Kim Marie Huffman, MD, PhD

Associate Professor of Medicine
Member of Duke Molecular Physiology Institute
Affiliate of the Regeneration Next Initiative
Campus mail 300 N Duke St, Carmichael, 51-202, Durham, NC 27701
Phone (919) 668-1644
Email address huffm007@mc.duke.edu

Determining the role of physical activity in modulating health outcomes (cardiovascular disease risk) in persons with rheumatologic diseases (rheumatoid arthritis, gout, osteoarthritis)

Integrating clinical rheumatology, basic immunology, metabolism, and exercise science in order to reduce morbidity in individuals with arthritis

Evaluating relationships between circulating and intra-muscular metabolic intermediates and insulin resistance in sedentary as well as individuals engaging in regular exercise

Addressing the role of physical activity in modulating inflammation, metabolism, and functional health in aging populations

Education and Training

  • Fellow, Rheumatology, Duke University, 2002 - 2005
  • Resident, Internal Medicine, Duke University, 2001 - 2002
  • M.D., Medical University of South Carolina School of Medicine, 2000
  • Ph.D., Medical University of South Carolina School of Medicine, 1998

Publications

Anderson, ML, Allen, KD, Golightly, YM, Arbeeva, LS, Goode, A, Huffman, KM, Schwartz, TA, and Hill, CH. "Fall Risk and Utilization of Balance Training for Adults With Symptomatic Knee Osteoarthritis: Secondary Analysis From a Randomized Clinical Trial." Journal of Geriatric Physical Therapy (2001) 42, no. 2 (April 2019): E39-E44.

PMID
30407270
Full Text

Karasik, D, Zillikens, MC, Hsu, Y-H, Aghdassi, A, Akesson, K, Amin, N, Barroso, I, Bennett, DA, Bertram, L, Bochud, M, Borecki, IB, Broer, L, Buchman, AS, Byberg, L, Campbell, H, Campos-Obando, N, Cauley, JA, Cawthon, PM, Chambers, JC, Chen, Z, Cho, NH, Choi, HJ, Chou, W-C, Cummings, SR, de Groot, LCPGM, De Jager, PL, Demuth, I, Diatchenko, L, Econs, MJ, Eiriksdottir, G, Enneman, AW, Eriksson, J, Eriksson, JG, Estrada, K, Evans, DS, Feitosa, MF, Fu, M, Gieger, C, Grallert, H, Gudnason, V, Lenore, LJ, Hayward, C, Hofman, A, Homuth, G, Huffman, KM, Husted, LB, Illig, T, Ingelsson, E, Ittermann, T, Jansson, J-O, Johnson, T, Biffar, R, Jordan, JM, Jula, A, Karlsson, M, Khaw, K-T, Kilpeläinen, TO, Klopp, N, Kloth, JSL, Koller, DL, Kooner, JS, Kraus, WE, Kritchevsky, S, Kutalik, Z, Kuulasmaa, T, Kuusisto, J, Laakso, M, Lahti, J, Lang, T, Langdahl, BL, Lerch, MM, Lewis, JR, Lill, C, Lind, L, Lindgren, C, Liu, Y, Livshits, G, Ljunggren, Ö, Loos, RJF, Lorentzon, M, Luan, J, Luben, RN, Malkin, I, McGuigan, FE, Medina-Gomez, C, Meitinger, T, Melhus, H, Mellström, D, Michaëlsson, K, Mitchell, BD, Morris, AP, Mosekilde, L, Nethander, M, Newman, AB, O'Connell, JR, Oostra, BA, Orwoll, ES, Palotie, A, Peacock, M, Perola, M, Peters, A, Prince, RL, Psaty, BM, Räikkönen, K, Ralston, SH, Ripatti, S, Rivadeneira, F, Robbins, JA, Rotter, JI, Rudan, I, Salomaa, V, Satterfield, S, Schipf, S, Shin, CS, Smith, AV, Smith, SB, Soranzo, N, Spector, TD, Stancáková, A, Stefansson, K, Steinhagen-Thiessen, E, Stolk, L, Streeten, EA, Styrkarsdottir, U, Swart, KMA, Thompson, P, Thomson, CA, Thorleifsson, G, Thorsteinsdottir, U, Tikkanen, E, Tranah, GJ, Uitterlinden, AG, van Duijn, CM, van Schoor, NM, Vandenput, L, Vollenweider, P, Völzke, H, Wactawski-Wende, J, Walker, M, J Wareham, N, Waterworth, D, Weedon, MN, Wichmann, H-E, Widen, E, Williams, FMK, Wilson, JF, Wright, NC, Yerges-Armstrong, LM, Yu, L, Zhang, W, Zhao, JH, Zhou, Y, Nielson, CM, Harris, TB, Demissie, S, Kiel, DP, and Ohlsson, C. "Disentangling the genetics of lean mass." The American Journal of Clinical Nutrition 109, no. 2 (February 2019): 276-287.

