Loretta Georgina Que, MD

Professor of Medicine
Campus mail 279 Msrb1, Durham, NC 27710
Phone (919) 681-8551
Email address loretta.que@duke.edu

My research interests focus on studying the role of nitric oxide and related enzymes in the pathogenesis of lung disease, specifically that caused by nitrosative/oxidative stress. Proposed studies are performed in cell culture and applied to animal models of disease, then examined in human disease where relevant. It is our hope that by better understanding the role of NO and reactive nitrogen species in mediating inflammation, and regulating cell signaling, that we will not only help to unravel the basic mechanisms of NO related lung disease, but also provide a rationale for targeted therapeutic use of NO.

Key words: nitrosative defense, lung injury, nitric oxide

Education and Training

  • Pulmonary Fellow, Medicine, Duke University, 1993 - 1996
  • Clinical Instructor, Medicine, Yale University, 1992 - 1993
  • Medical Resident, Medicine, Yale University, 1989 - 1992
  • M.D., The University of Chicago, 1989

Grants

Publications

Tang, Monica, Robert J. Henderson, Janet T. Holbrook, Loretta G. Que, Anne M. Mathews, Robert A. Wise, Anne E. Dixon, et al. “Does Obesity Increase Respiratory Tract Infections in Patients with Asthma?” J Allergy Clin Immunol Pract, March 2019. https://doi.org/10.1016/j.jaip.2018.09.033.

PMID
30312805
Full Text

Ihrie, Mark, Victoria McQuade, Akhil Hegde, Jingjing Niu, Jenny Tong, David D’Alessio, Julia K. L. Walker, Loretta G. Que, and Jennifer L. Ingram. “Sleeve gastrectomy surgery reduces airway resistance and inflammation in chronically allergen-challenged obese mice.” In Journal of Allergy and Clinical Immunology, 143:AB307–AB307. Elsevier BV, 2019. https://doi.org/10.1016/j.jaci.2018.12.935.

Full Text

Yang, Zhonghui, Yury A. Bochkov, Dennis R. Voelker, Matthew W. Foster, and Loretta G. Que. “Identification of a Novel Inhibitor of Human Rhinovirus Replication and Inflammation in Airway Epithelial Cells.” Am J Respir Cell Mol Biol, January 2019. https://doi.org/10.1165/rcmb.2018-0058OC.

PMID
30156431
Full Text

Riley, I., R. A. Pleasants, D. Crabtree, S. Riebel, L. Svetkey, L. G. Que, M. Handley, A. Cattamanchi, H. Bosworth, and L. E. Boulware. “AdheRence to Inhaled Corticosteroids in Asthma (ARICA): Intervention Development.” In American Journal of Respiratory and Critical Care Medicine, Vol. 199. AMER THORACIC SOC, 2019.

Scholars@Duke

Holguin, F., S. Sharma, D. E. Winnica, K. Wasil, V. L. Smith, M. H. Cruse, N. Perez, et al. “L-Citrulline as Add-On Therapy to Increase Exhaled Nitric Oxide and Improve Lung Function and Asthma Control in Obese Asthmatics.” In American Journal of Respiratory and Critical Care Medicine, Vol. 199. AMER THORACIC SOC, 2019.

Scholars@Duke

Winnica, D. E., S. Sharma, L. G. Que, S. Ye, V. L. Smith, M. H. Cruse, N. Perez, and F. Holguin. “Up-Regulation of Paraoxonase 2 in Human Bronchial Epithelial Cells.” In American Journal of Respiratory and Critical Care Medicine, Vol. 199. AMER THORACIC SOC, 2019.

Scholars@Duke

Yu, Y. A., J. Daly, S. Phelan, R. I. Cumming, A. Birukova, Y. Malakhau, J. L. Ingram, M. D. Gunn, L. G. Que, and R. M. Tighe. “Replacement of Fetal-Derived with Bone Marrow-Derived Pulmonary Resident Macrophages Reduces House Dust Mite-Induced Airway Hyperresponsiveness.” In American Journal of Respiratory and Critical Care Medicine, Vol. 199. AMER THORACIC SOC, 2019.

Scholars@Duke

Baker, Anna M., Janet T. Holbrook, Abebaw M. Yohannes, Michelle N. Eakin, Elizabeth A. Sugar, Robert J. Henderson, Anne S. Casper, et al. “Test Performance Characteristics of the AIR, GAD-7, and HADS-Anxiety Screening Questionnaires for Anxiety in Chronic Obstructive Pulmonary Disease.” Ann Am Thorac Soc, August 2018. https://doi.org/10.1513/AnnalsATS.201708-631OC.

PMID
29986152
Full Text

Que, Loretta G., Zhonghui Yang, Njira L. Lugogo, Rohit K. Katial, Steven A. Shoemaker, Janice M. Troha, David M. Rodman, Robert M. Tighe, and Monica Kraft. “Effect of the S-nitrosoglutathione reductase inhibitor N6022 on bronchial hyperreactivity in asthma.” Immun Inflamm Dis, June 2018. https://doi.org/10.1002/iid3.220.

PMID
29642282
Full Text

Paul, Devon W., Nigel B. Neely, Meredith Clement, Isaretta Riley, Mashael Al-Hegelan, Matthew Phelan, Monica Kraft, et al. “Development and validation of an electronic medical record (EMR)-based computed phenotype of HIV-1 infection.” J Am Med Inform Assoc, February 1, 2018. https://doi.org/10.1093/jamia/ocx061.

PMID
28645207
Full Text

Pages