John Hunter Peel Alexander, MD

Professor of Medicine
Member in the Duke Clinical Research Institute
Campus mail 2400 Pratt St, Durham, NC 27705
Phone (919) 668-8955
Email address john.h.alexander@duke.edu

John H. Alexander, MD, MHS is a cardiologist and Professor of Medicine in the Department of Medicine, Division of Cardiology at Duke University School of Medicine, as well as the Vice Chief, Clinical Research in the Division of Cardiology. He is the Director of Cardiovascular Research at the Duke Clinical Research Institute where he oversees a large group of clinical research faculty and a broad portfolio of cardiovascular clinical trials and observational clinical research programs. He is a member of the American Society of Clinical Investigation.

Dr. Alexander’s clinical interests are in acute and general cardiovascular disease, valvular heart disease, and echocardiology. His research is focused on the translation of novel therapeutic concepts into clinical data through clinical trials, specifically on the therapeutics of acute coronary syndromes, chronic coronary artery disease, and cardiac surgery and on novel methodological approaches to clinical trials. He was on the Executive Committee of the ARISTOTLE trial of apixaban in patients with atrial fibrillation and was the Principal Investigator of the APPRAISE-2 trial of apixaban in patients with acute coronary syndromes.

Dr. Alexander has published extensively and has served as the principal investigator of numerous multicenter clinical trials. He currently serves as the co-chair of the Clinical Trial Transformation Initiative (CTTI).

Education and Training

  • Fellow in Cardiology, Medicine, Duke University, 1996 - 2000
  • Medical Resident, Medicine, Children's Hospital Boston, 1993 - 1996
  • M.D., University of Pennsylvania, 1993

Publications

Vora, AN, Alexander, JH, and Lopes, RD. "Dabigatran Compared With Rivaroxaban vs Warfarin." JAMA internal medicine 177, no. 5 (May 2017): 742-743.

PMID
28460098
Full Text

Guimarães, PO, Lopes, RD, Stevens, SR, Zimerman, A, Wruck, L, James, SK, Haque, G, Giraldez, RRCV, Alexander, JH, and Alexander, KP. "Reporting Clinical End Points and Safety Events in an Acute Coronary Syndrome Trial: Results With Integrated Collection." Journal of the American Heart Association 6, no. 4 (April 24, 2017).

PMID
28438739
Full Text

Bahit, MC, Lopes, RD, Wojdyla, DM, Held, C, Hanna, M, Vinereanu, D, Hylek, EM, Verheugt, F, Goto, S, Alexander, JH, Wallentin, L, and Granger, CB. "Non-major bleeding with apixaban versus warfarin in patients with atrial fibrillation." Heart 103, no. 8 (April 2017): 623-628.

PMID
27798052
Full Text

de Souza Brito, F, Mehta, RH, Lopes, RD, Harskamp, RE, Lucas, BD, Schulte, PJ, Tardif, J-C, and Alexander, JH. "Nonsteroidal Anti-Inflammatory Drugs and Clinical Outcomes in Patients Undergoing Coronary Artery Bypass Surgery." The American journal of medicine 130, no. 4 (April 2017): 462-468.

PMID
27888052
Full Text

Hess, PL, Healey, JS, Granger, CB, Connolly, SJ, Ziegler, PD, Alexander, JH, Kowey, PR, Ruff, CT, Flaker, G, Halperin, JL, Hart, RG, and Lopes, RD. "The Role of Cardiovascular Implantable Electronic Devices in the Detection and Treatment of Subclinical Atrial Fibrillation: A Review." JAMA cardiology 2, no. 3 (March 2017): 324-331.

PMID
28097334
Full Text

Westenbrink, BD, Alings, M, Granger, CB, Alexander, JH, Lopes, RD, Hylek, EM, Thomas, L, Wojdyla, DM, Hanna, M, Keltai, M, Steg, PG, De Caterina, R, Wallentin, L, and van Gilst, WH. "Anemia is associated with bleeding and mortality, but not stroke, in patients with atrial fibrillation: Insights from the Apixaban for Reduction in Stroke and Other Thromboembolic Events in Atrial Fibrillation (ARISTOTLE) trial." American heart journal 185 (March 2017): 140-149.

PMID
28267467
Full Text

Hu, PT, Lopes, RD, Stevens, SR, Wallentin, L, Thomas, L, Alexander, JH, Hanna, M, Lewis, BS, Verheugt, FWA, Granger, CB, and Jones, WS. "Efficacy and Safety of Apixaban Compared With Warfarin in Patients With Atrial Fibrillation and Peripheral Artery Disease: Insights From the ARISTOTLE Trial." Journal of the American Heart Association 6, no. 1 (January 17, 2017).

PMID
28096100
Full Text

Browndyke, JN, Berger, M, Harshbarger, TB, Smith, PJ, White, W, Bisanar, TL, Alexander, JH, Gaca, JG, Welsh-Bohmer, K, Newman, MF, and Mathew, JP. "Resting-State Functional Connectivity and Cognition After Major Cardiac Surgery in Older Adults without Preoperative Cognitive Impairment: Preliminary Findings." Journal of the American Geriatrics Society 65, no. 1 (January 2017): e6-e12.

PMID
27858963
Full Text

Guimarães, PO, Wojdyla, DM, Alexander, JH, Thomas, L, Alings, M, Flaker, GC, Al-Khatib, SM, Hanna, M, Horowitz, JD, Wallentin, L, Granger, CB, and Lopes, RD. "Anticoagulation therapy and clinical outcomes in patients with recently diagnosed atrial fibrillation: Insights from the ARISTOTLE trial." International journal of cardiology 227 (January 2017): 443-449.

PMID
27852444
Full Text

Povsic, TJ, Lawrence, MG, Lincoff, AM, Mehran, R, Rusconi, CP, Zelenkofske, SL, Huang, Z, Sailstad, J, Armstrong, PW, Steg, PG, Bode, C, Becker, RC, Alexander, JH, Adkinson, NF, Levinson, AI, and REGULATE-PCI Investigators, . "Pre-existing anti-PEG antibodies are associated with severe immediate allergic reactions to pegnivacogin, a PEGylated aptamer." The Journal of allergy and clinical immunology 138, no. 6 (December 2016): 1712-1715.

PMID
27522158
Full Text

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