Kim Marie Huffman, MD, PhD

Associate Professor of Medicine
Member of Duke Molecular Physiology Institute
Affiliate of the Regeneration Next Initiative
Campus mail 300 N Duke St, Carmichael, 51-202, Durham, NC 27701
Phone (919) 668-1644
Email address huffm007@mc.duke.edu

Determining the role of physical activity in modulating health outcomes (cardiovascular disease risk) in persons with rheumatologic diseases (rheumatoid arthritis, gout, osteoarthritis)

Integrating clinical rheumatology, basic immunology, metabolism, and exercise science in order to reduce morbidity in individuals with arthritis

Evaluating relationships between circulating and intra-muscular metabolic intermediates and insulin resistance in sedentary as well as individuals engaging in regular exercise

Addressing the role of physical activity in modulating inflammation, metabolism, and functional health in aging populations

Education and Training

  • Fellow, Rheumatology, Duke University, 2002 - 2005
  • Resident, Internal Medicine, Duke University, 2001 - 2002
  • M.D., Medical University of South Carolina School of Medicine, 2000
  • Ph.D., Medical University of South Carolina School of Medicine, 1998

Publications

Barber, JL, Kraus, WE, Church, TS, Hagberg, JM, Thompson, PD, Bartlett, DB, Beets, MW, Earnest, CP, Huffman, KM, Landers-Ramos, RQ, Leon, AS, Rao, DC, Seip, RL, Skinner, JS, Slentz, CA, Wilund, KR, Bouchard, C, and Sarzynski, MA. "Effects of regular endurance exercise on GlycA: Combined analysis of 14 exercise interventions." Atherosclerosis 277 (October 2018): 1-6.

PMID
30170218
Full Text

Koeberl, DD, Case, LE, Smith, EC, Walters, C, Han, S-O, Li, Y, Chen, W, Hornik, CP, Huffman, KM, Kraus, WE, Thurberg, BL, Corcoran, DL, Bali, D, Bursac, N, and Kishnani, PS. "Correction of Biochemical Abnormalities and Improved Muscle Function in a Phase I/II Clinical Trial of Clenbuterol in Pompe Disease." Molecular Therapy : the Journal of the American Society of Gene Therapy 26, no. 9 (September 2018): 2304-2314.

PMID
30025991
Full Text

Iversen, MD, Schwartz, TA, von Heideken, J, Callahan, LF, Golightly, YM, Goode, A, Hill, C, Huffman, K, Pathak, A, Cooke, J, and Allen, KD. "Sociodemographic and Clinical Correlates of Physical Therapy Utilization in Adults With Symptomatic Knee Osteoarthritis." August 2018.

PMID
29718472
Full Text

White, JP, Billin, AN, Campbell, ME, Russell, AJ, Huffman, KM, and Kraus, WE. "The AMPK/p27Kip1 Axis Regulates Autophagy/Apoptosis Decisions in Aged Skeletal Muscle Stem Cells." Stem Cell Reports 11, no. 2 (August 2018): 425-439.

PMID
30033086
Full Text

Pignato, M, Arbeeva, L, Schwartz, TA, Callahan, LF, Cooke, J, Golightly, YM, Goode, AP, Heiderscheit, BC, Hill, C, Huffman, KM, Severson, HH, and Allen, KD. "Level of participation in physical therapy or an internet-based exercise training program: associations with outcomes for patients with knee osteoarthritis." Bmc Musculoskeletal Disorders 19, no. 1 (July 19, 2018): 238-null.

PMID
30025540
Full Text

Bartlett, DB, Willis, LH, Slentz, CA, Hoselton, A, Kelly, L, Huebner, JL, Kraus, VB, Moss, J, Muehlbauer, MJ, Spielmann, G, Kraus, WE, Lord, JM, and Huffman, KM. "Ten weeks of high-intensity interval walk training is associated with reduced disease activity and improved innate immune function in older adults with rheumatoid arthritis: a pilot study." Arthritis Research & Therapy 20, no. 1 (June 14, 2018): 127-null.

PMID
29898765
Full Text

Stanifer, JW, Landerman, L, Pieper, CF, Huffman, KM, and Kraus, WE. "Relations of established aging biomarkers (IL-6, D-dimer, s-VCAM) to glomerular filtration rate and mortality in community-dwelling elderly adults." Clinical Kidney Journal 11, no. 3 (June 2018): 377-382.

PMID
29942503
Full Text

Il'yasova, D, Fontana, L, Bhapkar, M, Pieper, CF, Spasojevic, I, Redman, LM, Das, SK, Huffman, KM, Kraus, WE, and CALERIE Study Investigators, . "Effects of 2 years of caloric restriction on oxidative status assessed by urinary F2-isoprostanes: The CALERIE 2 randomized clinical trial." Aging Cell 17, no. 2 (April 2018).

PMID
29424490
Full Text

Allen, KD, Arbeeva, L, Callahan, LF, Golightly, YM, Goode, AP, Heiderscheit, BC, Huffman, KM, Severson, HH, and Schwartz, TA. "Physical therapy vs internet-based exercise training for patients with knee osteoarthritis: results of a randomized controlled trial." March 2018.

PMID
29307722
Full Text

Lewis, LS, Huffman, KM, Smith, IJ, Donahue, MP, Slentz, CA, Houmard, JA, Hubal, MJ, Hoffman, EP, Hauser, ER, Siegler, IC, and Kraus, WE. "Genetic Variation in Acid Ceramidase Predicts Non-completion of an Exercise Intervention." Frontiers in Physiology 9 (January 2018): 781-null.

PMID
30008672
Full Text

Pages