Lan Mao, MD

Assistant Professor in Medicine
Campus mail 231 Clin Res Lab Bldg, Durham, NC 27710
Phone (919) 668-2530
Email address mao00004@mc.duke.edu

I. Research:
As the director of mouse physiology laboratory, in charge for the all events related with Dr. Howard Rockman's molecular biology laboratory studies needs.
Participate in research in rodents model:
Perform surgery and serve as co-investigator in studies on transgenic mice with heart failure. Develop models of hypertrophy in small animal using micro-surgical techniques (aortic constriction, left ventricular infarction and abdominal aortocaval fistula) and perform a variety physiological studies, obtain and analysis data on hemodynamic study and prepare tissue specimens for father molecular biological study.
Develop and apply surgical techniques for in vivo myocardial function study on small animal, such as, using new developed devices study in vivo mice cardiac function (pressure-volume lop), instrumented mice for conscious blood pressure measure or administration of medicine---carotid artery or gull duck catheterization, and conscious mice echocardiography.
Develop techniques for micro-injection of proteins and vectors in to mouse left ventricle, coronary artery and portal vein.

II. Teaching
10% of time allocated/spent---
Train postdoctoral fellows, visiting scientists and students from all over the world in laboratory procedure involving, including endotracheal intubations, cardiac catheterization, coronary occlusion and intrathoracic/intra-abdominal surgical procedures.
Teach methods of data recording and analysis using laboratory equipments and computer programs, echocardiography apply and measurement.

III. Consultant
Consult and teach microsurgical techniques related on small animals such as, rabbits, rat, hamsters and mice, like mice heart-lung transplantation, portal vein injection and mini-pump implant.
Co-laboratory with large range of Universities and Research Institutes from United States an other countries.

Education and Training

  • M.D., Beijing Medical University (China), 1979

Publications

Yoo, ByungSu, Kriti Rakesh, Lan Mao, and Howard A. Rockman. “Mechanical Stretch Activates beta-arrestin-mediated Signaling of the AT1 Receptor.” In Circulation, 120:S866–S866. LIPPINCOTT WILLIAMS & WILKINS, 2009.

Scholars@Duke

Mangmool, Supachoke, Weili Zou, Lan Mao, and Howard A. Rockman. “beta-Arrestin-Dependent Activation of Ca2+/Calmodulin-Dependent Kinase II Following beta(1)-Adrenergic Receptor Activation.” In Circulation, 120:S1147–S1147. LIPPINCOTT WILLIAMS & WILKINS, 2009.

Scholars@Duke

Yoo, ByungSu, Anthony Lemaire, Supachoke Mangmool, Matthew J. Wolf, Antonio Curcio, Lan Mao, and Howard A. Rockman. “Beta1-adrenergic receptors stimulate cardiac contractility and CaMKII activation in vivo and enhance cardiac dysfunction following myocardial infarction.” Am J Physiol Heart Circ Physiol 297, no. 4 (October 2009): H1377–86. https://doi.org/10.1152/ajpheart.00504.2009.

PMID
19633206
Full Text

Wheeler, Ferrin C., Hao Tang, Odessa A. Marks, Tracy N. Hadnott, Pei-Lun Chu, Lan Mao, Howard A. Rockman, and Douglas A. Marchuk. “Tnni3k modifies disease progression in murine models of cardiomyopathy.” Plos Genet 5, no. 9 (September 2009): e1000647. https://doi.org/10.1371/journal.pgen.1000647.

PMID
19763165
Full Text

Francois, Helene, Natalia Makhanova, Philip Ruiz, Jonathan Ellison, Lan Mao, Howard A. Rockman, and Thomas M. Coffman. “A role for the thromboxane receptor in L-NAME hypertension.” Am J Physiol Renal Physiol 295, no. 4 (October 2008): F1096–1102. https://doi.org/10.1152/ajprenal.00369.2007.

PMID
18684890
Full Text

Pandya, Kumar, John Cowhig, Joe Brackhan, Hyung Suk Kim, John Hagaman, Mauricio Rojas, Charles W. Carter, et al. “Discordant on/off switching of gene expression in myocytes during cardiac hypertrophy in vivo.” Proc Natl Acad Sci U S A 105, no. 35 (September 2, 2008): 13063–68. https://doi.org/10.1073/pnas.0805120105.

PMID
18755891
Full Text

Edwards, Claire, Hong-Qiang Feng, Christopher Reynolds, Lan Mao, and Don C. Rockey. “Effect of the nitric oxide donor V-PYRRO/NO on portal pressure and sinusoidal dynamics in normal and cirrhotic mice.” Am J Physiol Gastrointest Liver Physiol 294, no. 6 (June 2008): G1311–17. https://doi.org/10.1152/ajpgi.00368.2007.

PMID
18356534
Full Text

Zhu, Ming, Agnieszka A. Gach, GongXin Liu, Xiaomei Xu, Chee Chew Lim, Julie X. Zhang, Lan Mao, et al. “Enhanced calcium cycling and contractile function in transgenic hearts expressing constitutively active G alpha o* protein.” Am J Physiol Heart Circ Physiol 294, no. 3 (March 2008): H1335–47. https://doi.org/10.1152/ajpheart.00584.2007.

PMID
18192223
Full Text

Esposito, Giovanni, Cinzia Perrino, Tohru Ozaki, Hideyuki Takaoka, Nicole Defer, Maria Piera Petretta, Maria Carmen De Angelis, et al. “Increased myocardial contractility and enhanced exercise function in transgenic mice overexpressing either adenylyl cyclase 5 or 8.” Basic Res Cardiol 103, no. 1 (January 2008): 22–30. https://doi.org/10.1007/s00395-007-0688-6.

PMID
18034275
Full Text

Seth, Malini, Zhu-Shan Zhang, Lan Mao, Jarrett Burch, Victoria Graham, Howard A. Rockman, Lutz Birnbaumer, and Paul Rosenberg. “Transient receptor potential channel C1 deficiency protects the murine heart from pressure overload.” In Circulation, 116:5–5. LIPPINCOTT WILLIAMS & WILKINS, 2007.

Scholars@Duke

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