John Hunter Peel Alexander, MD

Professor of Medicine
Member in the Duke Clinical Research Institute
Campus mail 2400 Pratt St, Durham, NC 27705
Phone (919) 668-8955
Email address john.h.alexander@duke.edu

John H. Alexander, MD, MHS is a cardiologist and Professor of Medicine in the Department of Medicine, Division of Cardiology at Duke University School of Medicine, as well as the Vice Chief, Clinical Research in the Division of Cardiology. He is the Director of Cardiovascular Research at the Duke Clinical Research Institute where he oversees a large group of clinical research faculty and a broad portfolio of cardiovascular clinical trials and observational clinical research programs. He is a member of the American Society of Clinical Investigation.

Dr. Alexander’s clinical interests are in acute and general cardiovascular disease, valvular heart disease, and echocardiology. His research is focused on the translation of novel therapeutic concepts into clinical data through clinical trials, specifically on the therapeutics of acute coronary syndromes, chronic coronary artery disease, and cardiac surgery and on novel methodological approaches to clinical trials. He was on the Executive Committee of the ARISTOTLE trial of apixaban in patients with atrial fibrillation and was the Principal Investigator of the APPRAISE-2 trial of apixaban in patients with acute coronary syndromes.

Dr. Alexander has published extensively and has served as the principal investigator of numerous multicenter clinical trials. He currently serves as the co-chair of the Clinical Trial Transformation Initiative (CTTI).

Education and Training

  • Fellow in Cardiology, Medicine, Duke University, 1996 - 2000
  • Medical Resident, Medicine, Children's Hospital Boston, 1993 - 1996
  • M.D., University of Pennsylvania, 1993

Publications

Akkerhuis, KM, Alexander, JH, Tardiff, BE, Boersma, E, Harrington, RA, Lincoff, AM, and Simoons, ML. "Minor myocardial damage and prognosis: are spontaneous and percutaneous coronary intervention-related events different?." Circulation 105, no. 5 (February 2002): 554-556.

PMID
11827918
Full Text

Angeja, BG, Alexander, JH, Chin, R, Li, X, Barron, HV, Armstrong, PW, Granger, CB, Van de Werf, F, and Gibson, CM. "Safety of the weight-adjusted dosing regimen of tenecteplase in the ASSENT-Trial." Am J Cardiol 88, no. 11 (December 1, 2001): 1240-1245.

PMID
11728350
Scholars@Duke

Daniels, SR. "Short-term trials and long-term effects." Science (New York, N.Y.) 293, no. 5539 (September 2001): 2392-2394. (Letter)

PMID
11579936
Full Text

Al-Khatib, SM, Califf, RM, Hasselblad, V, Alexander, JH, McCrory, DC, and Sugarman, J. "Medecine: Placebo-controls in short-term clinical trials of hypertension." Science 292, no. 5524 (June 15, 2001).

Full Text

Al-Khatib, SM, Califf, RM, Hasselblad, V, Alexander, JH, McCrory, DC, and Sugarman, J. "Medicine. Placebo-controls in short-term clinical trials of hypertension." Science (New York, N.Y.) 292, no. 5524 (June 2001): 2013-2015. (Review)

PMID
11408643
Full Text

Callahan, KP, Malinin, AI, Gurbel, PA, Alexander, JH, Granger, CB, and Serebruany, VL. "Platelet function and fibrinolytic agents: two sides of a coin?." Cardiology 95, no. 2 (2001): 55-60.

PMID
11423707
Full Text

Callahan, KP, Malinin, AI, Gurbel, PA, Alexander, JH, Granger, CB, Atar, D, and Serebruany, VL. "Platelets and thrombolysis: Cooperation or contrariety?." HeartDrug 1, no. 5 (2001): 281-290.

Full Text

Patel, M, Han, SS, Vaux, K, Saalfeld, J, and Alexander, JH. "A protocol of early spiral computed tomography for the detection of stones in patients with renal colic has reduced the time to diagnosis and overall management costs." Aust N Z J Surg 70, no. 1 (January 2000): 39-42.

PMID
10696941
Scholars@Duke

McGuire, DK, Hudson, MP, East, MA, Dyke, CK, Cantor, WJ, Battle, J, Bahit, MC, Al-Khatib, SM, and Alexander, JH. "Highlights from the American Heart Association 72nd Scientific Sessions: November 6 to 10, 1999." American Heart Journal 139, no. 2 I (2000): 359-370.

Scholars@Duke

Alexander, JH, Sparapani, RA, Mahaffey, KW, Deckers, JW, Newby, LK, Ohman, EM, Corbalán, R, Chierchia, SL, Boland, JB, Simoons, ML, Califf, RM, Topol, EJ, and Harrington, RA. "Association between minor elevations of creatine kinase-MB level and mortality in patients with acute coronary syndromes without ST-segment elevation." Journal of the American Medical Association 283, no. 3 (2000): 347-353.

PMID
10647797
Scholars@Duke

Pages