Kim Marie Huffman, MD, PhD

Associate Professor of Medicine
Member of Duke Molecular Physiology Institute
Affiliate of the Regeneration Next Initiative
Campus mail 300 N Duke St, Carmichael, 51-202, Durham, NC 27701
Phone (919) 668-1644
Email address huffm007@mc.duke.edu

Determining the role of physical activity in modulating health outcomes (cardiovascular disease risk) in persons with rheumatologic diseases (rheumatoid arthritis, gout, osteoarthritis)

Integrating clinical rheumatology, basic immunology, metabolism, and exercise science in order to reduce morbidity in individuals with arthritis

Evaluating relationships between circulating and intra-muscular metabolic intermediates and insulin resistance in sedentary as well as individuals engaging in regular exercise

Addressing the role of physical activity in modulating inflammation, metabolism, and functional health in aging populations

Education and Training

  • Fellow, Rheumatology, Duke University, 2002 - 2005
  • Resident, Internal Medicine, Duke University, 2001 - 2002
  • M.D., Medical University of South Carolina School of Medicine, 2000
  • Ph.D., Medical University of South Carolina School of Medicine, 1998

Publications

Kraus, William E., Manjushri Bhapkar, Kim M. Huffman, Carl F. Pieper, Sai Krupa Das, Leanne M. Redman, Dennis T. Villareal, et al. “2 years of calorie restriction and cardiometabolic risk (CALERIE): exploratory outcomes of a multicentre, phase 2, randomised controlled trial..” Lancet Diabetes Endocrinol, July 11, 2019. https://doi.org/10.1016/S2213-8587(19)30151-2.

PMID
31303390
Full Text

Davis, Brittany N. J., Jeffrey W. Santoso, Michaela J. Walker, Catherine E. Oliver, Michael M. Cunningham, Christian A. Boehm, Danielle Dawes, et al. “Modeling the Effect of TNF-α upon Drug-Induced Toxicity in Human, Tissue-Engineered Myobundles..” Ann Biomed Eng 47, no. 7 (July 2019): 1596–1610. https://doi.org/10.1007/s10439-019-02263-8.

PMID
30963383
Full Text

Flowers, Portia P. E., Todd A. Schwartz, Liubov Arbeeva, Yvonne M. Golightly, Ami Pathak, Jennifer Cooke, Jyotsna J. Gupta, et al. “Racial differences in performance-based function and potential explanatory factors among individuals with knee osteoarthritis..” Arthritis Care Res (Hoboken), June 29, 2019. https://doi.org/10.1002/acr.24018.

PMID
31254451
Full Text

Allen, Kelli D., Dennis Bongiorni, Kevin Caves, Cynthia J. Coffman, Theresa A. Floegel, Heather M. Greysen, Katherine S. Hall, et al. “STepped exercise program for patients with knee OsteoArthritis (STEP-KOA): protocol for a randomized controlled trial..” Bmc Musculoskelet Disord 20, no. 1 (May 28, 2019). https://doi.org/10.1186/s12891-019-2627-8.

PMID
31138256
Full Text

Reavis, Zackery W., Cynthia M. Kuhn, Redford B. Williams, Richard S. Surwit, William E. Kraus, Kim M. Huffman, James D. Lane, Paul Costa, Ilene C. Siegler, and Anastasia Georgiades. “EIGHT-MONTH STABILITY OF PLASMA EPINEPHRINE AND CORTISOL IN FASTED ADULTS AT BASELINE AND IN RESPONSE TO A GLUCOSE BOLUS.” In Psychosomatic Medicine, 81:A41–42. LIPPINCOTT WILLIAMS & WILKINS, 2019.

Scholars@Duke

Georgiades, Anastasia, Zackery W. Reavis, Redford B. Williams, Cynthia M. Kuhn, William E. Kraus, Kim M. Huffman, James D. Lane, Paul Costa, Ilene C. Siegler, and Richard S. Surwit. “EPINEPHRINE, CORTISOL AND NON-ESTERIFIED FATTY ACID LEVELS DURING AN INTRAVENOUS GLUCOSE TOLERANCE TEST ARE ASSOCIATED WITH THE ACUTE INSULIN RESPONSE (AIR), AN EARLY RISK MARKER FOR TYPE 2 DIABETES.” In Psychosomatic Medicine, 81:A42–A42. LIPPINCOTT WILLIAMS & WILKINS, 2019.

Scholars@Duke

Colón-Emeric, Cathleen, Carl F. Pieper, Kenneth E. Schmader, Richard Sloane, Allison Bloom, Micah McClain, Jay Magaziner, et al. “Two Approaches to Classifying and Quantifying Physical Resilience in Longitudinal Data..” J Gerontol a Biol Sci Med Sci, April 17, 2019. https://doi.org/10.1093/gerona/glz097.

PMID
30993327
Full Text

Parker, D. C., W. E. Kraus, C. Pieper, H. J. Cohen, and K. M. Huffman. “Data-Driven Cluster Analysis Identifies Unique Inflammatory and Metabolic Signatures Associated with Self-Rated Health, Cognitive Performance, and Function..” In Journal of the American Geriatrics Society, 67:S10–S10. WILEY, 2019.

Scholars@Duke

Gomoll, A., A. Spitzer, J. C. Richmond, V. B. Kraus, D. G. Jones, K. M. Huffman, A. Cinar, J. Lufkin, and S. Kelley. “Repeat administration of triamcinolone acetonide extended-release affords consistent, clinically relevant improvements in pain: results from a phase 3B, single-arm, open-label study.” In Osteoarthritis and Cartilage, 27:S505–6. Elsevier BV, 2019. https://doi.org/10.1016/j.joca.2019.02.570.

Full Text

Spitzer, Andrew I., John C. Richmond, Virginia B. Kraus, Andreas Gomoll, Deryk G. Jones, Kim M. Huffman, Charles Peterfy, Amy Cinar, Joelle Lufkin, and Scott D. Kelley. “Safety and Efficacy of Repeat Administration of Triamcinolone Acetonide Extended-release in Osteoarthritis of the Knee: A Phase 3b, Open-label Study..” Rheumatol Ther 6, no. 1 (March 2019): 109–24. https://doi.org/10.1007/s40744-019-0140-z.

PMID
30741382
Full Text

Pages