Karen Patton Alexander, MD

Professor of Medicine
Member in the Duke Clinical Research Institute
Campus mail 2400 Pratt St Ste 7068, Durham, NC 27705
Phone (919) 668-8871

My research focus is on cardiovascular disease management and outcomes in special populations, specifically older adults. Historically there has been a lack of randomized controlled data regarding treatment efficacy and outcomes in this growing population. Because of this, certain therapies may have different risk benefit profiles, which may cause physicians to alter their therapeutic interventions. My research explores evidence based treatment for older adults, including preferences and decision-making as well as frailty and aging assessments in clinical trials and registries. Diagnosis and management of stable ischemic heart disease is also an area of focus.

Education and Training

  • Cardiology Fellow, Medicine, Duke University, 1995 - 1998
  • Resident, Internal Medicine, Brigham and Women's Hospital, 1993 - 1995
  • Intern, Internal Medicine, Brigham and Women's Hospital, 1992 - 1993
  • M.D., Duke University, 1992

Publications

Dunlay, Shannon M., Li Liang, Chiara Melloni, Jennifer L. Kraschnewski, Karen P. Alexander, W Brian Gibler, Matthew T. Roe, E Magnus Ohman, and Eric D. Peterson. “Quality of medical record documentation in an acute coronary syndrome population: Results from CRUSADE.” In Circulation, 113:E802–3. LIPPINCOTT WILLIAMS & WILKINS, 2006.

Scholars@Duke

Alexander, Karen P., Jyotsna Mulgund, Barbara Lytle, and Eric Peterson. “Long-term implications of discharge anemia in a cardiovascular population.” In Circulation, 113:E795–E795. LIPPINCOTT WILLIAMS & WILKINS, 2006.

Scholars@Duke

Peterson, E. D., A. Y. Chen, K. P. Alexander, N. M. A. LaPointe, E. S. Fraulo, L. K. Newby, M. T. Roe, W. B. Gibler, and E. M. Ohman. “The association between hospital guideline adherence, dosing safety, and patient outcomes: Results from the CRUSADE quality improvement initiative.” In Journal of the American College of Cardiology, 47:255A-255A. ELSEVIER SCIENCE INC, 2006.

Scholars@Duke

LaPointe, N. M. A., K. P. Alexander, A. Y. Chen, M. T. Roe, C. V. Pollack, E. M. Ohman, W. B. Gibler, and E. D. Peterson. “Enoxaparin dosing and bleeding in real world practice: Results from CRUSADE.” In Journal of the American College of Cardiology, 47:235A-235A. ELSEVIER SCIENCE INC, 2006.

Scholars@Duke

Kulkarni, Sonali P., Karen P. Alexander, Barbara Lytle, Gerardo Heiss, and Eric D. Peterson. “Long-term adherence with cardiovascular drug regimens..” Am Heart J 151, no. 1 (January 2006): 185–91. https://doi.org/10.1016/j.ahj.2005.02.038.

PMID
16368315
Full Text

Alexander, Karen P., and Eric D. Peterson. “Treatment of non-ST-elevation acute coronary syndrome in the elderly: current practice and future opportunities..” Am J Geriatr Cardiol 15, no. 1 (January 2006): 42–49.

PMID
16415646
Scholars@Duke

Alexander, Karen P., Anita Y. Chen, Matthew T. Roe, L Kristin Newby, C Michael Gibson, Nancy M. Allen-LaPointe, Charles Pollack, et al. “Excess dosing of antiplatelet and antithrombin agents in the treatment of non-ST-segment elevation acute coronary syndromes..” Jama 294, no. 24 (December 28, 2005): 3108–16. https://doi.org/10.1001/jama.294.24.3108.

PMID
16380591
Full Text

Alexander, K. P., A. Y. Chen, M. T. Roe, L. K. Newby, C. M. Gibson, J. Schwartz, J. S. Hochman, et al. “Sex differences in glycoprotein 11b/111a inhibitor dosing and bleeding in acute coronary syndromes: Results from CRUSADE.” In Circulation, 112:U491–92. LIPPINCOTT WILLIAMS & WILKINS, 2005.

Scholars@Duke

Melloni, C., M. T. Roe, S. Milford-Boland, K. P. Alexander, L. K. Newby, L. A. Szczech, C. V. Pollack, et al. “Renal insufficiency, troponin, and risk of death among patients with non-ST-segment elevation acute coronary syndromes.” In Circulation, 112:U587–88. LIPPINCOTT WILLIAMS & WILKINS, 2005.

Scholars@Duke

Pages