Karen Patton Alexander, MD

Professor of Medicine
Member in the Duke Clinical Research Institute
Campus mail 2400 Pratt St Ste 7068, Durham, NC 27705
Phone (919) 668-8871

My research focus is on cardiovascular disease management and outcomes in special populations, specifically older adults. Historically there has been a lack of randomized controlled data regarding treatment efficacy and outcomes in this growing population. Because of this, certain therapies may have different risk benefit profiles, which may cause physicians to alter their therapeutic interventions. My research explores evidence based treatment for older adults, including preferences and decision-making as well as frailty and aging assessments in clinical trials and registries. Diagnosis and management of stable ischemic heart disease is also an area of focus.

Education and Training

  • Cardiology Fellow, Medicine, Duke University, 1995 - 1998
  • Resident, Internal Medicine, Brigham and Women's Hospital, 1993 - 1995
  • Intern, Internal Medicine, Brigham and Women's Hospital, 1992 - 1993
  • M.D., Duke University, 1992

Publications

Alexander, JH, Alexander, KP, Joski, PJ, Cuffe, MS, and Peter, RH. "Morbidly obese patients undergoing cardiac catheterization: Less disease, less aggressive revascularization, and similar outcomes." JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY 37, no. 2 (February 2001): 367A-368A.

Scholars@Duke

Alexander, KP, Malenka, DJ, Hannan, EL, McCallister, BD, and Peterson, ED. "Outcomes of PCI in the aged: Results from 6 large registries." CIRCULATION 102, no. 18 (October 31, 2000): 642-642.

Scholars@Duke

Bahit, MC, Granger, CB, Alexander, KP, Kramer, J, Lapointe, NMA, and Califf, RM. "Applying the evidence: Opportunity in US for 80,000 additional lives saved per year." CIRCULATION 102, no. 18 (October 31, 2000): 873-873.

Scholars@Duke

Alexander, KP, Barbara, LL, Choi, LL, Daniel, MB, and Eric, PD. "Women have worse functional outcomes following bypass surgery." CIRCULATION 102, no. 18 (October 31, 2000): 839-839.

Scholars@Duke

Peterson, ED, Alexander, KP, O'Connor, GT, Grover, FL, Hannan, EL, McCallister, BD, and Weintraub, WS. "The safety of coronary artery bypass surgery in the aged." CIRCULATION 102, no. 18 (October 31, 2000): 680-+.

Scholars@Duke

Alexander, KP, Anstrom, KJ, Muhlbaier, LH, Grosswald, RD, Smith, PK, Jones, RH, and Peterson, ED. or = 80 years: results from the National Cardiovascular Network." Journal of the American College of Cardiology 35, no. 3 (March 2000): 731-738.

PMID
10716477
Full Text

Alexander, K, Shaw, LJ, Shaw, LK, DeLong, E, Mark, D, and Peterson, E. "Erratum: Value of exercise treadmill testing in women. Low dose dobutamine echocardiography predicts improvement in functional capacity after exercise training in patients with ischemic cardiomyopathy (Journal of the American College of Cardiology (1998) 32 (1657-1664))." Journal of the American College of Cardiology 33, no. 1 (February 10, 1999): 289-null.

Full Text

Alexander, KP, Peterson, ED, Granger, CB, Casas, AC, Van De Werf, F, Armstrong, PW, Guerci, A, Topol, EJ, and Califf, RM. "Potential impact of evidence-based medicine in acute coronary syndromes: Insights from GUSTO-IIb." Journal of the American College of Cardiology 32, no. 7 (December 1, 1998): 2023-2030.

Full Text

Alexander, KP, Peterson, ED, Granger, CB, Casas, AC, Van de Werf, F, Armstrong, PW, Guerci, A, Topol, EJ, and Califf, RM. "Potential impact of evidence-based medicine in acute coronary syndromes: insights from GUSTO-IIb. Global Use of Strategies to Open Occluded Arteries in Acute Coronary Syndromes trial." Journal of the American College of Cardiology 32, no. 7 (December 1998): 2023-2030.

PMID
9857888
Full Text

Alexander, KP, Shaw, LJ, Shaw, LK, Delong, ER, Mark, DB, and Peterson, ED. "Value of exercise treadmill testing in women." Journal of the American College of Cardiology 32, no. 6 (November 1998): 1657-1664.

PMID
9822093
Full Text

Pages