Pulmonary, Allergy, and Critical Care Medicine

Loretta Georgina Que, MD

Professor of Medicine
Campus mail 279 Msrb1, Durham, NC 27710
Phone (919) 681-8551
Email address loretta.que@duke.edu

My research interests focus on studying the role of nitric oxide and related enzymes in the pathogenesis of lung disease, specifically that caused by nitrosative/oxidative stress. Proposed studies are performed in cell culture and applied to animal models of disease, then examined in human disease where relevant. It is our hope that by better understanding the role of NO and reactive nitrogen species in mediating inflammation, and regulating cell signaling, that we will not only help to unravel the basic mechanisms of NO related lung disease, but also provide a rationale for targeted therapeutic use of NO.

Key words: nitrosative defense, lung injury, nitric oxide

Education and Training

  • Pulmonary Fellow, Medicine, Duke University, 1993 - 1996
  • Clinical Instructor, Medicine, Yale University, 1992 - 1993
  • Medical Resident, Medicine, Yale University, 1989 - 1992
  • M.D., University of Chicago, 1989

Grants

Publications

Riley, IL, Murphy, B, Razouki, Z, Krishnan, JA, Apter, A, Okelo, S, Kraft, M, Feltner, C, Que, LG, and Boulware, LE. "A Systematic Review of Patient- and Family-Level Inhaled Corticosteroid Adherence Interventions in Black/African Americans." The Journal of Allergy and Clinical Immunology. in Practice 7, no. 4 (April 2019): 1184-1193.e3.

PMID
30395992
Full Text

Birukova, Anastasiya, Jaime Cyphert-Daly, R Ian Cumming, Yen-Rei Yu, Kymberly M. Gowdy, Loretta G. Que, and Robert M. Tighe. “Sex Modifies Acute Ozone-Mediated Airway Physiologic Responses..” Toxicological Sciences : An Official Journal of the Society of Toxicology, March 2, 2019. https://doi.org/10.1093/toxsci/kfz056.

PMID
30825310
Full Text

Tang, M, Henderson, RJ, Holbrook, JT, Que, LG, Mathews, AM, Wise, RA, Dixon, AE, Peters, SP, Rogers, L, Smith, LJ, Teague, WG, and Lang, JE. "Does Obesity Increase Respiratory Tract Infections in Patients with Asthma?." The Journal of Allergy and Clinical Immunology. in Practice 7, no. 3 (March 2019): 954-961.e6.

PMID
30312805
Full Text

Yang, Z, Bochkov, YA, Voelker, DR, Foster, MW, and Que, LG. "Identification of a Novel Inhibitor of Human Rhinovirus Replication and Inflammation in Airway Epithelial Cells." American Journal of Respiratory Cell and Molecular Biology 60, no. 1 (January 2019): 58-67.

PMID
30156431
Full Text

Baker, AM, Holbrook, JT, Yohannes, AM, Eakin, MN, Sugar, EA, Henderson, RJ, Casper, AS, Kaminsky, DA, Rea, AL, Mathews, AM, Que, LG, Ramsdell, JW, Gerald, LB, Wise, RA, Hanania, NA, and for American Lung Association Airways Clinical Research Centers, . "Test Performance Characteristics of the AIR, GAD-7 and HADS-Anxiety Screening Questionnaires for Anxiety in Chronic Obstructive Pulmonary Disease." Annals of the American Thoracic Society (July 9, 2018).

PMID
29986152
Full Text

Que, Loretta G., Zhonghui Yang, Njira L. Lugogo, Rohit K. Katial, Steven A. Shoemaker, Janice M. Troha, David M. Rodman, Robert M. Tighe, and Monica Kraft. “Effect of the S-nitrosoglutathione reductase inhibitor N6022 on bronchial hyperreactivity in asthma..” Immun Inflamm Dis 6, no. 2 (June 2018): 322–31. https://doi.org/10.1002/iid3.220.

PMID
29642282
Full Text

Riley, Isaretta L., L Ebony Boulware, Jie-Lena Sun, Karen Chiswell, Loretta G. Que, Monica Kraft, Jamie L. Todd, Scott M. Palmer, and Monique L. Anderson. “Factors associated with reporting results for pulmonary clinical trials in ClinicalTrials.gov..” Clinical Trials (London, England) 15, no. 1 (February 2018): 87–94. https://doi.org/10.1177/1740774517740352.

PMID
29121787
Full Text

Paul, Devon W., Nigel B. Neely, Meredith Clement, Isaretta Riley, Mashael Al-Hegelan, Matthew Phelan, Monica Kraft, et al. “Development and validation of an electronic medical record (EMR)-based computed phenotype of HIV-1 infection..” Journal of the American Medical Informatics Association : Jamia 25, no. 2 (February 2018): 150–57. https://doi.org/10.1093/jamia/ocx061.

PMID
28645207
Full Text

Paul, DW, Lagat, DK, MacIntyre, N, Egger, JR, Murdoch, DM, Que, LG, and Kussin, PS. "Validation of spirometry prediction equations in western Kenya." The International Journal of Tuberculosis and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease 22, no. 1 (January 2018): 112-118.

PMID
29297435
Full Text

Wu, J, Yang, J, Yang, K, Wang, H, Gorentla, B, Shin, J, Qiu, Y, Que, LG, Foster, WM, Xia, Z, Chi, H, and Zhong, X-P. "iNKT cells require TSC1 for terminal maturation and effector lineage fate decisions." The Journal of Clinical Investigation 127, no. 11 (November 2017): 4216-null.

PMID
29091076
Full Text

Pages