Karen Patton Alexander, MD

Professor of Medicine
Member in the Duke Clinical Research Institute
Campus mail 2400 Pratt St Ste 7068, Durham, NC 27705
Phone (919) 668-8871

My research focus is on cardiovascular disease management and outcomes in special populations, specifically older adults. Historically there has been a lack of randomized controlled data regarding treatment efficacy and outcomes in this growing population. Because of this, certain therapies may have different risk benefit profiles, which may cause physicians to alter their therapeutic interventions. My research explores evidence based treatment for older adults, including preferences and decision-making as well as frailty and aging assessments in clinical trials and registries. Diagnosis and management of stable ischemic heart disease is also an area of focus.

Education and Training

  • Cardiology Fellow, Medicine, Duke University, 1995 - 1998
  • Resident, Internal Medicine, Brigham and Women's Hospital, 1993 - 1995
  • Intern, Internal Medicine, Brigham and Women's Hospital, 1992 - 1993
  • M.D., Duke University, 1992

Publications

Alexander, K. P., and E. D. Peterson. “Medical and surgical management of coronary artery disease in women..” Am J Manag Care 7, no. 10 (October 2001): 951–56.

PMID
11669359
Scholars@Duke

Lee, P. Y., K. P. Alexander, B. G. Hammill, S. K. Pasquali, and E. D. Peterson. “Representation of elderly persons and women in published randomized trials of acute coronary syndromes..” Jama 286, no. 6 (August 8, 2001): 708–13. https://doi.org/10.1001/jama.286.6.708.

PMID
11495621
Full Text

Alexander, K. P., A. N. Galanos, J. G. Jollis, J. A. Stafford, and E. D. Peterson. “Post-myocardial infarction risk stratification in elderly patients..” Am Heart J 142, no. 1 (July 2001): 37–42. https://doi.org/10.1067/mhj.2001.115589.

PMID
11431654
Full Text

Alexander, K. P., L. K. Newby, A. S. Hellkamp, R. A. Harrington, E. D. Peterson, S. Kopecky, A. Langer, et al. “Initiation of hormone replacement therapy after acute myocardial infarction is associated with more cardiac events during follow-up..” J Am Coll Cardiol 38, no. 1 (July 2001): 1–7. https://doi.org/10.1016/s0735-1097(01)01329-8.

PMID
11451256
Full Text

Lee, P. Y., K. P. Alexander, B. G. Hammill, S. K. Pasquali, and E. D. Peterson. “Representation of the elderly in cardiovascular clinical trials.” Journal of the American College of Cardiology 37, no. 2 (February 1, 2001): 497A-497A.

Scholars@Duke

Alexander, J. H., K. P. Alexander, P. J. Joski, M. S. Cuffe, and R. H. Peter. “Morbidly obese patients undergoing cardiac catheterization: Less disease, less aggressive revascularization, and similar outcomes.” Journal of the American College of Cardiology 37, no. 2 (February 1, 2001): 367A-368A.

Scholars@Duke

Alexander, K. P., L. L. Barbara, L. L. Choi, M. B. Daniel, and P. D. Eric. “Women have worse functional outcomes following bypass surgery.” Circulation 102, no. 18 (October 31, 2000): 839–839.

Scholars@Duke

Peterson, E. D., K. P. Alexander, G. T. O’Connor, F. L. Grover, E. L. Hannan, B. D. McCallister, and W. S. Weintraub. “The safety of coronary artery bypass surgery in the aged.” Circulation 102, no. 18 (October 31, 2000): 680-+.

Scholars@Duke

Alexander, K. P., D. J. Malenka, E. L. Hannan, B. D. McCallister, and E. D. Peterson. “Outcomes of PCI in the aged: Results from 6 large registries.” Circulation 102, no. 18 (October 31, 2000): 642–642.

Scholars@Duke

Bahit, M. C., C. B. Granger, K. P. Alexander, J. Kramer, N. M. A. Lapointe, and R. M. Califf. “Applying the evidence: Opportunity in US for 80,000 additional lives saved per year..” Circulation 102, no. 18 (October 31, 2000): 873–873.

Scholars@Duke

Pages