Karen Patton Alexander, MD

Professor of Medicine
Member in the Duke Clinical Research Institute
Campus mail 2400 Pratt St Ste 7068, Durham, NC 27705
Phone (919) 668-8871

My research focus is on cardiovascular disease management and outcomes in special populations, specifically older adults. Historically there has been a lack of randomized controlled data regarding treatment efficacy and outcomes in this growing population. Because of this, certain therapies may have different risk benefit profiles, which may cause physicians to alter their therapeutic interventions. My research explores evidence based treatment for older adults, including preferences and decision-making as well as frailty and aging assessments in clinical trials and registries. Diagnosis and management of stable ischemic heart disease is also an area of focus.

Education and Training

  • Cardiology Fellow, Medicine, Duke University, 1995 - 1998
  • Resident, Internal Medicine, Brigham and Women's Hospital, 1993 - 1995
  • Intern, Internal Medicine, Brigham and Women's Hospital, 1992 - 1993
  • M.D., Duke University, 1992


Alexander, K. P., E. D. Peterson, K. W. Mahaffey, A. C. Casas, C. B. Granger, F. VandeWerf, P. W. Armstrong, D. B. Mark, E. J. Topol, and R. M. Califf. “Medical interventions in unstable angina: Does international clinical practice match evidence-based guidelines?.” Journal of the American College of Cardiology 29, no. 2 (February 1, 1997): 23138–23138.


Alexander, K. P., and D. B. Mark. “Effect of gender on angioplasty outcome: are we closer to the answer?.” Mayo Clin Proc 72, no. 1 (January 1997): 89–91. https://doi.org/10.4065/72.1.89.

Full Text

Cooper, Lauren B., Bradley G. Hammill, Larry A. Allen, JoAnn Lindenfeld, Robert J. Mentz, Joseph G. Rogers, Carmelo A. Milano, Chetan B. Patel, Karen P. Alexander, and Adrian F. Hernandez. “Assessing Frailty in Patients Undergoing Destination Therapy Left Ventricular Assist Device: Observations from Interagency Registry for Mechanically Assisted Circulatory Support..” Asaio J 64, no. 1 (n.d.): 16–23. https://doi.org/10.1097/MAT.0000000000000600.

Full Text