John Hunter Peel Alexander, MD

Professor of Medicine
Member in the Duke Clinical Research Institute
Campus mail 2400 Pratt St, Durham, NC 27705
Phone (919) 668-8955
Email address john.h.alexander@duke.edu

John H. Alexander, MD, MHS is a cardiologist and Professor of Medicine in the Department of Medicine, Division of Cardiology at Duke University School of Medicine, as well as the Vice Chief, Clinical Research in the Division of Cardiology. He is the Director of Cardiovascular Research at the Duke Clinical Research Institute where he oversees a large group of clinical research faculty and a broad portfolio of cardiovascular clinical trials and observational clinical research programs. He is a member of the American Society of Clinical Investigation.

Dr. Alexander’s clinical interests are in acute and general cardiovascular disease, valvular heart disease, and echocardiology. His research is focused on the translation of novel therapeutic concepts into clinical data through clinical trials, specifically on the therapeutics of acute coronary syndromes, chronic coronary artery disease, and cardiac surgery and on novel methodological approaches to clinical trials. He was on the Executive Committee of the ARISTOTLE trial of apixaban in patients with atrial fibrillation and was the Principal Investigator of the APPRAISE-2 trial of apixaban in patients with acute coronary syndromes.

Dr. Alexander has published extensively and has served as the principal investigator of numerous multicenter clinical trials. He currently serves as the co-chair of the Clinical Trial Transformation Initiative (CTTI).

Education and Training

  • Fellow in Cardiology, Medicine, Duke University, 1996 - 2000
  • Medical Resident, Medicine, Children's Hospital Boston, 1993 - 1996
  • M.D., University of Pennsylvania, 1993

Publications

Steinberg, BA, Schulte, PJ, Hofmann, P, Ersbøll, M, Alexander, JH, Broderick-Forsgren, K, Anstrom, KJ, Granger, CB, Piccini, JP, Velazquez, EJ, and Shah, BR. "Outcomes after nonemergent electrical cardioversion for atrial arrhythmias." The American journal of cardiology 115, no. 10 (May 2015): 1407-1414.

PMID
25784514
Full Text

Cornel, JH, Lopes, RD, James, S, Stevens, SR, Neely, ML, Liaw, D, Miller, J, Mohan, P, Amerena, J, Raev, D, Huo, Y, Urina-Triana, M, Gallegos Cazorla, A, Vinereanu, D, Fridrich, V, Harrington, RA, Wallentin, L, Alexander, JH, and APPRAISE-2 Study Group, . "Anticoagulant therapy and outcomes in patients with prior or acute heart failure and acute coronary syndromes: Insights from the APixaban for PRevention of Acute ISchemic Events 2 trial." American heart journal 169, no. 4 (April 2015): 531-538.

PMID
25819860
Full Text

Ezekowitz, JA, Lewis, BS, Lopes, RD, Wojdyla, DM, McMurray, JJV, Hanna, M, Atar, D, Cecilia Bahit, M, Keltai, M, Lopez-Sendon, JL, Pais, P, Ruzyllo, W, Wallentin, L, Granger, CB, and Alexander, JH. "Clinical outcomes of patients with diabetes and atrial fibrillation treated with apixaban: results from the ARISTOTLE trial." European heart journal. Cardiovascular pharmacotherapy 1, no. 2 (April 2015): 86-94.

PMID
27533976
Full Text

Castleberry, AW, Williams, JB, Daneshmand, MA, Honeycutt, E, Shaw, LK, Samad, Z, Lopes, RD, Alexander, JH, Mathew, JP, Velazquez, EJ, Milano, CA, and Smith, PK. "Response to letter regarding article, "surgical revascularization is associated with maximal survival in patients with ischemic mitral regurgitation: a 20-year experience"." Circulation 131, no. 11 (March 2015): e378-e379. (Letter)

PMID
25779550
Full Text

Hijazi, Z, Siegbahn, A, Andersson, U, Lindahl, B, Granger, CB, Alexander, JH, Atar, D, Gersh, BJ, Hanna, M, Harjola, V-P, Horowitz, J, Husted, S, Hylek, EM, Lopes, RD, McMurray, JJV, and Wallentin, L. "Comparison of cardiac troponins I and T measured with high-sensitivity methods for evaluation of prognosis in atrial fibrillation: an ARISTOTLE substudy." Clinical chemistry 61, no. 2 (February 2015): 368-378.

PMID
25451868
Full Text

Povsic, TJ, Broderick, S, Anstrom, KJ, Shaw, LK, Ohman, EM, Eisenstein, EL, Smith, PK, and Alexander, JH. "Predictors of long-term clinical endpoints in patients with refractory angina." Journal of the American Heart Association 4, no. 2 (February 2015).

PMID
25637344
Full Text

Cornel, JH, Lopes, RD, James, S, Stevens, SR, Neely, ML, Liaw, D, Miller, J, Mohan, P, Amerena, J, Raev, D, Huo, Y, Urina-Triana, M, Gallegos Cazorla, A, Vinereanu, D, Fridrich, V, Harrington, RA, Wallentin, L, and Alexander, JH. "Anticoagulant therapy and outcomes in patients with prior or acute heart failure and acute coronary syndromes: Insights from the APixaban for PRevention of Acute ISchemic Events 2 trial." American Heart Journal 169, no. 4 (January 1, 2015): 531-538.

Full Text

Roe, MT, Mahaffey, KW, Ezekowitz, JA, Alexander, JH, Goodman, SG, Hernandez, A, Temple, T, Berdan, L, Califf, RM, Harrington, RA, Peterson, ED, and Armstrong, PW. "The future of cardiovascular clinical research in North America and beyond - Addressing challenges and leveraging opportunities through unique academic and grassroots collaborations." American Heart Journal 169, no. 6 (January 1, 2015): 743-750.

Scholars@Duke

Granger, CB, Lopes, RD, Hanna, M, Ansell, J, Hylek, EM, Alexander, JH, Thomas, L, Wang, J, Bahit, MC, Verheugt, F, Lawrence, J, Xavier, D, and Wallentin, L. "Clinical events after transitioning from apixaban versus warfarin to warfarin at the end of the Apixaban for Reduction in Stroke and Other Thromboembolic Events in Atrial Fibrillation (ARISTOTLE) trial." American heart journal 169, no. 1 (January 2015): 25-30.

PMID
25497244
Full Text

Koshizaka, M, Lopes, RD, Reyes, EM, Gibson, CM, Schulte, PJ, Hafley, GE, Hernandez, AF, Green, JB, Kouchoukos, NT, Califf, RM, Ferguson, TB, Peterson, ED, and Alexander, JH. "Long-term clinical and angiographic outcomes in patients with diabetes undergoing coronary artery bypass graft surgery: results from the Project of Ex-vivo Vein Graft Engineering via Transfection IV trial." American heart journal 169, no. 1 (January 2015): 175-184.

PMID
25497264
Full Text

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