Karen Patton Alexander, MD

Professor of Medicine
Member in the Duke Clinical Research Institute
Campus mail 2400 Pratt St Ste 7068, Durham, NC 27705
Phone (919) 668-8871

My research focus is on cardiovascular disease management and outcomes in special populations, specifically older adults. Historically there has been a lack of randomized controlled data regarding treatment efficacy and outcomes in this growing population. Because of this, certain therapies may have different risk benefit profiles, which may cause physicians to alter their therapeutic interventions. My research explores evidence based treatment for older adults, including preferences and decision-making as well as frailty and aging assessments in clinical trials and registries. Diagnosis and management of stable ischemic heart disease is also an area of focus.

Education and Training

  • Cardiology Fellow, Medicine, Duke University, 1995 - 1998
  • Resident, Internal Medicine, Brigham and Women's Hospital, 1993 - 1995
  • Intern, Internal Medicine, Brigham and Women's Hospital, 1992 - 1993
  • M.D., Duke University, 1992

Publications

Lee, PY, Alexander, KP, Hammill, BG, Pasquali, SK, and Peterson, ED. "Representation of elderly persons and women in published randomized trials of acute coronary syndromes." Jama 286, no. 6 (August 2001): 708-713.

PMID
11495621
Full Text

Alexander, KP, Galanos, AN, Jollis, JG, Stafford, JA, and Peterson, ED. "Post-myocardial infarction risk stratification in elderly patients." American Heart Journal 142, no. 1 (July 2001): 37-42.

PMID
11431654
Full Text

Alexander, KP, Newby, LK, Hellkamp, AS, Harrington, RA, Peterson, ED, Kopecky, S, Langer, A, O'Gara, P, O'Connor, CM, Daly, RN, Califf, RM, Khan, S, and Fuster, V. "Initiation of hormone replacement therapy after acute myocardial infarction is associated with more cardiac events during follow-up." Journal of the American College of Cardiology 38, no. 1 (July 2001): 1-7.

PMID
11451256
Full Text

Lee, PY, Alexander, KP, Hammill, BG, Pasquali, SK, and Peterson, ED. "Representation of the elderly in cardiovascular clinical trials." JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY 37, no. 2 (February 2001): 497A-497A.

Scholars@Duke

Alexander, JH, Alexander, KP, Joski, PJ, Cuffe, MS, and Peter, RH. "Morbidly obese patients undergoing cardiac catheterization: Less disease, less aggressive revascularization, and similar outcomes." JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY 37, no. 2 (February 2001): 367A-368A.

Scholars@Duke

Alexander, KP, Malenka, DJ, Hannan, EL, McCallister, BD, and Peterson, ED. "Outcomes of PCI in the aged: Results from 6 large registries." CIRCULATION 102, no. 18 (October 31, 2000): 642-642.

Scholars@Duke

Bahit, MC, Granger, CB, Alexander, KP, Kramer, J, Lapointe, NMA, and Califf, RM. "Applying the evidence: Opportunity in US for 80,000 additional lives saved per year." CIRCULATION 102, no. 18 (October 31, 2000): 873-873.

Scholars@Duke

Alexander, KP, Barbara, LL, Choi, LL, Daniel, MB, and Eric, PD. "Women have worse functional outcomes following bypass surgery." CIRCULATION 102, no. 18 (October 31, 2000): 839-839.

Scholars@Duke

Peterson, ED, Alexander, KP, O'Connor, GT, Grover, FL, Hannan, EL, McCallister, BD, and Weintraub, WS. "The safety of coronary artery bypass surgery in the aged." CIRCULATION 102, no. 18 (October 31, 2000): 680-+.

Scholars@Duke

Alexander, KP, Anstrom, KJ, Muhlbaier, LH, Grosswald, RD, Smith, PK, Jones, RH, and Peterson, ED. or = 80 years: results from the National Cardiovascular Network." Journal of the American College of Cardiology 35, no. 3 (March 2000): 731-738.

PMID
10716477
Full Text

Pages