Karen Elizabeth Welty-Wolf, MD

Professor of Medicine
Campus mail 0570 Clin Res II, Durham, NC 27710
Phone (919) 684-4938
Email address welty001@mc.duke.edu

Dr. Welty-Wolf studies (1) pathophysiology and treatment of acute lung injury and (2) multiple organ failure and disordered energy metabolism in sepsis. Injury models include hyperoxic lung injury and ARDS with multiple organ failure due to sepsis. In addition to evaluating mechanisms of lung injury in sepsis, current studies are being conducted to evaluate the potential role of monoclinal antibodies to neutrophil adhesion molecules in the prevention of this injury. Other sepsis work includes evaluating mechanisms of oxidative damage to mitochondria. Additional research efforts include evaluating the use of human recombinant manganese superoxide dismutase in preventing hyperoxic lung injury.

Education and Training

  • Fellow in Pulmonary and Critical Care Medicine, Medicine, Duke University, 1990 - 1993
  • Fellow in Infectious Diseases, Medicine, Duke University, 1989 - 1990
  • Medical Resident, Medicine, Duke University, 1986 - 1989
  • M.D., Duke University, 1986

Publications

Pecorella, Shelly R. H., Jennifer V. F. Potter, Anne D. Cherry, Dionne F. Peacher, Karen E. Welty-Wolf, Richard E. Moon, Claude A. Piantadosi, and Hagir B. Suliman. “The HO-1/CO system regulates mitochondrial-capillary density relationships in human skeletal muscle..” Am J Physiol Lung Cell Mol Physiol 309, no. 8 (October 15, 2015): L857–71. https://doi.org/10.1152/ajplung.00104.2015.

PMID
26186946
Full Text

Fredenburgh, Laura E., Bryan D. Kraft, Dean R. Hess, R Scott Harris, Monroe A. Wolf, Hagir B. Suliman, Victor L. Roggli, et al. “Effects of inhaled CO administration on acute lung injury in baboons with pneumococcal pneumonia..” Am J Physiol Lung Cell Mol Physiol 309, no. 8 (October 15, 2015): L834–46. https://doi.org/10.1152/ajplung.00240.2015.

PMID
26320156
Full Text

Dalli, Jesmond, Bryan D. Kraft, Romain A. Colas, Masakazu Shinohara, Laura E. Fredenburgh, Dean R. Hess, Nan Chiang, et al. “The Regulation of Proresolving Lipid Mediator Profiles in Baboon Pneumonia by Inhaled Carbon Monoxide..” Am J Respir Cell Mol Biol 53, no. 3 (September 2015): 314–25. https://doi.org/10.1165/rcmb.2014-0299OC.

PMID
25568926
Full Text

Durheim, Michael T., Patrick J. Smith, Michael A. Babyak, Stephanie K. Mabe, Tereza Martinu, Karen E. Welty-Wolf, Charles F. Emery, Scott M. Palmer, and James A. Blumenthal. “Six-minute-walk distance and accelerometry predict outcomes in chronic obstructive pulmonary disease independent of Global Initiative for Chronic Obstructive Lung Disease 2011 Group..” Ann Am Thorac Soc 12, no. 3 (March 2015): 349–56. https://doi.org/10.1513/AnnalsATS.201408-365OC.

PMID
25568929
Full Text

Blumenthal, James A., Charles F. Emery, Patrick J. Smith, Francis J. Keefe, Karen Welty-Wolf, Stephanie Mabe, Tereza Martinu, et al. “The effects of a telehealth coping skills intervention on outcomes in chronic obstructive pulmonary disease: primary results from the INSPIRE-II study..” Psychosom Med 76, no. 8 (October 2014): 581–92. https://doi.org/10.1097/PSY.0000000000000101.

PMID
25251888
Full Text

Kraft, Bryan D., Claude A. Piantadosi, Ashlee M. Benjamin, Joseph E. Lucas, Aimee K. Zaas, Marisol Betancourt-Quiroz, Christopher W. Woods, et al. “Development of a novel preclinical model of pneumococcal pneumonia in nonhuman primates..” Am J Respir Cell Mol Biol 50, no. 5 (May 2014): 995–1004. https://doi.org/10.1165/rcmb.2013-0340OC.

PMID
24328793
Full Text

Bartz, Raquel R., Ping Fu, Hagir B. Suliman, Stephen D. Crowley, Nancy Chou MacGarvey, Karen Welty-Wolf, and Claude A. Piantadosi. “Staphylococcus aureus sepsis induces early renal mitochondrial DNA repair and mitochondrial biogenesis in mice..” Plos One 9, no. 7 (2014). https://doi.org/10.1371/journal.pone.0100912.

PMID
24988481
Full Text

Kraft, B., C. A. Piantadosi, H. B. Suliman, G. S. Ginsburg, R. R. Bartz, A. Zaas, M. Betancourt, and K. E. Welty-Wolf. “Pneumococcal Pneumonia And Sepsis In Baboons Mirrors The Human Disease.” In American Journal of Respiratory and Critical Care Medicine, Vol. 187. AMER THORACIC SOC, 2013.

Scholars@Duke

Doyle, Todd, Scott Palmer, Julie Johnson, Michael A. Babyak, Patrick Smith, Stephanie Mabe, Karen Welty-Wolf, Tereza Martinu, and James A. Blumenthal. “Association of anxiety and depression with pulmonary-specific symptoms in chronic obstructive pulmonary disease..” Int J Psychiatry Med 45, no. 2 (2013): 189–202. https://doi.org/10.2190/PM.45.2.g.

PMID
23977821
Full Text

Athale, Janhavi, Allison Ulrich, Nancy Chou MacGarvey, Raquel R. Bartz, Karen E. Welty-Wolf, Hagir B. Suliman, and Claude A. Piantadosi. “Nrf2 promotes alveolar mitochondrial biogenesis and resolution of lung injury in Staphylococcus aureus pneumonia in mice..” Free Radic Biol Med 53, no. 8 (October 15, 2012): 1584–94. https://doi.org/10.1016/j.freeradbiomed.2012.08.009.

PMID
22940620
Full Text

Pages