Karen Patton Alexander, MD

Professor of Medicine
Member in the Duke Clinical Research Institute
Campus mail 2400 Pratt St Ste 7068, Durham, NC 27705
Phone (919) 668-8871

My research focus is on cardiovascular disease management and outcomes in special populations, specifically older adults. Historically there has been a lack of randomized controlled data regarding treatment efficacy and outcomes in this growing population. Because of this, certain therapies may have different risk benefit profiles, which may cause physicians to alter their therapeutic interventions. My research explores evidence based treatment for older adults, including preferences and decision-making as well as frailty and aging assessments in clinical trials and registries. Diagnosis and management of stable ischemic heart disease is also an area of focus.

Education and Training

  • Cardiology Fellow, Medicine, Duke University, 1995 - 1998
  • Resident, Internal Medicine, Brigham and Women's Hospital, 1993 - 1995
  • Intern, Internal Medicine, Brigham and Women's Hospital, 1992 - 1993
  • M.D., Duke University, 1992

Publications

Riley, R. F., L. K. Newby, C. W. Don, K. P. Alexander, E. D. Peterson, S. A. Peng, S. K. Gandhi, M. A. Kutcher, E. A. Amsterdam, and D. M. Herrington. “Guidelines-based treatment of anaemic STEMI patients: Practice patterns and effects on in-hospital mortality: A retrospective analysis from the NCDR.” European Heart Journal: Acute Cardiovascular Care 2, no. 1 (January 1, 2013): 35–43. https://doi.org/10.1177/2048872612471216.

Full Text

Williams, Judson B., Karen P. Alexander, Jean-François Morin, Yves Langlois, Nicolas Noiseux, Louis P. Perrault, Kim Smolderen, et al. “70 years undergoing cardiac surgery..” Am J Cardiol 111, no. 1 (January 1, 2013): 137–42. https://doi.org/10.1016/j.amjcard.2012.08.060.

PMID
23245838
Full Text

Martin, Seth S., Kensey Gosch, Krishnaji R. Kulkarni, John A. Spertus, Robin Mathews, P Michael Ho, Thomas M. Maddox, L Kristin Newby, Karen P. Alexander, and Tracy Y. Wang. “Modifiable factors associated with failure to attain low-density lipoprotein cholesterol goal at 6 months after acute myocardial infarction..” Am Heart J 165, no. 1 (January 2013): 26-33.e3. https://doi.org/10.1016/j.ahj.2012.10.005.

PMID
23237130
Full Text

Hall, Hurst M., Jonathan R. Enriquez, James A. de Lemos, Nihar Desai, S Andrew Peng, Karen P. Alexander, Matthew T. Roe, Darren K. McGuire, Stephen D. Wiviott, and Sandeep R. Das. “Patterns of Discharge Aspirin Dosing in 213,344 US Patients after Acute Myocardial Infarction: Results from the NCDR.” Circulation 126, no. 21 (November 20, 2012).

Scholars@Duke

Rao, Krishnasree K., Jonathan R. Enriquez, James A. de Lemos, Karen P. Alexander, Anita Y. Chen, Darren K. McGuire, Gregg C. Fonarow, and Sandeep R. Das. “Use ofAldosterone Antagonists at Discharge after Myocardial Infarction: Results from the NCDR.” Circulation 126, no. 21 (November 20, 2012).

Scholars@Duke

Hess, Connie N., Samuel Broderick, Jonathan P. Piccini, Karen P. Alexander, L Kristin Newby, Linda K. Shaw, Kenneth W. Mahaffey, et al. “Antithrombotic therapy for atrial fibrillation and coronary artery disease in older patients..” Am Heart J 164, no. 4 (October 2012): 607–15. https://doi.org/10.1016/j.ahj.2012.07.004.

PMID
23067921
Full Text

Prvu Bettger, Janet, Karen P. Alexander, Rowena J. Dolor, DaiWai M. Olson, Amy S. Kendrick, Liz Wing, Remy R. Coeytaux, Carmelo Graffagnino, and Pamela W. Duncan. “Transitional care after hospitalization for acute stroke or myocardial infarction: a systematic review..” Ann Intern Med 157, no. 6 (September 18, 2012): 407–16. https://doi.org/10.7326/0003-4819-157-6-201209180-00004.

PMID
22986378
Full Text

Lopes, Renato D., Li Li, Christopher B. Granger, Tracy Y. Wang, JoAnne M. Foody, Marjorie Funk, Eric D. Peterson, and Karen P. Alexander. “Atrial fibrillation and acute myocardial infarction: antithrombotic therapy and outcomes..” Am J Med 125, no. 9 (September 2012): 897–905. https://doi.org/10.1016/j.amjmed.2012.04.006.

PMID
22795814
Full Text

Holmes, David R., Michael J. Mack, Sanjay Kaul, Arvind Agnihotri, Karen P. Alexander, Steven R. Bailey, John H. Calhoon, et al. “2012 ACCF/AATS/SCAI/STS expert consensus document on transcatheter aortic valve replacement: developed in collabration with the American Heart Association, American Society of Echocardiography, European Association for Cardio-Thoracic Surgery, Heart Failure Society of America, Mended Hearts, Society of Cardiovascular Anesthesiologists, Society of Cardiovascular Computed Tomography, and Society for Cardiovascular Magnetic Resonance..” J Thorac Cardiovasc Surg 144, no. 3 (September 2012): e29–84. https://doi.org/10.1016/j.jtcvs.2012.03.001.

PMID
22898522
Full Text

Lopes, Renato D., Sumeet Subherwal, Dajuanicia N. Holmes, Laine Thomas, Tracy Y. Wang, Sunil V. Rao, Erik Magnus Ohman, Matthew T. Roe, Eric D. Peterson, and Karen P. Alexander. “The association of in-hospital major bleeding with short-, intermediate-, and long-term mortality among older patients with non-ST-segment elevation myocardial infarction..” Eur Heart J 33, no. 16 (August 2012): 2044–53. https://doi.org/10.1093/eurheartj/ehs012.

PMID
22396323
Full Text

Pages