Kim Marie Huffman, MD, PhD

Associate Professor of Medicine
Member of Duke Molecular Physiology Institute
Affiliate of the Duke Regeneration Center
Campus mail 300 N Duke St, Carmichael, 51-202, Durham, NC 27701
Email address huffm007@mc.duke.edu

Determining the role of physical activity in modulating health outcomes (cardiovascular disease risk) in persons with rheumatologic diseases (rheumatoid arthritis, gout, osteoarthritis)

Integrating clinical rheumatology, basic immunology, metabolism, and exercise science in order to reduce morbidity in individuals with arthritis

Evaluating relationships between circulating and intra-muscular metabolic intermediates and insulin resistance in sedentary as well as individuals engaging in regular exercise

Addressing the role of physical activity in modulating inflammation, metabolism, and functional health in aging populations

Education and Training

  • Fellow, Rheumatology, Duke University, 2002 - 2005
  • Resident, Internal Medicine, Duke University, 2001 - 2002
  • M.D., Medical University of South Carolina, College of Medicine, 2000
  • Ph.D., Medical University of South Carolina, College of Medicine, 1998

Publications

Andonian, Brian J., Alec Koss, Timothy R. Koves, Elizabeth R. Hauser, Monica J. Hubal, David M. Pober, Janet M. Lord, et al. “Rheumatoid arthritis T cell and muscle oxidative metabolism associate with exercise-induced changes in cardiorespiratory fitness.” Sci Rep 12, no. 1 (May 6, 2022): 7450. https://doi.org/10.1038/s41598-022-11458-4.

PMID
35523821
Full Text

Dvergsten, Jeffrey A., Ann M. Reed, Lawrence Landerman, David S. Pisetsky, Olga Ilkayeva, and Kim M. Huffman. “Metabolomics analysis identifies a lipidomic profile in treatment-naïve juvenile dermatomyositis patients vs healthy control subjects.” Rheumatology (Oxford) 61, no. 4 (April 11, 2022): 1699–1708. https://doi.org/10.1093/rheumatology/keab520.

PMID
34185053
Full Text

Kaufman, Brystana G., Kelli D. Allen, Cynthia J. Coffman, Sandra Woolson, Kevin Caves, Katherine Hall, Helen M. Hoenig, et al. “Cost and Quality of Life Outcomes of the STepped Exercise Program for Patients With Knee OsteoArthritis Trial.” Value Health 25, no. 4 (April 2022): 614–21. https://doi.org/10.1016/j.jval.2021.09.018.

PMID
35365305
Full Text

Oliver, Catherine E., Hailee Patel, James Hong, Jonathan Carter, William E. Kraus, Kim M. Huffman, and George A. Truskey. “Tissue engineered skeletal muscle model of rheumatoid arthritis using human primary skeletal muscle cells.” J Tissue Eng Regen Med 16, no. 2 (February 2022): 128–39. https://doi.org/10.1002/term.3266.

PMID
34781416
Full Text

Somers, Tamara J., James A. Blumenthal, Caroline S. Dorfman, Kim M. Huffman, Sara N. Edmond, Shannon N. Miller, Anava A. Wren, David Caldwell, and Francis J. Keefe. “Effects of a Weight and Pain Management Program in Patients With Rheumatoid Arthritis With Obesity: A Randomized Controlled Pilot Investigation.” J Clin Rheumatol 28, no. 1 (January 1, 2022): 7–13. https://doi.org/10.1097/RHU.0000000000001793.

PMID
34670994
Full Text

Huffman, Kim M., Daniel C. Parker, Manjushri Bhapkar, Susan B. Racette, Corby K. Martin, Leanne M. Redman, Sai Krupa Das, et al. “Calorie restriction improves lipid-related emerging cardiometabolic risk factors in healthy adults without obesity: Distinct influences of BMI and sex from CALERIE™ a multicentre, phase 2, randomised controlled trial.” Eclinicalmedicine 43 (January 2022): 101261. https://doi.org/10.1016/j.eclinm.2021.101261.

PMID
35028547
Full Text

Collins, Katherine A., Leanna M. Ross, Lucy W. Piner, Liezl B. Fos, Cris A. Slentz, Lori A. Bateman, Leslie H. Willis, et al. “Amount and intensity effects of exercise training alone versus a combined diet and exercise lifestyle intervention on health-related quality of life in the STRRIDE-PD randomized trial.” Bmj Open Diabetes Res Care 10, no. 1 (January 2022). https://doi.org/10.1136/bmjdrc-2021-002584.

PMID
35086944
Full Text

Hirsch, Katie R., Casey E. Greenwalt, Hannah E. Cabre, Lacey M. Gould, Gabrielle J. Brewer, Malia N. M. Blue, Arny A. Ferrando, et al. “Metabolic effects of high-intensity interval training and essential amino acids.” Eur J Appl Physiol 121, no. 12 (December 2021): 3297–3311. https://doi.org/10.1007/s00421-021-04792-4.

PMID
34427732
Full Text

Dorling, James L., Daniel W. Belsky, Susan B. Racette, Sai Krupa Das, Eric Ravussin, Leanne M. Redman, Christoph Höchsmann, et al. “Association between the FTO rs9939609 single nucleotide polymorphism and dietary adherence during a 2-year caloric restriction intervention: Exploratory analyses from CALERIE™ phase 2.” Exp Gerontol 155 (November 2021): 111555. https://doi.org/10.1016/j.exger.2021.111555.

PMID
34543722
Full Text

Andonian, Brian J., Andrew Johannemann, Monica J. Hubal, David M. Pober, Alec Koss, William E. Kraus, David B. Bartlett, and Kim M. Huffman. “Altered skeletal muscle metabolic pathways, age, systemic inflammation, and low cardiorespiratory fitness associate with improvements in disease activity following high-intensity interval training in persons with rheumatoid arthritis.” Arthritis Res Ther 23, no. 1 (July 10, 2021): 187. https://doi.org/10.1186/s13075-021-02570-3.

PMID
34246305
Full Text

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