Karen Patton Alexander, MD

Professor of Medicine
Member in the Duke Clinical Research Institute
Campus mail 2400 Pratt St Ste 7068, Durham, NC 27705
Phone (919) 668-8871

My research focus is on cardiovascular disease management and outcomes in special populations, specifically older adults. Historically there has been a lack of randomized controlled data regarding treatment efficacy and outcomes in this growing population. Because of this, certain therapies may have different risk benefit profiles, which may cause physicians to alter their therapeutic interventions. My research explores evidence based treatment for older adults, including preferences and decision-making as well as frailty and aging assessments in clinical trials and registries. Diagnosis and management of stable ischemic heart disease is also an area of focus.

Education and Training

  • Cardiology Fellow, Medicine, Duke University, 1995 - 1998
  • Resident, Internal Medicine, Brigham and Women's Hospital, 1993 - 1995
  • Intern, Internal Medicine, Brigham and Women's Hospital, 1992 - 1993
  • M.D., Duke University, 1992

Publications

Alexander, K. P., K. J. Anstrom, L. H. Muhlbaier, R. D. Grosswald, P. K. Smith, R. H. Jones, and E. D. Peterson. “ or = 80 years: results from the National Cardiovascular Network..” J Am Coll Cardiol 35, no. 3 (March 1, 2000): 731–38. https://doi.org/10.1016/s0735-1097(99)00606-3.

PMID
10716477
Full Text

Alexander, K., L. J. Shaw, L. K. Shaw, E. DeLong, D. Mark, and E. Peterson. “Erratum: Value of exercise treadmill testing in women. Low dose dobutamine echocardiography predicts improvement in functional capacity after exercise training in patients with ischemic cardiomyopathy (Journal of the American College of Cardiology (1998) 32 (1657-1664)).” Journal of the American College of Cardiology 33, no. 1 (February 10, 1999). https://doi.org/10.1016/S0735-1097(98)00655-X.

Full Text

Alexander, K. P., E. D. Peterson, C. B. Granger, A. C. Casas, F. Van de Werf, P. W. Armstrong, A. Guerci, E. J. Topol, and R. M. Califf. “Potential impact of evidence-based medicine in acute coronary syndromes: insights from GUSTO-IIb. Global Use of Strategies to Open Occluded Arteries in Acute Coronary Syndromes trial..” J Am Coll Cardiol 32, no. 7 (December 1998): 2023–30. https://doi.org/10.1016/s0735-1097(98)00466-5.

PMID
9857888
Full Text

Alexander, K. P., L. J. Shaw, L. K. Shaw, E. R. Delong, D. B. Mark, and E. D. Peterson. “Value of exercise treadmill testing in women..” J Am Coll Cardiol 32, no. 6 (November 15, 1998): 1657–64. https://doi.org/10.1016/s0735-1097(98)00451-3.

PMID
9822093
Full Text

Alexander, J. H., K. Alexander, D. F. Kong, C. Y. Tung, and D. Whellan. “Session highlights from the American Heart Association Scientific Sessions: November 9-12, 1997..” Am Heart J 135, no. 1 (January 1998): 157–80. https://doi.org/10.1016/s0002-8703(98)70357-6.

PMID
9453536
Full Text

Alexander, K. P., and E. D. Peterson. “Coronary artery bypass grafting in the elderly..” Am Heart J 134, no. 5 Pt 1 (November 1997): 856–64. https://doi.org/10.1016/s0002-8703(97)80008-7.

PMID
9398097
Full Text

Alexander, K. P., E. D. Peterson, L. H. Muhlbaier, R. D. Grosswald, and M. J. Lanzilotta. “Cardiac surgery outcomes in 3,220 octogenarians: Results from the National Cardiovascular Network.” Circulation 96, no. 8 (October 21, 1997): 59–59.

Scholars@Duke

Alexander, K. P., E. D. Peterson, N. E. ClappChanning, L. C. Lam, R. B. Williams, and D. B. Mark. “Functional outcome of CABG in the elderly.” Circulation 96, no. 8 (October 21, 1997): 2066–2066.

Scholars@Duke

Alexander, K. P., E. D. Peterson, A. S. Hellkamp, C. B. Granger, E. J. Topol, and R. M. Califf. “Early catheterization is standard strategy in unstable angina/NQWMI: Results from GUSTO IIb.” Journal of the American College of Cardiology 29, no. 2 (February 1, 1997): 5614–5614.

Scholars@Duke

Pages