Li-Tzy Wu, DSc

Professor in Psychiatry and Behavioral Sciences
Professor in Medicine
Faculty Network Member of the Duke Institute for Brain Sciences
Affiliate of the Center for Child and Family Policy
Member in the Duke Clinical Research Institute
Campus mail Duke South Hospital, Rm 3521, Box 3903, Durham, NC 27710
Phone (919) 889-9369
Email address

Education/Training: Pre- and post-doctoral training in mental health service research, psychiatric epidemiology (NIMH T32), and addiction epidemiology (NIDA T32) from Johns Hopkins University School of Public Health (Maryland); Fellow of the NIH Summer Institute on the Design and Conduct of Randomized Clinical Trials.

Director: Duke Community Based Substance Use Disorder Research Program.
Node Principal Investigator/Director: Mid-Southern Node (Primary Care Networks), NIDA National Drug Abuse Treatment Clinical Trials Network.

Research interests: Opioid misuse, Opioid overdose, Opioid use disorder, Opioid addiction prevention and treatment, Pain and addiction, Chronic diseases and substance use disorders, diabetes, pharmacy services, Drug overdose, Polysubstance use and disorders, cannabis, alcohol, tobacco, hallucinogens, stimulants, SBIRT (substance use Screening, Brief Intervention, Referral to Treatment), EHR-based research and intervention, data science, psychometric analysis (IRT), epidemiology of addictions and comorbidity, behavioral health care integration, health services research (mental health disorders, substance use disorders, chronic diseases), nosology, research design/methods, HIV risk behavior. 

FUNDED Research projects (Principal Investigator, PI): 
Substance use/dependence (R03).
Treatment use for alcohol use disorders (R21).
Inhalant use & disorders (R21).
MDMA/hallucinogen use/disorders (R01).
Prescription opioid misuse/use disorders (R01).
Substance use disorders in adolescents (R01).
Substance use diagnoses & treatment (R21, R33).
Evolution of Psychopathology in the Population (R01: ECA Duke site PI).
Substance use disorders and treatment use among Asian Americans and Pacific Islanders (R01).
SBIRT in Primary Care (UG1: SBIRT, NIDA Clinical Trials Network).
Substance use screening tool validation in primary care (UG1: TAPS Tool, NIDA Clinical Trials Network).
Computer-facilitated intervention for adolescent marijuana use prevention (UG1: CAMP, NIDA CTN).
NIDA CTN Mid Southern Node (UG1: NIDA Clinical Trials Network).
EHR Data Element Study (UG1: EHR-DARE, NIDA Clinical Trials Network).
Buprenorphine Physician-Pharmacist Collaboration in the Management of Patients With Opioid Use Disorder (UG1: CTN-0075, NIDA Clinical Trials Network).
INSPIRE: Integrated Health Services to Reduce Opioid Use While Managing Chronic Pain (PCORI: Duke Site PI).
Evaluation of state-mandated acute and post-surgical pain-specific CDC opioid prescribing (R01: Duke Site PI).
Measuring Opioid Use Disorders in Secondary Electronic Health Records Data (Carolinas Collaborative Grant: Duke PI).
Developing a prevention model of alcohol use disorder for Pacific Islander young adults (R21: Duke subaward PI).

Committee member of the NIDA Asian American and Pacific Islander Researchers and Scholars Workgroup (NIDA AAPI Workgroup).

Education and Training

  • D.Sc., Johns Hopkins University, 1997
  • M.A., State University of New York at New Paltz, 1992


Zhu, H, and Wu, L-T. "Discharge against medical advice from hospitalizations for substance use disorders: The potential impact of the Affordable Care Act." Drug and Alcohol Dependence 197 (April 2019): 115-119.

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Mannelli, P, and Wu, L-T. "Opioid use disorder deaths and the effects of medication therapy." The American Journal of Drug and Alcohol Abuse (March 8, 2019): 1-3.

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John, WS, and Wu, L-T. "Sex differences in the prevalence and correlates of emergency department utilization among adults with prescription opioid use disorder." Substance Use & Misuse (February 6, 2019): 1-13.

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Campbell, ANC, McCarty, D, Rieckmann, T, McNeely, J, Rotrosen, J, Wu, L-T, and Bart, G. "Interpretation and integration of the federal substance use privacy protection rule in integrated health systems: A qualitative analysis." Journal of Substance Abuse Treatment 97 (February 2019): 41-46.

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Jung, J-G, Wu, L-T, Kim, J-S, Kim, E-D, and Yoon, S-J. "Relationship between Smoking and Abdominal Aorta Calcification on Computed Tomography." Korean Journal of Family Medicine (January 4, 2019).

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John, WS, Zhu, H, Mannelli, P, Subramaniam, GA, Schwartz, RP, McNeely, J, and Wu, L-T. "Prevalence and patterns of opioid misuse and opioid use disorder among primary care patients who use tobacco." Drug and Alcohol Dependence 194 (January 2019): 468-475.

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Schranz, AJ, Fleischauer, A, Chu, VH, Wu, L-T, and Rosen, DL. "Trends in Drug Use-Associated Infective Endocarditis and Heart Valve Surgery, 2007 to 2017: A Study of Statewide Discharge Data." Annals of Internal Medicine (December 4, 2018).

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Wu, L-T, Zhu, H, and Ghitza, UE. "Multicomorbidity of chronic diseases and substance use disorders and their association with hospitalization: Results from electronic health records data." Drug and Alcohol Dependence 192 (November 2018): 316-323.

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Mannelli, P, Swartz, M, and Wu, L-T. "Withdrawal severity and early response to treatment in the outpatient transition from opioid use to extended release naltrexone." The American Journal on Addictions 27, no. 6 (September 2018): 471-476.

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Zhu, H, and Wu, L-T. "National trends and characteristics of inpatient detoxification for drug use disorders in the United States." Bmc Public Health 18, no. 1 (August 29, 2018): 1073-null.

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