John Hunter Peel Alexander, MD

Professor of Medicine
Member in the Duke Clinical Research Institute
Campus mail 2400 Pratt St, Durham, NC 27705
Phone (919) 668-8955
Email address john.h.alexander@duke.edu

John H. Alexander, MD, MHS is a cardiologist and Professor of Medicine in the Department of Medicine, Division of Cardiology at Duke University School of Medicine, as well as the Vice Chief, Clinical Research in the Division of Cardiology. He is the Director of Cardiovascular Research at the Duke Clinical Research Institute where he oversees a large group of clinical research faculty and a broad portfolio of cardiovascular clinical trials and observational clinical research programs. He is a member of the American Society of Clinical Investigation.

Dr. Alexander’s clinical interests are in acute and general cardiovascular disease, valvular heart disease, and echocardiology. His research is focused on the translation of novel therapeutic concepts into clinical data through clinical trials, specifically on the therapeutics of acute coronary syndromes, chronic coronary artery disease, and cardiac surgery and on novel methodological approaches to clinical trials. He was on the Executive Committee of the ARISTOTLE trial of apixaban in patients with atrial fibrillation and was the Principal Investigator of the APPRAISE-2 trial of apixaban in patients with acute coronary syndromes.

Dr. Alexander has published extensively and has served as the principal investigator of numerous multicenter clinical trials. He currently serves as the co-chair of the Clinical Trial Transformation Initiative (CTTI).

Education and Training

  • Fellow in Cardiology, Medicine, Duke University, 1996 - 2000
  • Medical Resident, Medicine, Children's Hospital Boston, 1993 - 1996
  • M.D., University of Pennsylvania, 1993

Publications

Prates, PRL, Williams, JB, Mehta, RH, Stevens, SR, Thomas, L, Smith, PK, Newby, LK, Kalil, RAK, Alexander, JH, and Lopes, RD. "Clopidogrel use After Myocardial Revascularization: Prevalence, Predictors, and One-Year Survival Rate." Brazilian journal of cardiovascular surgery 31, no. 2 (April 2016): 106-114.

PMID
27556308
Full Text

Kragholm, K, Goldstein, SA, Yang, Q, Lopes, RD, Schulte, PJ, Bernacki, GM, White, HD, Mahaffey, KW, Giugliano, RP, Armstrong, PW, Harrington, RA, Tricoci, P, Van de Werf, F, Alexander, JH, Alexander, KP, and Newby, LK. "Trends in Enrollment, Clinical Characteristics, Treatment, and Outcomes According to Age in Non-ST-Segment-Elevation Acute Coronary Syndromes Clinical Trials." Circulation 133, no. 16 (April 2016): 1560-1573.

PMID
26957532
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Hijazi, Z, Aulin, J, Andersson, U, Alexander, JH, Gersh, B, Granger, CB, Hanna, M, Horowitz, J, Hylek, EM, Lopes, RD, Siegbahn, A, Wallentin, L, and ARISTOTLE Investigators, . "Biomarkers of inflammation and risk of cardiovascular events in anticoagulated patients with atrial fibrillation." Heart (British Cardiac Society) 102, no. 7 (April 2016): 508-517.

PMID
26839066
Full Text

Zimerman, A, Lopes, RD, Stebbins, AL, Guimarães, PO, Haque, G, Melloni, C, Trollinger, K, James, SK, Alexander, JH, Tricoci, P, Roe, MT, Ohman, EM, Mahaffey, KW, Held, C, Tinga, B, Pieper, KS, and Alexander, KP. "Pooled analysis of adverse event collection from 4 acute coronary syndrome trials." American heart journal 174 (April 2016): 60-67.

