Pulmonary, Allergy, and Critical Care Medicine

Loretta Georgina Que, MD

Professor of Medicine
Campus mail 279 Msrb1, Durham, NC 27710
Phone (919) 681-8551
Email address loretta.que@duke.edu

My research interests focus on studying the role of nitric oxide and related enzymes in the pathogenesis of lung disease, specifically that caused by nitrosative/oxidative stress. Proposed studies are performed in cell culture and applied to animal models of disease, then examined in human disease where relevant. It is our hope that by better understanding the role of NO and reactive nitrogen species in mediating inflammation, and regulating cell signaling, that we will not only help to unravel the basic mechanisms of NO related lung disease, but also provide a rationale for targeted therapeutic use of NO.

Key words: nitrosative defense, lung injury, nitric oxide

Education and Training

  • Pulmonary Fellow, Medicine, Duke University, 1993 - 1996
  • Clinical Instructor, Medicine, Yale University, 1992 - 1993
  • Medical Resident, Medicine, Yale University, 1989 - 1992
  • M.D., The University of Chicago, 1989

Grants

Publications

Holguin, Fernando, Hartmut Grasemann, Sunita Sharma, Daniel Winnica, Karen Wasil, Vong Smith, Margaret H. Cruse, et al. “L-Citrulline increases nitric oxide and improves control in obese asthmatics.” Jci Insight 4, no. 24 (December 19, 2019). https://doi.org/10.1172/jci.insight.131733.

PMID
31714895
Full Text

Bose, Sonali, Robert J. Henderson, Linda Rogers, Thomas Casale, Gwen Skloot, Xavier Soler, Robert A. Wise, and Loretta G. Que. “Identifying an at-risk population for poor asthma outcomes: Data from the American Lung Association Asthma Clinical Trials Registry.” J Allergy Clin Immunol Pract, November 2019. https://doi.org/10.1016/j.jaip.2019.04.024.

PMID
31042562
Full Text

Cyphert-Daly, Jaime M., Zhonghui Yang, Jennifer L. Ingram, Robert M. Tighe, and Loretta G. Que. “Physiologic response to chronic house dust mite exposure in mice is dependent on lot characteristics.” In J Allergy Clin Immunol, 144:1428-1432.e8, 2019. https://doi.org/10.1016/j.jaci.2019.07.019.

PMID
31369802
Full Text

Winnica, Daniel, Catherine Corey, Steven Mullett, Michael Reynolds, Gabrielle Hill, Stacy Wendell, Loretta Que, Fernando Holguin, and Sruti Shiva. “Bioenergetic Differences in the Airway Epithelium of Lean Versus Obese Asthmatics Are Driven by Nitric Oxide and Reflected in Circulating Platelets.” Antioxid Redox Signal 31, no. 10 (October 1, 2019): 673–86. https://doi.org/10.1089/ars.2018.7627.

PMID
30608004
Full Text

Wechsler, Michael E., Stanley J. Szefler, Victor E. Ortega, Jacqueline A. Pongracic, Vernon Chinchilli, John J. Lima, Jerry A. Krishnan, et al. “Step-Up Therapy in Black Children and Adults with Poorly Controlled Asthma.” N Engl J Med 381, no. 13 (September 26, 2019): 1227–39. https://doi.org/10.1056/NEJMoa1905560.

PMID
31553835
Full Text

Dy, Alane Blythe C., Muhammad Z. Arif, Kenneth J. Addison, Loretta G. Que, Scott Boitano, Monica Kraft, and Julie G. Ledford. “Genetic Variation in Surfactant Protein-A2 Delays Resolution of Eosinophilia in Asthma.” J Immunol 203, no. 5 (September 1, 2019): 1122–30. https://doi.org/10.4049/jimmunol.1900546.

PMID
31350355
Full Text

Birukova, Anastasiya, Jaime Cyphert-Daly, Robert Ian Cumming, Yen-Rei Yu, Kymberly M. Gowdy, Loretta G. Que, and Robert M. Tighe. “Sex Modifies Acute Ozone-Mediated Airway Physiologic Responses.” Toxicol Sci, June 1, 2019. https://doi.org/10.1093/toxsci/kfz056.

PMID
30825310
Full Text

Lazarus, Stephen C., Jerry A. Krishnan, Tonya S. King, Jason E. Lang, Kathryn V. Blake, Ronina Covar, Njira Lugogo, et al. “Mometasone or Tiotropium in Mild Asthma with a Low Sputum Eosinophil Level.” N Engl J Med 380, no. 21 (May 23, 2019): 2009–19. https://doi.org/10.1056/NEJMoa1814917.

PMID
31112384
Full Text

Yang, Shigao, Alfred T. Harding, Catherine Sweeney, David Miao, Gregory Swan, Connie Zhou, Zhaozhao Jiang, et al. “Control of antiviral innate immune response by protein geranylgeranylation.” Sci Adv, May 2019. https://doi.org/10.1126/sciadv.aav7999.

PMID
31149635
Full Text

Riley, Isaretta L., Beverly Murphy, Zayd Razouki, Jerry A. Krishnan, Andrea Apter, Sande Okelo, Monica Kraft, Cindy Feltner, Loretta G. Que, and L Ebony Boulware. “A Systematic Review of Patient- and Family-Level Inhaled Corticosteroid Adherence Interventions in Black/African Americans.” J Allergy Clin Immunol Pract 7, no. 4 (April 2019): 1184-1193.e3. https://doi.org/10.1016/j.jaip.2018.10.036.

PMID
30395992
Full Text

Pages