Hematologic Malignancies and Cellular Therapy

Lindsay Anne Magura Rein, MD

Assistant Professor of Medicine

Member of the Duke Cancer Institute

Campus mail Dept of Medicine, Box 31079 DUMC, Durham, NC 27710

Phone (919) 684-8111

Email address lindsay.magura@duke.edu

Education and Training

Resident, Internal Medicine, Duke University School of Medicine, 2008 - 2011
M.D., University of North Dakota, School of Medicine and Health Sciences, 2008

Grants

A Phase 2 Multi-Center, Open Label Study to Assess the Safety, Efficacy and Pharmacodynamics of IMG-7289 in Patients with Essential Thrombocythemia
Myelofibrosis, Post Polycythemia Vera Myelofibrosis, or Post-Essential Thrombocythemia Myelofibrosis
Phase 2 study of 9-ING-41, a Glycogen Synthase Kinase-3 Beta (GSK-3ss) inhibitor, as a single agent or combined with Ruxolitinib, in patients with myelofibrosis
COVID-19 Phase 3 Assess Efficacy of Ruxolitinib
BBI Ph1 TP-3654 and Ruxolitinb in patients with Intermediate and High Risk Myelofibrosis
A Phase 1b, multicenter, open-label dose escalation and expansion platform study of select combinations in adult patients with myelofibrosis
Targeting beta-arrestins in myeloid malignancies

Publications

Gerds, Aaron T., Jason Gotlib, Prithviraj Bose, Michael W. Deininger, Andrew Dunbar, Amro Elshoury, Tracy I. George, et al. “Myeloid/Lymphoid Neoplasms with Eosinophilia and TK Fusion Genes, Version 3.2021, NCCN Clinical Practice Guidelines in Oncology.” J Natl Compr Canc Netw 18, no. 9 (September 2020): 1248–69. https://doi.org/10.6004/jnccn.2020.0042.

PMID

32886902

Full Text

Paul, Barry, Yue Zhao, Gavin Loitsch, Daniel Feinberg, Parker Mathews, Ian Barak, Megan Dupuis, et al. “The impact of bone marrow fibrosis and JAK2 expression on clinical outcomes in patients with newly diagnosed multiple myeloma treated with immunomodulatory agents and/or proteasome inhibitors.” Cancer Med 9, no. 16 (August 2020): 5869–80. https://doi.org/10.1002/cam4.3265.

PMID

32628819

Full Text

Gotlib, Jason, Aaron T. Gerds, Prithviraj Bose, Mariana C. Castells, Michael W. Deininger, Ivana Gojo, Krishna Gundabolu, et al. “Systemic Mastocytosis, Version 2.2019, NCCN Clinical Practice Guidelines in Oncology.” J Natl Compr Canc Netw 16, no. 12 (December 2018): 1500–1537. https://doi.org/10.6004/jnccn.2018.0088.

PMID

30545997

Full Text

Rein, Lindsay A. M., Haeyoon Yang, and Nelson J. Chao. “Applications of Gene Editing Technologies to Cellular Therapies.” Biol Blood Marrow Transplant 24, no. 8 (August 2018): 1537–45. https://doi.org/10.1016/j.bbmt.2018.03.021.

PMID

29601858

Full Text

Rein, Lindsay Am, James W. Wisler, Jihee Kim, Barbara Theriot, LiYin Huang, Trevor Price, Haeyoon Yang, et al. “β-Arrestin2 mediates progression of murine primary myelofibrosis.” Jci Insight 2, no. 24 (December 21, 2017). https://doi.org/10.1172/jci.insight.98094.

PMID

29263312

Full Text

Mesa, Ruben A., Catriona Jamieson, Ravi Bhatia, Michael W. Deininger, Christopher D. Fletcher, Aaron T. Gerds, Ivana Gojo, et al. “NCCN Guidelines Insights: Myeloproliferative Neoplasms, Version 2.2018.” J Natl Compr Canc Netw 15, no. 10 (October 2017): 1193–1207. https://doi.org/10.6004/jnccn.2017.0157.

PMID

28982745

Full Text

Rein, Lindsay A. M., and David A. Rizzieri. “Clinical potential of elacytarabine in patients with acute myeloid leukemia.” Ther Adv Hematol 5, no. 6 (December 2014): 211–20. https://doi.org/10.1177/2040620714552615.

PMID

25469211

Full Text

Rein, Lindsay A. M., and Nelson J. Chao. “WT1 vaccination in acute myeloid leukemia: new methods of implementing adoptive immunotherapy.” Expert Opinion on Investigational Drugs 23, no. 3 (March 2014): 417–26. https://doi.org/10.1517/13543784.2014.889114.

PMID

24521058

Full Text

Friedman, Daphne R., Lindsay A. Magura, Holly A. C. Warren, Jeremy D. Harrison, Louis F. Diehl, and J Brice Weinberg. “Statin use and need for therapy in chronic lymphocytic leukemia.” Leuk Lymphoma 51, no. 12 (December 2010): 2295–98. https://doi.org/10.3109/10428194.2010.520050.

PMID

20929315

Full Text

Magura, Lindsay, Richelle Blanchard, Brian Hope, James R. Beal, Gary G. Schwartz, and Abe E. Sahmoun. “Hypercholesterolemia and prostate cancer: a hospital-based case-control study.” Cancer Causes Control 19, no. 10 (December 2008): 1259–66. https://doi.org/10.1007/s10552-008-9197-7.

PMID

18704722

Full Text