Lan Mao, MD

Assistant Professor in Medicine
Campus mail 231 Clin Res Lab Bldg, Durham, NC 27710
Phone (919) 668-2530
Email address mao00004@mc.duke.edu

I. Research:
As the director of mouse physiology laboratory, in charge for the all events related with Dr. Howard Rockman's molecular biology laboratory studies needs.
Participate in research in rodents model:
Perform surgery and serve as co-investigator in studies on transgenic mice with heart failure. Develop models of hypertrophy in small animal using micro-surgical techniques (aortic constriction, left ventricular infarction and abdominal aortocaval fistula) and perform a variety physiological studies, obtain and analysis data on hemodynamic study and prepare tissue specimens for father molecular biological study.
Develop and apply surgical techniques for in vivo myocardial function study on small animal, such as, using new developed devices study in vivo mice cardiac function (pressure-volume lop), instrumented mice for conscious blood pressure measure or administration of medicine---carotid artery or gull duck catheterization, and conscious mice echocardiography.
Develop techniques for micro-injection of proteins and vectors in to mouse left ventricle, coronary artery and portal vein.

II. Teaching
10% of time allocated/spent---
Train postdoctoral fellows, visiting scientists and students from all over the world in laboratory procedure involving, including endotracheal intubations, cardiac catheterization, coronary occlusion and intrathoracic/intra-abdominal surgical procedures.
Teach methods of data recording and analysis using laboratory equipments and computer programs, echocardiography apply and measurement.

III. Consultant
Consult and teach microsurgical techniques related on small animals such as, rabbits, rat, hamsters and mice, like mice heart-lung transplantation, portal vein injection and mini-pump implant.
Co-laboratory with large range of Universities and Research Institutes from United States an other countries.

Education and Training

  • M.D., Beijing Medical University (China), 1979

Publications

Palakodeti, V., S. Oh, B. H. Oh, L. Mao, M. Hongo, K. L. Peterson, and J. Ross. “Force-frequency effect is a powerful determinant of myocardial contractility in the mouse.” Am J Physiol 273, no. 3 Pt 2 (September 1997): H1283–90. https://doi.org/10.1152/ajpheart.1997.273.3.H1283.

PMID
9321817
Full Text

Ryu, K. H., N. Tanaka, N. Dalton, L. Mao, H. A. Rockman, C. A. Milano, and J. Ross. “Force-frequency relations in the failing rabbit heart and responses to adrenergic stimulation.” J Card Fail 3, no. 1 (March 1997): 27–39. https://doi.org/10.1016/s1071-9164(97)90006-3.

PMID
9110253
Full Text

Tanaka, N., N. Dalton, L. Mao, H. A. Rockman, K. L. Peterson, K. R. Gottshall, J. J. Hunter, K. R. Chien, and J. Ross. “Transthoracic echocardiography in models of cardiac disease in the mouse.” Circulation 94, no. 5 (September 1, 1996): 1109–17. https://doi.org/10.1161/01.cir.94.5.1109.

PMID
8790053
Full Text

Rockman, H. A., R. A. Hamilton, L. R. Jones, C. A. Milano, L. Mao, and R. J. Lefkowitz. “Enhanced myocardial relaxation in vivo in transgenic mice overexpressing the beta2-adrenergic receptor is associated with reduced phospholamban protein.” J Clin Invest 97, no. 7 (April 1, 1996): 1618–23. https://doi.org/10.1172/JCI118587.

PMID
8601626
Full Text

Eising, G. P., L. Mao, G. W. Schmid-Schonbein, R. L. Engler, and J. Ross. “Effects of induced tolerance to bacterial lipopolysaccharide on myocardial infarct size in rats.” Cardiovasc Res 31, no. 1 (January 1996): 73–81.

PMID
8849591
Scholars@Duke

Rockman, H. A., S. P. Wachhorst, L. Mao, and J. Ross. “ANG II receptor blockade prevents ventricular hypertrophy and ANF gene expression with pressure overload in mice.” Am J Physiol 266, no. 6 Pt 2 (June 1994): H2468–75. https://doi.org/10.1152/ajpheart.1994.266.6.H2468.

PMID
8024008
Full Text

Ono, S., V. Bhargava, L. Mao, G. Hagan, H. A. Rockman, and J. Ross. “In vivo assessment of left ventricular remodelling after myocardial infarction by digital video contrast angiography in the rat.” Cardiovasc Res 28, no. 3 (March 1994): 349–57. https://doi.org/10.1093/cvr/28.3.349.

PMID
8174155
Full Text

Pages