John Hunter Peel Alexander, MD

Professor of Medicine
Member in the Duke Clinical Research Institute
Campus mail 2400 Pratt St, Durham, NC 27705
Phone (919) 668-8955
Email address john.h.alexander@duke.edu

John H. Alexander, MD, MHS is a cardiologist and Professor of Medicine in the Department of Medicine, Division of Cardiology at Duke University School of Medicine, as well as the Vice Chief, Clinical Research in the Division of Cardiology. He is the Director of Cardiovascular Research at the Duke Clinical Research Institute where he oversees a large group of clinical research faculty and a broad portfolio of cardiovascular clinical trials and observational clinical research programs. He is a member of the American Society of Clinical Investigation.

Dr. Alexander’s clinical interests are in acute and general cardiovascular disease, valvular heart disease, and echocardiology. His research is focused on the translation of novel therapeutic concepts into clinical data through clinical trials, specifically on the therapeutics of acute coronary syndromes, chronic coronary artery disease, and cardiac surgery and on novel methodological approaches to clinical trials. He was on the Executive Committee of the ARISTOTLE trial of apixaban in patients with atrial fibrillation and was the Principal Investigator of the APPRAISE-2 trial of apixaban in patients with acute coronary syndromes.

Dr. Alexander has published extensively and has served as the principal investigator of numerous multicenter clinical trials. He currently serves as the co-chair of the Clinical Trial Transformation Initiative (CTTI).

Education and Training

  • Fellow in Cardiology, Medicine, Duke University, 1996 - 2000
  • Medical Resident, Medicine, Children's Hospital Boston, 1993 - 1996
  • M.D., University of Pennsylvania, 1993

Publications

Al-Khatib, SM, Califf, RM, Hasselblad, V, Alexander, JH, McCrory, DC, and Sugarman, J. "Medecine: Placebo-controls in short-term clinical trials of hypertension." Science 292, no. 5524 (2001): 2013+2015-.

Scholars@Duke

Callahan, KP, Malinin, AI, Gurbel, PA, Alexander, JH, Granger, CB, Atar, D, and Serebruany, VL. "Platelets and thrombolysis: Cooperation or contrariety?." HeartDrug 1, no. 5 (2001): 281-290.

Full Text

Patel, M, Han, SS, Vaux, K, Saalfeld, J, and Alexander, JH. "A protocol of early spiral computed tomography for the detection of stones in patients with renal colic has reduced the time to diagnosis and overall management costs." Aust N Z J Surg 70, no. 1 (January 2000): 39-42.

PMID
10696941
Scholars@Duke

McGuire, DK, Hudson, MP, East, MA, Dyke, CK, Cantor, WJ, Battle, J, Bahit, MC, Al-Khatib, SM, and Alexander, JH. "Highlights from the American Heart Association 72nd Scientific Sessions: November 6 to 10, 1999." American Heart Journal 139, no. 2 I (2000): 359-370.

Scholars@Duke

Alexander, JH, Sparapani, RA, Mahaffey, KW, Deckers, JW, Newby, LK, Ohman, EM, Corbalán, R, Chierchia, SL, Boland, JB, Simoons, ML, Califf, RM, Topol, EJ, and Harrington, RA. "Association between minor elevations of creatine kinase-MB level and mortality in patients with acute coronary syndromes without ST-segment elevation." Journal of the American Medical Association 283, no. 3 (2000): 347-353.

PMID
10647797
Scholars@Duke

Alexander, JH, Al-Khatib, S, Cantor, W, Greenbaum, AB, Hudson, MP, Kong, DF, and Shah, M. "Highlights from the American College of Cardiology 48th Annual Scientific Sessions: March 7 to 10, 1999." Am Heart J 138, no. 1 Pt 1 (July 1999): 175-190.

PMID
10385783
Scholars@Duke

Pertusi, RM, Godwin, KS, House, JK, Knebl, JA, Alexander, JH, Rubin, BR, and Forman, MD. "Gastropathy induced by nonsteroidal anti-inflammatory drugs: prescribing patterns among geriatric practitioners." J Am Osteopath Assoc 99, no. 6 (June 1999): 305-310.

PMID
10405516
Scholars@Duke

Alexander, JH, Granger, CB, Sadowski, Z, Aylward, PE, White, HD, Thompson, TD, Califf, RM, and Topol, EJ. "Prophylactic lidocaine use in acute myocardial infarction: incidence and outcomes from two international trials. The GUSTO-I and GUSTO-IIb Investigators." Am Heart J 137, no. 5 (May 1999): 799-805.

PMID
10220627
Scholars@Duke

Sadowski, ZP, Alexander, JH, Skrabucha, B, Dyduszynski, A, Kuch, J, Nartowicz, E, Swiatecka, G, Kong, DF, and Granger, CB. "Multicenter randomized trial and a systematic overview of lidocaine in acute myocardial infarction." Am Heart J 137, no. 5 (May 1999): 792-798.

PMID
10220626
Scholars@Duke

Eachempati, SR, Young, C, Alexander, J, Cirisano, FD, Rodriguez, GC, and Reed, RL. "The clinical use of an esophageal Doppler monitor for hemodynamic monitoring in sepsis." J Clin Monit Comput 15, no. 3-4 (May 1999): 223-225.

PMID
12568174
Scholars@Duke

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