Karen Patton Alexander, MD

Professor of Medicine
Member in the Duke Clinical Research Institute
Campus mail 2400 Pratt St Ste 7068, Durham, NC 27705
Phone (919) 668-8871

My research focus is on cardiovascular disease management and outcomes in special populations, specifically older adults. Historically there has been a lack of randomized controlled data regarding treatment efficacy and outcomes in this growing population. Because of this, certain therapies may have different risk benefit profiles, which may cause physicians to alter their therapeutic interventions. My research explores evidence based treatment for older adults, including preferences and decision-making as well as frailty and aging assessments in clinical trials and registries. Diagnosis and management of stable ischemic heart disease is also an area of focus.

Education and Training

  • Cardiology Fellow, Medicine, Duke University, 1995 - 1998
  • Resident, Internal Medicine, Brigham and Women's Hospital, 1993 - 1995
  • Intern, Internal Medicine, Brigham and Women's Hospital, 1992 - 1993
  • M.D., Duke University, 1992

Publications

Peterson, ED, Alexander, KP, Malenka, DJ, Hannan, EL, O'Conner, GT, McCallister, BD, Weintraub, WS, Grover, FL, and American Heart Association Chronic CAD Working Group, . "Multicenter experience in revascularization of very elderly patients." American Heart Journal 148, no. 3 (September 2004): 486-492.

PMID
15389237
Full Text

Lytle, BL, Shook, GJ, Alexander, KP, Cowper, PA, Mark, DB, and DeLong, ER. "1153-74 Physician counseling can influence health-related quality of life.": Elsevier BV, March 2004.

Full Text

Alexander, KP, and Biswas, MS. "Heart failure and the elderly: disease diversity, data, and delivery of care." American Heart Journal 146, no. 2 (August 2003): 194-196.

PMID
12891180
Full Text

Jones, DL, Ishii, M, LaPerriere, A, Stanley, H, Antoni, M, Ironson, G, Schneiderman, N, Van Splunteren, F, Cassells, A, Alexander, K, Gousse, YP, Vaughn, A, Brondolo, E, Tobin, JN, and Weiss, SM. "Influencing medication adherence among women with AIDS." Aids Care 15, no. 4 (August 2003): 463-474.

PMID
14509861
Full Text

Lytle, BL, Coombs, LP, Shook, GJ, Cowper, PA, Alexander, KP, Peterson, ED, Mark, DB, and DeLong, ER. "Home health care for coronary artery disease patients impacts quality of life." March 19, 2003.

Scholars@Duke

Alexander, KP, Lytle, B, Li, Y, and Peterson, E. "Elderly patients have better functioning, less angina at one year with coronary artery bypass graft." March 19, 2003.

Scholars@Duke

Alexander, KP, Harding, T, Coombs, L, and Peterson, E. "Are patients properly informed prior to revascularization decisions?." March 19, 2003.

Scholars@Duke

Shah, SH, Alexander, KP, and Peterson, ED. "PCI in women." Cardiology Review 20, no. 3 (March 1, 2003): 24-29. (Review)

Scholars@Duke

Alexander, KP, and Peterson, ED. "Evidence-based care for all patients." The American Journal of Medicine 114, no. 4 (March 2003): 333-335.

PMID
12681466
Full Text

Pasquali, SK, Alexander, KP, Coombs, LP, Lytle, BL, and Peterson, ED. "Effect of cardiac rehabilitation on functional outcomes after coronary revascularization." American Heart Journal 145, no. 3 (March 2003): 445-451.

PMID
12660667
Full Text

Pages