Karen Patton Alexander, MD

Professor of Medicine
Member in the Duke Clinical Research Institute
Campus mail 2400 Pratt St Ste 7068, Durham, NC 27705
Phone (919) 668-8871

My research focus is on cardiovascular disease management and outcomes in special populations, specifically older adults. Historically there has been a lack of randomized controlled data regarding treatment efficacy and outcomes in this growing population. Because of this, certain therapies may have different risk benefit profiles, which may cause physicians to alter their therapeutic interventions. My research explores evidence based treatment for older adults, including preferences and decision-making as well as frailty and aging assessments in clinical trials and registries. Diagnosis and management of stable ischemic heart disease is also an area of focus.

Education and Training

  • Cardiology Fellow, Medicine, Duke University, 1995 - 1998
  • Resident, Internal Medicine, Brigham and Women's Hospital, 1993 - 1995
  • Intern, Internal Medicine, Brigham and Women's Hospital, 1992 - 1993
  • M.D., Duke University, 1992

Publications

Patel, Ashish, Shaun G. Goodman, Andrew T. Yan, Karen P. Alexander, Camilla L. Wong, Asim N. Cheema, Jacob A. Udell, et al. “Frailty and Outcomes After Myocardial Infarction: Insights From the CONCORDANCE Registry.” J Am Heart Assoc 7, no. 18 (September 18, 2018): e009859. https://doi.org/10.1161/JAHA.118.009859.

PMID
30371219
Full Text

ISCHEMIA Trial Research Group, Yves, David J. Maron, Judith S. Hochman, Sean M. O’Brien, Harmony R. Reynolds, William E. Boden, Gregg W. Stone, et al. “International Study of Comparative Health Effectiveness with Medical and Invasive Approaches (ISCHEMIA) trial: Rationale and design.” Am Heart J 201 (July 2018): 124–35. https://doi.org/10.1016/j.ahj.2018.04.011.

PMID
29778671
Full Text

Miller, Andrew P., Mathew Maurer, and Karen P. Alexander. “Geriatric Cardiology: Two Decades of Progress and Strategy for the Future.” J Am Coll Cardiol 71, no. 25 (June 26, 2018): 2970–73. https://doi.org/10.1016/j.jacc.2018.05.014.

PMID
29929619
Full Text

Madhavan, Mahesh V., Bernard J. Gersh, Karen P. Alexander, Christopher B. Granger, and Gregg W. Stone. “Coronary Artery Disease in Patients ≥80 Years of Age.” J Am Coll Cardiol 71, no. 18 (May 8, 2018): 2015–40. https://doi.org/10.1016/j.jacc.2017.12.068.

PMID
29724356
Full Text

Gorodeski, Eiran Z., Parag Goyal, Scott L. Hummel, Ashok Krishnaswami, Sarah J. Goodlin, Linda L. Hart, Daniel E. Forman, et al. “Domain Management Approach to Heart Failure in the Geriatric Patient: Present and Future.” J Am Coll Cardiol 71, no. 17 (May 1, 2018): 1921–36. https://doi.org/10.1016/j.jacc.2018.02.059.

PMID
29699619
Full Text

Bangalore, Sripal, David J. Maron, Harmony R. Reynolds, Gregg W. Stone, Sean M. O’Brien, Karen P. Alexander, and Judith S. Hochman. “ISCHEMIA: Establishing the Primary End Point.” Circ Cardiovasc Qual Outcomes 11, no. 5 (May 2018): e004791. https://doi.org/10.1161/CIRCOUTCOMES.118.004791.

PMID
29752391
Full Text

Patel, Krishna K., Suzanne V. Arnold, Philip G. Jones, Mohammed Qintar, Karen P. Alexander, and John A. Spertus. “Relation of Age and Health-Related Quality of Life to Invasive Versus Ischemia-Guided Management of Patients with Non-ST Elevation Myocardial Infarction.” Am J Cardiol 121, no. 7 (April 1, 2018): 789–95. https://doi.org/10.1016/j.amjcard.2017.12.034.

PMID
29397885
Full Text

Flint, Kelsey, Kevin Kennedy, Suzanne V. Arnold, John A. Dodson, Sharon Cresci, and Karen P. Alexander. “Slow Gait Speed and Cardiac Rehabilitation Participation in Older Adults After Acute Myocardial Infarction.” J Am Heart Assoc 7, no. 5 (February 24, 2018). https://doi.org/10.1161/JAHA.117.008296.

PMID
29478024
Full Text

Guimarães, Patrícia O., Sergio Leonardi, Zhen Huang, Lars Wallentin, Frans Van de Werf, Philip E. Aylward, Claes Held, et al. “Clinical features and outcomes of patients with type 2 myocardial infarction: Insights from the Thrombin Receptor Antagonist for Clinical Event Reduction in Acute Coronary Syndrome (TRACER) trial.” Am Heart J 196 (February 2018): 28–35. https://doi.org/10.1016/j.ahj.2017.10.007.

PMID
29421012
Full Text

Krishnaswami, Ashok, Mathew S. Maurer, and Karen P. Alexander. “Contextualizing Myocardial Infarction: Comorbidities and Priorities in Older Adults.” Am J Med 130, no. 10 (October 2017): 1144–47. https://doi.org/10.1016/j.amjmed.2017.05.043.

PMID
28687265
Full Text

Pages