Karen Elizabeth Welty-Wolf, MD

Professor of Medicine
Campus mail 0570 Clin Res II, Durham, NC 27710
Phone (919) 684-4938
Email address welty001@mc.duke.edu

Dr. Welty-Wolf studies (1) pathophysiology and treatment of acute lung injury and (2) multiple organ failure and disordered energy metabolism in sepsis. Injury models include hyperoxic lung injury and ARDS with multiple organ failure due to sepsis. In addition to evaluating mechanisms of lung injury in sepsis, current studies are being conducted to evaluate the potential role of monoclinal antibodies to neutrophil adhesion molecules in the prevention of this injury. Other sepsis work includes evaluating mechanisms of oxidative damage to mitochondria. Additional research efforts include evaluating the use of human recombinant manganese superoxide dismutase in preventing hyperoxic lung injury.

Education and Training

  • Fellow in Pulmonary and Critical Care Medicine, Medicine, Duke University, 1990 - 1993
  • Fellow in Infectious Diseases, Medicine, Duke University, 1989 - 1990
  • Medical Resident, Medicine, Duke University, 1986 - 1989
  • M.D., Duke University, 1986

Publications

Chen, L, Welty-Wolf, KE, and Kraft, BD. "Nonhuman primate species as models of human bacterial sepsis." Lab Animal 48, no. 2 (February 2019): 57-65. (Review)

PMID
30643274
Full Text

Fredenburgh, LE, Perrella, MA, Barragan-Bradford, D, Hess, DR, Peters, E, Welty-Wolf, KE, Kraft, BD, Harris, RS, Maurer, R, Nakahira, K, Oromendia, C, Davies, JD, Higuera, A, Schiffer, KT, Englert, JA, Dieffenbach, PB, Berlin, DA, Lagambina, S, Bouthot, M, Sullivan, AI, Nuccio, PF, Kone, MT, Malik, MJ, Porras, MAP, Finkelsztein, E, Winkler, T, Hurwitz, S, Serhan, CN, Piantadosi, CA, Baron, RM, Thompson, BT, and Choi, AM. "A phase I trial of low-dose inhaled carbon monoxide in sepsis-induced ARDS." Jci Insight 3, no. 23 (December 6, 2018).

PMID
30518685
Full Text

Chen, L, Kraft, BD, Roggli, VL, Suliman, HB, Piantadosi, CA, and Welty-Wolf, KE. "Severe Pneumococcal Pneumonia Causes Cardiac and Skeletal Muscle Injuries in Baboons." International Conference of the American-Thoracic-Society. San Diego, CA. May 18, 2018 - May 23, 2018.: AMER THORACIC SOC, January 1, 2018.

Scholars@Duke

Reihman, A, Bedoya, A, Pleasants, RA, Boggan, J, Howard, L, Kundich, R, Welty-Wolf, KE, and Tighe, RM. "Initial Pulmonary Function Patterns Define Clinical Characteristics in Veterans Affairs Cohort with Interstitial Lung Disease." International Conference of the American-Thoracic-Society. San Diego, CA. May 18, 2018 - May 23, 2018.: AMER THORACIC SOC, January 1, 2018.

Scholars@Duke

Pleasants, RA, Bedoya, A, Kundich, R, Boggan, J, Reihman, A, Seaman, D, Howard, L, Welty-Wolf, KE, and Tighe, RM. "Characteristics of Connective Tissue Related Interstitial Lung Disease in the Mid- Atlantic Veterans Affairs Regional Network." International Conference of the American-Thoracic-Society. San Diego, CA. May 18, 2018 - May 23, 2018.: AMER THORACIC SOC, January 1, 2018.

Scholars@Duke

Suliman, HB, Kraft, B, Bartz, R, Chen, L, Welty-Wolf, KE, and Piantadosi, CA. "Mitochondrial quality control in alveolar epithelial cells damaged by S. aureus pneumonia in mice." American Journal of Physiology. Lung Cellular and Molecular Physiology 313, no. 4 (October 2017): L699-L709.

PMID
28663335
Full Text

Bedoya, AD, Pleasants, R, Boggan, J, Seaman, D, Howard, L, Reihman, A, Welty-Wolf, K, and Tighe, RM. "Characteristics Of Interstitial Lung Disease In The Mid-Atlantic Veterans Affairs Regional Network." International Conference of the American-Thoracic-Society (ATS). Washington, DC. May 19, 2017 - May 24, 2017.: AMER THORACIC SOC, January 1, 2017.

Scholars@Duke

Tsalik, EL, Li, Y, Hudson, LL, Chu, VH, Himmel, T, Limkakeng, AT, Katz, JN, Glickman, SW, McClain, MT, Welty-Wolf, KE, Fowler, VG, Ginsburg, GS, Woods, CW, and Reed, SD. "Potential Cost-effectiveness of Early Identification of Hospital-acquired Infection in Critically Ill Patients." Annals of the American Thoracic Society 13, no. 3 (March 2016): 401-413.

PMID
26700878
Full Text

Blumenthal, JA, Smith, PJ, Durheim, M, Mabe, S, Emery, CF, Martinu, T, Diaz, PT, Babyak, M, Welty-Wolf, K, and Palmer, S. "Biobehavioral Prognostic Factors in Chronic Obstructive Pulmonary Disease: Results From the INSPIRE-II Trial." Psychosomatic Medicine 78, no. 2 (February 2016): 153-162.

PMID
26780299
Full Text

Pecorella, SRH, Potter, JVF, Cherry, AD, Peacher, DF, Welty-Wolf, KE, Moon, RE, Piantadosi, CA, and Suliman, HB. "The HO-1/CO system regulates mitochondrial-capillary density relationships in human skeletal muscle." American Journal of Physiology. Lung Cellular and Molecular Physiology 309, no. 8 (October 2015): L857-L871.

PMID
26186946
Full Text

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