John Hunter Peel Alexander, MD

Professor of Medicine
Member in the Duke Clinical Research Institute
Campus mail 2400 Pratt St, Durham, NC 27705
Phone (919) 668-8955
Email address john.h.alexander@duke.edu

John H. Alexander, MD, MHS is a cardiologist and Professor of Medicine in the Department of Medicine, Division of Cardiology at Duke University School of Medicine, as well as the Vice Chief, Clinical Research in the Division of Cardiology. He is the Director of Cardiovascular Research at the Duke Clinical Research Institute where he oversees a large group of clinical research faculty and a broad portfolio of cardiovascular clinical trials and observational clinical research programs. He is a member of the American Society of Clinical Investigation.

Dr. Alexander’s clinical interests are in acute and general cardiovascular disease, valvular heart disease, and echocardiology. His research is focused on the translation of novel therapeutic concepts into clinical data through clinical trials, specifically on the therapeutics of acute coronary syndromes, chronic coronary artery disease, and cardiac surgery and on novel methodological approaches to clinical trials. He was on the Executive Committee of the ARISTOTLE trial of apixaban in patients with atrial fibrillation and was the Principal Investigator of the APPRAISE-2 trial of apixaban in patients with acute coronary syndromes.

Dr. Alexander has published extensively and has served as the principal investigator of numerous multicenter clinical trials. He currently serves as the co-chair of the Clinical Trial Transformation Initiative (CTTI).

Education and Training

  • Fellow in Cardiology, Medicine, Duke University, 1996 - 2000
  • Medical Resident, Medicine, Children's Hospital Boston, 1993 - 1996
  • M.D., University of Pennsylvania, 1993

Publications

Mahaffey, KW, Roe, MT, Kilaru, R, Alexander, JH, Van de Werf, F, Califf, RM, Simoons, ML, Topol, EJ, and Harrington, RA. "Creatine kinase-MB elevation after coronary artery bypass grafting surgery in patients with non-ST-segment elevation acute coronary syndromes predict worse outcomes: results from four large clinical trials." European Heart Journal 28, no. 4 (February 2007): 425-432.

PMID
17267458
Full Text

Dyke, CK, Steinhubl, SR, Kleiman, NS, Cannon, RO, Aberle, LG, Lin, M, Myles, SK, Melloni, C, Harrington, RA, Alexander, JH, Becker, RC, and Rusconi, CP. "First-in-human experience of an antidote-controlled anticoagulant using RNA aptamer technology: a phase 1a pharmacodynamic evaluation of a drug-antidote pair for the controlled regulation of factor IXa activity." Circulation 114, no. 23 (December 2006): 2490-2497.

PMID
17101847
Full Text

Madsen, LH, Christensen, G, Lund, T, Serebruany, VL, Granger, CB, Hoen, I, Grieg, Z, Alexander, JH, Jaffe, AS, Van Eyk, JE, and Atar, D. "Time course of degradation of cardiac troponin I in patients with acute ST-elevation myocardial infarction: the ASSENT-2 troponin substudy." Circulation Research 99, no. 10 (November 2006): 1141-1147.

PMID
17038641
Full Text

Alexander, JH, and Harrington, RA. "Advances in antithrombotic therapy in acute myocardial infarction: the ExTRACT-TIMI 25 and OASIS-6 Trials." Current Cardiology Reports 8, no. 4 (July 2006): 279-281.

PMID
16883666
Full Text

Alexander, JH, Harrington, RA, Ferguson, TB, Peterson, ED, Gibson, CM, and Kouchoukos, NT. "In reply [4]." Journal of the American Medical Association 295, no. 13 (April 5, 2006): 1514-1515. (Letter)

Full Text

Galla, JM, Mahaffey, KW, Sapp, SK, Alexander, JH, Roe, MT, Ohman, EM, Granger, CB, Armstrong, PW, Harrington, RA, White, HD, Simoons, ML, Newby, LK, Califf, RM, and Topol, EJ. "Elevated creatine kinase-MB with normal creatine kinase predicts worse outcomes in patients with acute coronary syndromes: results from 4 large clinical trials." American Heart Journal 151, no. 1 (January 2006): 16-24.

PMID
16368286
Full Text

Becker, RC, Alexander, JH, Dyke, C, Huang, Y, Saint-Jacques, H, Hasselblad, V, Harrington, RA, Bovill, EG, and XaNADU-1B Investigators, . "Effect of the novel direct factor Xa inhibitor DX-9065a on thrombin generation and inhibition among patients with stable atherosclerotic coronary artery disease." Thrombosis Research 117, no. 4 (January 2006): 439-446.

PMID
15882894
Full Text

Halabi, AR, Alexander, JH, Shaw, LK, Lorenz, TJ, Liao, L, Kong, DF, Milano, CA, Harrington, RA, and Smith, PK. "Relation of early saphenous vein graft failure to outcomes following coronary artery bypass surgery." The American Journal of Cardiology 96, no. 9 (November 2005): 1254-1259.

PMID
16253593
Full Text

Alexander, JH, Hafley, G, Harrington, RA, Peterson, ED, Ferguson, TB, Lorenz, TJ, Goyal, A, Gibson, M, Mack, MJ, Gennevois, D, Califf, RM, Kouchoukos, NT, and PREVENT IV Investigators, . "Efficacy and safety of edifoligide, an E2F transcription factor decoy, for prevention of vein graft failure following coronary artery bypass graft surgery: PREVENT IV: a randomized controlled trial." Jama 294, no. 19 (November 2005): 2446-2454.

PMID
16287955
Full Text

Alexander, JH, Ferguson, TB, Joseph, DM, Mack, MJ, Wolf, RK, Gibson, CM, Gennevois, D, Lorenz, TJ, Harrington, RA, Peterson, ED, Lee, KL, Califf, RM, Kouchoukos, NT, and PREVENT IV Investigators, . "The PRoject of Ex-vivo Vein graft ENgineering via Transfection IV (PREVENT IV) trial: study rationale, design, and baseline patient characteristics." American Heart Journal 150, no. 4 (October 2005): 643-649.

PMID
16209958
Full Text

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