Li-Tzy Wu, DSc

Professor in Psychiatry and Behavioral Sciences
Professor in Medicine
Faculty Network Member of the Duke Institute for Brain Sciences
Affiliate of the Center for Child and Family Policy
Member in the Duke Clinical Research Institute
Campus mail Duke South Hospital, Rm 3521, Box 3903, Durham, NC 27710
Phone (919) 889-9369
Email address

Education/Training: Pre- and post-doctoral training in mental health service research, psychiatric epidemiology (NIMH T32), and addiction epidemiology (NIDA T32) from Johns Hopkins University School of Public Health (Maryland); Fellow of the NIH Summer Institute on the Design and Conduct of Randomized Clinical Trials.

Director: Duke Community Based Substance Use Disorder Research Program.
Node Principal Investigator/Director: Mid-Southern Node of the National Drug Abuse Treatment Clinical Trials Network (NIDA CTN)

Research interests: Opioid misuse, Opioid overdose, Opioid use disorder, Opioid addiction prevention and treatment, Pain and addiction, Chronic diseases and substance use disorders, diabetes, pharmacy-based care models and services, medication treatment for opioid use disorder (MOUD), Drug overdose, Polysubstance use and disorders, cannabis, alcohol, tobacco, hallucinogens, stimulants, e-cigarette, SBIRT (substance use Screening, Brief Intervention, Referral to Treatment), EHR-based research and intervention, data science, psychometric analysis (IRT), epidemiology of addictions and comorbidity, behavioral health care integration, health services research (mental health disorders, substance use disorders, chronic diseases), nosology, research design, HIV risk behavior. 

FUNDED Research projects (Principal Investigator: PI, Site PI, or Subaward PI): 
R03: Substance use/dependence (PI).
R21: Treatment use for alcohol use disorders (PI).
R21: Inhalant use & disorders (PI).
R01: MDMA/hallucinogen use/disorders (PI).
R01: Prescription pain reliever (opioids) misuse and use disorders (PI).
R01: Substance use disorders in adolescents (PI).
R21: CTN Substance use diagnoses & treatment (PI).
R33: CTN Substance use diagnoses & treatment (PI).
R01: Evolution of Psychopathology in the Population (ECA Duke site PI).
R01: Substance use disorders and treatment use among Asian Americans and Pacific Islanders (PI).
UG1: SBIRT in Primary Care (NIDA CTN-0057, PI).
UG1: TAPS Tool, Substance use screening tool validation in primary care (NIDA CTN-0059, PI).
UG1: CAMP, Computer-facilitated intervention for adolescent marijuana use prevention (NIDA CTN-0060, PI).
UG1: NIDA CTN Mid-Southern Node (NIDA Clinical Trials Network, PI).
UG1: EHR Data Element Study (NIDA CTN-0071, PI).
UG1: Buprenorphine Physician-Pharmacist Collaboration in the Management of Patients With Opioid Use Disorder (NIDA CTN-0075, PI).
PCORI: INSPIRE-Integrated Health Services to Reduce Opioid Use While Managing Chronic Pain (Duke Site PI).
R01: Evaluation of state-mandated acute and post-surgical pain-specific CDC opioid prescribing (Duke Site PI).
Pilot: Measuring Opioid Use Disorders in Secondary Electronic Health Records Data (Carolinas Collaborative Grant: Duke PI).
R21: Developing a prevention model of alcohol use disorder for Pacific Islander young adults (Subaward to Wu, Investigator).
UG1: Medication Treatment for Opioid-dependent Expecting Mothers: A Pragmatic Randomized Trial Comparing Two Buprenorphine Formulations (supplement award to Wu for study site, NIDA CTN-0080)
UG1: Subthreshold Opioid Use Disorder Prevention Trial (NIH HEAL Initiative) (supplement award to Wu, CTN-0101, Investigator)
NIDA: A Pilot Study to Permit Opioid Treatment Program Physicians to Prescribe Methadone through Community Pharmacies for their Stable Methadone Patients (NIDA/FRI: Study PI)
UG1: Integrating pharmacy-based prevention and treatment of opioid and other substance use disorders: A survey of pharmacists and stakeholder (NIH HEAL Initiative, CTN-0105, PI)
UG1: COMPUTE 2.0: Clinic-Randomized Trial of Clinical Decision Support for Opioid Use Disorders in Medical Settings (NIH HEAL Initiative, CTN-0095 Site PI)

Committee member of the NIDA Asian American and Pacific Islander Researchers and Scholars Workgroup (NIDA AAPI Workgroup).

