Jonathan Allen Cohn, MD

Professor of Medicine
Associate Professor of Cell Biology
Professor in Pediatrics
Campus mail 466 Sands Bldg, Durham, NC 27710
Phone (919) 684-6879
Email address jonathan.cohn@duke.edu

In many epithelial tissues, the protein mainly responsible for controlling transepithelial fluid movement is the the cystic fibrosis transmembrane conductance regulator (CFTR). CFTR was originally identified as the protein product of the gene causing cystic fibrosis (CF). CFTR functions as a chloride channel regulated by protein kinase A (PKA). This laboratory is studying the role and regulation of CFTR. One project focuses on how PKA acts on CFTR. In this project, recombinant peptide models are being used to model the cytoplasmic domains of CFTR responsible for activating the protein's chloride's chloride channel function. Site-directed mutagenesis is being used to produce modified peptides to study how different individual serine phosphoryation contribute to CFTR regulation. A second project concerns DF508, the most common mutation among patients with CF. This mutation affects CFTR function by preventing normal folding and intracellular trafficking of the newly synthesized mutant protein. This project is examining the mislocalization of DF508-CFTR in tissues and cell lines with the long term goal of developing strategies to prevent the mutant protein from mislocalizing. A third project concerns the role of CFTR in chronic pancreatitic diseases. Emerging data about the role of CFTR during normal pancreatic secretion suggests that dysfunction of this protein may lead to pancreatic diseases such as chronic pancreatitis and pancreatic cancer. Patients with these chronic pancreatic diseases are being tested for CFTR mutations and for evidence of defective CFTR function.

Education and Training

  • Fellow in Gastroenterology, Medicine, Yale University, 1981 - 1984
  • Medical Resident, Medicine, University of California, San Francisco, School of Medicine, 1980 - 1981
  • Medical Resident, Medicine, University of Alabama at Birmingham, 1978 - 1980
  • M.D., Cornell University, 1978

Publications

Cohn, JA. "Hereditary Diseases of the Pancreas." 2 (February 17, 2009): 1921-1939. (Chapter)

Full Text

Cohn, JA, Englesbe, MJ, Ads, YM, Paruch, JL, Pelletier, SJ, Welling, TH, Sonnenday, CJ, Magee, JC, Punch, JD, Campbell, DA, and Sung, RS. "Financial implications of pancreas transplant complications: a business case for quality improvement." Am J Transplant 7, no. 6 (June 2007): 1656-1660.

PMID
17425623
Full Text

Sadler, GR, Ko, CM, Cohn, JA, White, M, Weldon, R-N, and Wu, P. "Breast cancer knowledge, attitudes, and screening behaviors among African American women: the Black cosmetologists promoting health program. (Published online)" BMC Public Health 7 (April 17, 2007): 57-.

PMID
17439662
Full Text

Whitcomb, DC, and Cohn, JA. "Pancreatic exocrine dysfunction." (December 1, 2006): 573-580. (Chapter)

Full Text

Cohn, JA, Skorpinski, E, and Cohn, JR. "Prevention of pneumococcal infection in a patient with normal immunoglobulin levels but impaired polysaccharide antibody production." Ann Allergy Asthma Immunol 97, no. 5 (November 2006): 603-605.

PMID
17165266
Full Text

Ying, H, Lin, F, MacArthur, RD, Cohn, JA, Barth-Jones, DC, Ye, H, and Crane, LR. "A fuzzy discrete event system approach to determining optimal HIV/AIDS treatment regimens." IEEE Trans Inf Technol Biomed 10, no. 4 (October 2006): 663-676.

PMID
17044400
Scholars@Duke

Cohn, JA, Neoptolemos, JP, Feng, J, Yan, J, Jiang, Z, Greenhalf, W, McFaul, C, Mountford, R, and Sommer, SS. "Increased risk of idiopathic chronic pancreatitis in cystic fibrosis carriers." Hum Mutat 26, no. 4 (October 2005): 303-307.

PMID
16134171
Full Text

Cohn, JA. "A word of thanks." Gastroenterology 129, no. 3 (September 2005): 784-null.

PMID
16143116
Full Text

Cohn, JA, Hashemi, FB, Camarca, M, Kong, F, Xu, J, Beckner, SK, Kovacs, AA, Reichelderfer, PS, and Spear, GT. "HIV-inducing factor in cervicovaginal secretions is associated with bacterial vaginosis in HIV-1-infected women." J Acquir Immune Defic Syndr 39, no. 3 (July 1, 2005): 340-346.

PMID
15980696
Scholars@Duke

Cohn, JA. "Reduced CFTR function and the pathobiology of idiopathic pancreatitis." J Clin Gastroenterol 39, no. 4 Suppl 2 (April 2005): S70-S77. (Review)

PMID
15758663
Scholars@Duke

Pages