Kim Marie Huffman, MD, PhD

Associate Professor of Medicine
Member of Duke Molecular Physiology Institute
Affiliate of the Regeneration Next Initiative
Campus mail 300 N Duke St, Carmichael, 51-202, Durham, NC 27701
Phone (919) 668-1644
Email address huffm007@mc.duke.edu

Determining the role of physical activity in modulating health outcomes (cardiovascular disease risk) in persons with rheumatologic diseases (rheumatoid arthritis, gout, osteoarthritis)

Integrating clinical rheumatology, basic immunology, metabolism, and exercise science in order to reduce morbidity in individuals with arthritis

Evaluating relationships between circulating and intra-muscular metabolic intermediates and insulin resistance in sedentary as well as individuals engaging in regular exercise

Addressing the role of physical activity in modulating inflammation, metabolism, and functional health in aging populations

Education and Training

  • Fellow, Rheumatology, Duke University, 2002 - 2005
  • Resident, Internal Medicine, Duke University, 2001 - 2002
  • M.D., Medical University of South Carolina School of Medicine, 2000
  • Ph.D., Medical University of South Carolina School of Medicine, 1998

Publications

Il'yasova, D, Fontana, L, Bhapkar, M, Pieper, CF, Spasojevic, I, Redman, LM, Das, SK, Huffman, KM, Kraus, WE, and CALERIE Study Investigators, . "Effects of 2 years of caloric restriction on oxidative status assessed by urinary F2-isoprostanes: The CALERIE 2 randomized clinical trial." Aging Cell 17, no. 2 (April 2018).

PMID
29424490
Full Text

Allen, KD, Arbeeva, L, Callahan, LF, Golightly, YM, Goode, AP, Heiderscheit, BC, Huffman, KM, Severson, HH, and Schwartz, TA. "Physical therapy vs internet-based exercise training for patients with knee osteoarthritis: results of a randomized controlled trial." March 2018.

PMID
29307722
Full Text

Gunn, AH, Schwartz, TA, Arbeeva, LS, Callahan, LF, Golightly, Y, Goode, A, Hill, CH, Huffman, K, Iversen, MD, Pathak, A, Taylor, SS, and Allen, KD. "Fear of Movement and Associated Factors Among Adults With Symptomatic Knee Osteoarthritis." Arthritis care & research 69, no. 12 (December 2017): 1826-1833.

PMID
28371481
Full Text

Belsky, DW, Huffman, KM, Pieper, CF, Shalev, I, and Kraus, WE. "Change in the Rate of Biological Aging in Response to Caloric Restriction: CALERIE Biobank Analysis." The Journals of Gerontology Series A: Biological Sciences and Medical Sciences 73, no. 1 (December 2017): 4-10.

PMID
28531269
Full Text

Zillikens, MC, Demissie, S, Hsu, Y-H, Yerges-Armstrong, LM, Chou, W-C, Stolk, L, Livshits, G, Broer, L, Johnson, T, Koller, DL, Kutalik, Z, Luan, J, Malkin, I, Ried, JS, Smith, AV, Thorleifsson, G, Vandenput, L, Hua Zhao, J, Zhang, W, Aghdassi, A, Åkesson, K, Amin, N, Baier, LJ, Barroso, I, Bennett, DA, Bertram, L, Biffar, R, Bochud, M, Boehnke, M, Borecki, IB, Buchman, AS, Byberg, L, Campbell, H, Campos Obanda, N, Cauley, JA, Cawthon, PM, Cederberg, H, Chen, Z, Cho, NH, and Jin Choi, H et al. "Erratum: Large meta-analysis of genome-wide association studies identifies five loci for lean body mass." Nature communications 8, no. 1 (November 7, 2017): 1414-.

PMID
29116125
Full Text

Jessee, R, Peart, E, Beineke, P, Rosenberg, S, Wingrove, JA, Kraus, WE, and Huffman, KM. "Rheumatoid arthritis complicates noninvasive whole blood gene expression testing for coronary artery disease." American heart journal 192 (October 2017): 13-18.

PMID
28938959
Full Text

Andonian, BJ, Bartlett, D, Kraus, VB, Huebner, J, Kraus, WE, and Huffman, KM. "Skeletal Muscle Cytokine and Myostatin Responses to High-Intensity Interval Training in Rheumatoid Arthritis Contrasted with Prediabetes Mellitus." October 2017.

Scholars@Duke

Andonian, BJ, Bartlett, D, Kraus, VB, Huebner, J, Kraus, WE, and Huffman, KM. "Serum Galectin-3 in Rheumatoid Arthritis Compared with Healthy Controls and Subjects with Prediabetes before and after High-Intensity Interval Training." October 2017.

Scholars@Duke

Oliver, CE, Davis, BN, Hong, J, Huffman, KM, and Truskey, GA. "Tissue-Engineered Human Skeletal Muscle Model of Rheumatoid Arthritis." October 2017.

Scholars@Duke

Zillikens, MC, Demissie, S, Hsu, Y-H, Yerges-Armstrong, LM, Chou, W-C, Stolk, L, Livshits, G, Broer, L, Johnson, T, Koller, DL, Kutalik, Z, Luan, J, Malkin, I, Ried, JS, Smith, AV, Thorleifsson, G, Vandenput, L, Hua Zhao, J, Zhang, W, Aghdassi, A, Åkesson, K, Amin, N, Baier, LJ, Barroso, I, Bennett, DA, Bertram, L, Biffar, R, Bochud, M, Boehnke, M, Borecki, IB, Buchman, AS, Byberg, L, Campbell, H, Campos Obanda, N, Cauley, JA, Cawthon, PM, Cederberg, H, Chen, Z, Cho, NH, and Jin Choi, H et al. "Large meta-analysis of genome-wide association studies identifies five loci for lean body mass." Nature communications 8, no. 1 (July 19, 2017): 80-.

PMID
28724990
Full Text

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