John Hunter Peel Alexander, MD

Professor of Medicine
Member in the Duke Clinical Research Institute
Campus mail 2400 Pratt St, Durham, NC 27705
Phone (919) 668-8955
Email address john.h.alexander@duke.edu

John H. Alexander, MD, MHS is a cardiologist and Professor of Medicine in the Department of Medicine, Division of Cardiology at Duke University School of Medicine, as well as the Vice Chief, Clinical Research in the Division of Cardiology. He is the Director of Cardiovascular Research at the Duke Clinical Research Institute where he oversees a large group of clinical research faculty and a broad portfolio of cardiovascular clinical trials and observational clinical research programs. He is a member of the American Society of Clinical Investigation.

Dr. Alexander’s clinical interests are in acute and general cardiovascular disease, valvular heart disease, and echocardiology. His research is focused on the translation of novel therapeutic concepts into clinical data through clinical trials, specifically on the therapeutics of acute coronary syndromes, chronic coronary artery disease, and cardiac surgery and on novel methodological approaches to clinical trials. He was on the Executive Committee of the ARISTOTLE trial of apixaban in patients with atrial fibrillation and was the Principal Investigator of the APPRAISE-2 trial of apixaban in patients with acute coronary syndromes.

Dr. Alexander has published extensively and has served as the principal investigator of numerous multicenter clinical trials. He currently serves as the co-chair of the Clinical Trial Transformation Initiative (CTTI).

Education and Training

  • Fellow in Cardiology, Medicine, Duke University, 1996 - 2000
  • Medical Resident, Medicine, Children's Hospital Boston, 1993 - 1996
  • M.D., University of Pennsylvania, 1993

Publications

Rebeiz, AG, Roe, MT, Alexander, JH, Mahaffey, KW, Granger, CB, Peterson, ED, Califf, RM, and Harrington, RA. "Integrating antithrombin and antiplatelet therapies with early invasive management for non-ST-segment elevation acute coronary syndromes." The American Journal of Medicine 116, no. 2 (January 2004): 119-129. (Review)

PMID
14715326
Full Text

Becker, RC, Alexander, J, Li, YF, Bovill, E, Spencer, FA, Robertson, TL, Kunitada, S, Dyke, CK, and Harrington, RA. "Combined coagulation phase-directed factor Xa inhibition with heparin compounds and DX-9065a - A direct and selective antagonist [1]." Thrombosis and Haemostasis 92, no. 6 (2004): 1229-1231.

PMID
15622616
Scholars@Duke

Alexander, JH, Harrington, RA, Bhapkar, M, Mahaffey, KW, Lincoff, AM, Ohman, EM, Klootwijk, P, Pahlm, O, Henden, B, Deckers, JW, Simoons, ML, Califf, RM, and Wagner, GS. "Prognostic importance of new small Q waves following non-ST-elevation acute coronary syndromes." The American Journal of Medicine 115, no. 8 (December 2003): 613-619.

PMID
14656613
Full Text

Alexander, JH, and Patel, MR. "Screening for structural heart disease: time to stop listening and start looking." Am Heart J 146, no. 4 (October 2003): 570-571.

PMID
14564308
Full Text

Sinnaeve, P, Alexander, J, Belmans, A, Bogaerts, K, Langer, A, Diaz, R, Ardissino, D, Vahanian, A, Pehrsson, K, Armstrong, P, Van de Werf, F, and ASSENT-2 Investigators, . "One-year follow-up of the ASSENT-2 trial: a double-blind, randomized comparison of single-bolus tenecteplase and front-loaded alteplase in 16,949 patients with ST-elevation acute myocardial infarction." American heart journal 146, no. 1 (July 2003): 27-32.

PMID
12851604
Full Text

Serebruany, VL, Malinin, AI, Callahan, KP, Binbrek, A, Van De Werf, F, Alexander, JH, Granger, CB, Gurbel, PA, and Assessment of the Safety and Efficacy of a New Thrombolytic Agent platelet substudy, . "Effect of tenecteplase versus alteplase on platelets during the first 3 hours of treatment for acute myocardial infarction: the Assessment of the Safety and Efficacy of a New Thrombolytic Agent (ASSENT-2) platelet substudy." Am Heart J 145, no. 4 (April 2003): 636-642.

PMID
12679759
Full Text

Akkerhuis, KM, Alexander, JH, Tardiff, BE, Boersma, E, Harrington, RA, Lincoff, AM, and Simoons, ML. "Minor myocardial damage and prognosis: are spontaneous and percutaneous coronary intervention-related events different?." Circulation 105, no. 5 (February 2002): 554-556.

PMID
11827918
Full Text

Angeja, BG, Alexander, JH, Chin, R, Li, X, Barron, HV, Armstrong, PW, Granger, CB, Van de Werf, F, and Gibson, CM. "Safety of the weight-adjusted dosing regimen of tenecteplase in the ASSENT-Trial." Am J Cardiol 88, no. 11 (December 1, 2001): 1240-1245.

PMID
11728350
Scholars@Duke

Daniels, SR. "Short-term trials and long-term effects." Science (New York, N.Y.) 293, no. 5539 (September 2001): 2392-2394. (Letter)

PMID
11579936
Full Text

Al-Khatib, SM, Califf, RM, Hasselblad, V, Alexander, JH, McCrory, DC, and Sugarman, J. "Medecine: Placebo-controls in short-term clinical trials of hypertension." Science 292, no. 5524 (June 15, 2001).

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