Loretta Georgina Que, MD

Professor of Medicine
Campus mail 279 Msrb1, Durham, NC 27710
Phone (919) 681-8551
Email address loretta.que@duke.edu

My research interests focus on studying the role of nitric oxide and related enzymes in the pathogenesis of lung disease, specifically that caused by nitrosative/oxidative stress. Proposed studies are performed in cell culture and applied to animal models of disease, then examined in human disease where relevant. It is our hope that by better understanding the role of NO and reactive nitrogen species in mediating inflammation, and regulating cell signaling, that we will not only help to unravel the basic mechanisms of NO related lung disease, but also provide a rationale for targeted therapeutic use of NO.

Key words: nitrosative defense, lung injury, nitric oxide

Education and Training

  • Pulmonary Fellow, Medicine, Duke University, 1993 - 1996
  • Clinical Instructor, Medicine, Yale University, 1992 - 1993
  • Medical Resident, Medicine, Yale University, 1989 - 1992
  • M.D., University of Chicago, 1989

Grants

Publications

Paul, D. W., D. K. Lagat, N. MacIntyre, J. R. Egger, D. M. Murdoch, L. G. Que, and P. S. Kussin. “Validation of spirometry prediction equations in western Kenya..” Int J Tuberc Lung Dis 22, no. 1 (January 1, 2018): 112–18. https://doi.org/10.5588/ijtld.17.0005.

PMID
29297435
Full Text

Yang, Z., Y. A. Bochkov, D. R. Voelker, M. W. Foster, and L. G. Que. “S-Nitrosoglutathione Reductase Inhibitor Blockade of Rhinovirus A16 Replication by Targeting ICAM-1.” In American Journal of Respiratory and Critical Care Medicine, Vol. 197. AMER THORACIC SOC, 2018.

Scholars@Duke

Yang, Z., J. Daly, D. E. Winnica, F. Holguin, V. McQuade, J. L. Ingram, R. M. Tighe, and L. G. Que. “Characterization of Paraoxonases in Mice with Obese Allergic Asthma.” In American Journal of Respiratory and Critical Care Medicine, Vol. 197. AMER THORACIC SOC, 2018.

Scholars@Duke

Ingram, J. L., V. McQuade, B. Theriot, J. Niu, J. Daly, J. Wong, J. Tong, R. M. Tighe, L. G. Que, and D. D’Alessio. “Vertical Sleeve Gastrectomy in Allergen-Challenged Obese Mice Is Associated with Reduced Airway Resistance and Fibrosis.” In American Journal of Respiratory and Critical Care Medicine, Vol. 197. AMER THORACIC SOC, 2018.

Scholars@Duke

Holguin, F., C. Liu, S. A. A. Comhair, S. Hazen, E. R. Bleecker, W. W. Busse, W. J. Calhoun, et al. “Upregulation of Paraxonase 1 (PON1) in Severe Asthma.” In American Journal of Respiratory and Critical Care Medicine, Vol. 197. AMER THORACIC SOC, 2018.

Scholars@Duke

Mathews, A. M., A. M. Baker, J. T. Holbrook, A. M. Yohannes, M. Eakin, E. A. Sugar, R. Henderson, et al. “The Relationship Between Sleep Quality, Age, and Quality of Life in Patients with COPD and Clinical Depression and Anxiety.” In American Journal of Respiratory and Critical Care Medicine, Vol. 197. AMER THORACIC SOC, 2018.

Scholars@Duke

Yohannes, A. M., M. Eakin, J. T. Holbrook, E. M. Sugar, R. Henderson, A. M. Baker, D. A. Kaminsky, et al. “Chronic Obstructive Pulmonary Disease Related with Increased Risk of Mild Cognitive Impairment.” In American Journal of Respiratory and Critical Care Medicine, Vol. 197. AMER THORACIC SOC, 2018.

Scholars@Duke

Pederson, W., M. Prasetyo, J. M. Cyphert, R. M. Tighe, L. G. Que, and J. G. Ledford. “Genetic Variation in Surfactant Protein-A2 Differentially Mediates Responses to Ozone.” In American Journal of Respiratory and Critical Care Medicine, Vol. 197. AMER THORACIC SOC, 2018.

Scholars@Duke

Winnica, D. E., C. Corey, L. G. Que, F. Holguin, and S. Shiva. “Platelet and Airway Epithelium Bioenergetics Are Different in Obese Versus Lean Asthmatics.” In American Journal of Respiratory and Critical Care Medicine, Vol. 197. AMER THORACIC SOC, 2018.

Scholars@Duke

Wu, Jinhong, Jialong Yang, Kai Yang, Hongxia Wang, Balachandra Gorentla, Jinwook Shin, Yurong Qiu, et al. “iNKT cells require TSC1 for terminal maturation and effector lineage fate decisions..” J Clin Invest, November 1, 2017. https://doi.org/10.1172/JCI98066.

PMID
29091076
Full Text

Pages