Loretta Georgina Que, MD

Professor of Medicine
Campus mail 279 Msrb1, Durham, NC 27710
Phone (919) 681-8551
Email address loretta.que@duke.edu

My research interests focus on studying the role of nitric oxide and related enzymes in the pathogenesis of lung disease, specifically that caused by nitrosative/oxidative stress. Proposed studies are performed in cell culture and applied to animal models of disease, then examined in human disease where relevant. It is our hope that by better understanding the role of NO and reactive nitrogen species in mediating inflammation, and regulating cell signaling, that we will not only help to unravel the basic mechanisms of NO related lung disease, but also provide a rationale for targeted therapeutic use of NO.

Key words: nitrosative defense, lung injury, nitric oxide

Education and Training

  • Pulmonary Fellow, Medicine, Duke University, 1993 - 1996
  • Clinical Instructor, Medicine, Yale University, 1992 - 1993
  • Medical Resident, Medicine, Yale University, 1989 - 1992
  • M.D., University of Chicago, 1989

Publications

Birukova, Anastasiya, Jaime Cyphert-Daly, Robert Ian Cumming, Yen-Rei Yu, Kymberly M. Gowdy, Loretta G. Que, and Robert M. Tighe. “Sex Modifies Acute Ozone-Mediated Airway Physiologic Responses..” Toxicol Sci, June 1, 2019. https://doi.org/10.1093/toxsci/kfz056.

PMID
30825310
Full Text

Lazarus, Stephen C., Jerry A. Krishnan, Tonya S. King, Jason E. Lang, Kathryn V. Blake, Ronina Covar, Njira Lugogo, et al. “Mometasone or Tiotropium in Mild Asthma with a Low Sputum Eosinophil Level..” N Engl J Med 380, no. 21 (May 23, 2019): 2009–19. https://doi.org/10.1056/NEJMoa1814917.

PMID
31112384
Full Text

Yang, Shigao, Alfred T. Harding, Catherine Sweeney, David Miao, Gregory Swan, Connie Zhou, Zhaozhao Jiang, et al. “Control of antiviral innate immune response by protein geranylgeranylation..” Sci Adv, May 2019. https://doi.org/10.1126/sciadv.aav7999.

PMID
31149635
Full Text

Bose, Sonali, Robert J. Henderson, Linda Rogers, Thomas Casale, Gwen Skloot, Xavier Soler, Robert A. Wise, and Loretta G. Que. “Identifying an at-risk population for poor asthma outcomes: Data from the American Lung Association Asthma Clinical Trials Registry..” J Allergy Clin Immunol Pract, April 28, 2019. https://doi.org/10.1016/j.jaip.2019.04.024.

PMID
31042562
Full Text

Riley, Isaretta L., Beverly Murphy, Zayd Razouki, Jerry A. Krishnan, Andrea Apter, Sande Okelo, Monica Kraft, Cindy Feltner, Loretta G. Que, and L Ebony Boulware. “A Systematic Review of Patient- and Family-Level Inhaled Corticosteroid Adherence Interventions in Black/African Americans..” J Allergy Clin Immunol Pract 7, no. 4 (April 2019): 1184-1193.e3. https://doi.org/10.1016/j.jaip.2018.10.036.

PMID
30395992
Full Text

Tang, Monica, Robert J. Henderson, Janet T. Holbrook, Loretta G. Que, Anne M. Mathews, Robert A. Wise, Anne E. Dixon, et al. “Does Obesity Increase Respiratory Tract Infections in Patients with Asthma?.” J Allergy Clin Immunol Pract, March 2019. https://doi.org/10.1016/j.jaip.2018.09.033.

PMID
30312805
Full Text

Ihrie, Mark, Victoria McQuade, Akhil Hegde, Jingjing Niu, Jenny Tong, David D’Alessio, Julia K. L. Walker, Loretta G. Que, and Jennifer L. Ingram. “Sleeve gastrectomy surgery reduces airway resistance and inflammation in chronically allergen-challenged obese mice.” In Journal of Allergy and Clinical Immunology, 143:AB307–AB307. Elsevier BV, 2019. https://doi.org/10.1016/j.jaci.2018.12.935.

Full Text

Yu, Y. A., J. Daly, S. Phelan, R. I. Cumming, A. Birukova, Y. Malakhau, J. L. Ingram, M. D. Gunn, L. G. Que, and R. M. Tighe. “Replacement of Fetal-Derived with Bone Marrow-Derived Pulmonary Resident Macrophages Reduces House Dust Mite-Induced Airway Hyperresponsiveness.” In American Journal of Respiratory and Critical Care Medicine, Vol. 199. AMER THORACIC SOC, 2019.

Scholars@Duke

Daly, J., Z. Yang, J. L. Ingram, R. M. Tighe, and L. G. Que. “Physiologic Response to Chronic House Dust Mite Exposure in Mice Is Dependent on Lot Characteristics.” In American Journal of Respiratory and Critical Care Medicine, Vol. 199. AMER THORACIC SOC, 2019.

Scholars@Duke

Yang, Zhonghui, Yury A. Bochkov, Dennis R. Voelker, Matthew W. Foster, and Loretta G. Que. “Identification of a Novel Inhibitor of Human Rhinovirus Replication and Inflammation in Airway Epithelial Cells..” Am J Respir Cell Mol Biol, January 2019. https://doi.org/10.1165/rcmb.2018-0058OC.

PMID
30156431
Full Text

Pages