Karen Patton Alexander, MD

Professor of Medicine
Member in the Duke Clinical Research Institute
Campus mail 2400 Pratt St Ste 7068, Durham, NC 27705
Phone (919) 668-8871

My research focus is on cardiovascular disease management and outcomes in special populations, specifically older adults. Historically there has been a lack of randomized controlled data regarding treatment efficacy and outcomes in this growing population. Because of this, certain therapies may have different risk benefit profiles, which may cause physicians to alter their therapeutic interventions. My research explores evidence based treatment for older adults, including preferences and decision-making as well as frailty and aging assessments in clinical trials and registries. Diagnosis and management of stable ischemic heart disease is also an area of focus.

Education and Training

  • Cardiology Fellow, Medicine, Duke University, 1995 - 1998
  • Resident, Internal Medicine, Brigham and Women's Hospital, 1993 - 1995
  • Intern, Internal Medicine, Brigham and Women's Hospital, 1992 - 1993
  • M.D., Duke University, 1992

Publications

Diepen, Sean van, Anita Y. Chen, Tracy Y. Wang, Karen P. Alexander, Justin A. Ezekowitz, Eric D. Peterson, and Matthew T. Roe. “Influence of heart failure symptoms and ejection fraction on short- and long-term outcomes for older patients with non-ST-segment elevation myocardial infarction..” Am Heart J 167, no. 2 (February 2014): 267-273.e1. https://doi.org/10.1016/j.ahj.2013.11.005.

PMID
24439989
Full Text

Chin, Chee Tang, Tracy Y. Wang, Anita Y. Chen, Robin Mathews, Karen P. Alexander, Matthew T. Roe, and Eric D. Peterson. “Trends in outcomes among older patients with non-ST-segment elevation myocardial infarction..” Am Heart J 167, no. 1 (January 2014): 36-42.e1. https://doi.org/10.1016/j.ahj.2013.10.008.

PMID
24332140
Full Text

O’Brien, Emily C., Emil L. Fosbol, S Andrew Peng, Karen P. Alexander, Matthew T. Roe, and Eric D. Peterson. “Association of body mass index and long-term outcomes in older patients with non-ST-segment-elevation myocardial infarction: results from the CRUSADE Registry..” Circ Cardiovasc Qual Outcomes 7, no. 1 (January 2014): 102–9. https://doi.org/10.1161/CIRCOUTCOMES.113.000421.

PMID
24326936
Full Text

Desai, Nihar R., Eric D. Peterson, Anita Y. Chen, Stephen D. Wiviott, Marc S. Sabatine, Karen P. Alexander, Matthew T. Roe, and Bimal R. Shah. “Balancing the risk of mortality and major bleeding in the treatment of NSTEMI patients - a report from the National Cardiovascular Data Registry..” Am Heart J 166, no. 6 (December 2013): 1043-1049.e1. https://doi.org/10.1016/j.ahj.2013.09.004.

PMID
24268219
Full Text

Weisz, Giora, Ramin Farzaneh-Far, Ori Ben-Yehuda, Bernard Debruyne, Gilles Montalescot, Amir Lerman, Ehtisham Mahmud, et al. “Use of ranolazine in patients with incomplete revascularization after percutaneous coronary intervention: design and rationale of the Ranolazine for Incomplete Vessel Revascularization Post-Percutaneous Coronary Intervention (RIVER-PCI) trial..” Am Heart J 166, no. 6 (December 2013): 953-959.e3. https://doi.org/10.1016/j.ahj.2013.08.004.

PMID
24268208
Full Text

Shen, Lan, Eric D. Peterson, Shuang Li, Laine Thomas, Karen Alexander, Ying Xian, Tracy Y. Wang, Matthew T. Roe, Ben He, and Bimal R. Shah. “The association between smoking and long-term outcomes after non-ST-segment elevation myocardial infarction in older patients..” Am Heart J 166, no. 6 (December 2013): 1056–62. https://doi.org/10.1016/j.ahj.2013.09.011.

PMID
24268221
Full Text

Bagai, Akshay, Yongfei Wang, Tracy Y. Wang, Jeptha Curtis, Hitinder S. Gurm, Eric D. Peterson, Jorge F. Saucedo, et al. “In-Hospital ADP Receptor Inhibitor Switching in Myocardial Infarction Patients Treated With Percutaneous Coronary Intervention: Insights From the National Cardiovascular Data Registry (R).” In Circulation, Vol. 128. LIPPINCOTT WILLIAMS & WILKINS, 2013.

Scholars@Duke

Dodson, John A., Yun Wang, Karen P. Alexander, Fred Masoudi, John A. Spertus, Sarwat I. Chaudhry, Iersey Chen, et al. “National Trends in Rehospitalization for Bleeding After Acute Myocardial Infarction in Older Patients, 1999-2010.” In Circulation, Vol. 128. LIPPINCOTT WILLIAMS & WILKINS, 2013.

Scholars@Duke

Shen, Lan, Shuang Li, Laine Thomas, Tracy Y. Wang, Karen P. Alexander, Bimal Shah, Eric Peterson, and Matthew T. Roe. “The Association of Transfer-out Rates from Hospitals Without Revascularization Capabilities and Long-term Mortality Risk Among Older Nstemi Patients.” In Circulation, Vol. 128. LIPPINCOTT WILLIAMS & WILKINS, 2013.

Scholars@Duke

Rao, Krishnasree K., Jonathan R. Enriquez, James A. de Lemos, Karen P. Alexander, Anita Y. Chen, Darren K. McGuire, Gregg C. Fonarow, and Sandeep R. Das. “Use of aldosterone antagonists at discharge after myocardial infarction: results from the National Cardiovascular Data Registry Acute Coronary Treatment and Intervention Outcomes Network (ACTION) Registry-Get with the Guidelines (GWTG)..” Am Heart J 166, no. 4 (October 2013): 709–15. https://doi.org/10.1016/j.ahj.2013.06.020.

PMID
24093851
Full Text

Pages