John Hunter Peel Alexander, MD

Professor of Medicine
Member in the Duke Clinical Research Institute
Campus mail 2400 Pratt St, Durham, NC 27705
Phone (919) 668-8955
Email address john.h.alexander@duke.edu

John H. Alexander, MD, MHS is a cardiologist and Professor of Medicine in the Department of Medicine, Division of Cardiology at Duke University School of Medicine, as well as the Vice Chief, Clinical Research in the Division of Cardiology. He is the Director of Cardiovascular Research at the Duke Clinical Research Institute where he oversees a large group of clinical research faculty and a broad portfolio of cardiovascular clinical trials and observational clinical research programs. He is a member of the American Society of Clinical Investigation.

Dr. Alexander’s clinical interests are in acute and general cardiovascular disease, valvular heart disease, and echocardiology. His research is focused on the translation of novel therapeutic concepts into clinical data through clinical trials, specifically on the therapeutics of acute coronary syndromes, chronic coronary artery disease, and cardiac surgery and on novel methodological approaches to clinical trials. He was on the Executive Committee of the ARISTOTLE trial of apixaban in patients with atrial fibrillation and was the Principal Investigator of the APPRAISE-2 trial of apixaban in patients with acute coronary syndromes.

Dr. Alexander has published extensively and has served as the principal investigator of numerous multicenter clinical trials. He currently serves as the co-chair of the Clinical Trial Transformation Initiative (CTTI).

Education and Training

  • Fellow in Cardiology, Medicine, Duke University, 1996 - 2000
  • Medical Resident, Medicine, Children's Hospital Boston, 1993 - 1996
  • M.D., University of Pennsylvania, 1993

Publications

Mahaffey, KW, Roe, MT, Kilaru, R, French, JK, Alexander, JH, Berdan, LG, Van De Werf, F, Simoons, ML, Weaver, WD, White, HD, Lincoff, AM, Kleiman, NS, Topol, EJ, and Harrington, RA. "Characterization of myocardial infarction as an end point in two large trials of acute coronary syndromes." Am J Cardiol 95, no. 12 (June 15, 2005): 1404-1408.

PMID
15950560
Full Text

Mehta, RH, Califf, RM, Garg, J, Pieper, KS, Alexander, JH, Moliterno, DJ, Van de Werf, F, Ohman, EM, White, HD, Topol, EJ, and Granger, CB. "Association of height with outcomes in patients with acute myocardial infarction receiving reperfusion therapy." The American Journal of Cardiology 95, no. 11 (June 2005): 1371-1375.

PMID
15904648
Full Text

Meine, TJ, Al-Khatib, SM, Alexander, JH, Granger, CB, White, HD, Kilaru, R, Williams, K, Ohman, EM, Topol, E, and Califf, RM. "Incidence, predictors, and outcomes of high-degree atrioventricular block complicating acute myocardial infarction treated with thrombolytic therapy." American Heart Journal 149, no. 4 (April 2005): 670-674.

PMID
15990751
Full Text

Mehta, RH, Alexander, JH, Van de Werf, F, Armstrong, PW, Pieper, KS, Garg, J, Califf, RM, and Granger, CB. "Relationship of incorrect dosing of fibrinolytic therapy and clinical outcomes." Jama 293, no. 14 (April 2005): 1746-1750.

PMID
15827313
Full Text

Alexander, JH, Yang, H, Becker, RC, Kodama, K, Goodman, S, Dyke, CK, Kleiman, NS, Hochman, JS, Berger, PB, Cohen, EA, Lincoff, AM, Burton, JR, Bovill, EG, Kawai, C, Armstrong, PW, Harrington, RA, and XaNADU-ACS INVESTIGATORS, . "First experience with direct, selective factor Xa inhibition in patients with non-ST-elevation acute coronary syndromes: results of the XaNADU-ACS Trial." J Thromb Haemost 3, no. 3 (March 2005): 439-447.

PMID
15748230
Full Text

Alexander, JH, and Singh, KP. "Inhibition of Factor Xa : a potential target for the development of new anticoagulants." American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions 5, no. 5 (January 2005): 279-290. (Review)

PMID
16156684
Full Text

Borges-Neto, S, Shaw, LK, Tuttle, RH, Alexander, JH, Smith, WT, Chambless, M, Coleman, RE, Harrington, RA, and Califf, RM. "Incremental prognostic power of single-photon emission computed tomographic myocardial perfusion imaging in patients with known or suspected coronary artery disease." The American Journal of Cardiology 95, no. 2 (January 2005): 182-188.

PMID
15642549
Full Text

Weston, P, Alexander, JH, Patel, MR, Maynard, C, Crawford, L, and Wagner, GS. "Hand-held echocardiographic examination of patients with symptoms of acute coronary syndromes in the emergency department: the 30-day outcome associated with normal left ventricular wall motion." Am Heart J 148, no. 6 (December 2004): 1096-1101.

PMID
15632899
Full Text

Becker, RC, Alexander, JH, Li, Y, Robertson, T, Kunitada, S, Spencer, FA, Yang, H, and Harrington, RA. "Vascular endothelial tissue factor pathway inhibitor kinetics in culture following exposure to DX-9065a--a selective and direct factor Xa inhibitor." J Thromb Thrombolysis 18, no. 3 (December 2004): 193-197.

PMID
15815881
Full Text

Becker, RC, Alexander, J, Dyke, CK, and Harrington, RA. "Development of DX-9065a, a novel direct factor Xa antagonist, in cardiovascular disease." Thrombosis and Haemostasis 92, no. 6 (December 2004): 1182-1193. (Review)

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