Karen Elizabeth Welty-Wolf, MD

Professor of Medicine
Campus mail 0570 Clin Res II, Durham, NC 27710
Phone (919) 684-4938
Email address welty001@mc.duke.edu

Dr. Welty-Wolf studies (1) pathophysiology and treatment of acute lung injury and (2) multiple organ failure and disordered energy metabolism in sepsis. Injury models include hyperoxic lung injury and ARDS with multiple organ failure due to sepsis. In addition to evaluating mechanisms of lung injury in sepsis, current studies are being conducted to evaluate the potential role of monoclinal antibodies to neutrophil adhesion molecules in the prevention of this injury. Other sepsis work includes evaluating mechanisms of oxidative damage to mitochondria. Additional research efforts include evaluating the use of human recombinant manganese superoxide dismutase in preventing hyperoxic lung injury.

Education and Training

  • Fellow in Pulmonary and Critical Care Medicine, Medicine, Duke University, 1990 - 1993
  • Fellow in Infectious Diseases, Medicine, Duke University, 1989 - 1990
  • Medical Resident, Medicine, Duke University, 1986 - 1989
  • M.D., Duke University, 1986

Publications

Suliman, Hagir B., Zachary Healy, Fabio Zobi, Bryan D. Kraft, Karen Welty-Wolf, Joshua Smith, Christina Barkauskas, and Claude A. Piantadosi. “Nuclear respiratory factor-1 negatively regulates TGF-β1 and attenuates pulmonary fibrosis.” Iscience 25, no. 1 (January 21, 2022): 103535. https://doi.org/10.1016/j.isci.2021.103535.

PMID
34977500
Full Text

Chen, Lingye, Bryan D. Kraft, Victor L. Roggli, Zachary R. Healy, Christopher W. Woods, Ephraim L. Tsalik, Geoffrey S. Ginsburg, et al. “Heparin-based blood purification attenuates organ injury in baboons with Streptococcus pneumoniae pneumonia.” Am J Physiol Lung Cell Mol Physiol 321, no. 2 (August 1, 2021): L321–35. https://doi.org/10.1152/ajplung.00337.2020.

PMID
34105359
Full Text

Stanfield, Brent A., Todd Purves, Scott Palmer, Bruce Sullenger, Karen Welty-Wolf, Krista Haines, Suresh Agarwal, and George Kasotakis. “IL-10 and class 1 histone deacetylases act synergistically and independently on the secretion of proinflammatory mediators in alveolar macrophages.” Plos One 16, no. 1 (2021): e0245169. https://doi.org/10.1371/journal.pone.0245169.

PMID
33471802
Full Text

Bedoya, Armando, Roy A. Pleasants, Joel C. Boggan, Danielle Seaman, Anne Reihman, Lauren Howard, Robert Kundich, Karen Welty-Wolf, and Robert M. Tighe. “Interstitial lung disease in a veterans affairs regional network; a retrospective cohort study.” Plos One 16, no. 3 (2021): e0247316. https://doi.org/10.1371/journal.pone.0247316.

PMID
33735247
Full Text

Kaur, A., A. Reihman, R. A. Pleasants, J. Boggan, L. Howard, R. Kundich, K. E. Welty-Wolf, A. Bedoya, and R. M. Tighe. “Assessing the Frequency of Pulmonary Function Testing in Veterans with Idiopathic Pulmonary Fibrosis at Time of Diagnosis.” In American Journal of Respiratory and Critical Care Medicine, Vol. 201, 2020.

Scholars@Duke

Kraft, Bryan D., Lingye Chen, Hagir B. Suliman, Claude A. Piantadosi, and Karen E. Welty-Wolf. “Peripheral Blood Mononuclear Cells Demonstrate Mitochondrial Damage Clearance During Sepsis.” Crit Care Med 47, no. 5 (May 2019): 651–58. https://doi.org/10.1097/CCM.0000000000003681.

PMID
30730439
Full Text

Chen, L., B. D. Kraft, V. L. Roggli, H. Suliman, C. A. Piantadosi, and K. E. Welty-Wolf. “Blood Filtration Using Dialysis-Like Therapy Attenuates Organ Injury in Nonhuman Primates with Severe Streptococcus Pneumoniae Sepsis.” In American Journal of Respiratory and Critical Care Medicine, Vol. 199. AMER THORACIC SOC, 2019.

Scholars@Duke

Fredenburgh, Laura E., Mark A. Perrella, Diana Barragan-Bradford, Dean R. Hess, Elizabeth Peters, Karen E. Welty-Wolf, Bryan D. Kraft, et al. “A phase I trial of low-dose inhaled carbon monoxide in sepsis-induced ARDS.” Jci Insight 3, no. 23 (December 6, 2018). https://doi.org/10.1172/jci.insight.124039.

PMID
30518685
Full Text

Chen, L., B. D. Kraft, V. L. Roggli, H. B. Suliman, C. A. Piantadosi, and K. E. Welty-Wolf. “Severe Pneumococcal Pneumonia Causes Cardiac and Skeletal Muscle Injuries in Baboons.” In American Journal of Respiratory and Critical Care Medicine, Vol. 197. AMER THORACIC SOC, 2018.

Scholars@Duke

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