John Hunter Peel Alexander, MD

Professor of Medicine
Member in the Duke Clinical Research Institute
Campus mail 200 Morris Street, Durham, NC 27701
Phone (919) 668-8955
Email address john.h.alexander@duke.edu

John H. Alexander, MD, MHS is a cardiologist and Professor of Medicine in the Department of Medicine, Division of Cardiology at Duke University School of Medicine, as well as the Vice Chief, Clinical Research in the Division of Cardiology. He is the Director of Cardiovascular Research at the Duke Clinical Research Institute where he oversees a large group of clinical research faculty and a broad portfolio of cardiovascular clinical trials and observational clinical research programs. He is a member of the American Society of Clinical Investigation.

Dr. Alexander’s clinical interests are in acute and general cardiovascular disease, valvular heart disease, and echocardiology. His research is focused on the translation of novel therapeutic concepts into clinical data through clinical trials, specifically on the therapeutics of acute coronary syndromes, chronic coronary artery disease, and cardiac surgery and on novel methodological approaches to clinical trials. He was on the Executive Committee of the ARISTOTLE trial of apixaban in patients with atrial fibrillation and was the Principal Investigator of the APPRAISE-2 trial of apixaban in patients with acute coronary syndromes.

Dr. Alexander has published extensively and has served as the principal investigator of numerous multicenter clinical trials. He currently serves as the co-chair of the Clinical Trial Transformation Initiative (CTTI).

Education and Training

  • Fellow in Cardiology, Medicine, Duke University, 1996 - 2000
  • Medical Resident, Medicine, Children's Hospital Boston, 1993 - 1996
  • M.D., University of Pennsylvania, 1993

Publications

Bahit, M Cecilia, Christopher B. Granger, John H. Alexander, Hillary Mulder, Daniel M. Wojdyla, Michael Hanna, Shinya Goto, et al. “Regional variation in clinical characteristics and outcomes in patients with atrial fibrillation: Findings from the ARISTOTLE trial.” Int J Cardiol 302 (March 1, 2020): 53–58. https://doi.org/10.1016/j.ijcard.2019.12.060.

PMID
31932116
Full Text

Garcia, David A., Deborah A. Fisher, Hillary Mulder, Lisa Wruck, Raffele De Caterina, Sigrun Halvorsen, Christopher B. Granger, et al. “Gastrointestinal bleeding in patients with atrial fibrillation treated with Apixaban or warfarin: Insights from the Apixaban for Reduction in Stroke and Other Thromboembolic Events in Atrial Fibrillation (ARISTOTLE) trial.” Am Heart J 221 (March 2020): 1–8. https://doi.org/10.1016/j.ahj.2019.10.013.

PMID
31896036
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Lopes, Renato D., Pedro G. M. de Barros E Silva, Lucas Petri Damiani, Renato Hideo Nakagawa Santos, John H. Alexander, Christopher B. Granger, and Otavio Berwanger. “Major Adverse Cardiovascular Events After 12 Months Among Patients With Acute Coronary Syndrome Receiving Loading Doses of Atorvastatin Prior to Planned PCI.” Jama 323, no. 8 (February 25, 2020): 787–89. https://doi.org/10.1001/jama.2020.0118.

PMID
32096839
Full Text

Dalgaard, Frederik, Hillary Mulder, Daniel M. Wojdyla, Renato D. Lopes, Claes Held, John H. Alexander, Raffaele De Caterina, et al. “Patients With Atrial Fibrillation Taking Nonsteroidal Anti-Inflammatory Drugs and Oral Anticoagulants in the ARISTOTLE Trial.” Circulation 141, no. 1 (January 7, 2020): 10–20. https://doi.org/10.1161/CIRCULATIONAHA.119.041296.

PMID
31747786
Full Text

Harskamp, Ralf E., John H. Alexander, and Renato D. Lopes. “Clinical Considerations Prior to Transition From Triple Antithrombotic Therapy to Dual Antithrombotic Therapy-Reply.” Jama Cardiol 5, no. 1 (January 1, 2020): 111–12. https://doi.org/10.1001/jamacardio.2019.4551.

PMID
31799984
Full Text

Lopes, Renato D., Hwanhee Hong, and John H. Alexander. “Antithrombotic therapy after acute coronary syndrome and/or percutaneous coronary intervention in atrial fibrillation: finding the sweet spot.” Eur Heart J 40, no. 46 (December 7, 2019): 3768–70. https://doi.org/10.1093/eurheartj/ehz823.

PMID
31774111
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Vora, Amit N., John H. Alexander, Daniel M. Wojdyla, Ronald Aronson, Christopher B. Granger, Harald Darius, Stephan Windecker, et al. “Hospitalization Among Patients With Atrial Fibrillation and a Recent Acute Coronary Syndrome or Percutaneous Coronary Intervention Treated With Apixaban or Aspirin: Insights From the AUGUSTUS Trial.” Circulation 140, no. 23 (December 3, 2019): 1960–63. https://doi.org/10.1161/CIRCULATIONAHA.119.043754.

PMID
31553201
Full Text

Windecker, Stephan, Renato D. Lopes, Tyler Massaro, Charlotte Jones-Burton, Christopher B. Granger, Ronald Aronson, Gretchen Heizer, et al. “Antithrombotic Therapy in Patients With Atrial Fibrillation and Acute Coronary Syndrome Treated Medically or With Percutaneous Coronary Intervention or Undergoing Elective Percutaneous Coronary Intervention: Insights From the AUGUSTUS Trial.” Circulation 140, no. 23 (December 3, 2019): 1921–32. https://doi.org/10.1161/CIRCULATIONAHA.119.043308.

PMID
31557056
Full Text

Brennan, J Matthew, Lisa Wruck, Michael J. Pencina, Robert M. Clare, Renato D. Lopes, John H. Alexander, Sean O’Brien, et al. “Claims-based cardiovascular outcome identification for clinical research: Results from 7 large randomized cardiovascular clinical trials.” Am Heart J 218 (December 2019): 110–22. https://doi.org/10.1016/j.ahj.2019.09.002.

PMID
31726314
Full Text

Pages