John Hunter Peel Alexander, MD

Professor of Medicine
Member in the Duke Clinical Research Institute
Campus mail 200 Morris Street, Durham, NC 27701
Phone (919) 668-8955
Email address john.h.alexander@duke.edu

John H. Alexander, MD, MHS is a cardiologist and Professor of Medicine in the Department of Medicine, Division of Cardiology at Duke University School of Medicine, as well as the Vice Chief, Clinical Research in the Division of Cardiology. He is the Director of Cardiovascular Research at the Duke Clinical Research Institute where he oversees a large group of clinical research faculty and a broad portfolio of cardiovascular clinical trials and observational clinical research programs. He is a member of the American Society of Clinical Investigation.

Dr. Alexander’s clinical interests are in acute and general cardiovascular disease, valvular heart disease, and echocardiology. His research is focused on the translation of novel therapeutic concepts into clinical data through clinical trials, specifically on the therapeutics of acute coronary syndromes, chronic coronary artery disease, and cardiac surgery and on novel methodological approaches to clinical trials. He was on the Executive Committee of the ARISTOTLE trial of apixaban in patients with atrial fibrillation and was the Principal Investigator of the APPRAISE-2 trial of apixaban in patients with acute coronary syndromes.

Dr. Alexander has published extensively and has served as the principal investigator of numerous multicenter clinical trials. He currently serves as the co-chair of the Clinical Trial Transformation Initiative (CTTI).

Education and Training

  • Fellow in Cardiology, Medicine, Duke University, 1996 - 2000
  • Medical Resident, Medicine, Children's Hospital, Boston, 1993 - 1996
  • M.D., University of Pennsylvania, 1993

Publications

Dzavík, Vladimir, Gad Cotter, Harmony R. Reynolds, John H. Alexander, Krishnan Ramanathan, Amanda L. Stebbins, David Hathaway, et al. “Effect of nitric oxide synthase inhibition on haemodynamics and outcome of patients with persistent cardiogenic shock complicating acute myocardial infarction: a phase II dose-ranging study..” Eur Heart J 28, no. 9 (May 2007): 1109–16. https://doi.org/10.1093/eurheartj/ehm075.

PMID
17459901
Full Text

TRIUMPH Investigators, Judith S., John H. Alexander, Harmony R. Reynolds, Amanda L. Stebbins, Vladimir Dzavik, Robert A. Harrington, Frans Van de Werf, and Judith S. Hochman. “Effect of tilarginine acetate in patients with acute myocardial infarction and cardiogenic shock: the TRIUMPH randomized controlled trial..” Jama 297, no. 15 (April 18, 2007): 1657–66. https://doi.org/10.1001/jama.297.15.joc70035.

PMID
17387132
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Gheorghiade, Mihai, Marvin A. Konstam, John C. Burnett, Liliana Grinfeld, Aldo P. Maggioni, Karl Swedberg, James E. Udelson, et al. “Short-term clinical effects of tolvaptan, an oral vasopressin antagonist, in patients hospitalized for heart failure: the EVEREST Clinical Status Trials..” Jama 297, no. 12 (March 28, 2007): 1332–43. https://doi.org/10.1001/jama.297.12.1332.

PMID
17384438
Full Text

Goyal, Abhinav, John H. Alexander, Gail E. Hafley, Stacy H. Graham, Rajendra H. Mehta, Michael J. Mack, Randall K. Wolf, et al. “Outcomes associated with the use of secondary prevention medications after coronary artery bypass graft surgery..” Ann Thorac Surg 83, no. 3 (March 2007): 993–1001. https://doi.org/10.1016/j.athoracsur.2006.10.046.

PMID
17307447
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Mahaffey, Kenneth W., Matthew T. Roe, Rakhi Kilaru, John H. Alexander, Frans Van de Werf, Robert M. Califf, Maarten L. Simoons, Eric J. Topol, and Robert A. Harrington. “Creatine kinase-MB elevation after coronary artery bypass grafting surgery in patients with non-ST-segment elevation acute coronary syndromes predict worse outcomes: results from four large clinical trials..” Eur Heart J 28, no. 4 (February 2007): 425–32. https://doi.org/10.1093/eurheartj/ehl483.

PMID
17267458
Full Text

Dyke, Christopher K., Steven R. Steinhubl, Neal S. Kleiman, Richard O. Cannon, Laura G. Aberle, Min Lin, Shelley K. Myles, et al. “First-in-human experience of an antidote-controlled anticoagulant using RNA aptamer technology: a phase 1a pharmacodynamic evaluation of a drug-antidote pair for the controlled regulation of factor IXa activity..” Circulation 114, no. 23 (December 5, 2006): 2490–97. https://doi.org/10.1161/CIRCULATIONAHA.106.668434.

PMID
17101847
Full Text

Madsen, Lene H., Geir Christensen, Terje Lund, Victor L. Serebruany, Chris B. Granger, Ingvild Hoen, Zanina Grieg, et al. “Time course of degradation of cardiac troponin I in patients with acute ST-elevation myocardial infarction: the ASSENT-2 troponin substudy..” Circ Res 99, no. 10 (November 10, 2006): 1141–47. https://doi.org/10.1161/01.RES.0000249531.23654.e1.

PMID
17038641
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Alexander, John H., and Robert A. Harrington. “Advances in antithrombotic therapy in acute myocardial infarction: the ExTRACT-TIMI 25 and OASIS-6 Trials..” Curr Cardiol Rep 8, no. 4 (July 2006): 279–81.

PMID
16883666
Scholars@Duke

Alexander, J. H., R. A. Harrington, T. B. Ferguson, E. D. Peterson, C. M. Gibson, and N. T. Kouchoukos. “In reply [4].” Journal of the American Medical Association 295, no. 13 (April 5, 2006): 1514–15. https://doi.org/10.1001/jama.295.13.1514-b.

Full Text

Galla, John M., Kenneth W. Mahaffey, Shelly K. Sapp, John H. Alexander, Matthew T. Roe, E Magnus Ohman, Christopher B. Granger, et al. “Elevated creatine kinase-MB with normal creatine kinase predicts worse outcomes in patients with acute coronary syndromes: results from 4 large clinical trials..” Am Heart J 151, no. 1 (January 2006): 16–24. https://doi.org/10.1016/j.ahj.2005.01.045.

PMID
16368286
Full Text

Pages