Karen Elizabeth Welty-Wolf, MD

Professor of Medicine
Campus mail 0570 Clin Res II, Durham, NC 27710
Phone (919) 684-4938
Email address welty001@mc.duke.edu

Dr. Welty-Wolf studies (1) pathophysiology and treatment of acute lung injury and (2) multiple organ failure and disordered energy metabolism in sepsis. Injury models include hyperoxic lung injury and ARDS with multiple organ failure due to sepsis. In addition to evaluating mechanisms of lung injury in sepsis, current studies are being conducted to evaluate the potential role of monoclinal antibodies to neutrophil adhesion molecules in the prevention of this injury. Other sepsis work includes evaluating mechanisms of oxidative damage to mitochondria. Additional research efforts include evaluating the use of human recombinant manganese superoxide dismutase in preventing hyperoxic lung injury.

Education and Training

  • Fellow in Pulmonary and Critical Care Medicine, Medicine, Duke University, 1990 - 1993
  • Fellow in Infectious Diseases, Medicine, Duke University, 1989 - 1990
  • Medical Resident, Medicine, Duke University, 1986 - 1989
  • M.D., Duke University, 1986

Publications

Kraft, Bryan D., Lingye Chen, Hagir B. Suliman, Claude A. Piantadosi, and Karen E. Welty-Wolf. “Peripheral Blood Mononuclear Cells Demonstrate Mitochondrial Damage Clearance During Sepsis..” Crit Care Med 47, no. 5 (May 2019): 651–58. https://doi.org/10.1097/CCM.0000000000003681.

PMID
30730439
Full Text

Fredenburgh, Laura E., Mark A. Perrella, Diana Barragan-Bradford, Dean R. Hess, Elizabeth Peters, Karen E. Welty-Wolf, Bryan D. Kraft, et al. “A phase I trial of low-dose inhaled carbon monoxide in sepsis-induced ARDS..” Jci Insight 3, no. 23 (December 6, 2018). https://doi.org/10.1172/jci.insight.124039.

PMID
30518685
Full Text

Chen, L., B. D. Kraft, V. L. Roggli, H. B. Suliman, C. A. Piantadosi, and K. E. Welty-Wolf. “Severe Pneumococcal Pneumonia Causes Cardiac and Skeletal Muscle Injuries in Baboons.” In American Journal of Respiratory and Critical Care Medicine, Vol. 197. AMER THORACIC SOC, 2018.

Scholars@Duke

Reihman, A., A. Bedoya, R. A. Pleasants, J. Boggan, L. Howard, R. Kundich, K. E. Welty-Wolf, and R. M. Tighe. “Initial Pulmonary Function Patterns Define Clinical Characteristics in Veterans Affairs Cohort with Interstitial Lung Disease.” In American Journal of Respiratory and Critical Care Medicine, Vol. 197. AMER THORACIC SOC, 2018.

Scholars@Duke

Pleasants, R. A., A. Bedoya, R. Kundich, J. Boggan, A. Reihman, D. Seaman, L. Howard, K. E. Welty-Wolf, and R. M. Tighe. “Characteristics of Connective Tissue Related Interstitial Lung Disease in the Mid- Atlantic Veterans Affairs Regional Network.” In American Journal of Respiratory and Critical Care Medicine, Vol. 197. AMER THORACIC SOC, 2018.

Scholars@Duke

Suliman, Hagir B., Bryan Kraft, Raquel Bartz, Lingye Chen, Karen E. Welty-Wolf, and Claude A. Piantadosi. “Mitochondrial quality control in alveolar epithelial cells damaged by S. aureus pneumonia in mice..” Am J Physiol Lung Cell Mol Physiol 313, no. 4 (October 1, 2017): L699–709. https://doi.org/10.1152/ajplung.00197.2017.

PMID
28663335
Full Text

Bedoya, A. D., R. Pleasants, J. Boggan, D. Seaman, L. Howard, A. Reihman, K. Welty-Wolf, and R. M. Tighe. “Characteristics Of Interstitial Lung Disease In The Mid-Atlantic Veterans Affairs Regional Network.” In American Journal of Respiratory and Critical Care Medicine, Vol. 195. AMER THORACIC SOC, 2017.

Scholars@Duke

Tsalik, Ephraim L., Yanhong Li, Lori L. Hudson, Vivian H. Chu, Tiffany Himmel, Alex T. Limkakeng, Jason N. Katz, et al. “Potential Cost-effectiveness of Early Identification of Hospital-acquired Infection in Critically Ill Patients..” Ann Am Thorac Soc 13, no. 3 (March 2016): 401–13. https://doi.org/10.1513/AnnalsATS.201504-205OC.

PMID
26700878
Full Text

Blumenthal, James A., Patrick J. Smith, Michael Durheim, Stephanie Mabe, Charles F. Emery, Tereza Martinu, Philip T. Diaz, Michael Babyak, Karen Welty-Wolf, and Scott Palmer. “Biobehavioral Prognostic Factors in Chronic Obstructive Pulmonary Disease: Results From the INSPIRE-II Trial..” Psychosom Med 78, no. 2 (February 2016): 153–62. https://doi.org/10.1097/PSY.0000000000000260.

PMID
26780299
Full Text

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