Lan Mao, MD

Assistant Professor in Medicine
Campus mail 231 Clin Res Lab Bldg, Durham, NC 27710
Phone (919) 668-2530
Email address mao00004@mc.duke.edu

I. Research:
As the director of mouse physiology laboratory, in charge for the all events related with Dr. Howard Rockman's molecular biology laboratory studies needs.
Participate in research in rodents model:
Perform surgery and serve as co-investigator in studies on transgenic mice with heart failure. Develop models of hypertrophy in small animal using micro-surgical techniques (aortic constriction, left ventricular infarction and abdominal aortocaval fistula) and perform a variety physiological studies, obtain and analysis data on hemodynamic study and prepare tissue specimens for father molecular biological study.
Develop and apply surgical techniques for in vivo myocardial function study on small animal, such as, using new developed devices study in vivo mice cardiac function (pressure-volume lop), instrumented mice for conscious blood pressure measure or administration of medicine---carotid artery or gull duck catheterization, and conscious mice echocardiography.
Develop techniques for micro-injection of proteins and vectors in to mouse left ventricle, coronary artery and portal vein.

II. Teaching
10% of time allocated/spent---
Train postdoctoral fellows, visiting scientists and students from all over the world in laboratory procedure involving, including endotracheal intubations, cardiac catheterization, coronary occlusion and intrathoracic/intra-abdominal surgical procedures.
Teach methods of data recording and analysis using laboratory equipments and computer programs, echocardiography apply and measurement.

III. Consultant
Consult and teach microsurgical techniques related on small animals such as, rabbits, rat, hamsters and mice, like mice heart-lung transplantation, portal vein injection and mini-pump implant.
Co-laboratory with large range of Universities and Research Institutes from United States an other countries.

Education and Training

  • M.D., Beijing Medical University (China), 1979

Publications

Esposito, G., S. V. Prasad, A. Rapacciuolo, L. Mao, W. J. Koch, and H. A. Rockman. “Cardiac overexpression of a G(q) inhibitor blocks induction of extracellular signal-regulated kinase and c-Jun NH(2)-terminal kinase activity in in vivo pressure overload.” Circulation 103, no. 10 (March 13, 2001): 1453–58. https://doi.org/10.1161/01.cir.103.10.1453.

PMID
11245652
Full Text

Esposito, G., L. F. Santana, K. Dilly, J. D. Cruz, L. Mao, W. J. Lederer, and H. A. Rockman. “Cellular and functional defects in a mouse model of heart failure.” Am J Physiol Heart Circ Physiol 279, no. 6 (December 2000): H3101–12. https://doi.org/10.1152/ajpheart.2000.279.6.H3101.

PMID
11087268
Full Text

Manning, B. S., K. Shotwell, L. Mao, H. A. Rockman, and W. J. Koch. “Physiological induction of a beta-adrenergic receptor kinase inhibitor transgene preserves ss-adrenergic responsiveness in pressure-overload cardiac hypertrophy.” Circulation 102, no. 22 (November 28, 2000): 2751–57. https://doi.org/10.1161/01.cir.102.22.2751.

PMID
11094043
Full Text

Chao, H., L. Mao, A. T. Bruce, and C. E. Walsh. “Sustained expression of human factor VIII in mice using a parvovirus-based vector.” Blood 95, no. 5 (March 1, 2000): 1594–99.

PMID
10688813
Scholars@Duke

Naga Prasad, S. V., G. Esposito, L. Mao, W. J. Koch, and H. A. Rockman. “Gbetagamma-dependent phosphoinositide 3-kinase activation in hearts with in vivo pressure overload hypertrophy.” J Biol Chem 275, no. 7 (February 18, 2000): 4693–98. https://doi.org/10.1074/jbc.275.7.4693.

PMID
10671499
Full Text

Ryoke, T., Y. Gu, L. Mao, M. Hongo, R. G. Clark, K. L. Peterson, and J. Ross. “Progressive cardiac dysfunction and fibrosis in the cardiomyopathic hamster and effects of growth hormone and angiotensin-converting enzyme inhibition.” Circulation 100, no. 16 (October 19, 1999): 1734–43. https://doi.org/10.1161/01.cir.100.16.1734.

PMID
10525494
Full Text

Hongo, M., E. M. Sentianin, N. Tanaka, L. Mao, M. D. McKirnan, R. G. Clark, W. Won, K. R. Chien, and J. Ross. “Angiotensin II blockade followed by growth hormone as adjunctive therapy after experimental myocardial infarction.” J Card Fail 4, no. 3 (September 1998): 213–24. https://doi.org/10.1016/s1071-9164(98)80008-0.

PMID
9754592
Full Text

Tanaka, N., T. Ryoke, M. Hongo, L. Mao, H. A. Rockman, R. G. Clark, and J. Ross. “Effects of growth hormone and IGF-I on cardiac hypertrophy and gene expression in mice.” Am J Physiol 275, no. 2 (August 1998): H393–99. https://doi.org/10.1152/ajpheart.1998.275.2.H393.

PMID
9683425
Full Text

Palakodeti, V., O. H. Samuel, B. H. Oh, L. A. N. Mao, M. Kongo, K. L. Peterson, and J. Ross. “Force-frequency effect is a powerful determinant of myocardial contractility in the mouse.” American Journal of Physiology  Heart and Circulatory Physiology 42, no. 3 (December 1, 1997).

Scholars@Duke

Tanaka, N., L. Mao, F. A. DeLano, E. M. Sentianin, K. R. Chien, G. W. Schmid-Schönbein, and J. Ross. “Left ventricular volumes and function in the embryonic mouse heart.” Am J Physiol 273, no. 3 Pt 2 (September 1997): H1368–76. https://doi.org/10.1152/ajpheart.1997.273.3.H1368.

PMID
9321827
Full Text

Pages