Jonathan Paul Piccini, MD

Associate Professor of Medicine
Associate Professor in Population Health Sciences
Member in the Duke Clinical Research Institute
Campus mail Dept of Medicine, Durham, NC 27710
Phone (919) 684-8111
Email address jonathan.piccini@duke.edu

Jonathan P. Piccini, MD, MHS is a clinical cardiac electrophysiologist and Associate Professor of Medicine at Duke University Medical Center and the Duke Clinical Research Institute. His research interests include the conduct of clinical trials and the assessment of cardiovascular therapeutics for the care of patients with heart rhythm disorders. At present, he is the Director of the EP Clinical Trials Program and Arrhythmia Core Laboratory at Duke University. He also serves on the Clinical Working Group of the American Heart Association’s Get With The Guidelines – Atrial fibrillation (GWTG-Afib) registry program. He is an associate editor for the American Heart Journal and serves on the editorial board of Heart Rhythm, the European Heart Journal, and the Journal of Cardiac Electrophysiology. He is the Principal Investigator of the data and coordinating center for ORBIT AF, a 25,000 patient registry focused on quality of care and improving outcomes in patients with atrial fibrillation. He is also the PI of the GENETIC AF clinical trial, the first clinical trial to study genotype-directed rhythm control therapy for atrial fibrillation. He also serves on the steering committees of multiple international randomized trials focused on the treatment of atrial fibrillation.  Dr. Piccini has more than 175 publications in the field of heart rhythm medicine. Clinically, his focus is on the care of patients with atrial fibrillation and complex arrhythmias, with particular emphasis on catheter ablation and lead extraction.

Education and Training

  • Clinical Cardiac Electrophysiology Fellowship, Medicine, Duke University School of Medicine, 2009 - 2011
  • Cardiology Fellowship, Medicine, Duke University School of Medicine, 2005 - 2009
  • Internal Medicine Residency, Medicine, Johns Hopkins University School of Medicine, 2002 - 2005
  • M.H.S., Duke University, 2009
  • M.D., Northwestern University Feinberg School of Medicine, 2002

Publications

Piccini, JP, Garg, J, Hellkamp, A, Pieper, KS, and Patel, MR. "Reply to letter by Bamford et al. regarding the article: Management of major bleeding events in patients treated with rivaroxaban vs. warfarin: results from the ROCKET AF trial." European Heart Journal 40, no. 19 (May 2019): 1568-null.

PMID
30476238
Full Text

Terricabras, M, Piccini, JP, and Verma, A. "Randomized Clinical Trials of Catheter Ablation of Atrial Fibrillation in Congestive Heart Failure: Knowns and Unmet Needs." Cardiology Clinics 37, no. 2 (May 2019): 167-176. (Review)

PMID
30926018
Full Text

Vemulapalli, S, Inohara, T, Kim, S, Thomas, L, Piccini, JP, Patel, MR, Chang, P, Fonarow, GC, Ezekowitz, MD, Hylek, E, Go, AS, Kowey, PR, Mahaffey, KW, Gersh, BJ, and Peterson, ED. "Blood Pressure Control and Cardiovascular Outcomes in Patients With Atrial Fibrillation (From the ORBIT-AF Registry)." The American Journal of Cardiology 123, no. 10 (May 2019): 1628-1636.

PMID
30846214
Full Text

Madhavan, M, Holmes, DN, Piccini, JP, Ansell, JE, Fonarow, GC, Hylek, EM, Kowey, PR, Mahaffey, KW, Thomas, L, Peterson, ED, Chan, P, Allen, LA, Gersh, BJ, and ORBIT AF Investigators, . "Association of frailty and cognitive impairment with benefits of oral anticoagulation in patients with atrial fibrillation." American Heart Journal 211 (May 2019): 77-89.

PMID
30901602
Full Text

Steinberg, BA, and Piccini, JP. "Tackling Patient-Reported Outcomes in Atrial Fibrillation and Heart Failure: Identifying Disease-Specific Symptoms?." Cardiology Clinics 37, no. 2 (May 2019): 139-146. (Review)

PMID
30926015
Full Text

Steinberg, BA, and Piccini, JP. "Atrial Fibrillation and Heart Failure: In This Challenge Lies Opportunity." Cardiology Clinics 37, no. 2 (May 2019): xiii-null.

PMID
30926026
Full Text

Piccini, JP, Abraham, WT, Dufton, C, Carroll, IA, Healey, JS, van Veldhuisen, DJ, Sauer, WH, Anand, IS, White, M, Wilton, SB, Aleong, R, Rienstra, M, Krueger, SK, Ayala-Paredes, F, Khaykin, Y, Merkely, B, Miloradović, V, Wranicz, JK, Ilkhanoff, L, Ziegler, PD, Davis, G, Emery, LL, Marshall, D, Kao, DP, Bristow, MR, Connolly, SJ, and Genotype-Directed Comparative Effectiveness Trial of Bucindolol and Toprol-XL for Prevention of Atrial Fibrillation/Atrial Flutter in Patients with Heart Failure Trial Investigators, . "GENETIC-AF: Bucindolol for the Maintenance of Sinus Rhythm in a Genotype-Defined Heart Failure Population." Jacc. Heart Failure (April 29, 2019).

PMID
31042551
Full Text

El-Chami, MF, Johansen, JB, Zaidi, A, Faerestrand, S, Reynolds, D, Garcia-Seara, J, Mansourati, J, Pasquie, J-L, McElderry, HT, Roberts, PR, Soejima, K, Stromberg, K, and Piccini, JP. "Leadless pacemaker implant in patients with pre-existing infections: Results from the Micra postapproval registry." Journal of Cardiovascular Electrophysiology 30, no. 4 (April 2019): 569-574.

PMID
30661279
Full Text

Noseworthy, PA, Gersh, BJ, Kent, DM, Piccini, JP, Packer, DL, Shah, ND, and Yao, X. "Atrial fibrillation ablation in practice: assessing CABANA generalizability." European Heart Journal 40, no. 16 (April 2019): 1257-1264.

PMID
30875424
Full Text

Chen, ST, Hellkamp, AS, Becker, RC, Berkowitz, SD, Breithardt, G, Fox, KAA, Hacke, W, Halperin, JL, Hankey, GJ, Mahaffey, KW, Nessel, CC, Piccini, JP, Singer, DE, Patel, MR, and Melloni, C. "Efficacy and safety of rivaroxaban vs. warfarin in patients with non-valvular atrial fibrillation and a history of cancer: observations from ROCKET AF." European Heart Journal. Quality of Care & Clinical Outcomes 5, no. 2 (April 2019): 145-152.

PMID
30219887
Full Text

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