Loretta Georgina Que, MD

Associate Professor of Medicine
Campus mail 279 MSRB1, Durham, NC 27710
Phone (919) 681-8551
Email address que00001@duke.edu

My research interests focus on studying the role of nitric oxide and related enzymes in the pathogenesis of lung disease, specifically that caused by nitrosative/oxidative stress. Proposed studies are performed in cell culture and applied to animal models of disease, then examined in human disease where relevant. It is our hope that by better understanding the role of NO and reactive nitrogen species in mediating inflammation, and regulating cell signaling, that we will not only help to unravel the basic mechanisms of NO related lung disease, but also provide a rationale for targeted therapeutic use of NO.

Key words: nitrosative defense, lung injury, nitric oxide

Education and Training

  • Pulmonary Fellow, Medicine, Duke University, 1993 - 1996
  • Clinical Instructor, Medicine, Yale University, 1992 - 1993
  • Medical Resident, Medicine, Yale University, 1989 - 1992
  • M.D., University of Chicago, 1989

Publications

Durack, J, Lynch, SV, Nariya, S, Bhakta, NR, Beigelman, A, Castro, M, Dyer, A-M, Israel, E, Kraft, M, Martin, RJ, Mauger, DT, Rosenberg, SR, Sharp-King, T, White, SR, Woodruff, PG, Avila, PC, Denlinger, LC, Holguin, F, Lazarus, SC, Lugogo, N, Moore, WC, Peters, SP, Que, L, Smith, LJ, Sorkness, CA, Wechsler, ME, Wenzel, SE, Boushey, HA, Huang, YJ, National Heart, and Lung and Blood Institute's “AsthmaNet”, . "Features of the bronchial bacterial microbiome associated with atopy, asthma, and responsiveness to inhaled corticosteroid treatment." The Journal of allergy and clinical immunology 140, no. 1 (July 2017): 63-75.

PMID
27838347
Full Text

Winnica, D, Que, LG, Baffi, C, Grasemann, H, Fiedler, K, Yang, Z, Etling, E, Wasil, K, Wenzel, SE, Freeman, B, and Holguin, F. "l-citrulline prevents asymmetric dimethylarginine-mediated reductions in nitric oxide and nitrosative stress in primary human airway epithelial cells." Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 47, no. 2 (February 2017): 190-199.

PMID
27562295
Full Text

He, M, Driehuys, B, Que, LG, and Huang, Y-CT. "Using Hyperpolarized 129Xe MRI to Quantify the Pulmonary Ventilation Distribution." Academic radiology 23, no. 12 (December 2016): 1521-1531.

PMID
27617823
Full Text

Ray, S, Chiba, N, Yao, C, Guan, X, McConnell, AM, Brockway, B, Que, L, McQualter, JL, and Stripp, BR. "Rare SOX2+ Airway Progenitor Cells Generate KRT5+ Cells that Repopulate Damaged Alveolar Parenchyma following Influenza Virus Infection." Stem cell reports 7, no. 5 (November 2016): 817-825.

PMID
27773701
Full Text

Baffi, CW, Wood, L, Winnica, D, Strollo, PJ, Gladwin, MT, Que, LG, and Holguin, F. "Metabolic Syndrome and the Lung." Chest 149, no. 6 (June 2016): 1525-1534. (Review)

PMID
26836925
Full Text

Ingram, JL, Slade, D, Church, TD, Francisco, D, Heck, K, Sigmon, RW, Ghio, M, Murillo, A, Firszt, R, Lugogo, NL, Que, L, Sunday, ME, and Kraft, M. "Role of Matrix Metalloproteinases-1 and -2 in Interleukin-13-Suppressed Elastin in Airway Fibroblasts in Asthma." American journal of respiratory cell and molecular biology 54, no. 1 (January 2016): 41-50.

PMID
26074138
Full Text

Mehta, K, Soderblom, EJ, Thompson, JW, Que, LG, Marshall, HE, Moseley, MA, and Foster, MW. "Targeted proteomics for unraveling the post-translational regulation of human nitric oxide synthase 2." Nitric Oxide 42C (November 15, 2014): 132-.

PMID
25519622
Full Text

Ledford, JG, Addison, KJ, Foster, MW, and Que, LG. "Eosinophil-associated lung diseases. A cry for surfactant proteins A and D help?." American journal of respiratory cell and molecular biology 51, no. 5 (November 2014): 604-614. (Review)

PMID
24960334
Full Text

Castro, M, King, TS, Kunselman, SJ, Cabana, MD, Denlinger, L, Holguin, F, Kazani, SD, Moore, WC, Moy, J, Sorkness, CA, Avila, P, Bacharier, LB, Bleecker, E, Boushey, HA, Chmiel, J, Fitzpatrick, AM, Gentile, D, Hundal, M, Israel, E, Kraft, M, Krishnan, JA, LaForce, C, Lazarus, SC, Lemanske, R, Lugogo, N, Martin, RJ, Mauger, DT, Naureckas, E, Peters, SP, Phipatanakul, W, Que, LG, Sheshadri, A, Smith, L, Solway, J, Sullivan-Vedder, L, Sumino, K, Wechsler, ME, Wenzel, S, White, SR, and Sutherland, ER et al. "Effect of vitamin D3 on asthma treatment failures in adults with symptomatic asthma and lower vitamin D levels: the VIDA randomized clinical trial." JAMA 311, no. 20 (May 2014): 2083-2091.

PMID
24838406
Full Text

Catania, J, Que, LG, Govert, JA, Hollingsworth, JW, and Wolfe, CR. "High intensive care unit admission rate for 2013-2014 influenza is associated with a low rate of vaccination." American journal of respiratory and critical care medicine 189, no. 4 (February 2014): 485-487. (Letter)

PMID
24512430
Full Text

Pages