Kim Marie Huffman, MD, PhD

Associate Professor of Medicine
Member of Duke Molecular Physiology Institute
Affiliate of the Regeneration Next Initiative
Campus mail 300 N Duke St, Carmichael, 51-202, Durham, NC 27701
Phone (919) 668-1644
Email address huffm007@mc.duke.edu

Determining the role of physical activity in modulating health outcomes (cardiovascular disease risk) in persons with rheumatologic diseases (rheumatoid arthritis, gout, osteoarthritis)

Integrating clinical rheumatology, basic immunology, metabolism, and exercise science in order to reduce morbidity in individuals with arthritis

Evaluating relationships between circulating and intra-muscular metabolic intermediates and insulin resistance in sedentary as well as individuals engaging in regular exercise

Addressing the role of physical activity in modulating inflammation, metabolism, and functional health in aging populations

Education and Training

  • Fellow, Rheumatology, Duke University, 2002 - 2005
  • Resident, Internal Medicine, Duke University, 2001 - 2002
  • M.D., Medical University of South Carolina, School of Medicine, 2000
  • Ph.D., Medical University of South Carolina, School of Medicine, 1998

Publications

Dorling, James L., Eric Ravussin, Leanne M. Redman, Manju Bhapkar, Kim M. Huffman, Susan B. Racette, Sai K. Das, et al. “Effect of 2 years of calorie restriction on liver biomarkers: results from the CALERIE phase 2 randomized controlled trial.” Eur J Nutr 60, no. 3 (April 2021): 1633–43. https://doi.org/10.1007/s00394-020-02361-7.

PMID
32803412
Full Text

Huffman, Kim M., Brian J. Andonian, Dennis M. Abraham, Akshay Bareja, David E. Lee, Lauren H. Katz, Janet L. Huebner, William E. Kraus, and James P. White. “Exercise protects against cardiac and skeletal muscle dysfunction in a mouse model of inflammatory arthritis.” J Appl Physiol (1985) 130, no. 3 (March 1, 2021): 853–64. https://doi.org/10.1152/japplphysiol.00576.2020.

PMID
33411638
Full Text

Allen, Kelli D., Sandra Woolson, Helen M. Hoenig, Dennis Bongiorni, James Byrd, Kevin Caves, Katherine S. Hall, et al. “Stepped Exercise Program for Patients With Knee Osteoarthritis : A Randomized Controlled Trial.” Ann Intern Med 174, no. 3 (March 2021): 298–307. https://doi.org/10.7326/M20-4447.

PMID
33370174
Full Text

Coffman, Cynthia J., Liubov Arbeeva, Todd A. Schwartz, Leigh F. Callahan, Yvonne M. Golightly, Adam P. Goode, Kim M. Huffman, and Kelli D. Allen. “Application of Heterogeneity of Treatment Effect Methods: Exploratory Analyses of a Trial of Exercise-Based Interventions for Knee OA.” Arthritis Care Res (Hoboken), January 18, 2021. https://doi.org/10.1002/acr.24564.

PMID
33463020
Full Text

Dorling, James L., Stephan van Vliet, Kim M. Huffman, William E. Kraus, Manjushri Bhapkar, Carl F. Pieper, Tiffany Stewart, et al. “Effects of caloric restriction on human physiological, psychological, and behavioral outcomes: highlights from CALERIE phase 2.” Nutr Rev 79, no. 1 (January 1, 2021): 98–113. https://doi.org/10.1093/nutrit/nuaa085.

PMID
32940695
Full Text

Hirsch, Katie R., Casey E. Greenwalt, Hannah E. Saylor, Lacey M. Gould, Courtney H. Harrison, Gabrielle J. Brewer, Malia N. M. Blue, et al. “High-intensity interval training and essential amino acid supplementation: Effects on muscle characteristics and whole-body protein turnover.” Physiol Rep 9, no. 1 (January 2021): e14655. https://doi.org/10.14814/phy2.14655.

PMID
33369879
Full Text

Ross, Leanna M., Cris A. Slentz, Alyssa M. Zidek, Kim M. Huffman, Irina Shalaurova, James D. Otvos, Margery A. Connelly, et al. “Effects of Amount, Intensity, and Mode of Exercise Training on Insulin Resistance and Type 2 Diabetes Risk in the STRRIDE Randomized Trials.” Front Physiol 12 (2021): 626142. https://doi.org/10.3389/fphys.2021.626142.

PMID
33613319
Full Text

Duscha, Brian D., William E. Kraus, William S. Jones, Jennifer L. Robbins, Lucy W. Piner, Kim M. Huffman, Jason D. Allen, and Brian H. Annex. “Skeletal muscle capillary density is related to anaerobic threshold and claudication in peripheral artery disease.” Vasc Med 25, no. 5 (October 2020): 411–18. https://doi.org/10.1177/1358863X20945794.

PMID
32841100
Full Text

Parker, Daniel C., Cathleen Colόn-Emeric, Janet L. Huebner, Ching-Heng Chou, Virginia Byers Kraus, Carl F. Pieper, Richard Sloane, et al. “Biomarkers Associated with Physical Resilience After Hip Fracture.” J Gerontol a Biol Sci Med Sci 75, no. 10 (September 25, 2020): e166–72. https://doi.org/10.1093/gerona/glaa119.

PMID
32386291
Full Text

Flowers, Portia P. E., Todd A. Schwartz, Liubov Arbeeva, Yvonne M. Golightly, Ami Pathak, Jennifer Cooke, Jyotsna J. Gupta, et al. “Racial Differences in Performance-Based Function and Potential Explanatory Factors Among Individuals With Knee Osteoarthritis.” Arthritis Care Res (Hoboken) 72, no. 9 (September 2020): 1196–1204. https://doi.org/10.1002/acr.24018.

PMID
31254451
Full Text

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