Karen Elizabeth Welty-Wolf, MD

Professor of Medicine
Campus mail 0570 Clin Res II, Durham, NC 27710
Phone (919) 684-4938
Email address welty001@mc.duke.edu

Dr. Welty-Wolf studies (1) pathophysiology and treatment of acute lung injury and (2) multiple organ failure and disordered energy metabolism in sepsis. Injury models include hyperoxic lung injury and ARDS with multiple organ failure due to sepsis. In addition to evaluating mechanisms of lung injury in sepsis, current studies are being conducted to evaluate the potential role of monoclinal antibodies to neutrophil adhesion molecules in the prevention of this injury. Other sepsis work includes evaluating mechanisms of oxidative damage to mitochondria. Additional research efforts include evaluating the use of human recombinant manganese superoxide dismutase in preventing hyperoxic lung injury.

Education and Training

  • Fellow in Pulmonary and Critical Care Medicine, Medicine, Duke University, 1990 - 1993
  • Fellow in Infectious Diseases, Medicine, Duke University, 1989 - 1990
  • Medical Resident, Medicine, Duke University, 1986 - 1989
  • M.D., Duke University, 1986

Publications

Suliman, HB, Kraft, B, Bartz, R, Chen, L, Welty-Wolf, KE, and Piantadosi, CA. "Mitochondrial quality control in alveolar epithelial cells damaged by S. aureus pneumonia in mice." American Journal of Physiology. Lung Cellular and Molecular Physiology 313, no. 4 (October 2017): L699-L709.

PMID
28663335
Full Text

Tsalik, EL, Li, Y, Hudson, LL, Chu, VH, Himmel, T, Limkakeng, AT, Katz, JN, Glickman, SW, McClain, MT, Welty-Wolf, KE, Fowler, VG, Ginsburg, GS, Woods, CW, and Reed, SD. "Potential Cost-effectiveness of Early Identification of Hospital-acquired Infection in Critically Ill Patients." Annals of the American Thoracic Society 13, no. 3 (March 2016): 401-413.

PMID
26700878
Full Text

Blumenthal, JA, Smith, PJ, Durheim, M, Mabe, S, Emery, CF, Martinu, T, Diaz, PT, Babyak, M, Welty-Wolf, K, and Palmer, S. "Biobehavioral Prognostic Factors in Chronic Obstructive Pulmonary Disease: Results From the INSPIRE-II Trial." Psychosomatic medicine 78, no. 2 (February 2016): 153-162.

PMID
26780299
Full Text

Pecorella, SRH, Potter, JVF, Cherry, AD, Peacher, DF, Welty-Wolf, KE, Moon, RE, Piantadosi, CA, and Suliman, HB. "The HO-1/CO system regulates mitochondrial-capillary density relationships in human skeletal muscle." American Journal of Physiology. Lung Cellular and Molecular Physiology 309, no. 8 (October 2015): L857-L871.

PMID
26186946
Full Text

Fredenburgh, LE, Kraft, BD, Hess, DR, Harris, RS, Wolf, MA, Suliman, HB, Roggli, VL, Davies, JD, Winkler, T, Stenzler, A, Baron, RM, Thompson, BT, Choi, AM, Welty-Wolf, KE, and Piantadosi, CA. "Effects of inhaled CO administration on acute lung injury in baboons with pneumococcal pneumonia." American Journal of Physiology. Lung Cellular and Molecular Physiology 309, no. 8 (October 2015): L834-L846.

PMID
26320156
Full Text

Dalli, J, Kraft, BD, Colas, RA, Shinohara, M, Fredenburgh, LE, Hess, DR, Chiang, N, Welty-Wolf, K, Choi, AM, Piantadosi, CA, and Serhan, CN. "The Regulation of Proresolving Lipid Mediator Profiles in Baboon Pneumonia by Inhaled Carbon Monoxide." American journal of respiratory cell and molecular biology 53, no. 3 (September 2015): 314-325.

PMID
25568926
Full Text

Durheim, MT, Smith, PJ, Babyak, MA, Mabe, SK, Martinu, T, Welty-Wolf, KE, Emery, CF, Palmer, SM, and Blumenthal, JA. "Six-minute-walk distance and accelerometry predict outcomes in chronic obstructive pulmonary disease independent of Global Initiative for Chronic Obstructive Lung Disease 2011 Group." Annals of the American Thoracic Society 12, no. 3 (March 2015): 349-356.

PMID
25568929
Full Text

Blumenthal, JA, Emery, CF, Smith, PJ, Keefe, FJ, Welty-Wolf, K, Mabe, S, Martinu, T, Johnson, JJ, Babyak, MA, O'Hayer, VF, Diaz, PT, Durheim, M, Baucom, D, and Palmer, SM. "The effects of a telehealth coping skills intervention on outcomes in chronic obstructive pulmonary disease: primary results from the INSPIRE-II study." Psychosomatic Medicine 76, no. 8 (October 2014): 581-592.

PMID
25251888
Full Text

Kraft, BD, Piantadosi, CA, Benjamin, AM, Lucas, JE, Zaas, AK, Betancourt-Quiroz, M, Woods, CW, Chang, AL, Roggli, VL, Marshall, CD, Ginsburg, GS, and Welty-Wolf, K. "Development of a novel preclinical model of pneumococcal pneumonia in nonhuman primates." American journal of respiratory cell and molecular biology 50, no. 5 (May 2014): 995-1004.

PMID
24328793
Full Text

Bartz, RR, Fu, P, Suliman, HB, Crowley, SD, MacGarvey, NC, Welty-Wolf, K, and Piantadosi, CA. "Staphylococcus aureus sepsis induces early renal mitochondrial DNA repair and mitochondrial biogenesis in mice." PloS one 9, no. 7 (January 2014): e100912-.

PMID
24988481
Full Text

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