Education and Training

  • D.Sc., Johns Hopkins University, 1997
  • M.A., State University of New York at New Paltz, 1992


Subica, Andrew M., Erick Guerrero, Li-Tzy Wu, Nia Aitaoto, Derek Iwamoto, and Howard B. Moss. “Electronic Cigarette Use and Associated Risk Factors in U.S.-Dwelling Pacific Islander Young Adults.” Substance Use & Misuse, May 12, 2020, 1–7.

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Carmona, Jasmin, Jane Carlisle Maxwell, Ji-Yeun Park, and Li-Tzy Wu. “Prevalence and Health Characteristics of Prescription Opioid Use, Misuse, and Use Disorders Among U.S. Adolescents.” J Adolesc Health 66, no. 5 (May 2020): 536–44.

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John, William S., and Li-Tzy Wu. “Chronic non-cancer pain among adults with substance use disorders: Prevalence, characteristics, and association with opioid overdose and healthcare utilization.” Drug Alcohol Depend 209 (April 1, 2020): 107902.

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Nordeck, Courtney D., Jan Gryczynski, Kevin E. O’Grady, Kathryn Polak, Dace S. Svikis, Jennifer McNeely, Li-Tzy Wu, and Robert P. Schwartz. “Comparison of timeline follow-back self-report and oral fluid testing to detect substance use in adult primary care patients.” Drug Alcohol Depend 209 (April 1, 2020): 107939.

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Wu, Li-Tzy, Elizabeth H. Payne, Kimberly Roseman, Ashley Case, Casey Nelson, and Robert Lindblad. “Using a health information technology survey to explore the availability of addiction treatment data in the electronic health records: A National Drug Abuse Treatment Clinical Trials Network study.” J Subst Abuse Treat 112S (March 2020): 56–62.

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Subica, A. M., E. Guerrero, N. Aitaoto, H. B. Moss, D. Iwamoto, and L. T. Wu. “Hazardous Drinking, Alcohol Use Disorders, and Need for Treatment Among Pacific Islander Young Adults.” American Journal of Orthopsychiatry, January 1, 2020.

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John, William S., Kiran Grover, Lawrence H. Greenblatt, Robert P. Schwartz, and Li-Tzy Wu. “E-Cigarette Use Among Adult Primary Care Patients: Results from a Multisite Study.” J Gen Intern Med 35, no. 1 (January 2020): 268–75.

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Park, Ji-Yeun, and Li-Tzy Wu. “Sources of Misused Prescription Opioids and Their Association with Prescription Opioid Use Disorder in the United States: Sex and Age Differences.” Subst Use Misuse 55, no. 6 (2020): 928–36.

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Adam, Angéline, Robert P. Schwartz, Li-Tzy Wu, Geetha Subramaniam, Eugene Laska, Gaurav Sharma, Saima Mili, and Jennifer McNeely. “Electronic self-administered screening for substance use in adult primary care patients: feasibility and acceptability of the tobacco, alcohol, prescription medication, and other substance use (myTAPS) screening tool.” Addict Sci Clin Pract 14, no. 1 (October 15, 2019): 39.

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Wu, Li-Tzy, Elizabeth H. Payne, Kimberly Roseman, Carla Kingsbury, Ashley Case, Casey Nelson, and Robert Lindblad. “Clinical Workflow and Substance Use Screening, Brief Intervention, and Referral to Treatment Data in the Electronic Health Records: A National Drug Abuse Treatment Clinical Trials Network Study.” Egems (Wash Dc) 7, no. 1 (August 1, 2019): 35.

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