Pulmonary, Allergy, and Critical Care Medicine

Loretta Georgina Que, MD

Associate Professor of Medicine
Campus mail 279 MSRB1, Durham, NC 27710
Phone (919) 681-8551
Email address loretta.que@duke.edu

My research interests focus on studying the role of nitric oxide and related enzymes in the pathogenesis of lung disease, specifically that caused by nitrosative/oxidative stress. Proposed studies are performed in cell culture and applied to animal models of disease, then examined in human disease where relevant. It is our hope that by better understanding the role of NO and reactive nitrogen species in mediating inflammation, and regulating cell signaling, that we will not only help to unravel the basic mechanisms of NO related lung disease, but also provide a rationale for targeted therapeutic use of NO.

Key words: nitrosative defense, lung injury, nitric oxide

Education and Training

  • Pulmonary Fellow, Medicine, Duke University, 1993 - 1996
  • Clinical Instructor, Medicine, Yale University, 1992 - 1993
  • Medical Resident, Medicine, Yale University, 1989 - 1992
  • M.D., University of Chicago, 1989

Grants

Publications

Tang, M, Henderson, RJ, Holbrook, JT, Que, LG, Mathews, AM, Wise, RA, Dixon, AE, Peters, SP, Rogers, L, Smith, LJ, Teague, WG, and Lang, JE. "Does Obesity Increase Respiratory Tract Infections in Patients with Asthma?." The Journal of Allergy and Clinical Immunology. in Practice (October 9, 2018).

PMID
30312805
Full Text

Que, LG, Yang, Z, Lugogo, NL, Katial, RK, Shoemaker, SA, Troha, JM, Rodman, DM, Tighe, RM, and Kraft, M. "Effect of the S-nitrosoglutathione reductase inhibitor N6022 on bronchial hyperreactivity in asthma." Immunity, Inflammation and Disease 6, no. 2 (June 2018): 322-331.

PMID
29642282
Full Text

Riley, IL, Boulware, LE, Sun, J-L, Chiswell, K, Que, LG, Kraft, M, Todd, JL, Palmer, SM, and Anderson, ML. "Factors associated with reporting results for pulmonary clinical trials in ClinicalTrials.gov." Clinical Trials (London, England) 15, no. 1 (February 2018): 87-94.

PMID
29121787
Full Text

Paul, DW, Neely, NB, Clement, M, Riley, I, Al-Hegelan, M, Phelan, M, Kraft, M, Murdoch, DM, Lucas, J, Bartlett, J, McKellar, M, and Que, LG. "Development and validation of an electronic medical record (EMR)-based computed phenotype of HIV-1 infection." Journal of the American Medical Informatics Association : Jamia 25, no. 2 (February 2018): 150-157.

PMID
28645207
Full Text

Paul, DW, Lagat, DK, MacIntyre, N, Egger, JR, Murdoch, DM, Que, LG, and Kussin, PS. "Validation of spirometry prediction equations in western Kenya." The International Journal of Tuberculosis and Lung Disease 22, no. 1 (January 2018): 112-118.

PMID
29297435
Full Text

Suwanpradid, J, Shih, M, Pontius, L, Yang, B, Birukova, A, Guttman-Yassky, E, Corcoran, DL, Que, LG, Tighe, RM, and MacLeod, AS. "Arginase1 Deficiency in Monocytes/Macrophages Upregulates Inducible Nitric Oxide Synthase To Promote Cutaneous Contact Hypersensitivity." Journal of Immunology (Baltimore, Md. : 1950) 199, no. 5 (September 2017): 1827-1834.

PMID
28747341
Full Text

Durack, J, Lynch, SV, Nariya, S, Bhakta, NR, Beigelman, A, Castro, M, Dyer, A-M, Israel, E, Kraft, M, Martin, RJ, Mauger, DT, Rosenberg, SR, Sharp-King, T, White, SR, Woodruff, PG, Avila, PC, Denlinger, LC, Holguin, F, Lazarus, SC, Lugogo, N, Moore, WC, Peters, SP, Que, L, Smith, LJ, Sorkness, CA, Wechsler, ME, Wenzel, SE, Boushey, HA, Huang, YJ, National Heart, and Lung and Blood Institute's “AsthmaNet”, . "Features of the bronchial bacterial microbiome associated with atopy, asthma, and responsiveness to inhaled corticosteroid treatment." The Journal of Allergy and Clinical Immunology 140, no. 1 (July 2017): 63-75.

PMID
27838347
Full Text

Winnica, D, Que, LG, Baffi, C, Grasemann, H, Fiedler, K, Yang, Z, Etling, E, Wasil, K, Wenzel, SE, Freeman, B, and Holguin, F. "l-citrulline prevents asymmetric dimethylarginine-mediated reductions in nitric oxide and nitrosative stress in primary human airway epithelial cells." Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology 47, no. 2 (February 2017): 190-199.

PMID
27562295
Full Text

He, M, Driehuys, B, Que, LG, and Huang, Y-CT. "Using Hyperpolarized 129Xe MRI to Quantify the Pulmonary Ventilation Distribution." Academic Radiology 23, no. 12 (December 2016): 1521-1531.

PMID
27617823
Full Text

Ray, S, Chiba, N, Yao, C, Guan, X, McConnell, AM, Brockway, B, Que, L, McQualter, JL, and Stripp, BR. "Rare SOX2+ Airway Progenitor Cells Generate KRT5+ Cells that Repopulate Damaged Alveolar Parenchyma following Influenza Virus Infection." Stem Cell Reports 7, no. 5 (November 2016): 817-825.

PMID
27773701
Full Text

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