area Under the Curve and Tranexamic Acid Utilization in Patients Undergoing Coronary Artery Bypass Surgery." Journal of thrombosis and thrombolysis 43, no. 4 (May 2017): 446-453.

PMID
28194628
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Hess, CN, Clare, RM, Neely, ML, Tricoci, P, Mahaffey, KW, James, SK, Alexander, JH, Held, C, Lopes, RD, Fox, KAA, White, HD, Wallentin, L, Armstrong, PW, Harrington, RA, Ohman, EM, and Roe, MT. "Differential occurrence, profile, and impact of first recurrent cardiovascular events after an acute coronary syndrome." American heart journal 187 (May 2017): 194-203.

PMID
28454804
Full Text

Cowper, PA, Sheng, S, Lopes, RD, Anstrom, KJ, Stafford, JA, Davidson-Ray, L, Al-Khatib, SM, Ansell, J, Dorian, P, Husted, S, McMurray, JJV, Steg, PG, Alexander, JH, Wallentin, L, Granger, CB, and Mark, DB. "Economic Analysis of Apixaban Therapy for Patients With Atrial Fibrillation From a US Perspective: Results From the ARISTOTLE Randomized Clinical Trial." JAMA cardiology 2, no. 5 (May 2017): 525-534.

PMID
28355434
Full Text

Mehta, RH, Leimberger, JD, van Diepen, S, Meza, J, Wang, A, Jankowich, R, Harrison, RW, Hay, D, Fremes, S, Duncan, A, Soltesz, EG, Luber, J, Park, S, Argenziano, M, Murphy, E, Marcel, R, Kalavrouziotis, D, Nagpal, D, Bozinovski, J, Toller, W, Heringlake, M, Goodman, SG, Levy, JH, Harrington, RA, Anstrom, KJ, Alexander, JH, and LEVO-CTS Investigators, . "Levosimendan in Patients with Left Ventricular Dysfunction Undergoing Cardiac Surgery." The New England journal of medicine 376, no. 21 (May 2017): 2032-2042.

PMID
28316276
Full Text

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