Loretta Georgina Que, MD

Professor of Medicine
Campus mail 279 Msrb1, Durham, NC 27710
Phone (919) 681-8551
Email address loretta.que@duke.edu

My research interests focus on studying the role of nitric oxide and related enzymes in the pathogenesis of lung disease, specifically that caused by nitrosative/oxidative stress. Proposed studies are performed in cell culture and applied to animal models of disease, then examined in human disease where relevant. It is our hope that by better understanding the role of NO and reactive nitrogen species in mediating inflammation, and regulating cell signaling, that we will not only help to unravel the basic mechanisms of NO related lung disease, but also provide a rationale for targeted therapeutic use of NO.

Key words: nitrosative defense, lung injury, nitric oxide

Education and Training

  • Pulmonary Fellow, Medicine, Duke University, 1993 - 1996
  • Clinical Instructor, Medicine, Yale University, 1992 - 1993
  • Medical Resident, Medicine, Yale University, 1989 - 1992
  • M.D., The University of Chicago, 1989

Publications

Chun, Hyung J., Elias Coutavas, Alexander B. Pine, Alfred I. Lee, Vanessa L. Yu, Marcus K. Shallow, Coral X. Giovacchini, et al. “Immunofibrotic drivers of impaired lung function in postacute sequelae of SARS-CoV-2 infection.” Jci Insight 6, no. 14 (July 22, 2021). https://doi.org/10.1172/jci.insight.148476.

PMID
34111030
Full Text

Vose, Aaron, Matthew McCravy, Anastasiya Birukova, Zhonghui Yang, John W. Hollingsworth, Loretta G. Que, and Robert M. Tighe. “Wood smoke particle exposure in mice reduces the severity of influenza infection.” Toxicol Appl Pharmacol 426 (July 13, 2021): 115645. https://doi.org/10.1016/j.taap.2021.115645.

PMID
34271066
Full Text

Duchene, Brittany, Sarah Caffry, David A. Kaminsky, Loretta G. Que, Matthew E. Poynter, and Anne E. Dixon. “Functional significance of 8-isoprostanes in sinonasal disease and asthma.” Respir Med 185 (June 9, 2021): 106506. https://doi.org/10.1016/j.rmed.2021.106506.

PMID
34166960
Full Text

Heggestad, Jacob T., David S. Kinnamon, Lyra B. Olson, Jason Liu, Garrett Kelly, Simone A. Wall, Solomon Oshabaheebwa, et al. “Multiplexed, quantitative serological profiling of COVID-19 from blood by a point-of-care test.” Sci Adv 7, no. 26 (June 2021). https://doi.org/10.1126/sciadv.abg4901.

PMID
34172447
Full Text

Navuluri, Neelima, Maria L. Srour, Peter S. Kussin, David M. Murdoch, Neil R. MacIntyre, Loretta G. Que, Nathan M. Thielman, and Eric D. McCollum. “Oxygen delivery systems for adults in Sub-Saharan Africa: A scoping review.” J Glob Health 11 (May 8, 2021): 04018. https://doi.org/10.7189/jogh.11.04018.

PMID
34026051
Full Text

Wang, Ziyi, Leith Rankine, Elianna A. Bier, David Mummy, Junlan Lu, Alex Church, Robert M. Tighe, et al. “Using hyperpolarized 129Xe gas-exchange MRI to model the regional airspace, membrane, and capillary contributions to diffusing capacity.” J Appl Physiol (1985) 130, no. 5 (May 1, 2021): 1398–1409. https://doi.org/10.1152/japplphysiol.00702.2020.

PMID
33734831
Full Text

Olson, Lyra B., Ibtehaj A. Naqvi, Daniel J. Turner, Sarah A. Morrison, Bryan D. Kraft, Lingye Chen, Bruce A. Sullenger, Smita K. Nair, Loretta G. Que, and Jerrold H. Levy. “Key Pathogenic Factors in Coronavirus Disease 2019-Associated Coagulopathy and Acute Lung Injury Highlighted in a Patient With Copresentation of Acute Myelocytic Leukemia: A Case Report.” A a Pract 15, no. 4 (March 30, 2021): e01432. https://doi.org/10.1213/XAA.0000000000001432.

PMID
33783367
Full Text

Chun, Hyung J., Elias Coutavas, Alexander Pine, Alfred I. Lee, Vanessa Yu, Marcus Shallow, Coral X. Giovacchini, et al. “Immuno-fibrotic drivers of impaired lung function in post-COVID-19 syndrome.” Medrxiv, February 6, 2021. https://doi.org/10.1101/2021.01.31.21250870.

PMID
33564789
Full Text

Riley, Isaretta L., Bryonna Jackson, Donna Crabtree, Shaun Riebl, Loretta G. Que, Roy Pleasants, and L Ebony Boulware. “A Scoping Review of International Barriers to Asthma Medication Adherence Mapped to the Theoretical Domains Framework.” J Allergy Clin Immunol Pract 9, no. 1 (January 2021): 410-418.e4. https://doi.org/10.1016/j.jaip.2020.08.021.

PMID
32861047
Full Text

Yohannes, Abebaw M., Michelle N Eakin, Janet T. Holbrook, Elizabeth A. Sugar, Robert Henderson, Anna M. Baker, Anne S. Casper, et al. “Association of mild cognitive impairment and characteristic of COPD and overall health status in a cohort study.” Expert Rev Respir Med 15, no. 1 (January 2021): 153–59. https://doi.org/10.1080/17476348.2021.1838278.

PMID
33054443
Full Text

Pages