Loretta Georgina Que, MD

Associate Professor of Medicine
Campus mail 279 MSRB1, Durham, NC 27710
Phone (919) 681-8551
Email address loretta.que@duke.edu

My research interests focus on studying the role of nitric oxide and related enzymes in the pathogenesis of lung disease, specifically that caused by nitrosative/oxidative stress. Proposed studies are performed in cell culture and applied to animal models of disease, then examined in human disease where relevant. It is our hope that by better understanding the role of NO and reactive nitrogen species in mediating inflammation, and regulating cell signaling, that we will not only help to unravel the basic mechanisms of NO related lung disease, but also provide a rationale for targeted therapeutic use of NO.

Key words: nitrosative defense, lung injury, nitric oxide

Education and Training

  • Pulmonary Fellow, Medicine, Duke University, 1993 - 1996
  • Clinical Instructor, Medicine, Yale University, 1992 - 1993
  • Medical Resident, Medicine, Yale University, 1989 - 1992
  • M.D., University of Chicago, 1989

Publications

Ingram, JL, Slade, D, Church, TD, Francisco, D, Heck, K, Sigmon, RW, Ghio, M, Murillo, A, Firszt, R, Lugogo, NL, Que, L, Sunday, ME, and Kraft, M. "Role of Matrix Metalloproteinases-1 and -2 in Interleukin-13-Suppressed Elastin in Airway Fibroblasts in Asthma." American Journal of Respiratory Cell and Molecular Biology 54, no. 1 (January 2016): 41-50.

PMID
26074138
Full Text

Yu, Y-RA, O'Koren, EG, Hotten, DF, Kan, MJ, Kopin, D, Nelson, ER, Que, L, and Gunn, MD. "A Protocol for the Comprehensive Flow Cytometric Analysis of Immune Cells in Normal and Inflamed Murine Non-Lymphoid Tissues." Plos One 11, no. 3 (January 2016): e0150606-null.

PMID
26938654
Full Text

Mehta, K, Soderblom, EJ, Thompson, JW, Que, LG, Marshall, HE, Moseley, MA, and Foster, MW. "Targeted proteomics for unraveling the post-translational regulation of human nitric oxide synthase 2." Nitric Oxide 42C (November 15, 2014): 132-.

PMID
25519622
Full Text

Ledford, JG, Addison, KJ, Foster, MW, and Que, LG. "Eosinophil-associated lung diseases. A cry for surfactant proteins A and D help?." American Journal of Respiratory Cell and Molecular Biology 51, no. 5 (November 2014): 604-614. (Review)

PMID
24960334
Full Text

Castro, M, King, TS, Kunselman, SJ, Cabana, MD, Denlinger, L, Holguin, F, Kazani, SD, Moore, WC, Moy, J, Sorkness, CA, Avila, P, Bacharier, LB, Bleecker, E, Boushey, HA, Chmiel, J, Fitzpatrick, AM, Gentile, D, Hundal, M, Israel, E, Kraft, M, Krishnan, JA, LaForce, C, Lazarus, SC, Lemanske, R, Lugogo, N, Martin, RJ, Mauger, DT, Naureckas, E, Peters, SP, Phipatanakul, W, Que, LG, Sheshadri, A, Smith, L, Solway, J, Sullivan-Vedder, L, Sumino, K, Wechsler, ME, Wenzel, S, White, SR, Sutherland, ER, National Heart, Lung, and and Blood Institute’s AsthmaNet, . "Effect of vitamin D3 on asthma treatment failures in adults with symptomatic asthma and lower vitamin D levels: the VIDA randomized clinical trial." Jama 311, no. 20 (May 2014): 2083-2091.

PMID
24838406
Full Text

Catania, J, Que, LG, Govert, JA, Hollingsworth, JW, and Wolfe, CR. "High intensive care unit admission rate for 2013-2014 influenza is associated with a low rate of vaccination." American Journal of Respiratory and Critical Care Medicine 189, no. 4 (February 2014): 485-487. (Letter)

PMID
24512430
Full Text

Foster, MW, Thompson, JW, Que, LG, Yang, IV, Schwartz, DA, Moseley, MA, and Marshall, HE. "Proteomic analysis of human bronchoalveolar lavage fluid after subsgemental exposure." J Proteome Res 12, no. 5 (May 3, 2013): 2194-2205.

PMID
23550723
Full Text

Wang, Y, Zhu, Z, Church, TD, Lugogo, NL, Que, LG, Francisco, D, Ingram, JL, Huggins, M, Beaver, DM, Wright, JR, and Kraft, M. "SHP-1 as a critical regulator of Mycoplasma pneumoniae-induced inflammation in human asthmatic airway epithelial cells." J Immunol 188, no. 7 (April 1, 2012): 3371-3381.

PMID
22371396
Full Text

Foster, MW, Yang, Z, Gooden, DM, Thompson, JW, Ball, CH, Turner, ME, Hou, Y, Pi, J, Moseley, MA, and Que, LG. "Proteomic characterization of the cellular response to nitrosative stress mediated by s-nitrosoglutathione reductase inhibition." Journal of Proteome Research 11, no. 4 (April 2012): 2480-2491.

PMID
22390303
Full Text

Yang, IV, Tomfohr, J, Singh, J, Foss, CM, Marshall, HE, Que, LG, McElvania-Tekippe, E, Florence, S, Sundy, JS, and Schwartz, DA. "The clinical and environmental determinants of airway transcriptional profiles in allergic asthma." American Journal of Respiratory and Critical Care Medicine 185, no. 6 (March 2012): 620-627.

PMID
22246175
Full Text

Pages