Loretta Georgina Que, MD

Professor of Medicine
Campus mail 279 Msrb1, Durham, NC 27710
Phone (919) 681-8551
Email address loretta.que@duke.edu

My research interests focus on studying the role of nitric oxide and related enzymes in the pathogenesis of lung disease, specifically that caused by nitrosative/oxidative stress. Proposed studies are performed in cell culture and applied to animal models of disease, then examined in human disease where relevant. It is our hope that by better understanding the role of NO and reactive nitrogen species in mediating inflammation, and regulating cell signaling, that we will not only help to unravel the basic mechanisms of NO related lung disease, but also provide a rationale for targeted therapeutic use of NO.

Key words: nitrosative defense, lung injury, nitric oxide

Education and Training

  • Pulmonary Fellow, Medicine, Duke University, 1993 - 1996
  • Clinical Instructor, Medicine, Yale University, 1992 - 1993
  • Medical Resident, Medicine, Yale University, 1989 - 1992
  • M.D., The University of Chicago, 1989

Grants

Publications

Riley, Isaretta L., Bryonna Jackson, Donna Crabtree, Shaun Riebl, Loretta G. Que, Roy Pleasants, and L Ebony Boulware. “A Scoping Review of International Barriers to Asthma Medication Adherence Mapped to the Theoretical Domains Framework.” J Allergy Clin Immunol Pract 9, no. 1 (January 2021): 410-418.e4. https://doi.org/10.1016/j.jaip.2020.08.021.

PMID
32861047
Full Text

Yohannes, Abebaw M., Michelle N Eakin, Janet T. Holbrook, Elizabeth A. Sugar, Robert Henderson, Anna M. Baker, Anne S. Casper, et al. “Association of mild cognitive impairment and characteristic of COPD and overall health status in a cohort study.” Expert Rev Respir Med 15, no. 1 (January 2021): 153–59. https://doi.org/10.1080/17476348.2021.1838278.

PMID
33054443
Full Text

Pederson, William P., Jaime M. Cyphert-Daly, Robert M. Tighe, Loretta G. Que, and Julie G. Ledford. “Genetic variation in surfactant protein-A2 alters responses to ozone.” Plos One 16, no. 2 (2021): e0247504. https://doi.org/10.1371/journal.pone.0247504.

PMID
33617569
Full Text

McCravy, Matthew, Jennifer L. Ingram, and Loretta G. Que. “Dysregulated Metabolism in the Pathophysiology of Non-Allergic Obese Asthma.” J Asthma Allergy 14 (2021): 179–86. https://doi.org/10.2147/JAA.S282284.

PMID
33692628
Full Text

Duchene, B., S. Caffry, K. Black, J. H. Bates, D. A. Kaminsky, L. G. Que, and A. E. Dixon. “Elevated Airway Oxidative Stress in Obese Asthma Is Correlated with Increased Airway Closure.” In American Journal of Respiratory and Critical Care Medicine, Vol. 201, 2020.

Scholars@Duke

Ihrie, M., V. L. McQuade, C. V. Lacuesta, R. M. Tighe, L. G. Que, A. Hedge, J. K. Walker, and J. L. Ingram. “Chronic Leptin Administration in Lean, Allergen-Challenged Female Mice Promotes Small Airway Closure and Airway Fibrosis.” In American Journal of Respiratory and Critical Care Medicine, Vol. 201, 2020.

Scholars@Duke

Daly, J. M., Z. Yang, J. L. Ingram, K. M. Luginbuhl, A. Varanko, R. M. Tighe, A. Chilkoti, and L. G. Que. “Glucagon Like Peptide 1 Attenuates Airway Hyperresponsiveness in a Mouse Model of Obese Allergic Asthma.” In American Journal of Respiratory and Critical Care Medicine, Vol. 201, 2020.

Scholars@Duke

Navuluri, N., L. G. Que, D. M. Murdoch, N. Thielman, N. R. MacIntyre, J. A. Krishnan, D. K. Lagat, and P. S. Kussin. “Evaluation of Hypoxemia Among Patients Admitted to a Tertiary Referral Hospital in Western Kenya.” In American Journal of Respiratory and Critical Care Medicine, Vol. 201, 2020.

Scholars@Duke

Riley, I. L., L. Svetkey, L. G. Que, and L. Boulware. “Patient, Provider and Community Stakeholder Recommendations for Asthma Interventions in Adult High-Risk Populations.” In American Journal of Respiratory and Critical Care Medicine, Vol. 201, 2020.

Scholars@Duke

Riley, I. L., L. Svetkey, L. G. Que, and L. Boulware. “International Patient-Reported Barriers to Asthma Medication Adherence by Countries' Gross National Income and Presence of Universal Health Care.” In American Journal of Respiratory and Critical Care Medicine, Vol. 201, 2020.

Scholars@Duke

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