PMID
30721968
Full Text

Andonian, BJ, Bartlett, DB, Huebner, JL, Willis, L, Hoselton, A, Kraus, VB, Kraus, WE, and Huffman, KM. "Effect of high-intensity interval training on muscle remodeling in rheumatoid arthritis compared to prediabetes." Arthritis Research & Therapy 20, no. 1 (December 27, 2018): 283-null.

PMID
30587230
Full Text

Barber, JL, Kraus, WE, Church, TS, Hagberg, JM, Thompson, PD, Bartlett, DB, Beets, MW, Earnest, CP, Huffman, KM, Landers-Ramos, RQ, Leon, AS, Rao, DC, Seip, RL, Skinner, JS, Slentz, CA, Wilund, KR, Bouchard, C, and Sarzynski, MA. "Effects of regular endurance exercise on GlycA: Combined analysis of 14 exercise interventions." Atherosclerosis 277 (October 2018): 1-6.

PMID
30170218
Full Text

Koeberl, DD, Case, LE, Smith, EC, Walters, C, Han, S-O, Li, Y, Chen, W, Hornik, CP, Huffman, KM, Kraus, WE, Thurberg, BL, Corcoran, DL, Bali, D, Bursac, N, and Kishnani, PS. "Correction of Biochemical Abnormalities and Improved Muscle Function in a Phase I/II Clinical Trial of Clenbuterol in Pompe Disease." Molecular Therapy : the Journal of the American Society of Gene Therapy 26, no. 9 (September 2018): 2304-2314.

PMID
30025991
Full Text

Iversen, MD, Schwartz, TA, von Heideken, J, Callahan, LF, Golightly, YM, Goode, A, Hill, C, Huffman, K, Pathak, A, Cooke, J, and Allen, KD. "Sociodemographic and Clinical Correlates of Physical Therapy Utilization in Adults With Symptomatic Knee Osteoarthritis." Physical Therapy 98, no. 8 (August 2018): 670-678.

PMID
29718472
Full Text

White, JP, Billin, AN, Campbell, ME, Russell, AJ, Huffman, KM, and Kraus, WE. "The AMPK/p27Kip1 Axis Regulates Autophagy/Apoptosis Decisions in Aged Skeletal Muscle Stem Cells." Stem Cell Reports 11, no. 2 (August 2018): 425-439.

PMID
30033086
Full Text

Pignato, M, Arbeeva, L, Schwartz, TA, Callahan, LF, Cooke, J, Golightly, YM, Goode, AP, Heiderscheit, BC, Hill, C, Huffman, KM, Severson, HH, and Allen, KD. "Level of participation in physical therapy or an internet-based exercise training program: associations with outcomes for patients with knee osteoarthritis." Bmc Musculoskeletal Disorders 19, no. 1 (July 19, 2018): 238-null.

PMID
30025540
Full Text

Bartlett, DB, Willis, LH, Slentz, CA, Hoselton, A, Kelly, L, Huebner, JL, Kraus, VB, Moss, J, Muehlbauer, MJ, Spielmann, G, Kraus, WE, Lord, JM, and Huffman, KM. "Ten weeks of high-intensity interval walk training is associated with reduced disease activity and improved innate immune function in older adults with rheumatoid arthritis: a pilot study." Arthritis Research & Therapy 20, no. 1 (June 14, 2018): 127-null.

PMID
29898765
Full Text

Stanifer, JW, Landerman, L, Pieper, CF, Huffman, KM, and Kraus, WE. "Relations of established aging biomarkers (IL-6, D-dimer, s-VCAM) to glomerular filtration rate and mortality in community-dwelling elderly adults." Clinical Kidney Journal 11, no. 3 (June 2018): 377-382.

PMID
29942503
Full Text

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