PMID
26995371
Full Text

Lincoff, AM, Mehran, R, Povsic, TJ, Zelenkofske, SL, Huang, Z, Armstrong, PW, Steg, PG, Bode, C, Cohen, MG, Buller, C, Laanmets, P, Valgimigli, M, Marandi, T, Fridrich, V, Cantor, WJ, Merkely, B, Lopez-Sendon, J, Cornel, JH, Kasprzak, JD, Aschermann, M, Guetta, V, Morais, J, Sinnaeve, PR, Huber, K, Stables, R, Sellers, MA, Borgman, M, Glenn, L, Levinson, AI, Lopes, RD, Hasselblad, V, Becker, RC, Alexander, JH, and REGULATE-PCI Investigators, . "Effect of the REG1 anticoagulation system versus bivalirudin on outcomes after percutaneous coronary intervention (REGULATE-PCI): a randomised clinical trial." Lancet (London, England) 387, no. 10016 (January 2016): 349-356.

PMID
26547100
Full Text

Harskamp, RE, Alexander, JH, Ferguson, TB, Hager, R, Mack, MJ, Englum, B, Wojdyla, D, Schulte, PJ, Kouchoukos, NT, de Winter, RJ, Gibson, CM, Peterson, ED, Harrington, RA, Smith, PK, and Lopes, RD. "Frequency and Predictors of Internal Mammary Artery Graft Failure and Subsequent Clinical Outcomes: Insights From the Project of Ex-vivo Vein Graft Engineering via Transfection (PREVENT) IV Trial." Circulation 133, no. 2 (January 2016): 131-138.

PMID
26647082
Full Text

Vinereanu, D, Stevens, SR, Alexander, JH, Al-Khatib, SM, Avezum, A, Bahit, MC, Granger, CB, Lopes, RD, Halvorsen, S, Hanna, M, Husted, S, Hylek, EM, Mărgulescu, AD, Wallentin, L, and Atar, D. "Clinical outcomes in patients with atrial fibrillation according to sex during anticoagulation with apixaban or warfarin: a secondary analysis of a randomized controlled trial." European heart journal 36, no. 46 (December 2015): 3268-3275.

PMID
26371113
Full Text

Rao, MP, Halvorsen, S, Wojdyla, D, Thomas, L, Alexander, JH, Hylek, EM, Hanna, M, Bahit, MC, Lopes, RD, De Caterina, R, Erol, C, Goto, S, Lanas, F, Lewis, BS, Husted, S, Gersh, BJ, Wallentin, L, Granger, CB, and Apixaban for Reduction in Stroke and Other Thromboembolic Events in Atrial Fibrillation (ARISTOTLE) Steering Committee and Investigators, . "Blood Pressure Control and Risk of Stroke or Systemic Embolism in Patients With Atrial Fibrillation: Results From the Apixaban for Reduction in Stroke and Other Thromboembolic Events in Atrial Fibrillation (ARISTOTLE) Trial." Journal of the American Heart Association 4, no. 12 (December 2015).

PMID
26627878
Full Text

Samad, Z, Shaw, LK, Phelan, M, Ersboll, M, Risum, N, Al-Khalidi, HR, Glower, DD, Milano, CA, Alexander, JH, O'Connor, CM, Wang, A, and Velazquez, EJ. "Management and outcomes in patients with moderate or severe functional mitral regurgitation and severe left ventricular dysfunction." European heart journal 36, no. 40 (October 2015): 2733-2741.

PMID
26233850
Full Text

Khan, R, Lopes, RD, Neely, ML, Stevens, SR, Harrington, RA, Diaz, R, Cools, F, Jansky, P, Montalescot, G, Atar, D, Lopez-Sendon, J, Flather, M, Liaw, D, Wallentin, L, Alexander, JH, Goodman, SG, and Apixaban for Prevention of Acute Ischemic Safety Events (APPRAISE)-2 Steering Committee and Investigators, . "Characterising and predicting bleeding in high-risk patients with an acute coronary syndrome." Heart (British Cardiac Society) 101, no. 18 (September 2015): 1475-1484.

PMID
26109589
Full Text

Pages