Li-Tzy Wu, DSc

Professor in Psychiatry and Behavioral Sciences
Professor in Medicine
Faculty Network Member of the Duke Institute for Brain Sciences
Affiliate of the Center for Child and Family Policy
Campus mail Duke Psychiatry, DUMC Box # 11, Durham, NC 27710
Phone (919) 889-9369
Email address

Education/Training: Pre- and post-doctoral training in mental health service research, psychiatric epidemiology (NIMH T32), and addiction epidemiology (NIDA T32) from Johns Hopkins University School of Public Health (Maryland); Fellow of the NIH Summer Institute on the Design and Conduct of Randomized Clinical Trials.

Director: Duke Community Based Substance Use Disorder Research Program.
Research interests: COVID-19, Opioid misuse, Opioid overdose, Opioid use disorder, Opioid addiction prevention and treatment, Pain and addiction, Chronic diseases and substance use disorders, diabetes, pharmacy-based care models and services, medication treatment for opioid use disorder (MOUD), Drug overdose, Polysubstance use and disorders, cannabis, alcohol, tobacco, hallucinogens, stimulants, e-cigarette, SBIRT (substance use Screening, Brief Intervention, Referral to Treatment), EHR-based research and intervention, data science, psychometric analysis (IRT), epidemiology of addictions and comorbidity, behavioral health care integration, health services research (mental health disorders, substance use disorders, chronic diseases), nosology, research design, HIV risk behavior. 

FUNDED Research projects (Principal Investigator [PI], Site PI, or Sub-award PI): 
R03: Substance use/dependence (PI).
R21: Treatment use for alcohol use disorders (PI).
R21: Inhalant use & disorders (PI).
R01: MDMA/hallucinogen use/disorders (PI).
R01: Prescription pain reliever (opioids) misuse and use disorders (PI).
R01: Substance use disorders in adolescents (PI).
R21: CTN Substance use diagnoses & treatment (PI).
R33: CTN Substance use diagnoses & treatment (PI).
R01: Evolution of Psychopathology in the Population (ECA Duke site PI).
R01: Substance use disorders and treatment use among Asian Americans and Pacific Islanders (PI).
UG1: SBIRT in Primary Care (NIDA, PI).
UG1: TAPS Tool, Substance use screening tool validation in primary care (NIDA, PI).
UG1: NIDA CTN Mid-Southern Node (Clinical Trials Network, PI).
UG1: EHR Data Element Study (NIDA, PI).
UG1: Buprenorphine Physician-Pharmacist Collaboration in the Management of Patients With Opioid Use Disorder (NIDA, PI).
PCORI: INSPIRE-Integrated Health Services to Reduce Opioid Use While Managing Chronic Pain (Site PI).
CDC R01: Evaluation of state-mandated acute and post-surgical pain-specific CDC opioid prescribing (Site PI).
Pilot: Measuring Opioid Use Disorders in Secondary Electronic Health Records Data (Carolinas Collaborative Grant: Duke PI).
R21: Developing a prevention model of alcohol use disorder for Pacific Islander young adults (Subaward PI, Investigator).
UG1: Subthreshold Opioid Use Disorder Prevention Trial (NIH HEAL Initiative) (NIDA supplement, CTN-0101, Investigator).
NIDA: A Pilot Study to Permit Opioid Treatment Program Physicians to Prescribe Methadone through Community Pharmacies for their Stable Methadone Patients (NIDA/FRI: Study PI).
UG1: Integrating pharmacy-based prevention and treatment of opioid and other substance use disorders: A survey of pharmacists and stakeholder (NIH HEAL Initiative, NIDA, PI).
UG1: NorthStar Node of the Clinical Trials Network (NIDA, Site PI).
R34: Intervention Development and Pilot Study to Reduce Untreated Native Hawaiian and Pacific Islander Opioid Use Disorders (Subaward PI, Investigator).
UG1: Optimal Policies to Improve Methadone Maintenance Adherence Longterm (OPTIMMAL Study) (NIDA, Site PI).

Education and Training

  • D.Sc., Johns Hopkins University, 1997
  • M.A., State University of New York, New Paltz, 1992


Karnik, Niranjan S., John Marsden, Connor McCluskey, Randy A. Boley, Katharine A. Bradley, Cynthia I. Campbell, Megan E. Curtis, et al. “The opioid use disorder core outcomes set (OUD-COS) for treatment research: findings from a Delphi consensus study.” Addiction, March 16, 2022.

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Wu, Li-Tzy, William S. John, Eric D. Morse, Steve Adkins, Jennifer Pippin, Robert K. Brooner, and Robert P. Schwartz. “Opioid treatment program and community pharmacy collaboration for methadone maintenance treatment: results from a feasibility clinical trial.” Addiction 117, no. 2 (February 2022): 444–56.

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Blackburn, Natalie A., Elizabeth Joniak-Grant, Maryalice Nocera, Samantha Wooten Dorris, Nabarun Dasgupta, Paul R. Chelminski, Timothy S. Carey, et al. “Implementation of mandatory opioid prescribing limits in North Carolina: healthcare administrator and prescriber perspectives.” Bmc Health Serv Res 21, no. 1 (November 3, 2021): 1191.

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Subica, Andrew M., Erick G. Guerrero, Phong Hong, Nia Aitaoto, Howard B. Moss, Derek K. Iwamoto, and Li-Tzy Wu. “Alcohol Use Disorder Risk and Protective Factors and Associated Harms Among Pacific Islander Young Adults.” J Racial Ethn Health Disparities, August 10, 2021.

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Wu, Li-Tzy, William S. John, Udi E. Ghitza, Aimee Wahle, Abigail G. Matthews, Mitra Lewis, Brett Hart, et al. “Buprenorphine physician-pharmacist collaboration in the management of patients with opioid use disorder: results from a multisite study of the National Drug Abuse Treatment Clinical Trials Network.” Addiction 116, no. 7 (July 2021): 1805–16.

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Ranapurwala, S., I. Alam, M. Clark, T. Carey, P. Chelminski, B. Pence, J. Korte, et al. “0108 Limitations of opioid use disorder (OUD) ICD codes: development and validation of a new OUD identification algorithm in electronic medical records.” In Abstracts. BMJ Publishing Group Ltd, 2021.

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Bobashev, Georgiy, Lauren Warren, and Li-Tzy Wu. “Predictive model of multiple emergency department visits among adults: analysis of the data from the National Survey of Drug Use and Health (NSDUH).” Bmc Health Serv Res 21, no. 1 (March 25, 2021): 280.

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Von Gunten, Curtis D., and Li-Tzy Wu. “Comorbid Substance Use Disorder Profiles and Receipt of Substance Use Disorder Treatment Services: A National Study.” J Stud Alcohol Drugs 82, no. 2 (March 2021): 246–56.


Karnik, Niranjan S., Cynthia I. Campbell, Megan E. Curtis, David A. Fiellin, Udi Ghitza, Kathryn Hefner, Yih-Ing Hser, et al. “Core outcomes set for research on the treatment of opioid use disorder (COS-OUD): the National Institute on Drug Abuse Clinical Trials Network protocol for an e-Delphi consensus study.” Trials 22, no. 1 (January 28, 2021): 102.

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John, William S., He Zhu, Lawrence H. Greenblatt, and Li-Tzy Wu. “Recent and active problematic substance use among primary care patients: Results from the alcohol, smoking, and substance involvement screening test in a multisite study.” Subst Abus 42, no. 4 (2021): 487–92.

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