Loretta Georgina Que, MD

Professor of Medicine
Campus mail 279 Msrb1, Durham, NC 27710
Phone (919) 681-8551
Email address loretta.que@duke.edu

My research interests focus on studying the role of nitric oxide and related enzymes in the pathogenesis of lung disease, specifically that caused by nitrosative/oxidative stress. Proposed studies are performed in cell culture and applied to animal models of disease, then examined in human disease where relevant. It is our hope that by better understanding the role of NO and reactive nitrogen species in mediating inflammation, and regulating cell signaling, that we will not only help to unravel the basic mechanisms of NO related lung disease, but also provide a rationale for targeted therapeutic use of NO.

Key words: nitrosative defense, lung injury, nitric oxide

Education and Training

  • Pulmonary Fellow, Medicine, Duke University, 1993 - 1996
  • Clinical Instructor, Medicine, Yale University, 1992 - 1993
  • Medical Resident, Medicine, Yale University, 1989 - 1992
  • M.D., University of Chicago, 1989

Grants

Publications

Mehta, K., E. J. Soderblom, J. W. Thompson, L. G. Que, H. E. Marshall, M. A. Moseley, and M. W. Foster. “Targeted proteomics for unraveling the post-translational regulation of human nitric oxide synthase 2..” Nitric Oxide 42C (November 15, 2014). https://doi.org/10.1016/j.niox.2014.09.100.

PMID
25519622
Full Text

Ledford, Julie G., Kenneth J. Addison, Matthew W. Foster, and Loretta G. Que. “Eosinophil-associated lung diseases. A cry for surfactant proteins A and D help?.” Am J Respir Cell Mol Biol 51, no. 5 (November 2014): 604–14. https://doi.org/10.1165/rcmb.2014-0095TR.

PMID
24960334
Full Text

Castro, Mario, Tonya S. King, Susan J. Kunselman, Michael D. Cabana, Loren Denlinger, Fernando Holguin, Shamsah D. Kazani, et al. “Effect of vitamin D3 on asthma treatment failures in adults with symptomatic asthma and lower vitamin D levels: the VIDA randomized clinical trial..” Jama 311, no. 20 (May 2014): 2083–91. https://doi.org/10.1001/jama.2014.5052.

PMID
24838406
Full Text

Catania, Jelena, Loretta G. Que, Joseph A. Govert, John W. Hollingsworth, and Cameron R. Wolfe. “High intensive care unit admission rate for 2013-2014 influenza is associated with a low rate of vaccination..” Am J Respir Crit Care Med 189, no. 4 (February 15, 2014): 485–87. https://doi.org/10.1164/rccm.201401-0066LE.

PMID
24512430
Full Text

Wang, Y., D. C. Francisco, N. Lugogo, J. Thomas, D. M. Beaver, J. W. Hollingsworth, W. M. Foster, et al. “Genetic Variation In Surfactant Protein A2 Alters Airway Epithelial Response To Mycoplasma Pneumoniae Infection In Asthma.” In American Journal of Respiratory and Critical Care Medicine, Vol. 189. AMER THORACIC SOC, 2014.

Scholars@Duke

Foster, Matthew W., J Will Thompson, Loretta G. Que, Ivana V. Yang, David A. Schwartz, M Arthur Moseley, and Harvey E. Marshall. “Proteomic analysis of human bronchoalveolar lavage fluid after subsgemental exposure..” J Proteome Res 12, no. 5 (May 3, 2013): 2194–2205. https://doi.org/10.1021/pr400066g.

PMID
23550723
Full Text

Foster, M. W., J. W. Thompson, L. G. Que, I. V. Yang, D. A. Schwartz, M. A. Moseley, and H. E. Marshall. “Proteomic Analysis Of Human Bronchoalveolar Lavage Fluid After Subsegmental Challenge.” American Journal of Respiratory and Critical Care Medicine 187 (2013).

Scholars@Duke

Wang, Y., D. Francisco, J. M. Thomas, N. Lugogo, L. G. Que, J. G. Ledford, S. Choudhury, D. Beaver, and M. Kraft. “Surfactant Protein A Inhibits Il-13-Induced Pro-Inflammatory Response In Asthmatic Airway Epithelial Cells.” In American Journal of Respiratory and Critical Care Medicine, Vol. 187. AMER THORACIC SOC, 2013.

Scholars@Duke

Foster, Matthew W., Zhonghui Yang, David M. Gooden, J Will Thompson, Carol H. Ball, Meredith E. Turner, Yongyong Hou, Jingbo Pi, M Arthur Moseley, and Loretta G. Que. “Proteomic characterization of the cellular response to nitrosative stress mediated by s-nitrosoglutathione reductase inhibition..” J Proteome Res 11, no. 4 (April 6, 2012): 2480–91. https://doi.org/10.1021/pr201180m.

PMID
22390303
Full Text

Wang, Ying, Zhou Zhu, Tony D. Church, Njira L. Lugogo, Loretta G. Que, Dave Francisco, Jennifer L. Ingram, et al. “SHP-1 as a critical regulator of Mycoplasma pneumoniae-induced inflammation in human asthmatic airway epithelial cells..” J Immunol 188, no. 7 (April 1, 2012): 3371–81. https://doi.org/10.4049/jimmunol.1100573.

PMID
22371396
Full Text

Pages