Karen Patton Alexander, MD

Professor of Medicine
Member in the Duke Clinical Research Institute
Campus mail 2400 Pratt St Ste 7068, Durham, NC 27705
Phone (919) 668-8871

My research focus is on cardiovascular disease management and outcomes in special populations, specifically older adults. Historically there has been a lack of randomized controlled data regarding treatment efficacy and outcomes in this growing population. Because of this, certain therapies may have different risk benefit profiles, which may cause physicians to alter their therapeutic interventions. My research explores evidence based treatment for older adults, including preferences and decision-making as well as frailty and aging assessments in clinical trials and registries. Diagnosis and management of stable ischemic heart disease is also an area of focus.

Education and Training

  • Cardiology Fellow, Medicine, Duke University, 1995 - 1998
  • Resident, Internal Medicine, Brigham and Women's Hospital, 1993 - 1995
  • Intern, Internal Medicine, Brigham and Women's Hospital, 1992 - 1993
  • M.D., Duke University, 1992

Publications

Shah, SH, and Alexander, KP. "Hormone Replacement Therapy for Primary and Secondary Prevention of Heart Disease." Curr Treat Options Cardiovasc Med 5, no. 1 (February 2003): 25-33.

PMID
12686016
Scholars@Duke

Frazier, C, and Alexander, K. "The finer points of race and hypertension." American Heart Journal 145, no. 2 (2003): 206-208.

PMID
12595834
Full Text

Califf, RM, and Alexander, KP. "Cardiovascular research in the elderly: challenges, opportunities, and impact." Postgraduate Medicine 112, no. 6 Suppl Heart (December 2002): 6-11.

PMID
19667612
Full Text

Biswas, MS, Eisenstein, EL, and Alexander, KP. "The right test for the right price." November 5, 2002.

Scholars@Duke

Pasquali, SK, Alexander, KP, Coombs, LP, Lytle, BL, and Peterson, ED. "Effect of cardiac rehabilitation on functional outcomes following coronary revascularization." JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY 39, no. 5 (March 6, 2002): 151A-151A.

Scholars@Duke

Alexander, KP, Harding, T, Coombs, LP, Taylor, K, and Peterson, ED. "Aging and patient preferences regarding invasive cardiac care." JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY 39, no. 5 (March 6, 2002): 197A-197A.

Scholars@Duke

Alexander, KP, Bhapkar, MV, White, HD, Hochman, JS, Pfisterer, ME, Moliterno, DJ, Califf, RM, Peterson, ED, Van der Werf, F, Armstrong, PW, and Newby, K. "Paradoxical use of angiography with advancing age: Insights from an international trial population." JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY 39, no. 5 (March 6, 2002): 152A-152A.

Scholars@Duke

Pasquali, SK, Alexander, KP, Lytle, BL, Coombs, LP, and Peterson, ED. "Testing an intervention to increase cardiac rehabilitation enrollment after coronary artery bypass grafting." The American Journal of Cardiology 88, no. 12 (December 2001): 1415-A6.

PMID
11741563
Full Text

Pasquali, SK, Alexander, KP, and Peterson, ED. "Cardiac rehabilitation in the elderly." American Heart Journal 142, no. 5 (November 2001): 748-755. (Review)

PMID
11685158
Full Text

Alexander, KP, and Peterson, ED. "Medical and surgical management of coronary artery disease in women." The American Journal of Managed Care 7, no. 10 (October 2001): 951-956. (Review)

PMID
11669359
Scholars@Duke

Pages