Loretta Georgina Que, MD

Professor of Medicine
Campus mail 279 Msrb1, Durham, NC 27710
Phone (919) 681-8551
Email address loretta.que@duke.edu

My research interests focus on studying the role of nitric oxide and related enzymes in the pathogenesis of lung disease, specifically that caused by nitrosative/oxidative stress. Proposed studies are performed in cell culture and applied to animal models of disease, then examined in human disease where relevant. It is our hope that by better understanding the role of NO and reactive nitrogen species in mediating inflammation, and regulating cell signaling, that we will not only help to unravel the basic mechanisms of NO related lung disease, but also provide a rationale for targeted therapeutic use of NO.

Key words: nitrosative defense, lung injury, nitric oxide

Education and Training

  • Pulmonary Fellow, Medicine, Duke University, 1993 - 1996
  • Clinical Instructor, Medicine, Yale University, 1992 - 1993
  • Medical Resident, Medicine, Yale University, 1989 - 1992
  • M.D., The University of Chicago, 1989

Grants

Publications

Chabata, Charlene V., James W. Frederiksen, Lyra B. Olson, Ibtehaj A. Naqvi, Sharon E. Hall, Ruwan Gunaratne, Bryan D. Kraft, Loretta G. Que, Lingye Chen, and Bruce A. Sullenger. “Combining Heparin and a FX/Xa Aptamer to Reduce Thrombin Generation in Cardiopulmonary Bypass and COVID-19.” Nucleic Acid Ther, January 12, 2022. https://doi.org/10.1089/nat.2021.0077.

PMID
35021888
Full Text

Ortega, Victor E., Michelle Daya, Stanley J. Szefler, Eugene R. Bleecker, Vernon M. Chinchilli, Wanda Phipatanakul, Dave Mauger, et al. “Pharmacogenetic studies of long-acting beta agonist and inhaled corticosteroid responsiveness in randomised controlled trials of individuals of African descent with asthma.” Lancet Child Adolesc Health 5, no. 12 (December 2021): 862–72. https://doi.org/10.1016/S2352-4642(21)00268-6.

PMID
34762840
Full Text

Khatri, Sumita B., Jonathan M. Iaccarino, Amisha Barochia, Israa Soghier, Praveen Akuthota, Anna Brady, Ronina A. Covar, et al. “Use of Fractional Exhaled Nitric Oxide to Guide the Treatment of Asthma: An Official American Thoracic Society Clinical Practice Guideline.” Am J Respir Crit Care Med 204, no. 10 (November 15, 2021): e97–109. https://doi.org/10.1164/rccm.202109-2093ST.

PMID
34779751
Full Text

Khatri, Sumita B., Jonathan M. Laccarino, Amisha Barochia, Israa Soghier, Praveen Akuthota, Anna Brady, Ronina A. Covar, et al. “Use of Fractional Exhaled Nitric Oxide to Guide the Treatment of Asthma An Official American Thoracic Society Clinical Practice Guideline: Executive Summary.” American Journal of Respiratory and Critical Care Medicine 204, no. 10 (November 15, 2021): 1132–42.

Scholars@Duke

Vose, Aaron, Matthew McCravy, Anastasiya Birukova, Zhonghui Yang, John W. Hollingsworth, Loretta G. Que, and Robert M. Tighe. “Wood smoke particle exposure in mice reduces the severity of influenza infection.” Toxicol Appl Pharmacol 426 (September 1, 2021): 115645. https://doi.org/10.1016/j.taap.2021.115645.

PMID
34271066
Full Text

Duchene, Brittany, Sarah Caffry, David A. Kaminsky, Loretta G. Que, Matthew E. Poynter, and Anne E. Dixon. “Functional significance of 8-isoprostanes in sinonasal disease and asthma.” Respir Med 185 (August 2021): 106506. https://doi.org/10.1016/j.rmed.2021.106506.

PMID
34166960
Full Text

Chun, Hyung J., Elias Coutavas, Alexander B. Pine, Alfred I. Lee, Vanessa L. Yu, Marcus K. Shallow, Coral X. Giovacchini, et al. “Immunofibrotic drivers of impaired lung function in postacute sequelae of SARS-CoV-2 infection.” Jci Insight 6, no. 14 (July 22, 2021). https://doi.org/10.1172/jci.insight.148476.

PMID
34111030
Full Text

Heggestad, Jacob T., David S. Kinnamon, Lyra B. Olson, Jason Liu, Garrett Kelly, Simone A. Wall, Solomon Oshabaheebwa, et al. “Multiplexed, quantitative serological profiling of COVID-19 from blood by a point-of-care test.” Sci Adv 7, no. 26 (June 2021). https://doi.org/10.1126/sciadv.abg4901.

PMID
34172447
Full Text

Navuluri, Neelima, Maria L. Srour, Peter S. Kussin, David M. Murdoch, Neil R. MacIntyre, Loretta G. Que, Nathan M. Thielman, and Eric D. McCollum. “Oxygen delivery systems for adults in Sub-Saharan Africa: A scoping review.” J Glob Health 11 (May 8, 2021): 04018. https://doi.org/10.7189/jogh.11.04018.

PMID
34026051
Full Text

Pages