Karen Patton Alexander, MD

Professor of Medicine
Member in the Duke Clinical Research Institute
Campus mail 2400 Pratt St Ste 7068, Durham, NC 27705
Phone (919) 668-8871

My research focus is on cardiovascular disease management and outcomes in special populations, specifically older adults. Historically there has been a lack of randomized controlled data regarding treatment efficacy and outcomes in this growing population. Because of this, certain therapies may have different risk benefit profiles, which may cause physicians to alter their therapeutic interventions. My research explores evidence based treatment for older adults, including preferences and decision-making as well as frailty and aging assessments in clinical trials and registries. Diagnosis and management of stable ischemic heart disease is also an area of focus.

Education and Training

  • Cardiology Fellow, Medicine, Duke University, 1995 - 1998
  • Resident, Internal Medicine, Brigham and Women's Hospital, 1993 - 1995
  • Intern, Internal Medicine, Brigham and Women's Hospital, 1992 - 1993
  • M.D., Duke University, 1992

Publications

Skolnick, AH, Alexander, KP, Chen, AY, Roe, MT, Pollack, CV, Ohman, EM, Rumsfeld, JS, Gibler, WB, Peterson, ED, and Cohen, DJ. or =90 years with acute coronary syndromes: results from the CRUSADE Initiative." Journal of the American College of Cardiology 49, no. 17 (May 2007): 1790-1797.

PMID
17466230
Full Text

Alexander, KP, Newby, LK, Armstrong, PW, Cannon, CP, Gibler, WB, Rich, MW, Van de Werf, F, White, HD, Weaver, WD, Naylor, MD, Gore, JM, Krumholz, HM, Ohman, EM, American Heart Association Council on Clinical Cardiology, , and Society of Geriatric Cardiology, . "Acute coronary care in the elderly, part II: ST-segment-elevation myocardial infarction: a scientific statement for healthcare professionals from the American Heart Association Council on Clinical Cardiology: in collaboration with the Society of Geriatric Cardiology." Circulation 115, no. 19 (May 2007): 2570-2589.

PMID
17502591
Full Text

Frazier, CG, Alexander, KP, Newby, LK, Anderson, S, Iverson, E, Packer, M, Cohn, J, Goldstein, S, and Douglas, PS. "Associations of gender and etiology with outcomes in heart failure with systolic dysfunction: a pooled analysis of 5 randomized control trials." Journal of the American College of Cardiology 49, no. 13 (April 2007): 1450-1458.

PMID
17397674
Full Text

Wang, TY, Chen, AY, Roe, MT, Alexander, KP, Newby, LK, Smith, SC, Bangalore, S, Gibler, WB, Ohman, EM, and Peterson, ED. "Increased bleeding risk among Asians with non-ST-segment elevation acute coronary syndromes: Insights from the CRUSADE quality improvement initiative." 56th Annual Scientific Session of the American-College-of-Cardiology. New Orleans, LA. March 24, 2007 - March 27, 2007.: ELSEVIER SCIENCE INC, March 6, 2007.

Scholars@Duke

Alexander, KP, Cowper, PA, Lylte, BL, Kempf, JA, and Peterson, ED. "Predictors of persistent angina among coronary disease patients." 56th Annual Scientific Session of the American-College-of-Cardiology. New Orleans, LA. March 24, 2007 - March 27, 2007.: ELSEVIER SCIENCE INC, March 6, 2007.

Scholars@Duke

Roe, MT, Alexander, KP, Ou, F-S, Newby, LK, Gibler, WB, Pollack, CV, Ohman, EM, Smith, SC, and Peterson, ED. "Patterns of HDL levels in patients with non-ST-segment elevation acute coronary syndromes and association with clinical outcomes." 56th Annual Scientific Session of the American-College-of-Cardiology. New Orleans, LA. March 24, 2007 - March 27, 2007.: ELSEVIER SCIENCE INC, March 6, 2007.

Scholars@Duke

Alexander, KP, Cowper, PA, Lytle, BL, Kempf, JA, and Peterson, ED. "Less is better, none is best: Angina and health related quality of life." 56th Annual Scientific Session of the American-College-of-Cardiology. New Orleans, LA. March 24, 2007 - March 27, 2007.: ELSEVIER SCIENCE INC, March 6, 2007.

Scholars@Duke

Ali, R, and Alexander, KP. "Statins for the primary prevention of cardiovascular events in older adults: a review of the evidence." Am J Geriatr Pharmacother 5, no. 1 (March 2007): 52-63. (Review)

PMID
17608248
Scholars@Duke

Purser, JL, Kuchibhatla, MN, Fillenbaum, GG, Harding, T, Peterson, ED, and Alexander, KP. "Identifying frailty in hospitalized older adults with significant coronary artery disease." Journal of the American Geriatrics Society 54, no. 11 (November 2006): 1674-1681.

PMID
17087693
Full Text

Alexander, KP, Chen, AY, Newby, LK, LaPointe, NMA, Ohman, EM, Roe, MT, Boden, WE, and Peterson, ED. "Blood transfusion and mortality among patients with non-ST-segment elevation acute coronary syndromes: Results from CRUSADE." Circulation 114, no. 18 (October 31, 2006): 701-701.

Scholars@Duke

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