John Hunter Peel Alexander, MD

Professor of Medicine
Member in the Duke Clinical Research Institute
Campus mail 2400 Pratt St, Durham, NC 27705
Phone (919) 668-8955
Email address john.h.alexander@duke.edu

John H. Alexander, MD, MHS is a cardiologist and Professor of Medicine in the Department of Medicine, Division of Cardiology at Duke University School of Medicine, as well as the Vice Chief, Clinical Research in the Division of Cardiology. He is the Director of Cardiovascular Research at the Duke Clinical Research Institute where he oversees a large group of clinical research faculty and a broad portfolio of cardiovascular clinical trials and observational clinical research programs. He is a member of the American Society of Clinical Investigation.

Dr. Alexander’s clinical interests are in acute and general cardiovascular disease, valvular heart disease, and echocardiology. His research is focused on the translation of novel therapeutic concepts into clinical data through clinical trials, specifically on the therapeutics of acute coronary syndromes, chronic coronary artery disease, and cardiac surgery and on novel methodological approaches to clinical trials. He was on the Executive Committee of the ARISTOTLE trial of apixaban in patients with atrial fibrillation and was the Principal Investigator of the APPRAISE-2 trial of apixaban in patients with acute coronary syndromes.

Dr. Alexander has published extensively and has served as the principal investigator of numerous multicenter clinical trials. He currently serves as the co-chair of the Clinical Trial Transformation Initiative (CTTI).

Education and Training

  • Fellow in Cardiology, Medicine, Duke University, 1996 - 2000
  • Medical Resident, Medicine, Children's Hospital Boston, 1993 - 1996
  • M.D., University of Pennsylvania, 1993

Publications

Tricoci, P, D'Andrea, DM, Gurbel, PA, Yao, Z, Cuchel, M, Winston, B, Schott, R, Weiss, R, Blazing, MA, Cannon, L, Bailey, A, Angiolillo, DJ, Gille, A, Shear, CL, Wright, SD, and Alexander, JH. "Infusion of Reconstituted High-Density Lipoprotein, CSL112, in Patients With Atherosclerosis: Safety and Pharmacokinetic Results From a Phase 2a Randomized Clinical Trial." Journal of the American Heart Association 4, no. 8 (August 25, 2015): e002171-.

PMID
26307570
Full Text

Hess, CN, James, S, Lopes, RD, Wojdyla, DM, Neely, ML, Liaw, D, Hagstrom, E, Bhatt, DL, Husted, S, Goodman, SG, Lewis, BS, Verheugt, FWA, De Caterina, R, Ogawa, H, Wallentin, L, and Alexander, JH. "Apixaban Plus Mono Versus Dual Antiplatelet Therapy in Acute Coronary Syndromes: Insights From the APPRAISE-2 Trial." Journal of the American College of Cardiology 66, no. 7 (August 2015): 777-787.

PMID
26271059
Full Text

Kragholm, K, Halim, SA, Yang, Q, Schulte, PJ, Hochman, JS, Melloni, C, Mahaffey, KW, Moliterno, DJ, Harrington, RA, White, HD, Armstrong, PW, Ohman, EM, Van de Werf, F, Tricoci, P, Alexander, JH, Giugliano, RP, and Newby, LK. "Sex-Stratified Trends in Enrollment, Patient Characteristics, Treatment, and Outcomes Among Non-ST-Segment Elevation Acute Coronary Syndrome Patients: Insights From Clinical Trials Over 17 Years." Circulation. Cardiovascular quality and outcomes 8, no. 4 (July 7, 2015): 357-367.

PMID
26152683
Full Text

Williams, JB, Harskamp, RE, Bose, S, Lawson, JH, Alexander, JH, Smith, PK, and Lopes, RD. "The Preservation and Handling of Vein Grafts in Current Surgical Practice: Findings of a Survey Among Cardiovascular Surgeons of Top-Ranked US Hospitals." JAMA surgery 150, no. 7 (July 2015): 681-683.

PMID
25970819
Full Text

Hess, CN, Lopes, RD, Gibson, CM, Hager, R, Wojdyla, DM, Englum, BR, Mack, MJ, Kouchoukos, NT, Peterson, ED, and Alexander, JH. "Response to Letters Regarding Article, "Saphenous Vein Graft Failure After Coronary Artery Bypass Surgery: Insights From PREVENT IV"." Circulation 132, no. 4 (July 2015): e29-. (Letter)

PMID
26216091
Full Text

Mahaffey, KW, Hager, R, Wojdyla, D, White, HD, Armstrong, PW, Alexander, JH, Tricoci, P, Lopes, RD, Ohman, EM, Roe, MT, Harrington, RA, and Wallentin, L. "Meta-analysis of intracranial hemorrhage in acute coronary syndromes: incidence, predictors, and clinical outcomes." Journal of the American Heart Association 4, no. 6 (June 18, 2015): e001512-.

PMID
26089177
Full Text

Roe, MT, Mahaffey, KW, Ezekowitz, JA, Alexander, JH, Goodman, SG, Hernandez, A, Temple, T, Berdan, L, Califf, RM, Harrington, RA, Peterson, ED, and Armstrong, PW. "The future of cardiovascular clinical research in North America and beyond-addressing challenges and leveraging opportunities through unique academic and grassroots collaborations." American heart journal 169, no. 6 (June 1, 2015): 743-750. (Review)

Full Text

Roe, MT, Mahaffey, KW, Ezekowitz, JA, Alexander, JH, Goodman, SG, Hernandez, A, Temple, T, Berdan, L, Califf, RM, Harrington, RA, Peterson, ED, and Armstrong, PW. "The future of cardiovascular clinical research in North America and beyond-addressing challenges and leveraging opportunities through unique academic and grassroots collaborations." American heart journal 169, no. 6 (June 2015): 743-750. (Review)

PMID
26027610
Full Text

Kertai, MD, Li, Y-J, Li, Y-W, Ji, Y, Alexander, J, Newman, MF, Smith, PK, Joseph, D, Mathew, JP, Podgoreanu, MV, and Duke Perioperative Genetics and Safety Outcomes (PEGASUS) Investigative Team, . "Genome-wide association study of perioperative myocardial infarction after coronary artery bypass surgery." BMJ open 5, no. 5 (May 6, 2015): e006920-.

PMID
25948407
Full Text

Held, C, Hylek, EM, Alexander, JH, Hanna, M, Lopes, RD, Wojdyla, DM, Thomas, L, Al-Khalidi, H, Alings, M, Xavier, D, Ansell, J, Goto, S, Ruzyllo, W, Rosenqvist, M, Verheugt, FWA, Zhu, J, Granger, CB, and Wallentin, L. "Clinical outcomes and management associated with major bleeding in patients with atrial fibrillation treated with apixaban or warfarin: insights from the ARISTOTLE trial." European heart journal 36, no. 20 (May 2015): 1264-1272.

PMID
25499871
Full Text

Pages