General Internal Medicine

Lesley H. Curtis, PhD

Professor in Population Health Sciences
Professor in Medicine
Interim Executive Director, Duke Clinical Research Institute
Chair in the Department of Population Health Sciences
Member in the Duke Clinical Research Institute
Campus mail 215 Morris Street, Suite 210, Durham, NC 27701
Phone (919) 681-6709
Email address lesley.curtis@duke.edu

Dr. Curtis is a health services researcher who oversees a portfolio of projects that use observational data to address questions related to clinical and comparative effectiveness, pharmacoepidemiology, health care delivery, and epidemiological trends across a broad array of clinical conditions and clinical care settings. An expert in the use of Medicare claims data for health services and clinical outcomes research, she has led the linkage of Medicare claims with several large clinical registries and epidemiological cohort studies including the Framingham Heart Study and the Cardiovascular Health Study. 

Dr Curtis directs the Center for Pragmatic Health Systems Research at the Duke Clinical Research Institute and leads the Distributed Research Network Operations Center for PCORI’s National Clinical Research Network (PCORnet), working with health systems and patient networks to develop a harmonized data infrastructure for robust observational and interventional research.

Areas of expertise: Health Services Research and Health Policy

 

Education and Training

  • Ph.D., University of Rochester, 2000

Grants

Publications

Marsolo, Keith A., Jeffrey S. Brown, Adrian F. Hernandez, Bradley G. Hammill, Sudha R. Raman, Beth Syat, Richard Platt, and Lesley H. Curtis. “Considerations for using distributed research networks to conduct aspects of randomized trials.” Contemp Clin Trials Commun 17 (March 2020): 100515. https://doi.org/10.1016/j.conctc.2019.100515.

PMID
31956724
Full Text

Brennan, J Matthew, Lisa Wruck, Michael J. Pencina, Robert M. Clare, Renato D. Lopes, John H. Alexander, Sean O’Brien, et al. “Claims-based cardiovascular outcome identification for clinical research: Results from 7 large randomized cardiovascular clinical trials.” Am Heart J 218 (December 2019): 110–22. https://doi.org/10.1016/j.ahj.2019.09.002.

PMID
31726314
Full Text

Steinberg, Benjamin A., Nicholas G. Ballew, Melissa A. Greiner, Steven J. Lippmann, Lesley H. Curtis, Emily C. O’Brien, Manesh R. Patel, and Jonathan P. Piccini. “Ischemic and Bleeding Outcomes in Patients With Atrial Fibrillation and Contraindications to Oral Anticoagulation.” Jacc Clin Electrophysiol 5, no. 12 (December 2019): 1384–92. https://doi.org/10.1016/j.jacep.2019.07.011.

PMID
31857036
Full Text

Gewandter, Jennifer S., Amber S. Kleckner, James H. Marshall, Jeffrey S. Brown, Lesley H. Curtis, Javier Bautista, Robert H. Dworkin, et al. “Chemotherapy-induced peripheral neuropathy (CIPN) and its treatment: an NIH Collaboratory study of claims data.” Support Care Cancer, September 7, 2019. https://doi.org/10.1007/s00520-019-05063-x.

PMID
31494735
Full Text

Kusumoto, Fred M., Mark H. Schoenfeld, Coletta Barrett, James R. Edgerton, Kenneth A. Ellenbogen, Michael R. Gold, Nora F. Goldschlager, et al. “2018 ACC/AHA/HRS Guideline on the Evaluation and Management of Patients With Bradycardia and Cardiac Conduction Delay: Executive Summary: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines, and the Heart Rhythm Society.” J Am Coll Cardiol 74, no. 7 (August 20, 2019): 932–87. https://doi.org/10.1016/j.jacc.2018.10.043.

PMID
30412710
Full Text

Slotwiner, David J., Merritt H. Raitt, Freddy Del-Carpio Munoz, Siva K. Mulpuru, Naseer Nasser, and Pamela N. Peterson. “Impact of Physiologic Pacing Versus Right Ventricular Pacing Among Patients With Left Ventricular Ejection Fraction Greater Than 35%: A Systematic Review for the 2018 ACC/AHA/HRS Guideline on the Evaluation and Management of Patients With Bradycardia and Cardiac Conduction Delay: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Rhythm Society.” J Am Coll Cardiol 74, no. 7 (August 20, 2019): 988–1008. https://doi.org/10.1016/j.jacc.2018.10.045.

PMID
30412708
Full Text

Kusumoto, Fred M., Mark H. Schoenfeld, Coletta Barrett, James R. Edgerton, Kenneth A. Ellenbogen, Michael R. Gold, Nora F. Goldschlager, et al. “2018 ACC/AHA/HRS Guideline on the Evaluation and Management of Patients With Bradycardia and Cardiac Conduction Delay: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Rhythm Society.” J Am Coll Cardiol 74, no. 7 (August 20, 2019): e51–156. https://doi.org/10.1016/j.jacc.2018.10.044.

PMID
30412709
Full Text

Cooper, Lauren B., Steven J. Lippmann, Julia R. DiBello, Boris Gorsh, Lesley H. Curtis, Vanja Sikirica, Adrian F. Hernandez, et al. “The Burden of Congestion in Patients Hospitalized With Acute Decompensated Heart Failure.” Am J Cardiol 124, no. 4 (August 15, 2019): 545–53. https://doi.org/10.1016/j.amjcard.2019.05.030.

PMID
31208702
Full Text

Curtis, Lesley H., Laura M. Dember, Miguel A. Vazquez, David Murray, Lynn DeBar, Karen L. Staman, Edward Septimus, et al. “Addressing guideline and policy changes during pragmatic clinical trials.” Clin Trials 16, no. 4 (August 2019): 431–37. https://doi.org/10.1177/1740774519845682.

PMID
31084378
Full Text

Pages